Mohammed Asmal

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Antibody-dependent cell-mediated viral inhibition emerges after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys coincident with gp140-binding antibodies and is effective against neutralization-resistant viruses
    Mohammed Asmal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 85:5465-75. 2011
  2. pmc A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23673. 2011
  3. pmc Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys
    Wendy W Yeh
    Division of Viral Pathogenesis, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 84:6018-32. 2010
  4. pmc In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48234. 2012
  5. pmc Inhibition of HCV by the serpin antithrombin III
    Mohammed Asmal
    Division of Viral Pathogenesis, BIDMC, Boston, MA 02215, USA
    Virol J 9:226. 2012
  6. pmc Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys
    Yue Sun
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 330 Brookline Avenue, Boston, MA 02115, USA
    J Virol 85:6906-12. 2011
  7. pmc Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
    Norman L Letvin
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 3:81ra36. 2011
  8. pmc Efficiency of cell-free and cell-associated virus in mucosal transmission of human immunodeficiency virus type 1 and simian immunodeficiency virus
    Dror Kolodkin-Gal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 87:13589-97. 2013
  9. pmc Partial protection of Simian immunodeficiency virus (SIV)-infected rhesus monkeys against superinfection with a heterologous SIV isolate
    Wendy W Yeh
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, CLS 1043, 3 Blackfan Circle, Boston, MA 02115, USA
    J Virol 83:2686-96. 2009
  10. pmc Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication
    James B Whitney
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18589. 2011

Collaborators

Detail Information

Publications10

  1. pmc Antibody-dependent cell-mediated viral inhibition emerges after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys coincident with gp140-binding antibodies and is effective against neutralization-resistant viruses
    Mohammed Asmal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 85:5465-75. 2011
    ..These findings suggest that despite the ability of SIV to mutate and adapt to multiple immunologic pressures during the course of infection, SIV envelope may not escape the binding of autologous antibodies that mediate ADCVI...
  2. pmc A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, United States of America
    PLoS ONE 6:e23673. 2011
    ..These results support the potential utility of using a computational approach to examine large viral sequence data sets for functional signatures and indicate the importance of Envelope expression levels for efficient HIV transmission...
  3. pmc Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys
    Wendy W Yeh
    Division of Viral Pathogenesis, Department of Medicine, Harvard Medical School, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Virol 84:6018-32. 2010
    ..They also illustrate the capacity of the SIVmac quasispecies to modify antigenic determinants in response to very modest titers of neutralizing antibodies...
  4. pmc In vivo anti-HIV activity of the heparin-activated serine protease inhibitor antithrombin III encapsulated in lymph-targeting immunoliposomes
    Mohammed Asmal
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 7:e48234. 2012
    ..Ultimately, understanding how serpins, such as hep-ATIII, regulate host responses during HIV infection may reveal new avenues for therapeutic intervention...
  5. pmc Inhibition of HCV by the serpin antithrombin III
    Mohammed Asmal
    Division of Viral Pathogenesis, BIDMC, Boston, MA 02215, USA
    Virol J 9:226. 2012
    ..We have recently shown that ATIII, a serine protease inhibitor (serpin), has broad antiviral properties...
  6. pmc Antibody-dependent cell-mediated cytotoxicity in simian immunodeficiency virus-infected rhesus monkeys
    Yue Sun
    Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Center for Life Science, 330 Brookline Avenue, Boston, MA 02115, USA
    J Virol 85:6906-12. 2011
    ..This final observation raises the possibility that the antibodies that mediate ADCC are a subset of the antibodies detected in a binding assay and arise within weeks of infection...
  7. pmc Immune and Genetic Correlates of Vaccine Protection Against Mucosal Infection by SIV in Monkeys
    Norman L Letvin
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Sci Transl Med 3:81ra36. 2011
    ..This study begins to elucidate the mechanisms of vaccine protection against immunodeficiency viruses and highlights the need to analyze these immune and genetic correlates of protection in future trials of HIV vaccine strategies...
  8. pmc Efficiency of cell-free and cell-associated virus in mucosal transmission of human immunodeficiency virus type 1 and simian immunodeficiency virus
    Dror Kolodkin-Gal
    Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA
    J Virol 87:13589-97. 2013
    ..These findings may have significant implications for our understanding of the pathogenesis of mucosal transmission of HIV-1 and for the development of strategies to prevent HIV-1 transmission. ..
  9. pmc Partial protection of Simian immunodeficiency virus (SIV)-infected rhesus monkeys against superinfection with a heterologous SIV isolate
    Wendy W Yeh
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, CLS 1043, 3 Blackfan Circle, Boston, MA 02115, USA
    J Virol 83:2686-96. 2009
    ....
  10. pmc Serpin induced antiviral activity of prostaglandin synthetase-2 against HIV-1 replication
    James B Whitney
    Division of Viral Pathogenesis, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
    PLoS ONE 6:e18589. 2011
    ..These findings suggest a central role for serpins in the host innate anti-viral response. Host factors such as PTGS2 elicited by ATIII treatment could be exploited in the development of novel anti-viral interventions...