Research Topics
Genomes and Genes | Paul J AndersonSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Stressful initiationsPaul Anderson
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
J Cell Sci 115:3227-34. 2002....
Stress granules: the Tao of RNA triagePaul Anderson
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
Trends Biochem Sci 33:141-50. 2008..Thus, these ephemeral bodies represent more than just the dynamic sorting of mRNA between translation and decay...- Post-transcriptional regulons coordinate the initiation and resolution of inflammationPaul Anderson
Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Nat Rev Immunol 10:24-35. 2010..Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process... - Post-transcriptional regulation of proinflammatory proteinsPaul Anderson
Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
J Leukoc Biol 76:42-7. 2004..We hypothesize that TIA-1-/-TTP-/- neutrophils are a source of arthritigenic TNF-alpha, which promotes severe erosive arthritis in these mice... - RNA granules: post-transcriptional and epigenetic modulators of gene expressionPaul Anderson
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Nat Rev Mol Cell Biol 10:430-6. 2009..We propose that RNA granules can be both a cause and a consequence of altered mRNA translation, decay or editing. In this capacity, RNA granules serve as key modulators of post-transcriptional and epigenetic gene expression... - Post-transcriptional control of cytokine productionPaul Anderson
Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Nat Immunol 9:353-9. 2008..Understanding of these mechanisms has identified targets for the development of new classes of immunomodulatory drugs... 
Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translationPaul Anderson
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Cell Stress Chaperones 7:213-21. 2002..The role of the SG in the integration of translational efficiency, mRNA stability, and the stress response is discussed...- Mechanisms of differential immunogenicity of tumor necrosis factor inhibitorsPaul Anderson
Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA
Curr Rheumatol Rep 7:3-9. 2005 - Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritisKristine Phillips
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 101:2011-6. 2004..Our results suggest that TIA-1 and TTP are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines... - Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granulesNancy Kedersha
Division of Rheumatology and Immunology, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Mol Biol Cell 13:195-210. 2002..We discuss these results in the context of a translational checkpoint model wherein TIA and eIF2 are functional antagonists of translational initiation, and in which lack of ternary complex drives SG assembly... - Stress granule assembly is mediated by prion-like aggregation of TIA-1Natalie Gilks
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
Mol Biol Cell 15:5383-98. 2004..Our results reveal that prion-like aggregation of TIA-1 regulates SG formation downstream of eIF2alpha phosphorylation in response to stress... 
RNA granulesPaul Anderson
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Boston, MA 02115, USA
J Cell Biol 172:803-8. 2006..We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay...- T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAsSatoshi Yamasaki
Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
J Biol Chem 282:30070-7. 2007..These results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that TIA-1-induced translational silencing promotes the decay of selected mRNAs... - MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decayGeorg Stoecklin
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
EMBO J 23:1313-24. 2004..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression... - Mammalian stress granules and processing bodiesNancy Kedersha
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Methods Enzymol 431:61-81. 2007..We describe markers and staining procedures used to identify these distinct types of RNA granules, describe conditions that promote their assembly and disassembly, and establish YB-1 as a useful marker of SGs and PBs... - FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expressionWei Li
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Mol Cell Biol 24:10718-32. 2004..Because FAST is released from mitochondria in cells undergoing Fas- or UV-induced apoptosis, we propose that FAST serves as a sensor of mitochondrial stress that modulates a TIA-1-regulated posttranscriptional stress response program... - ARE-mRNA degradation requires the 5'-3' decay pathwayGeorg Stoecklin
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith 608, Boston, Massachusetts 02115, USA
EMBO Rep 7:72-7. 2006..On the other side, out of three exosome components tested, only knockdown of PmScl-75 caused a strong inhibition of AMD. Our results show that mammalian cells, similar to yeast, require the 5'-3' Xrn1 pathway to degrade ARE-mRNAs... - Stress granules and processing bodies are dynamically linked sites of mRNP remodelingNancy Kedersha
Division of Rheumatology and Immunology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
J Cell Biol 169:871-84. 2005..We propose that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation... - The tumor necrosis factor-alpha AU-rich element inhibits the stable association of the 40S ribosomal subunit with RNA transcriptsStephen D Wax
Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
Biochem Biophys Res Commun 333:1100-6. 2005..ARE-mediated translational repression was competitively inhibited by ARE-containing transcripts. These data indicate that a TNF-alpha ARE-binding trans-acting factor(s) inhibits the association of the 43S complex with RNA transcripts... - Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profilesPaul J Anderson
Harvard Medical School, Brigham and Women s Hospital, Division of Rheumatology, Immunology, and Allergy, Boston, MA 02115, USA
Semin Arthritis Rheum 34:19-22. 2005..This review will discuss our current understanding of the diverse immunogenic profiles of currently marketed anti-TNF agents... - FAST is a BCL-X(L)-associated mitochondrial proteinWei Li
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Biochem Biophys Res Commun 318:95-102. 2004..Our results suggest that FAST-BCL-X(L) interactions are likely to regulate mitochondrial metabolism during Fas-induced apoptosis... - A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assemblyTakbum Ohn
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
Nat Cell Biol 10:1224-31. 2008..The lack of enzymes of the hexosamine biosynthetic pathway in budding yeast may contribute to differences between mammalian SGs and related yeast EGP (eIF4E, 4G and Pab1 containing) bodies... - Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assemblyMohamed M Emara
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 285:10959-68. 2010..Natural 5'-tiRNAs but not 3'-tiRNAs are capped with a 5'-monophosphate that is required for optimal SG assembly. These findings reveal that SG assembly is a component of the ANG- and tiRNA-induced stress response program... - Mutations in the RNA granule component TDRD7 cause cataract and glaucomaSalil A Lachke
Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Science 331:1571-6. 2011..These findings demonstrate a role for RGs in vertebrate organogenesis... - Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcriptsStephen Wax
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Arthritis Rheum 48:541-50. 2003..CONCLUSION: These results indicate that the function of Hsp90 is important in the posttranscriptional control of inflammatory cytokine production... - Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolinGeorg Stoecklin
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
J Biol Chem 283:11689-99. 2008..IL-10 mRNA levels were found to be elevated because of a reduced decay rate in primary macrophages from TTP(-/-) mice. Our study demonstrates the importance of experimental approaches for identifying targets of RNA-binding proteins... - On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressorPaul Anderson
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
Mol Cell 25:796-7. 2007..2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines... - Angiogenin cleaves tRNA and promotes stress-induced translational repressionSatoshi Yamasaki
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Cell Biol 185:35-42. 2009..Finally, transfection of angiogenin-induced tiRNAs promotes phospho-eIF2alpha-independent translational arrest. Our results introduce angiogenin and tiRNAs as components of a phospho-eIF2alpha-independent stress response program... - Low over-expression of TNFalpha in the mouse heart increases contractile performance via TNFR1Ilka Pinz
NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Cell Biochem 105:99-107. 2008..We suggest that low levels of TNFalpha increase the Ca(2+) sensitivity of the heart via a TNFR1-mediated mechanism... - Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicingMaria Simarro
Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 104:11370-5. 2007..Mutational analysis reveals that FAST-mediated alternative splicing is separable from the survival effects of FAST. Our data reveal that nuclear FAST can regulate the splicing of FGFR2 transcripts... - Real-time and quantitative imaging of mammalian stress granules and processing bodiesNancy Kedersha
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
Methods Enzymol 448:521-52. 2008..We describe stably expressed, fluorescently tagged SG and PB markers that exhibit similar behavior to their endogenous counterparts, thus allowing real-time imaging of SGs and PBs... - A Place for RNAiPaul Anderson
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA
Dev Cell 9:311-2. 2005..In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the assembly of P bodies in C. elegans (Ding et al., 2005)... - Reprogramming mRNA translation during stressSatoshi Yamasaki
Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, United States
Curr Opin Cell Biol 20:222-6. 2008..In combination, these stress-activated processes coordinately reprogram mRNA translation and decay in a way that conserves anabolic energy, preserves essential mRNAs, and promotes the repair of stress-induced molecular damage... - Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammationMaria Simarro
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
J Immunol 184:5325-32. 2010..In conclusion, our results introduce FAST as a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation... - Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respirationMaria Simarro
Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
Biochem Biophys Res Commun 401:440-6. 2010..Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration...
Research Grants
- Characterization of mammalian stress granulesPaul Anderson; Fiscal Year: 2007..These studies have implications for our understanding of stress-regulated pathological conditions, including Alzheimer's disease, diabetes and cancer. ..
- Post-transcriptional regulation of TNF-alpha productionPaul Anderson; Fiscal Year: 2005..These studies might also identify molecular targets for the development of orally available TNFa blockers that can be used to treat patients with rheumatoid arthritis. ..
- The role of FAST in immune-mediated inflammatory diseasePaul Anderson; Fiscal Year: 2007..Finally, we will generate transgenic mice that overexpress FAST and mutant mice that lack FAST to determine its importance in the initiation and/or propagation of immune-mediated inflammatory disease. ..
- CHARACTERIZATION OF TIA-1/R+ MAMMALIAN STRESS GRANULESPaul Anderson; Fiscal Year: 2004..By understanding the function of TIA-1/R+ SGs, we hope to learn how stressed cells decide whether to survive and repair the damage, or die by apoptosis. This information is relevant to human cancer and autoimmune disease. ..
- CD16--ZETA-GAMMA RECEPTOR COMPLEXPaul Anderson; Fiscal Year: 2001....
- ROLE OF PSGL 1 IN NATURAL KILLER CELL FUNCTIONPaul Anderson; Fiscal Year: 2003..Consequently, the overall goal of the proposed experiments is to determine how PEN5:L-selectin interactions influence NK cell function. ..
- Characterization of mammalian stress granulesPaul J Anderson; Fiscal Year: 2010..These studies have implications for our understanding of stress-regulated pathological conditions, including Alzheimer's disease, diabetes and cancer. ..