M A Arnaout

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease
    M A Arnaout
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Annu Rev Med 52:93-123. 2001
  2. pmc Structure and mechanics of integrin-based cell adhesion
    M Amin Arnaout
    Nephrology Division, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 19:495-507. 2007
  3. ncbi request reprint Integrin structure, allostery, and bidirectional signaling
    M A Arnaout
    Structural Biology Program, Leukocyte Biology and Inflammation Program, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    Annu Rev Cell Dev Biol 21:381-410. 2005
  4. ncbi request reprint Coming to grips with integrin binding to ligands
    M Amin Arnaout
    Renal Unit, Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Cell Biol 14:641-51. 2002
  5. ncbi request reprint Integrin structure: new twists and turns in dynamic cell adhesion
    M Amin Arnaout
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Immunol Rev 186:125-40. 2002
  6. pmc Crystal structure of the extracellular segment of integrin alpha Vbeta3
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Science 294:339-45. 2001
  7. ncbi request reprint Integrins, cations and ligands: making the connection
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Thromb Haemost 1:1642-54. 2003
  8. pmc Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18
    N Dana
    Renal Unit, Massachusetts General Hospital, Boston, MA
    Proc Natl Acad Sci U S A 88:3106-10. 1991
  9. ncbi request reprint The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene
    Heiyoung Park
    Leukocyte Biology and Inflammation Program, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 101:894-902. 2003
  10. ncbi request reprint Two conformations of the integrin A-domain (I-domain): a pathway for activation?
    J O Lee
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Structure 3:1333-40. 1995

Research Grants

Collaborators

  • Wolfgang H Goldmann
  • G Mark Xu
  • Mark J Yeager
  • Carl S Shelley
  • Simon L Goodman
  • R Li
  • O Ibraghimov-Beskrovnaya
  • Q Zhang
  • C C Franklin
  • V Videm
  • K Kim
  • H Rabb
  • HORACIO CANTIELLO
  • Jian Ping Xiong
  • Vineet Gupta
  • Jose Luis Alonso
  • Heiyoung Park
  • Thilo Stehle
  • Takashi Sugimori
  • J P Xiong
  • V C Primo
  • Jiang Ping Xiong
  • Jun Y Park
  • Xiangen Li
  • Brian D Adair
  • Makram Essafi
  • Kaouther Ajroud
  • Fotini Nicolaou
  • T Stehle
  • Kah Tong Seow
  • C G Achaval
  • K J Moore
  • B Nikolic
  • R N Smith
  • S Marusic
  • Laura Ann Borrelli
  • Dirk Müller-Pompalla
  • Thomas Rysiok
  • Xianliang Rui
  • Bradley T Hyman
  • Bhuvaneshwari Mahalingham
  • Saurabh Anand
  • Makram Issafi
  • Petre Ianakiev
  • Annette Gylling
  • Jing Wei Xiong
  • Catherine Maddock
  • Dahmani M Fathallah
  • Nicolas Da Silva
  • Philippe Rousselot
  • Alexander Georgakis
  • Jens M Teodoridis
  • Omid C Farokhzad
  • Katalin Ferenczi
  • Christine Chomienne
  • Erwin P Bottinger
  • Jutta Welge
  • Rongguang Zhang
  • Friedrich Rippmann
  • Matthias Frech
  • Andrzej Joachimiak
  • R Zhang
  • A Joachimiak
  • R Dunker
  • D L Scott
  • B Diefenbach
  • B G Monks
  • R R Ingalls
  • L P Andersson
  • J O Lee
  • M W Freeman
  • D T Golenbock
  • E P Bottinger
  • D M Fathallah
  • M Michishita
  • R C Liddington
  • L A Bankston
  • O C Farokhzad
  • C Nelson
  • D Cherif
  • K Dellagi
  • N Dana
  • J L Niles
  • M F Ahmad
  • R T McCluskey

Detail Information

Publications42

  1. ncbi request reprint Molecular genetics and pathogenesis of autosomal dominant polycystic kidney disease
    M A Arnaout
    Renal Unit, Massachusetts General Hospital and Department of Medicine, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Annu Rev Med 52:93-123. 2001
    ....
  2. pmc Structure and mechanics of integrin-based cell adhesion
    M Amin Arnaout
    Nephrology Division, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, United States
    Curr Opin Cell Biol 19:495-507. 2007
    ..Recent advances in the structural elucidation of integrins and integrin-binding cytoskeleton proteins are the subjects of this review...
  3. ncbi request reprint Integrin structure, allostery, and bidirectional signaling
    M A Arnaout
    Structural Biology Program, Leukocyte Biology and Inflammation Program, Nephrology Division, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    Annu Rev Cell Dev Biol 21:381-410. 2005
    ..Newer NMR, crystallographic, and EM data, reviewed here, are providing a better picture of the dynamic integrin structure and the allosteric changes that guide its diverse functions...
  4. ncbi request reprint Coming to grips with integrin binding to ligands
    M Amin Arnaout
    Renal Unit, Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129, USA
    Curr Opin Cell Biol 14:641-51. 2002
    ..These models provide new insights into the molecular basis for ligand binding specificity in integrins and its regulation by activation-driven tertiary and quaternary changes...
  5. ncbi request reprint Integrin structure: new twists and turns in dynamic cell adhesion
    M Amin Arnaout
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Immunol Rev 186:125-40. 2002
    ..These findings provide the framework for new investigations of structure-activity relationships in integrins, with important implications for targeting these receptors therapeutically [corrected]...
  6. pmc Crystal structure of the extracellular segment of integrin alpha Vbeta3
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Science 294:339-45. 2001
    ..MIDAS lies adjacent to a calcium-binding site with a potential regulatory function...
  7. ncbi request reprint Integrins, cations and ligands: making the connection
    J P Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Thromb Haemost 1:1642-54. 2003
    ....
  8. pmc Expression of a soluble and functional form of the human beta 2 integrin CD11b/CD18
    N Dana
    Renal Unit, Massachusetts General Hospital, Boston, MA
    Proc Natl Acad Sci U S A 88:3106-10. 1991
    ..The secreted receptor exhibited direct and specific binding to its ligand, iC3b, the major complement C3 opsonin, and inhibited binding of polymorphonuclear cells to recombinant interleukin 1-activated endothelium...
  9. ncbi request reprint The zinc finger transcription factor ZBP-89 is a repressor of the human beta 2-integrin CD11b gene
    Heiyoung Park
    Leukocyte Biology and Inflammation Program, Renal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Blood 101:894-902. 2003
    ..A clear inverse relationship was observed in the latter but not the former state, suggesting that ZBP-89 represses CD11b gene expression during the further differentiation of monocytes into macrophages...
  10. ncbi request reprint Two conformations of the integrin A-domain (I-domain): a pathway for activation?
    J O Lee
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Structure 3:1333-40. 1995
    ....
  11. ncbi request reprint Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand
    Jian Ping Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Science 296:151-5. 2002
    ..Ligand binding induces small changes in the orientation of alphaV relative to beta3...
  12. ncbi request reprint New insights into the structural basis of integrin activation
    Jian Ping Xiong
    Renal Unit, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital, and Harvard Medical School, Charlestown, MA 02129, USA
    Blood 102:1155-9. 2003
    ..In this perspective, we develop a new hypothesis for integrin activation based on recent crystallographic, electron microscopic, and biochemical studies...
  13. pmc The beta-tail domain (betaTD) regulates physiologic ligand binding to integrin CD11b/CD18
    Vineet Gupta
    Nephrology Division, Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Blood 109:3513-20. 2007
    ..These data identify a role for the membrane proximal betaTD as an allosteric modulator of integrin activation...
  14. ncbi request reprint A novel adaptation of the integrin PSI domain revealed from its crystal structure
    Jian Ping Xiong
    Structural Biology Program, Leukocyte Biology and Inflammation Program, Renal Unit
    J Biol Chem 279:40252-4. 2004
    ..This architecture may be relevant to the evolution of integrins and should help refine the current models of integrin activation...
  15. ncbi request reprint Polycystin-1 interacts with intermediate filaments
    G M Xu
    Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 276:46544-52. 2001
    ..Polycystin-1 may utilize this association for structural, storage, or signaling functions...
  16. ncbi request reprint Mapping of the human CD11c (ITGAX) and CD11d (ITGAD) genes demonstrates that they are arranged in tandem separated by no more than 11.5 kb
    C S Shelley
    Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, Boston 02115, USA
    Genomics 49:334-6. 1998
  17. ncbi request reprint During differentiation of the monocytic cell line U937, Pur alpha mediates induction of the CD11c beta 2 integrin gene promoter
    C Simon Shelley
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Immunol 168:3887-93. 2002
    ..Together, these increases in the functional activity of both Puralpha and Sp1 combine to induce CD11c expression...
  18. pmc Crystal structure of the complete integrin alphaVbeta3 ectodomain plus an alpha/beta transmembrane fragment
    Jian Ping Xiong
    Program in Leukocyte Biology and Inflammation, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Cell Biol 186:589-600. 2009
    ....
  19. ncbi request reprint WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35
    G Mark Xu
    Polycystic Kidney Disease Program, Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    Genomics 79:87-94. 2002
    ..Immunofluorescence analysis colocalized WAC with SC35, the marker for pre-mRNA splicing machinery. Our analysis suggests that WAC represents a novel member of WW-domain-containing proteins for RNA processing...
  20. pmc The human beta 2 integrin CD18 promoter consists of two inverted Ets cis elements
    E P Bottinger
    Department of Medicine, Harvard Medical School, Charlestown, Massachusetts
    Mol Cell Biol 14:2604-15. 1994
    ....
  21. pmc Polycystin 1 is required for the structural integrity of blood vessels
    K Kim
    Renal Unit, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Proc Natl Acad Sci U S A 97:1731-6. 2000
    ..These data reveal a requisite role for polycystin 1 in maintaining the structural integrity of the vasculature as well as epithelium and suggest that the nature of the PKD1 mutation contributes to the phenotypic variance in ADPKD...
  22. ncbi request reprint Characterization of a conformationally sensitive murine monoclonal antibody directed to the metal ion-dependent adhesion site face of integrin CD11b
    Rui Li
    Leukocyte Biology and Inflammation Program, Structural Biology Program, Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    J Immunol 168:1219-25. 2002
    ..These data support a functional relevance of the protein movements on the MIDAS face and suggest that stabilizing the A domain in the low-affinity state may have therapeutic benefit...
  23. pmc Role of the beta-subunit arginine/lysine finger in integrin heterodimer formation and function
    Vineet Gupta
    Division of Nephrology, Leukocyte Biology and Inflammation Program, Structural Biology Program, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    J Immunol 180:1713-8. 2008
    ..These data demonstrate an important role of the Arg/Lys finger in formation of a stable integrin heterodimer, and suggest that subtle changes at this residue affect the activation state of the integrin...
  24. ncbi request reprint A novel divalent cation-binding site in the A domain of the beta 2 integrin CR3 (CD11b/CD18) is essential for ligand binding
    M Michishita
    Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown 02129
    Cell 72:857-67. 1993
    ....
  25. pmc Anti-PR3 immune responses induce segmental and necrotizing glomerulonephritis
    V C Primo
    The Nephrology Division, Massachusetts General Hospital Harvard Medical School, Boston, MA 02129, USA
    Clin Exp Immunol 159:327-37. 2010
    ....
  26. ncbi request reprint Divergent response to LPS and bacteria in CD14-deficient murine macrophages
    K J Moore
    Lipid Metabolism Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    J Immunol 165:4272-80. 2000
    ..coli. These data indicate that CD14 is essential for macrophage responses to free LPS, whereas other receptors, including CD11b/CD18, can compensate for the loss of CD14 in response to whole bacteria...
  27. pmc A simple, no-wash cell adhesion-based high-throughput assay for the discovery of small-molecule regulators of the integrin CD11b/CD18
    Jun Y Park
    Nephrology Division, Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    J Biomol Screen 12:406-17. 2007
    ..After testing the assay using 2 established blocking antibodies as reference biologicals, the authors performed a proof-of-concept primary screen using a library of 6612 compounds and identified both agonist and antagonist hits...
  28. ncbi request reprint CD11c gene expression in hairy cell leukemia is dependent upon activation of the proto-oncogenes ras and junD
    Fotini Nicolaou
    Renal Unit, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Blood 101:4033-41. 2003
    ..Together, these data indicate that the abnormal expression of the CD11c gene characteristic of HCL is dependent upon activation of the proto-oncogenes ras and junD...
  29. ncbi request reprint Interaction of purified human proteinase 3 (PR3) with reconstituted lipid bilayers
    W H Goldmann
    Leukocyte Biology and Inflammation Program, Rental Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA
    Eur J Biochem 261:155-62. 1999
    ..The lipid-associated PR3 exhibited two-fold lower Vmax and Km values, and its enzyme activity was slightly more inhibited (Ki) by the natural alpha1-proteinase inhibitor (alpha1-PI) or an autoantibody to PR3...
  30. ncbi request reprint Wegener's granulomatosis autoantigen is a novel neutrophil serine proteinase
    J L Niles
    Department of Medicine, Massachusetts General Hospital, Charlestown 02129
    Blood 74:1888-93. 1989
    ..We conclude that the neutrophil antigen responsible for the cytoplasmic staining pattern produced by autoantibodies in patients with active Wegener's granulomatosis is a distinctive serine proteinase...
  31. pmc Identification of cell-specific and developmentally regulated nuclear factors that direct myeloid and lymphoid expression of the CD11a gene
    C S Shelley
    Department of Medicine, Harvard Medical School, Charlestown, MA 02129
    Proc Natl Acad Sci U S A 90:5364-8. 1993
    ..Since MS-2 interacts with a number of different gene promoters and is developmentally regulated in myeloid cells, it may play a major role in regulating myeloid gene expression...
  32. ncbi request reprint Genetic cause of leukocyte adhesion molecule deficiency. Abnormal splicing and a missense mutation in a conserved region of CD18 impair cell surface expression of beta 2 integrins
    C Nelson
    Leukocyte Biology and Inflammation Program, Massachusetts General Hospital, Boston
    J Biol Chem 267:3351-7. 1992
    ..Both the insertion and the N351----S mutations occurred in a 250 amino acid extracellular region of CD18 that is highly conserved among beta integrins supporting a role for this region in heterodimer formation...
  33. ncbi request reprint Purification, analysis, and crystal structure of integrins
    Jian Ping Xiong
    Structural Biology Program, Leukocyte Biology and Inflammation Program, Nephrology Division, Massachusetts General Hospital and Harvard Medical School, Charlestown, USA
    Methods Enzymol 426:307-36. 2007
    ..In this chapter, we review the methods used to purify and characterize these proteins biophysically and functionally, and to derive their three-dimensional structures...
  34. ncbi request reprint The transcription factor ZBP-89 controls generation of the hematopoietic lineage in zebrafish and mouse embryonic stem cells
    Xiangen Li
    Nephrology Division, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Development 133:3641-50. 2006
    ..These findings establish a unique regulatory role for ZBP-89, positioned at the interface between early blood and blood vessel development...
  35. ncbi request reprint Molecular cloning of a novel human hsp70 from a B cell line and its assignment to chromosome 5
    D M Fathallah
    Department of Medicine, Massachusetts General Hospital, Charlestown 02129
    J Immunol 151:810-3. 1993
    ..Northern blotting revealed a single mRNA species of 3.0 kb in total RNA prepared from the patient's EBV cell line. In situ hybridization localized the single copy hsp70 RY gene to the long arm of chromosome 5 at 5 q31.1-5 q31.2...
  36. ncbi request reprint Use of a bovine model to study the role of adhesion molecule CD11/CD18 in hemodialysis-induced neutropenia
    Hamid Rabb
    Nephrology Division, Johns Hopkins University Hospital, Baltimore, MD, USA
    Am J Kidney Dis 39:587-93. 2002
    ..These data, although obtained in a small sample, show that a bovine model can be used to study the early neutropenia of dialysis. These data also suggest that a direct role of beta2 integrins may be occurring in this process...
  37. ncbi request reprint Binding Affinity of Metal Ions to the CD11b A-domain Is Regulated by Integrin Activation and Ligands
    Kaouther Ajroud
    Leukocyte Biology and Inflammation Program, Renal Unit, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129, USA
    J Biol Chem 279:25483-8. 2004
    ..These findings, which we expect will be applicable in vivo, elucidate a new level of regulation of the integrin-metal-ligand ternary complex and help explain some of the discrepant effects of Ca(2+) on integrin-ligand interactions...
  38. ncbi request reprint Polycystin-1 activates and stabilizes the polycystin-2 channel
    G Mark Xu
    Renal Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachussetts 02129, USA
    J Biol Chem 278:1457-62. 2003
    ..The modulation of polycystin-2 channel activity by polycystin-1 may be important for the various biological processes mediated by this molecular complex...
  39. ncbi request reprint Does the integrin alphaA domain act as a ligand for its betaA domain?
    Jose Luis Alonso
    Curr Biol 12:R340-2. 2002
  40. pmc Three-dimensional EM structure of the ectodomain of integrin {alpha}V{beta}3 in a complex with fibronectin
    Brian D Adair
    Department of Cell Biology, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Cell Biol 168:1109-18. 2005
    ..We conclude that the ectodomain of alphaVbeta3 manifests a bent conformation that is capable of stably binding a physiological ligand in solution...
  41. ncbi request reprint The structural basis of elasticity in fibrillin-based microfibrils
    M Amin Arnaout
    Structure 12:734-6. 2004
  42. ncbi request reprint Divalent cations and the relationship between alphaA and betaA domains in integrins
    Kah Tong Seow
    Department of Bio and Chemoinformatics, Merck KGaA, Frankfurterstr 250, Darmstadt, Germany
    Biochem Pharmacol 64:805-12. 2002
    ..Since the position of these loops are evolutionary conserved but their primary sequence varies between the various betaA domains, they represents potential targets for dissecting functional diversity among integrins...

Research Grants35

  1. TRAINING CELL STRUCTURE AND FUNCTION IN NEPHROLOGY
    M Amin Arnaout; Fiscal Year: 2007
    ..In addition, trainees can also access laboratories elsewhere at Harvard and MIT. Didactic formal courses are offered at MGH as well as at Harvard Medical School, Harvard School of Public Health, Harvard University and MIT. ..
  2. Molecular Basis of MO1/LFA-1 Deficiency
    M Amin Arnaout; Fiscal Year: 2007
    ..Consequently, four aims are proposed that build on these observations using biochemical, biophysical, crystallographic and genetic approaches in addition to murine models of renal inflammation. ..
  3. Pathogenesis of ADPKD-role of the transcriptional modulator TAZ
    M Amin Arnaout; Fiscal Year: 2007
    ..The results from these studies will help define a novel pathway regulating the expression level of PKD1 and hence contributing to the renal and extrarenal manifestations of ADPKD. ..
  4. THE PHAGOCYTE MEMBRANE
    M Amin Arnaout; Fiscal Year: 2009
    ..3) Identify novel intermediates that regulate inside-out activation of integrins using genetic (RNAi), immunochemical and biochemical approaches. ..
  5. Pathogenesis of ADPKD-role of the transcriptional modulator TAZ
    M Amin Arnaout; Fiscal Year: 2009
    ..The results from these studies will help define a novel pathway regulating the expression level of PKDl and hence contributing to the renal and extrarenal manifestationsofADPKD. ..
  6. Molecular Basis of MO1/LFA-1 Deficiency
    M Amin Arnaout; Fiscal Year: 2009
    ..Consequently, four aims are proposed that build on these observations using biochemical, biophysical, crystallographic and genetic approaches in addition to murine models of renal inflammation. ..
  7. Role of the zinc finger transcription factor ZBP89 in blood & vascular developmen
    M Amin Arnaout; Fiscal Year: 2010
    ..We are proposing a series of studies to pinpoint the role of this factor, and define the developmental networks it coordinates. ..
  8. Structure and function of integrins in the kidney
    M Amin Arnaout; Fiscal Year: 2010
    ..Elucidating how integrins are regulated at an atomic level is essential in understanding their biologic role, information that could be harnessed in devising new therapeutics. ..
  9. Structure-function of the Proangiogenic Integrin alphaVb
    M Amin Arnaout; Fiscal Year: 2006
    ....
  10. MOLECULAR BASIS OF MO1/LFA-L DEFICIENCY
    M Amin Arnaout; Fiscal Year: 2001
    ..Given the potential role of CD11b/CD18 in inflammation and injury, derivation of specific antagonists of this receptor could have therapeutic benefits. ..
  11. Structure and Function of beta2 Integrin
    M Amin Arnaout; Fiscal Year: 2005
    ..It should also facilitate rational drug design for this class of therapeutic targets. ..
  12. Metabolomic Analysis of Type 1 Diabetic Nephropathy
    M Amin Arnaout; Fiscal Year: 2005
    ..In this manner, we hone to identify potential metabolomic biomarkers worthy of subsequent validation. ..
  13. Pathogenesis of ADPKD-role of the transcriptional modulator TAZ
    M Amin Arnaout; Fiscal Year: 2010
    ..The results from these studies will help define a novel pathway regulating the expression level of PKDl and hence contributing to the renal and extrarenal manifestationsofADPKD. ..