Vadim Y Arshavsky

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation
    Koji M Nishiguchi
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 427:75-8. 2004
  2. ncbi request reprint G proteins and phototransduction
    Vadim Y Arshavsky
    Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Physiol 64:153-87. 2002
  3. ncbi request reprint Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation
    Vadim Y Arshavsky
    Dept of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Trends Neurosci 25:124-6. 2002
  4. ncbi request reprint Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision
    Vadim Y Arshavsky
    Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Sci STKE 2003:PE43. 2003
  5. ncbi request reprint Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin
    Katherine J Strissel
    Department of Ophthalmology, Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:1146-53. 2006
  6. ncbi request reprint Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse
    Maxim Sokolov
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Biol Chem 279:19149-56. 2004
  7. pmc Functional comparison of RGS9 splice isoforms in a living cell
    Kirill A Martemyanov
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:20988-93. 2008
  8. ncbi request reprint The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo
    Kirill A Martemyanov
    Howe Laboratory of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 23:10175-81. 2003
  9. ncbi request reprint Specificity of G protein-RGS protein recognition is regulated by affinity adapters
    Kirill A Martemyanov
    Howe Laboratory of Ophthalmology, Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Neuron 38:857-62. 2003
  10. ncbi request reprint Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse
    Gabor Keresztes
    Department of Otolaryngology Eaton Peabody Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Biol Chem 279:1581-4. 2004

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Defects in RGS9 or its anchor protein R9AP in patients with slow photoreceptor deactivation
    Koji M Nishiguchi
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Nature 427:75-8. 2004
    ..To our knowledge, these patients represent the first identified humans with a phenotype associated with reduced RGS activity in any organ...
  2. ncbi request reprint G proteins and phototransduction
    Vadim Y Arshavsky
    Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Annu Rev Physiol 64:153-87. 2002
    ..We examine how the interplay between the mechanisms that contribute to amplification and those that govern termination of G protein activity determine the speed and the sensitivity of the cellular response to light...
  3. ncbi request reprint Rhodopsin phosphorylation: from terminating single photon responses to photoreceptor dark adaptation
    Vadim Y Arshavsky
    Dept of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Trends Neurosci 25:124-6. 2002
    ....
  4. ncbi request reprint Protein translocation in photoreceptor light adaptation: a common theme in vertebrate and invertebrate vision
    Vadim Y Arshavsky
    Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Sci STKE 2003:PE43. 2003
    ..Protein translocation is likely to contribute to photoreceptor light adaptation by adjusting the sensitivity and speed of photoresponse to ever-changing conditions of ambient illumination...
  5. ncbi request reprint Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin
    Katherine J Strissel
    Department of Ophthalmology, Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 26:1146-53. 2006
    ..Thus, arrestin movement to the outer segment leads to an increase in the free arrestin concentration and thereby may serve as a powerful mechanism of light adaptation...
  6. ncbi request reprint Phosducin facilitates light-driven transducin translocation in rod photoreceptors. Evidence from the phosducin knockout mouse
    Maxim Sokolov
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Biol Chem 279:19149-56. 2004
    ..This increased solubility of transducin would make it more susceptible to translocation from the outer segments...
  7. pmc Functional comparison of RGS9 splice isoforms in a living cell
    Kirill A Martemyanov
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 105:20988-93. 2008
    ..Such versatility makes RGS9-2 an isoform advantageous for timely signal inactivation across a wide range of stimulus strengths and may explain its predominant representation throughout the nervous system...
  8. ncbi request reprint The DEP domain determines subcellular targeting of the GTPase activating protein RGS9 in vivo
    Kirill A Martemyanov
    Howe Laboratory of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurosci 23:10175-81. 2003
    ..This presents the possibility that DEP domains might serve to target various DEP-containing proteins to the sites of their intracellular action via interactions with the members of extended SNARE protein family...
  9. ncbi request reprint Specificity of G protein-RGS protein recognition is regulated by affinity adapters
    Kirill A Martemyanov
    Howe Laboratory of Ophthalmology, Harvard Medical School, The Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Neuron 38:857-62. 2003
    ..Thus, the specific timing needs of different signaling pathways can be accommodated by affinity adapters positioned at various pathway components...
  10. ncbi request reprint Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse
    Gabor Keresztes
    Department of Otolaryngology Eaton Peabody Laboratory, Harvard Medical School, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, USA
    J Biol Chem 279:1581-4. 2004
    ..Gbeta5 complex, and therefore all three proteins, RGS9, Gbeta5 , and R9AP, are obligate members of the regulatory complex that speeds the rate at which transducin hydrolyzes GTP...
  11. ncbi request reprint Noncatalytic domains of RGS9-1.Gbeta 5L play a decisive role in establishing its substrate specificity
    Kirill A Martemyanov
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston Massachusetts 02114, USA
    J Biol Chem 277:32843-8. 2002
    ..Gbeta5L play a decisive role in establishing its substrate specificity, yet the high degree of this specificity observed under physiological conditions requires an additional contribution from the catalytic domain...
  12. ncbi request reprint Recoverin undergoes light-dependent intracellular translocation in rod photoreceptors
    Katherine J Strissel
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Biol Chem 280:29250-5. 2005
    ..To the contrary, no translocation of rhodopsin kinase itself or either GCAP was identified...
  13. ncbi request reprint Kinetic approaches to study the function of RGS9 isoforms
    Kirill A Martemyanov
    Howe Laboratory of Ophthalmology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Methods Enzymol 390:196-209. 2004
    ....
  14. ncbi request reprint RPGR isoforms in photoreceptor connecting cilia and the transitional zone of motile cilia
    Dong Hyun Hong
    Berman Gund Laboratory for the Study of Retinal Degenerations, Harvard Medical School, Boston, Massachusetts 02114, USA
    Invest Ophthalmol Vis Sci 44:2413-21. 2003
    ..There is as yet no consensus concerning the subcellular localization of RPGR. This study was undertaken as a comprehensive effort to resolve current controversies...
  15. ncbi request reprint Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin
    Martin Obin
    Laboratory for Nutrition and Vision Research, JMUSDA HNRCA at Tufts University and Tufts Center for Vision Research, Boston, Massachusetts 02111, USA
    J Biol Chem 277:44566-75. 2002
    ..We conclude that Tbetagamma is a substrate of the ubiquitin-proteasome pathway and suggest that phosducin serves to protect Tbetagamma following the light-dependent dissociation of Talphabetagamma...
  16. ncbi request reprint R7BP, a novel neuronal protein interacting with RGS proteins of the R7 family
    Kirill A Martemyanov
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    J Biol Chem 280:5133-6. 2005
    ..This suggests that R7BP interactions with R7 proteins in the brain may also bear major functional significance...
  17. ncbi request reprint Myosin III illuminates the mechanism of arrestin translocation
    Katherine J Strissel
    Howe Laboratory of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Neuron 43:2-4. 2004
    ..They show that arrestin is carried into the light-sensitive microvilli by phosphoinositide-enriched vesicles driven by a myosin motor...
  18. ncbi request reprint Massive light-driven translocation of transducin between the two major compartments of rod cells: a novel mechanism of light adaptation
    Maxim Sokolov
    Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA
    Neuron 34:95-106. 2002
    ....
  19. pmc Two temporal phases of light adaptation in retinal rods
    Peter D Calvert
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Gen Physiol 119:129-45. 2002
    ..Other possible mechanisms are discussed...
  20. ncbi request reprint Specific binding of RGS9-Gbeta 5L to protein anchor in photoreceptor membranes greatly enhances its catalytic activity
    Polina V Lishko
    Department of Ophthalmology, Harvard Medical School and the Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Biol Chem 277:24376-81. 2002
    ....
  21. ncbi request reprint Light-driven translocation of signaling proteins in vertebrate photoreceptors
    Peter D Calvert
    Department of Ophthalmology, SUNY Upstate Medical University, Syracuse, NY 13210, USA
    Trends Cell Biol 16:560-8. 2006
    ....
  22. pmc Transducin gamma-subunit sets expression levels of alpha- and beta-subunits and is crucial for rod viability
    Ekaterina S Lobanova
    Albert Eye Research Institute, Duke University, Durham, North Carolina 27710, USA
    J Neurosci 28:3510-20. 2008
    ..They further suggest that the production of transducin beta-subunit without its constitutive gamma-subunit partner sufficiently stresses the cellular biosynthetic and/or chaperone machinery to induce cell death...
  23. pmc Phosducin regulates the expression of transducin betagamma subunits in rod photoreceptors and does not contribute to phototransduction adaptation
    Claudia M Krispel
    Center for Neuroscience and Department of Ophthamology and Vision Science, University of California, Davis, CA 95618, USA
    J Gen Physiol 130:303-12. 2007
    ....
  24. pmc Structure and function of the visual arrestin oligomer
    Susan M Hanson
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    EMBO J 26:1726-36. 2007
    ..Thus, the tetramer likely serves as a 'storage' form of arrestin, increasing the arrestin-binding capacity of microtubules while readily dissociating to supply active monomer when it is needed to quench rhodopsin signaling...
  25. ncbi request reprint Transducin translocation in rods is triggered by saturation of the GTPase-activating complex
    Ekaterina S Lobanova
    Albert Eye Research Institute, Duke University Medical Center, Durham, North Carolina 27710, USA
    J Neurosci 27:1151-60. 2007
    ....
  26. ncbi request reprint Beyond counting photons: trials and trends in vertebrate visual transduction
    Marie E Burns
    Center for Neuroscience and Department of Psychiatry and Behavioral Sciences, University of California, Davis, Davis, California 95616, USA
    Neuron 48:387-401. 2005
    ..The same trend brings us closer to understanding how defects in photoreceptor signaling can lead to cell death and retinal degeneration...
  27. ncbi request reprint RGS expression rate-limits recovery of rod photoresponses
    Claudia M Krispel
    Center for Neuroscience, University of California, Davis, 95616, USA
    Neuron 51:409-16. 2006
    ..Our results show that G protein deactivation is normally at least 2.5 times slower than rhodopsin deactivation, resolving a long-standing controversy concerning the mechanism underlying the recovery of rod visual transduction...
  28. ncbi request reprint Kinetic mechanism of RGS9-1 potentiation by R9AP
    Sheila A Baker
    Department of Ophthalmology, Duke University, Durham, North Carolina 27710, USA
    Biochemistry 45:10690-7. 2006
    ..Gbeta5L and transducin. Together, these mechanisms ensure timely transducin inactivation in the course of the photoresponse, a requisite for normal vision...
  29. ncbi request reprint Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina
    Alapakkam P Sampath
    Department of Physiology and Biophysics, University of Washington, Seattle, Washington 98195, USA
    Neuron 46:413-20. 2005
    ..An important implication of our findings is that the recovery phase of the rod photoresponse does not contribute significantly to visual sensitivity near absolute threshold...
  30. pmc The outer segment serves as a default destination for the trafficking of membrane proteins in photoreceptors
    Sheila A Baker
    Albert Eye Research Institute, Duke University Medical Center, Durham, NC 27710, USA
    J Cell Biol 183:485-98. 2008
    ..This also implies that every protein residing outside the outer segment must have a means to avoid this "default" trafficking flow...
  31. ncbi request reprint The N terminus of GTP gamma S-activated transducin alpha-subunit interacts with the C terminus of the cGMP phosphodiesterase gamma-subunit
    Jennifer E Grant
    Department of Pharmacology, University of Wisconsin Medical School, Madison, 53706, USA
    J Biol Chem 281:6194-202. 2006
    ..This novel Galphat/PDEgamma interaction suggests that the transducin N terminus plays an active role in signal transduction...