A Ascherio

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Caffeine, postmenopausal estrogen, and risk of Parkinson's disease
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 60:790-5. 2003
  2. ncbi request reprint Blood donations and risk of coronary heart disease in men
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 103:52-7. 2001
  3. ncbi request reprint Hepatitis B vaccination and the risk of multiple sclerosis
    A Ascherio
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 344:327-32. 2001
  4. ncbi request reprint Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:963-70. 1999
  5. ncbi request reprint Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 50:56-63. 2001
  6. ncbi request reprint Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study
    A Ascherio
    Harvard School of Public Health, Nutrition Department, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 286:3083-8. 2001
  7. ncbi request reprint Caffeinated clues from epidemiology of Parkinson's disease
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 61:S51-4. 2003
  8. ncbi request reprint Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men
    A Ascherio
    Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 98:1198-204. 1998
  9. pmc Temporal relationship between cigarette smoking and risk of Parkinson disease
    E L Thacker
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Neurology 68:764-8. 2007
  10. ncbi request reprint Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 57:75-80. 2001

Research Grants

Collaborators

Detail Information

Publications140 found, 100 shown here

  1. ncbi request reprint Caffeine, postmenopausal estrogen, and risk of Parkinson's disease
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 60:790-5. 2003
    ..Because this sex difference could be due to hormonal effects, the authors examined prospectively the risk of PD according to use of postmenopausal hormones and caffeine intake among participants in the Nurses' Health Study...
  2. ncbi request reprint Blood donations and risk of coronary heart disease in men
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 103:52-7. 2001
    ..In experimental animals, iron overload appears to promote atherosclerosis and ischemic myocardial damage, but the results of epidemiological studies that relate iron stores to risk of coronary heart disease (CHD) have been inconsistent...
  3. ncbi request reprint Hepatitis B vaccination and the risk of multiple sclerosis
    A Ascherio
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    N Engl J Med 344:327-32. 2001
    ..Reports of multiple sclerosis developing after hepatitis B vaccination have led to the concern that this vaccine might be a cause of multiple sclerosis in previously healthy subjects...
  4. ncbi request reprint Relation of consumption of vitamin E, vitamin C, and carotenoids to risk for stroke among men in the United States
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Ann Intern Med 130:963-70. 1999
    ..Antioxidants increase the resistance of low-density lipoprotein to oxidation and may thereby reduce risk for atherosclerosis...
  5. ncbi request reprint Prospective study of caffeine consumption and risk of Parkinson's disease in men and women
    A Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 50:56-63. 2001
    ..These results support a possible protective effect of moderate doses of caffeine on risk of Parkinson's disease...
  6. ncbi request reprint Epstein-Barr virus antibodies and risk of multiple sclerosis: a prospective study
    A Ascherio
    Harvard School of Public Health, Nutrition Department, 665 Huntington Ave, Boston, MA 02115, USA
    JAMA 286:3083-8. 2001
    ..Epidemiological studies suggest an association between infection with Epstein-Barr virus (EBV) and risk of multiple sclerosis (MS)...
  7. ncbi request reprint Caffeinated clues from epidemiology of Parkinson's disease
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 61:S51-4. 2003
  8. ncbi request reprint Intake of potassium, magnesium, calcium, and fiber and risk of stroke among US men
    A Ascherio
    Department of Nutrition, Epidemiology and Health and Social Behavior, Harvard School of Public Health, Boston, MA 02115, USA
    Circulation 98:1198-204. 1998
    ..Animal experiments and epidemiological studies have suggested that high potassium intake may reduce the risk of stroke, but the evidence is inconclusive, and the role of other nutrients in potassium-rich foods remains unknown...
  9. pmc Temporal relationship between cigarette smoking and risk of Parkinson disease
    E L Thacker
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Neurology 68:764-8. 2007
    ....
  10. ncbi request reprint Intakes of carotenoids, vitamin C, and vitamin E and MS risk among two large cohorts of women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 57:75-80. 2001
    ..Antioxidant nutrients may reduce the risk of MS. In a recent case-control study, vitamin C intake was significantly inversely associated with MS risk among women. However, no prospective data are available...
  11. ncbi request reprint Vitamin supplement use and the risk of non-Hodgkin's lymphoma among women and men
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 153:1056-63. 2001
    ..Because an elevated risk among multivitamin users was not observed consistently in the two cohorts and the pooled data were not significant, the elevated risk among women may be the result of chance...
  12. ncbi request reprint Smoking and risk of total and fatal prostate cancer in United States health professionals
    E Giovannucci
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Cancer Epidemiol Biomarkers Prev 8:277-82. 1999
    ..Our results indicate that although smoking was unrelated to prostate cancer incidence, recent tobacco use had a substantial impact on the occurrence of fatal prostate cancer...
  13. ncbi request reprint Fruit and vegetable intake in relation to risk of ischemic stroke
    K J Joshipura
    Department of Epidemiology, Harvard School of Public Health, Boston, Mass, USA
    JAMA 282:1233-9. 1999
    ..Few studies have evaluated the relationship between fruit and vegetable intake and cardiovascular disease...
  14. pmc Genetic predictors of 25-hydroxyvitamin D levels and risk of multiple sclerosis
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, 677 Huntington Ave, Building 2, 3rd Floor, Boston, MA 02115, USA
    J Neurol 258:1676-82. 2011
    ..91, 95% CI: 0.80, 1.04). This preliminary finding suggests the possibility that the putative beneficial effect of vitamin D on MS risk maybe attenuated in individuals carrying the HLA-DR15 MS risk allele...
  15. ncbi request reprint Adherence to the Dietary Guidelines for Americans and risk of major chronic disease in men
    M L McCullough
    Departments of Nutrition, Epidemiology, and Biostatistics, Harvard School of Public Health, Boston, MA, USA
    Am J Clin Nutr 72:1223-31. 2000
    ..The healthy eating index (HEI) measures the concordance of dietary patterns with these guidelines...
  16. ncbi request reprint Dietary saturated fats and their food sources in relation to the risk of coronary heart disease in women
    F B Hu
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA Hospital
    Am J Clin Nutr 70:1001-8. 1999
    ..Metabolic studies suggest that saturated fatty acids differ in their effects on blood lipids...
  17. pmc Habitual intake of dietary flavonoids and risk of Parkinson disease
    X Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA, USA
    Neurology 78:1138-45. 2012
    ..To prospectively examine whether higher intakes of total flavonoids and their subclasses (flavanones, anthocyanins, flavan-3-ols, flavonols, flavones, and polymers) were associated with a lower risk of developing Parkinson disease (PD)...
  18. ncbi request reprint Dietary fiber, glycemic load, and risk of NIDDM in men
    J Salmeron
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Diabetes Care 20:545-50. 1997
    ..Intake of carbohydrates that provide a large glycemic response has been hypothesized to increase the risk of NIDDM, whereas dietary fiber is suspected to reduce incidence. These hypotheses have not been evaluated prospectively...
  19. pmc Serum uric acid and risk of multiple sclerosis
    Jennifer Massa
    Departments of Epidemiology and Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    J Neurol 256:1643-8. 2009
    ..This lack of association is consistent with the interpretation that the lower urate levels among multiple sclerosis cases are a consequence rather than a cause of the disease...
  20. ncbi request reprint A prospective study of egg consumption and risk of cardiovascular disease in men and women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Boston, Mass 02115, USA
    JAMA 281:1387-94. 1999
    ..Reduction in egg consumption has been widely recommended to lower blood cholesterol levels and prevent coronary heart disease (CHD). Epidemiologic studies on egg consumption and risk of CHD are sparse...
  21. ncbi request reprint Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Neurology 59:1161-9. 2002
    ..Oxidative damage has been implicated in the pathogenesis of PD. Limited and mostly retrospective epidemiologic data suggest a reduction or no change in risk of PD associated with high vitamin E intake...
  22. ncbi request reprint Folate, vitamin B6, and B12 intakes in relation to risk of stroke among men
    Ka He
    Department of Nutrition, Harvard School of Public Health, Boston, Mass, USA
    Stroke 35:169-74. 2004
    ..However, the effects of intakes of these vitamins on risk of stroke are still uncertain. This study examines intakes of folate, vitamin B6, and B12 in relation to risk of ischemic and hemorrhagic stroke...
  23. ncbi request reprint Dietary fat in relation to risk of multiple sclerosis among two large cohorts of women
    S M Zhang
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 152:1056-64. 2000
    ..However, the authors observed a nonsignificantly lower risk of MS for a higher intake of linolenic acid. These findings do not support relations between intakes of total fat or major specific types of fat and the risk of MS...
  24. pmc Combined effects of smoking, anti-EBNA antibodies, and HLA-DRB1*1501 on multiple sclerosis risk
    K C Simon
    Departments of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Neurology 74:1365-71. 2010
    ..To examine the interplay between smoking, serum antibody titers to the Epstein-Barr virus nuclear antigens (anti-EBNA), and HLA-DR15 on multiple sclerosis (MS) risk...
  25. doi request reprint Integrating risk factors: HLA-DRB1*1501 and Epstein-Barr virus in multiple sclerosis
    P L De Jager
    Center for Neurologic Diseases, Department of Neurology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Neurology 70:1113-8. 2008
    ..Individuals with high levels of antibodies to the Epstein-Barr virus nuclear antigen 1 (EBNA-1) have an increased risk of developing multiple sclerosis (MS), but this association could be confounded by genetic susceptibility...
  26. ncbi request reprint The type of oil used for cooking is associated with the risk of nonfatal acute myocardial infarction in costa rica
    Edmond K Kabagambe
    Department of Nutrition, Harvard School of Public Health, Boston MA 02115, USA
    J Nutr 135:2674-9. 2005
    ..14; CI: 0.84-1.56). These data suggest that as currently used in Costa Rica, and most likely in many other developing countries, the replacement of palm oil with a polyunsaturated nonhydrogenated vegetable oil would reduce the risk of MI...
  27. pmc Bidirectional association between depression and obesity in middle-aged and older women
    A Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Int J Obes (Lond) 36:595-602. 2012
    ..We aimed to examine the bidirectional relationship in middle-aged and elderly women...
  28. ncbi request reprint Cigarette smoking and the incidence of Parkinson's disease in two prospective studies
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Ann Neurol 50:780-6. 2001
    ..These prospective findings confirm that an inverse association between smoking and the incidence of Parkinson's disease exists in both men and women...
  29. pmc Prospective study of chemical exposures and amyotrophic lateral sclerosis
    M G Weisskopf
    Harvard School of Public Health, Department of Environmental Health, Boston, MA 02215, USA
    J Neurol Neurosurg Psychiatry 80:558-61. 2009
    ..This study assessed the association between exposure to chemicals and risk of ALS in a prospective cohort study...
  30. ncbi request reprint Physical activity and risk of stroke in women
    F B Hu
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115
    JAMA 283:2961-7. 2000
    ..Persuasive evidence has demonstrated that increased physical activity is associated with substantial reduction in risk of coronary heart disease. However, the role of physical activity in the prevention of stroke is less well established...
  31. ncbi request reprint Physical activity and the risk of Parkinson disease
    H Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Neurology 64:664-9. 2005
    ..To investigate whether greater physical activity is associated with a lower risk of Parkinson disease (PD)...
  32. ncbi request reprint Vitamin D intake and incidence of multiple sclerosis
    K L Munger
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Neurology 62:60-5. 2004
    ..A protective effect of vitamin D on risk of multiple sclerosis (MS) has been proposed, but no prospective studies have addressed this hypothesis...
  33. ncbi request reprint Multiple sclerosis and age at infection with common viruses
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Epidemiology 12:301-6. 2001
    ..Late infection with other common viruses may also be associated with increased risk...
  34. pmc Anti-Epstein-Barr virus antibodies as serological markers of multiple sclerosis: a prospective study among United States military personnel
    K L Munger
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Mult Scler 17:1185-93. 2011
    ..Elevated Epstein-Barr virus (EBV) antibody titers are risk factors for multiple sclerosis (MS), but the strength and consistency of this association are not well characterized...
  35. ncbi request reprint The effect of fruit and vegetable intake on risk for coronary heart disease
    K J Joshipura
    Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Ann Intern Med 134:1106-14. 2001
    ..CONCLUSIONS: Consumption of fruits and vegetables, particularly green leafy vegetables and vitamin C-rich fruits and vegetables, appears to have a protective effect against coronary heart disease...
  36. ncbi request reprint Plasma titers of antibodies against Epstein-Barr virus BZLF1 and risk of multiple sclerosis
    J Massa
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neuroepidemiology 28:214-5. 2007
    ..Antibodies to BZLF1, the product of the homonymous early lytic gene, have been found to be related to risk of nasopharyngeal carcinoma, but have not been previously measured in MS studies...
  37. pmc Plasma urate and risk of Parkinson's disease
    M G Weisskopf
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 166:561-7. 2007
    ....
  38. doi request reprint Myelin oligodendrocyte glycoprotein antibodies and multiple sclerosis in healthy young adults
    H Wang
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Neurology 71:1142-6. 2008
    ..It remains uncertain whether the presence of serum anti-myelin oligodendrocyte glycoprotein (MOG) antibodies in healthy individuals contributes to predict their risk of developing multiple sclerosis (MS)...
  39. ncbi request reprint Prospective study of military service and mortality from ALS
    M G Weisskopf
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 64:32-7. 2005
    ..Two recent studies suggest that the risk of ALS is increased among Gulf War veterans. It is not known whether military service outside of the Gulf War is associated with increased risk of ALS...
  40. pmc Persistent organochlorine pesticides in serum and risk of Parkinson disease
    M G Weisskopf
    Harvard School of Public Health, Department of Environmental Health, Landmark Center, Boston, MA 02215, USA
    Neurology 74:1055-61. 2010
    ..No prior studies of pesticide exposure and PD used biomarkers of exposure collected before the onset of PD. Our investigation examined the association between prospective serum biomarkers of organochlorine pesticides and PD...
  41. pmc Bidirectional association between depression and type 2 diabetes mellitus in women
    An Pan
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Arch Intern Med 170:1884-91. 2010
    ..Although it has been hypothesized that the diabetes-depression relation is bidirectional, few studies have addressed this hypothesis in a prospective setting...
  42. ncbi request reprint Tooth loss and dietary intake
    Hsin Chia Hung
    Department of Epidemiology, Harvard School of Public Health, Boston, USA
    J Am Dent Assoc 134:1185-92. 2003
    ..Several studies have reported that impaired dentition status is associated with poor nutritional intake. However, most of these studies are cross-sectional and thus are unable to clarify the temporal sequence...
  43. pmc Caffeine and alcohol intakes have no association with risk of multiple sclerosis
    J Massa
    Department of Epidemiology, Harvard School of Public Health, USA
    Mult Scler 19:53-8. 2013
    ..The association between alcohol and caffeine intakes and risk of multiple sclerosis (MS) is unclear; no prospective studies have examined this relationship...
  44. ncbi request reprint Allergy, family history of autoimmune diseases, and the risk of multiple sclerosis
    A Alonso
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Acta Neurol Scand 117:15-20. 2008
    ..The present study assessed the association between history of allergy and autoimmune diseases, and the risk of MS...
  45. pmc Bidi and cigarette smoking and risk of acute myocardial infarction among males in urban India
    T Rastogi
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Tob Control 14:356-8. 2005
    ..1 (95% CI 4.7 to 17.7) and 8.1 (95% CI 4.3 to 15.3), respectively. It is estimated that smoking may cause 53% (95% CI 47% to 64%) of MIs among urban males in India...
  46. pmc Family history of melanoma and Parkinson disease risk
    X Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Neurology 73:1286-91. 2009
    ..If this was due to common genetic mechanisms, a positive family history of melanoma would be associated with an excessive PD risk, independent of environmental risk factors for PD...
  47. ncbi request reprint MAOB intron 13 and COMT codon 158 polymorphisms, cigarette smoking, and the risk of PD
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 58:1381-7. 2002
    ..Also, the association between never smoking and PD risk may be present only in people with the MAOB G allele...
  48. pmc Serum titers of IgG antibodies against tetanus and diphtheria toxoids and risk of multiple sclerosis
    J Massa
    Department of Nutrition, Harvard School of Public Health, Boston, MA, 02115, USA
    J Neuroimmunol 208:141-2. 2009
    ..76 (95% CI: 0.48-1.21) for tetanus (SD=4.71) and 1.03 (0.73-1.45) for diphtheria (SD=0.87). Results of this study suggest serum IgG antibodies against tetanus or diphtheria are not predictors of MS risk...
  49. pmc Human endogenous retrovirus-K18 Env as a risk factor in multiple sclerosis
    A K Tai
    Department of Pathology, Tufts University School of Medicine, Boston, Massachusetts, USA
    Mult Scler 14:1175-80. 2008
    ..3/K18.3 vs K18.2/K18.2 = 2.7; 95% confidence interval: 1.1-6.4).ConclusionVariation in EBV-associated superantigen HERV-K18 Env could influence the genetic susceptibility to MS...
  50. ncbi request reprint Coffee consumption and risk for type 2 diabetes mellitus
    Eduardo Salazar-Martinez
    Harvard School of Public Health, Channing Laboratory, Harvard Medical School, and Brigham and Women s Hospital, Boston, Massachusetts 02215, USA
    Ann Intern Med 140:1-8. 2004
    ..In small, short-term studies, acute administration of caffeine decreases insulin sensitivity and impairs glucose tolerance...
  51. pmc Plasma urate and progression of mild cognitive impairment
    Michael C Irizarry
    Department of Neurology, Massachusetts General Hospital, Boston, MA, USA
    Neurodegener Dis 6:23-8. 2009
    ..Impaired antioxidant defenses are implicated in neurodegenerative disease. The plasma levels of urate, a water-soluble antioxidant, are reduced in Alzheimer's disease (AD)...
  52. ncbi request reprint Soluble intercellular adhesion molecules, soluble vascular cell adhesion molecules, and risk of coronary heart disease
    Iris Shai
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Obesity (Silver Spring) 14:2099-106. 2006
    ....
  53. pmc 99th Dahlem conference on infection, inflammation and chronic inflammatory disorders: Epstein-Barr virus and multiple sclerosis: epidemiological evidence
    A Ascherio
    Harvard School of Public Health, 655 Huntington Avenue, Boston, MA 02115, USA
    Clin Exp Immunol 160:120-4. 2010
    ..However, while infection with EBV is consistent with many observations of MS epidemiology, there are some that remain unexplained, suggesting that other factors are also involved in determining risk...
  54. ncbi request reprint Cigarette smoking and incidence of multiple sclerosis
    M A Hernán
    Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 154:69-74. 2001
    ..Similar results were obtained after adjustment for other potential confounding factors. Although these prospective results do not prove a cause-and-effect relation, they suggest that smoking is associated with an increased risk of MS...
  55. pmc Polymorphisms of caffeine metabolism and estrogen receptor genes and risk of Parkinson's disease in men and women
    N Palacios
    Dept of Nutrition, Harvard School of Public Health 655 Huntington Ave, Boston, MA 02115, USA
    Parkinsonism Relat Disord 16:370-5. 2010
    ....
  56. pmc Serum urate as a predictor of clinical and radiographic progression in Parkinson disease
    Michael A Schwarzschild
    MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital, Boston, USA
    Arch Neurol 65:716-23. 2008
    ..To determine whether concentration of serum urate, a purine metabolite and potent antioxidant that has been linked to a reduced risk of Parkinson disease (PD), predicts prognosis in PD...
  57. ncbi request reprint Individual carotenoid concentrations in adipose tissue and plasma as biomarkers of dietary intake
    Ahmed El-Sohemy
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 76:172-9. 2002
    ..The ability of adipose tissue carotenoid concentrations to reflect dietary intake in population studies is unknown...
  58. ncbi request reprint Dietary and adipose tissue gamma-tocopherol and risk of myocardial infarction
    Ahmed El-Sohemy
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA
    Epidemiology 13:216-23. 2002
    ..Gamma-tocopherol, the most abundant form of dietary vitamin E, may lower the risk of coronary heart disease...
  59. ncbi request reprint Oral contraceptives and the incidence of multiple sclerosis
    M A Hernán
    Departments of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 55:848-54. 2000
    ..Experimental and clinical data suggest a protective effect of estrogens on the development and progression of MS...
  60. ncbi request reprint Prospective study of occupation and amyotrophic lateral sclerosis mortality
    M G Weisskopf
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 162:1146-52. 2005
    ..04). Results, which suggest that male programmers and laboratory technicians and female machine assemblers may be at increased risk of death from ALS, should be interpreted cautiously, however, because they are based on small numbers...
  61. ncbi request reprint Population-based study of alpha- and gamma-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults
    A el-Sohemy
    Department of Nutrition, Harvard School of Public Health, Boston 02115, USA
    Am J Clin Nutr 74:356-63. 2001
    ..The weak associations between alpha-tocopherol intake and plasma or adipose tissue concentrations suggest that these biomarkers are influenced more by factors other than alpha-tocopherol intake...
  62. ncbi request reprint Recent use of oral contraceptives and the risk of multiple sclerosis
    Alvaro Alonso
    Department of Epidemiology, Harvard School of Public Health, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arch Neurol 62:1362-5. 2005
    ..Exogenous estrogens affect the onset and clinical course of experimental allergic encephalomyelitis. Oral contraceptives, a frequent source of exogenous estrogens in humans, could have a role in the development of multiple sclerosis (MS)...
  63. pmc Smoking and disease progression in multiple sclerosis
    Brian C Healy
    Department of Neurology, Partners MS Center, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Arch Neurol 66:858-64. 2009
    ..Although cigarette smokers are at increased risk of developing multiple sclerosis (MS), the effect of smoking on the progression of MS remains uncertain...
  64. pmc Prenatal and early life factors and risk of Parkinson's disease
    Hannah Gardener
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 25:1560-7. 2010
    ..Left-handedness was associated with a 62% increased risk of PD in women but not in men. Further investigation of the relation between prenatal, perinatal, or neonatal factors and PD in other study populations is suggested...
  65. ncbi request reprint Alcohol consumption and risk for coronary heart disease among men with hypertension
    Joline W J Beulens
    Harvard School of Public Health, and Beth Israel Deaconess Medical Center, Boston, Massachusetts, USA
    Ann Intern Med 146:10-9. 2007
    ..However, data on the association between alcohol consumption and CVD among individuals with hypertension are scarce...
  66. pmc Infectious mononucleosis and risk of breast cancer in a prospective study of women
    J Massa
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Ave, Boston, MA 02115, USA
    Cancer Causes Control 23:1893-8. 2012
    ..We examined self-reported history and age at IM in relation to risk of invasive breast cancer...
  67. ncbi request reprint Reproducibility and validity of dietary patterns assessed with a food-frequency questionnaire
    F B Hu
    Department of Nutrition, Harvard School of Public Health, Brigham and Women s Hospital, Boston, MA 02115, USA
    Am J Clin Nutr 69:243-9. 1999
    ..Recently, the analysis of dietary patterns has emerged as a possible approach to examining diet-disease relations...
  68. pmc The relationship between handedness and risk of multiple sclerosis
    H Gardener
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA
    Mult Scler 15:587-92. 2009
    ..Left-handedness has been studied as a marker for in-utero exposure to sex steroid hormones, and an increased risk of autoimmune and immune disorders among left-handed individuals has been suggested...
  69. ncbi request reprint A prospective study of Chlamydia pneumoniae infection and risk of MS in two US cohorts
    K L Munger
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 62:1799-803. 2004
    ..Chlamydia pneumoniae (Cpn) has been proposed as a possible etiologic agent in multiple sclerosis (MS). However, previous studies were cross-sectional and could not assess whether Cpn infection preceded the onset of MS...
  70. pmc Use of ibuprofen and risk of Parkinson disease
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, 181 Longwood Ave, Boston, MA 02115, USA
    Neurology 76:863-9. 2011
    ..Use of nonsteroidal anti-inflammatory drugs (NSAID) in general, and possibly ibuprofen in particular, has been shown to be related to lower PD risk in previous epidemiologic studies...
  71. pmc Reproductive factors, exogenous estrogen use, and risk of Parkinson's disease
    Kelly Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 24:1359-65. 2009
    ..The use of postmenopausal hormone use may interact with other risk factors, but findings are preliminary and need confirmation in other populations...
  72. ncbi request reprint Diet and Parkinson's disease: a potential role of dairy products in men
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Ann Neurol 52:793-801. 2002
    ..Our results suggest that higher intake of dairy products may increase the risk of PD in men; however, this finding needs further evaluation, and the underlying active components need to be identified...
  73. pmc Obesity and restless legs syndrome in men and women
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Neurology 72:1255-61. 2009
    ..We therefore examined whether individuals who are obese have an increased risk of RLS in two ongoing US cohorts, the Nurses' Health Study II and the Health Professional Follow-up Study...
  74. ncbi request reprint Dietary fiber reduces peripheral arterial disease risk in men
    Anwar T Merchant
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 133:3658-63. 2003
    ..Fruit, vegetable and total fiber intakes were not associated with PAD risk. These results suggest an inverse association between cereal fiber intake and PAD risk in men. Increasing cereal fiber intake may prevent PAD...
  75. pmc Genetic determinants of hair color and Parkinson's disease risk
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA, USA
    Ann Neurol 65:76-82. 2009
    ....
  76. ncbi request reprint Dietary iron intake and blood donations in relation to risk of type 2 diabetes in men: a prospective cohort study
    Rui Jiang
    Departments of Nutrition and Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Clin Nutr 79:70-5. 2004
    ..Excessive iron stores may promote insulin resistance and lead to the development of type 2 diabetes. However, prospective data relating iron intake and blood donations (determinants of body iron stores) to diabetes incidence are limited...
  77. ncbi request reprint Obesity and the risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 159:547-55. 2004
    ..03) for waist-to-hip ratio. The results do not support a role of overall obesity in PD pathogenesis; however, central obesity may be associated with higher PD risk among never smokers, and this finding merits further investigation...
  78. pmc Dietary fat intake and risk of stroke in male US healthcare professionals: 14 year prospective cohort study
    Ka He
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    BMJ 327:777-82. 2003
    ..To examine the association between intake of total fat, specific types of fat, and cholesterol and risk of stroke in men. Design and setting Health professional follow up study with 14 year follow up...
  79. ncbi request reprint Diet and risk of ischemic heart disease in India
    Tanuja Rastogi
    Department of Nutrition, Harvard School of Public Health, Boston, USA
    Am J Clin Nutr 79:582-92. 2004
    ..Ischemic heart disease (IHD) is a leading cause of death in India. Dietary changes could reduce risk, but few studies have addressed the association between diet and IHD risk in India...
  80. doi request reprint Variations in gender ratios support the connection between smoking and Parkinson's disease
    Natalia Morozova
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Mov Disord 23:1414-9. 2008
    ..28; P = 0.0002) is comparable to the opposite trend observed for lung cancer, and supports an overall 74% reduction in risk of PD among smokers. Our results are consistent with the hypothesis that smoking reduces the risk of PD...
  81. pmc Vitamin C intake and serum uric acid concentration in men
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, Massachusetts 02115, USA
    J Rheumatol 35:1853-8. 2008
    ..We examined associations between vitamin C intake and serum uric acid in men in a population-based study...
  82. doi request reprint Familial aggregation of Parkinson's disease: a meta-analysis
    Evan L Thacker
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Mov Disord 23:1174-83. 2008
    ..Familial aggregation of PD is strong and unlikely to be due to chance or to deficiencies in study methodology...
  83. ncbi request reprint The use of B vitamin supplements and peripheral arterial disease risk in men are inversely related
    Anwar T Merchant
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    J Nutr 133:2863-7. 2003
    ..70, 95% CI 0.48-1.02, P-value, test for trend = 0.06) and B-12 (RR = 0.77, 95% CI 0.54-1.11, P-value, test for trend = 0.12). These results suggest that higher consumption of folate may contribute to the prevention of PAD...
  84. pmc Integration of genetic risk factors into a clinical algorithm for multiple sclerosis susceptibility: a weighted genetic risk score
    Philip L De Jager
    Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Lancet Neurol 8:1111-9. 2009
    ..We investigated the usefulness of an aggregate measure of risk of MS that is based on genetic susceptibility loci. We also assessed the added effect of environmental risk factors that are associated with susceptibility for MS...
  85. pmc Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality
    Eilis J O'Reilly
    Department of Epidemiology and Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Am J Epidemiol 169:678-82. 2009
    ..If the inverse association between smoking and Parkinson's disease were due to confounding by an environmental factor or were the result of reverse causation, it is unlikely that parental smoking would predict Parkinson's disease...
  86. pmc RLS in middle aged women and attention deficit/hyperactivity disorder in their offspring
    Xiang Gao
    Department of Nutrition, Harvard University School of Public Health, Boston, MA 02115, USA
    Sleep Med 12:89-91. 2011
    ..To test this hypothesis, we conducted a large-scaled cross-sectional study to examine whether women with a child with ADHD had a higher risk of having RLS than women of unaffected children...
  87. ncbi request reprint Adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction in Costa Rica
    Ana Baylin
    Department of Nutrition, Room 353A, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA
    Circulation 107:1586-91. 2003
    ..Alpha-linolenic acid may protect against cardiovascular disease. We examined the association between adipose tissue alpha-linolenic acid and nonfatal acute myocardial infarction (MI) in a population-based case-control study in Costa Rica...
  88. pmc Restless legs syndrome and Parkinson's disease in men
    Xiang Gao
    Channing Laboratory, Department of Medicine, Brigham and Women s Hospital, and Harvard Medical School, Boston, Massachusetts, USA
    Mov Disord 25:2654-7. 2010
    ..In conclusion, men with RLS are more likely to have concurrent PD. Prospective studies are warranted to clarify the temporal relationship between RLS and PD...
  89. pmc Plasma urate and Parkinson's disease in women
    Eilis J O'Reilly
    Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Am J Epidemiol 172:666-70. 2010
    ..Unlike in men, these findings do not support the hypothesis that urate is strongly associated with lower rates of Parkinson's disease among women...
  90. doi request reprint Vitamin D and multiple sclerosis
    Alberto Ascherio
    Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA
    Lancet Neurol 9:599-612. 2010
    ....
  91. ncbi request reprint Folate intake and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 160:368-75. 2004
    ..Intake of vitamin B(6) or vitamin B(12) also was not related to the risk of Parkinson's disease. The current study does not support the hypothesis that higher intake of folate or related B vitamins lowers the risk of Parkinson's disease...
  92. doi request reprint Epstein-barr virus infection and multiple sclerosis: a review
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Bldg 2, 3rd Fl, Boston, MA 02115, USA
    J Neuroimmune Pharmacol 5:271-7. 2010
    ..The biological mechanism by which EBV may cause MS is not known, but several possibilities are discussed...
  93. ncbi request reprint Dietary intakes of fat and risk of Parkinson's disease
    Honglei Chen
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Am J Epidemiol 157:1007-14. 2003
    ..65, 95% CI: 0.46, 0.91; p for trend = 0.05). Results do not support an important role of overall fat intake in the pathogenesis of Parkinson's disease, but a possible adverse effect of saturated fat for men could not be excluded...
  94. pmc Diethylstilbestrol exposure in utero and depression in women
    Eilis J O'Reilly
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, USA
    Am J Epidemiol 171:876-82. 2010
    ..Further research should assess whether in utero exposure to bisphenol A has similar adverse effects...
  95. pmc Polymorphisms in vitamin D metabolism related genes and risk of multiple sclerosis
    K Claire Simon
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Mult Scler 16:133-8. 2010
    ..The finding of a marginally significant gene-environment interaction requires replication in larger datasets, but suggests future genetic studies may benefit from considering relevant environmental context...
  96. ncbi request reprint Fish consumption and risk of stroke in men
    Ka He
    Department of Nutrition, Harvard School of Public Health, 665 Huntington Ave, Boston, Mass 02115, USA
    JAMA 288:3130-6. 2002
    ..The effect of fish consumption or long-chain omega-3 polyunsaturated fatty acid (PUFA) intake on risk of stroke remains uncertain...
  97. pmc Body size and risk of MS in two cohorts of US women
    Kassandra L Munger
    Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA
    Neurology 73:1543-50. 2009
    ..To examine whether obesity during childhood, adolescence, or adulthood is associated with an increased risk of multiple sclerosis (MS)...
  98. pmc Diet, urate, and Parkinson's disease risk in men
    Xiang Gao
    Department of Nutrition, School of Public Health, Harvard University, Boston, MA 02115, USA
    Am J Epidemiol 167:831-8. 2008
    ..These potential benefits, however, should be weighed against expected adverse effects on risk of gout and other chronic diseases...
  99. doi request reprint Diet and amyotrophic lateral sclerosis
    Natalia Morozova
    Departments of Nutrition, Harvard School of Public Health, Boston, MA 02215, USA
    Epidemiology 19:324-37. 2008
    ..Several dietary factors have been associated with risk of amyotrophic lateral sclerosis (ALS) in case-control studies, but no prospective studies have investigated diet and ALS...
  100. ncbi request reprint Vitamin E intake and risk of amyotrophic lateral sclerosis
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, 655 Huntington Avenue, Building 2, Boston, MA 02115, USA
    Ann Neurol 57:104-10. 2005
    ..004). In contrast, no significant associations were found for use of vitamin C or multivitamins. These results suggest that vitamin E supplementation could have a role in ALS prevention...
  101. ncbi request reprint Pesticide exposure and risk for Parkinson's disease
    Alberto Ascherio
    Department of Nutrition, Harvard School of Public Health, Boston, MA, USA
    Ann Neurol 60:197-203. 2006
    ..Chronic, low-dose exposure to pesticides is suspected to increase the risk for Parkinson's disease (PD), but data are inconclusive...

Research Grants1

  1. Epidemiology of cognitive dysfunction and Parkinson's
    Alberto Ascherio; Fiscal Year: 2003
    ..The interview will be conducted by telephone and take approximately 20-25 minutes to complete. As part of the proposed project, we will administer these tests to men and women with PD and age-matched healthy controls. ..