Paul J Anderson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Stressful initiations
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Cell Sci 115:3227-34. 2002
  2. doi request reprint Post-transcriptional control of cytokine production
    Paul Anderson
    Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 9:353-9. 2008
  3. ncbi request reprint Mechanisms of differential immunogenicity of tumor necrosis factor inhibitors
    Paul Anderson
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 7:3-9. 2005
  4. doi request reprint Stress granules: the Tao of RNA triage
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Trends Biochem Sci 33:141-50. 2008
  5. doi request reprint RNA granules: post-transcriptional and epigenetic modulators of gene expression
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 10:430-6. 2009
  6. ncbi request reprint Post-transcriptional regulation of proinflammatory proteins
    Paul Anderson
    Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Leukoc Biol 76:42-7. 2004
  7. doi request reprint Post-transcriptional regulons coordinate the initiation and resolution of inflammation
    Paul Anderson
    Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 10:24-35. 2010
  8. pmc Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell Stress Chaperones 7:213-21. 2002
  9. pmc Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis
    Kristine Phillips
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:2011-6. 2004
  10. pmc Stress granule assembly is mediated by prion-like aggregation of TIA-1
    Natalie Gilks
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Biol Cell 15:5383-98. 2004

Research Grants

  1. Characterization of mammalian stress granules
    Paul Anderson; Fiscal Year: 2007
  2. Post-transcriptional regulation of TNF-alpha production
    Paul Anderson; Fiscal Year: 2005
  3. The role of FAST in immune-mediated inflammatory disease
    Paul Anderson; Fiscal Year: 2007
  4. CHARACTERIZATION OF TIA-1/R+ MAMMALIAN STRESS GRANULES
    Paul Anderson; Fiscal Year: 2004
  5. CD16--ZETA-GAMMA RECEPTOR COMPLEX
    Paul Anderson; Fiscal Year: 2001
  6. ROLE OF PSGL 1 IN NATURAL KILLER CELL FUNCTION
    Paul Anderson; Fiscal Year: 2003
  7. Characterization of mammalian stress granules
    Paul J Anderson; Fiscal Year: 2010

Collaborators

Detail Information

Publications36

  1. ncbi request reprint Stressful initiations
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Cell Sci 115:3227-34. 2002
    ....
  2. doi request reprint Post-transcriptional control of cytokine production
    Paul Anderson
    Harvard Medical School, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Immunol 9:353-9. 2008
    ..Understanding of these mechanisms has identified targets for the development of new classes of immunomodulatory drugs...
  3. ncbi request reprint Mechanisms of differential immunogenicity of tumor necrosis factor inhibitors
    Paul Anderson
    Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Curr Rheumatol Rep 7:3-9. 2005
  4. doi request reprint Stress granules: the Tao of RNA triage
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, One Jimmy Fund Way, Boston, MA 02115, USA
    Trends Biochem Sci 33:141-50. 2008
    ..Thus, these ephemeral bodies represent more than just the dynamic sorting of mRNA between translation and decay...
  5. doi request reprint RNA granules: post-transcriptional and epigenetic modulators of gene expression
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Rev Mol Cell Biol 10:430-6. 2009
    ..We propose that RNA granules can be both a cause and a consequence of altered mRNA translation, decay or editing. In this capacity, RNA granules serve as key modulators of post-transcriptional and epigenetic gene expression...
  6. ncbi request reprint Post-transcriptional regulation of proinflammatory proteins
    Paul Anderson
    Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Leukoc Biol 76:42-7. 2004
    ..We hypothesize that TIA-1-/-TTP-/- neutrophils are a source of arthritigenic TNF-alpha, which promotes severe erosive arthritis in these mice...
  7. doi request reprint Post-transcriptional regulons coordinate the initiation and resolution of inflammation
    Paul Anderson
    Department of Medicine, Division of Rheumatology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 10:24-35. 2010
    ..Here, I review the surprising variety of post-transcriptional control mechanisms that regulate the initiation and resolution of inflammation and discuss how these mechanisms are integrated to coordinate this essential process...
  8. pmc Visibly stressed: the role of eIF2, TIA-1, and stress granules in protein translation
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Cell Stress Chaperones 7:213-21. 2002
    ..The role of the SG in the integration of translational efficiency, mRNA stability, and the stress response is discussed...
  9. pmc Arthritis suppressor genes TIA-1 and TTP dampen the expression of tumor necrosis factor alpha, cyclooxygenase 2, and inflammatory arthritis
    Kristine Phillips
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 101:2011-6. 2004
    ..Our results suggest that TIA-1 and TTP are genetic modifiers of inflammatory arthritis that can alter the spectrum of cells that produce arthritogenic cytokines...
  10. pmc Stress granule assembly is mediated by prion-like aggregation of TIA-1
    Natalie Gilks
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Mol Biol Cell 15:5383-98. 2004
    ..Our results reveal that prion-like aggregation of TIA-1 regulates SG formation downstream of eIF2alpha phosphorylation in response to stress...
  11. pmc Evidence that ternary complex (eIF2-GTP-tRNA(i)(Met))-deficient preinitiation complexes are core constituents of mammalian stress granules
    Nancy Kedersha
    Division of Rheumatology and Immunology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Mol Biol Cell 13:195-210. 2002
    ..We discuss these results in the context of a translational checkpoint model wherein TIA and eIF2 are functional antagonists of translational initiation, and in which lack of ternary complex drives SG assembly...
  12. pmc RNA granules
    Paul Anderson
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 172:803-8. 2006
    ..We review the relationship between different classes of these granules and discuss how spatial organization regulates messenger RNA translation/decay...
  13. ncbi request reprint T-cell intracellular antigen-1 (TIA-1)-induced translational silencing promotes the decay of selected mRNAs
    Satoshi Yamasaki
    Harvard Medical School, Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Biol Chem 282:30070-7. 2007
    ..These results suggest that TIA-1-induced polysome disassembly is required for enhanced mRNA decay and that TIA-1-induced translational silencing promotes the decay of selected mRNAs...
  14. pmc MK2-induced tristetraprolin:14-3-3 complexes prevent stress granule association and ARE-mRNA decay
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    EMBO J 23:1313-24. 2004
    ..Our data reveal the mechanism by which the p38-MAPK/MK2 kinase cascade inhibits TTP-mediated degradation of ARE-containing transcripts and thereby contributes to lipopolysaccharide-induced TNFalpha expression...
  15. pmc Stress granules and processing bodies are dynamically linked sites of mRNP remodeling
    Nancy Kedersha
    Division of Rheumatology and Immunology, Harvard Medical School, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Cell Biol 169:871-84. 2005
    ..We propose that mRNA released from disassembled polysomes is sorted and remodeled at SGs, from which selected transcripts are delivered to PBs for degradation...
  16. ncbi request reprint Mammalian stress granules and processing bodies
    Nancy Kedersha
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Methods Enzymol 431:61-81. 2007
    ..We describe markers and staining procedures used to identify these distinct types of RNA granules, describe conditions that promote their assembly and disassembly, and establish YB-1 as a useful marker of SGs and PBs...
  17. pmc ARE-mRNA degradation requires the 5'-3' decay pathway
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Smith 608, Boston, Massachusetts 02115, USA
    EMBO Rep 7:72-7. 2006
    ..On the other side, out of three exosome components tested, only knockdown of PmScl-75 caused a strong inhibition of AMD. Our results show that mammalian cells, similar to yeast, require the 5'-3' Xrn1 pathway to degrade ARE-mRNAs...
  18. pmc FAST is a survival protein that senses mitochondrial stress and modulates TIA-1-regulated changes in protein expression
    Wei Li
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Mol Cell Biol 24:10718-32. 2004
    ..Because FAST is released from mitochondria in cells undergoing Fas- or UV-induced apoptosis, we propose that FAST serves as a sensor of mitochondrial stress that modulates a TIA-1-regulated posttranscriptional stress response program...
  19. pmc The translational repressor T-cell intracellular antigen-1 (TIA-1) is a key modulator of Th2 and Th17 responses driving pulmonary inflammation induced by exposure to house dust mite
    Maria Simarro
    Department of Medicine, Harvard Medical School, and Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, MA 02115, USA
    Immunol Lett 146:8-14. 2012
    ..Our results identify TIA-1 as a negative regulator of allergen-mediated pulmonary inflammation in vivo. Thus, TIA-1 might be an important player in the pathogenesis of bronchial asthma...
  20. ncbi request reprint The tumor necrosis factor-alpha AU-rich element inhibits the stable association of the 40S ribosomal subunit with RNA transcripts
    Stephen D Wax
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Biochem Biophys Res Commun 333:1100-6. 2005
    ..ARE-mediated translational repression was competitively inhibited by ARE-containing transcripts. These data indicate that a TNF-alpha ARE-binding trans-acting factor(s) inhibits the association of the 43S complex with RNA transcripts...
  21. ncbi request reprint Tumor necrosis factor inhibitors: clinical implications of their different immunogenicity profiles
    Paul J Anderson
    Harvard Medical School, Brigham and Women s Hospital, Division of Rheumatology, Immunology, and Allergy, Boston, MA 02115, USA
    Semin Arthritis Rheum 34:19-22. 2005
    ..This review will discuss our current understanding of the diverse immunogenic profiles of currently marketed anti-TNF agents...
  22. pmc Angiogenin-induced tRNA-derived stress-induced RNAs promote stress-induced stress granule assembly
    Mohamed M Emara
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 285:10959-68. 2010
    ..Natural 5'-tiRNAs but not 3'-tiRNAs are capped with a 5'-monophosphate that is required for optimal SG assembly. These findings reveal that SG assembly is a component of the ANG- and tiRNA-induced stress response program...
  23. ncbi request reprint FAST is a BCL-X(L)-associated mitochondrial protein
    Wei Li
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Biochem Biophys Res Commun 318:95-102. 2004
    ..Our results suggest that FAST-BCL-X(L) interactions are likely to regulate mitochondrial metabolism during Fas-induced apoptosis...
  24. doi request reprint A functional RNAi screen links O-GlcNAc modification of ribosomal proteins to stress granule and processing body assembly
    Takbum Ohn
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, 1 Jimmy Fund Way, Boston, Massachusetts 02115, USA
    Nat Cell Biol 10:1224-31. 2008
    ..The lack of enzymes of the hexosamine biosynthetic pathway in budding yeast may contribute to differences between mammalian SGs and related yeast EGP (eIF4E, 4G and Pab1 containing) bodies...
  25. pmc Mutations in the RNA granule component TDRD7 cause cataract and glaucoma
    Salil A Lachke
    Division of Genetics, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 331:1571-6. 2011
    ..These findings demonstrate a role for RGs in vertebrate organogenesis...
  26. ncbi request reprint Geldanamycin inhibits the production of inflammatory cytokines in activated macrophages by reducing the stability and translation of cytokine transcripts
    Stephen Wax
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Arthritis Rheum 48:541-50. 2003
    ..GD has been used to investigate the mechanisms by which Hsp90 regulates inflammatory cytokine production...
  27. ncbi request reprint On again, off again: the SRC-3 transcriptional coactivator moonlights as a translational corepressor
    Paul Anderson
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital and Harvard Medical School, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    Mol Cell 25:796-7. 2007
    ..2007) reported that the steroid receptor coactivator-3 (SRC-3) has a novel cytoplasmic function: it activates the translational silencers TIA-1 and TIAR and thus inhibits the translation of proinflammatory cytokines...
  28. pmc Genome-wide analysis identifies interleukin-10 mRNA as target of tristetraprolin
    Georg Stoecklin
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 283:11689-99. 2008
    ..IL-10 mRNA levels were found to be elevated because of a reduced decay rate in primary macrophages from TTP(-/-) mice. Our study demonstrates the importance of experimental approaches for identifying targets of RNA-binding proteins...
  29. pmc Angiogenin cleaves tRNA and promotes stress-induced translational repression
    Satoshi Yamasaki
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Biol 185:35-42. 2009
    ..Finally, transfection of angiogenin-induced tiRNAs promotes phospho-eIF2alpha-independent translational arrest. Our results introduce angiogenin and tiRNAs as components of a phospho-eIF2alpha-independent stress response program...
  30. doi request reprint Low over-expression of TNFalpha in the mouse heart increases contractile performance via TNFR1
    Ilka Pinz
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Cell Biochem 105:99-107. 2008
    ..We suggest that low levels of TNFalpha increase the Ca(2+) sensitivity of the heart via a TNFR1-mediated mechanism...
  31. pmc Fas-activated serine/threonine phosphoprotein promotes immune-mediated pulmonary inflammation
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, USA
    J Immunol 184:5325-32. 2010
    ..In conclusion, our results introduce FAST as a proinflammatory factor that modulates the function of lung resident hematopoietic cells to promote neutrophil recruitment and pulmonary inflammation...
  32. pmc Fast kinase domain-containing protein 3 is a mitochondrial protein essential for cellular respiration
    Maria Simarro
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, United States
    Biochem Biophys Res Commun 401:440-6. 2010
    ..Our results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration...
  33. doi request reprint Real-time and quantitative imaging of mammalian stress granules and processing bodies
    Nancy Kedersha
    Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Boston, Massachusetts, USA
    Methods Enzymol 448:521-52. 2008
    ..We describe stably expressed, fluorescently tagged SG and PB markers that exhibit similar behavior to their endogenous counterparts, thus allowing real-time imaging of SGs and PBs...
  34. pmc Reprogramming mRNA translation during stress
    Satoshi Yamasaki
    Harvard Medical School, Division of Rheumatology, Immunology and Allergy, Brigham and Women s Hospital, Smith 652, One Jimmy Fund Way, Boston, MA 02115, United States
    Curr Opin Cell Biol 20:222-6. 2008
    ..In combination, these stress-activated processes coordinately reprogram mRNA translation and decay in a way that conserves anabolic energy, preserves essential mRNAs, and promotes the repair of stress-induced molecular damage...
  35. ncbi request reprint A Place for RNAi
    Paul Anderson
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Dev Cell 9:311-2. 2005
    ..In a recent issue of Molecular Cell, Ding and coworkers described an argonaute-interacting protein that appears to promote the assembly of P bodies in C. elegans (Ding et al., 2005)...
  36. pmc Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing
    Maria Simarro
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 104:11370-5. 2007
    ..Mutational analysis reveals that FAST-mediated alternative splicing is separable from the survival effects of FAST. Our data reveal that nuclear FAST can regulate the splicing of FGFR2 transcripts...

Research Grants29

  1. Characterization of mammalian stress granules
    Paul Anderson; Fiscal Year: 2007
    ..These studies have implications for our understanding of stress-regulated pathological conditions, including Alzheimer's disease, diabetes and cancer. ..
  2. Post-transcriptional regulation of TNF-alpha production
    Paul Anderson; Fiscal Year: 2005
    ..These studies might also identify molecular targets for the development of orally available TNFa blockers that can be used to treat patients with rheumatoid arthritis. ..
  3. The role of FAST in immune-mediated inflammatory disease
    Paul Anderson; Fiscal Year: 2007
    ..Finally, we will generate transgenic mice that overexpress FAST and mutant mice that lack FAST to determine its importance in the initiation and/or propagation of immune-mediated inflammatory disease. ..
  4. CHARACTERIZATION OF TIA-1/R+ MAMMALIAN STRESS GRANULES
    Paul Anderson; Fiscal Year: 2004
    ..By understanding the function of TIA-1/R+ SGs, we hope to learn how stressed cells decide whether to survive and repair the damage, or die by apoptosis. This information is relevant to human cancer and autoimmune disease. ..
  5. CD16--ZETA-GAMMA RECEPTOR COMPLEX
    Paul Anderson; Fiscal Year: 2001
    ....
  6. ROLE OF PSGL 1 IN NATURAL KILLER CELL FUNCTION
    Paul Anderson; Fiscal Year: 2003
    ..Consequently, the overall goal of the proposed experiments is to determine how PEN5:L-selectin interactions influence NK cell function. ..
  7. Characterization of mammalian stress granules
    Paul J Anderson; Fiscal Year: 2010
    ..These studies have implications for our understanding of stress-regulated pathological conditions, including Alzheimer's disease, diabetes and cancer. ..