Mark S Anderson
Affiliation: Harvard University
- Autoimmune endocrine diseaseMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Harvard Medical School, Boston, Massachusetts 02215, USA
Curr Opin Immunol 14:760-4. 2002..Finally, the recent cloning of the causative gene for autoimmune polyglandular syndrome type I, called AIRE, has brought central tolerance back into focus as an important mechanism in these endocrine diseases...
- The cellular mechanism of Aire control of T cell toleranceMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
Immunity 23:227-39. 2005..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
- Modifier loci condition autoimmunity provoked by Aire deficiencyWenyu Jiang
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
J Exp Med 202:805-15. 2005....
- Projection of an immunological self shadow within the thymus by the aire proteinMark S Anderson
Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
Science 298:1395-401. 2002..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
- Deletional tolerance mediated by extrathymic Aire-expressing cellsJames M Gardner
Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
Science 321:843-7. 2008..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection...
- Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in AireMaureen A Su
Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
J Clin Invest 118:1712-26. 2008..Together, these results may demonstrate a mechanism by which autoimmune predisposition to phenotypes distinct from APS 1 can be mediated in a dominant-negative fashion by Aire...
- Expression of Aire and the early wave of apoptosis in spermatogenesisClaudia E Schaller
Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
J Immunol 180:1338-43. 2008..We suggest that there is a link between the scheduled and sporadic apoptotic processes and propose that scheduled apoptosis provides a counterselection mechanism that keeps the germline stable...
- What's new in the Aire?Mickie H Cheng
Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
Trends Immunol 28:321-7. 2007..Recent characterization of Aire-targeted antigens continues to bear this out. Here, we review the current progress surrounding the role of Aire in central tolerance from a molecular, genetic and developmental basis...
- Lessons on immune tolerance from the monogenic disease APS1Jason J DeVoss
University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
Curr Opin Genet Dev 17:193-200. 2007..Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this disorder--autoimmune regulator (AIRE)--is providing new lessons on how immune tolerance is maintained...
- Spontaneous autoimmunity prevented by thymic expression of a single self-antigenJason DeVoss
Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 203:2727-35. 2006..These results suggest that failure of thymic expression of selective single self-antigens can be sufficient to cause organ-specific autoimmune disease, even in otherwise self-tolerant individuals...
- Aire: an updateMaureen A Su
Diabetes Center, University of California, San Francisco, Box 0540, 513 Parnassus Avenue, San Francisco, California 94143, USA
Curr Opin Immunol 16:746-52. 2004..Although these molecular details await further characterization, the association of Aire with the prevention of autoimmunity highlights the importance of thymic mechanisms in the maintenance of tolerance...
- Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1Jason J DeVoss
Diabetes Center, University of California, San Francisco, CA 94143, USA
J Immunol 181:4072-9. 2008..Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1...