Mark S Anderson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Autoimmune endocrine disease
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Immunol 14:760-4. 2002
  2. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
  3. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
  4. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
  5. pmc Deletional tolerance mediated by extrathymic Aire-expressing cells
    James M Gardner
    Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
    Science 321:843-7. 2008
  6. pmc Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    Maureen A Su
    Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
    J Clin Invest 118:1712-26. 2008
  7. ncbi request reprint Expression of Aire and the early wave of apoptosis in spermatogenesis
    Claudia E Schaller
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 180:1338-43. 2008
  8. ncbi request reprint What's new in the Aire?
    Mickie H Cheng
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Immunol 28:321-7. 2007
  9. ncbi request reprint Lessons on immune tolerance from the monogenic disease APS1
    Jason J DeVoss
    University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
    Curr Opin Genet Dev 17:193-200. 2007
  10. pmc Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    Jason DeVoss
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2727-35. 2006

Collaborators

  • Christophe Benoist
  • Diane Mathis
  • Stuart P Berzins
  • Wenyu Jiang
  • Harald von Boehmer
  • Ludger Klein
  • Shannon J Turley
  • Jason J DeVoss
  • Maureen A Su
  • Wen Lu
  • James M Gardner
  • Claudia E Schaller
  • Howard Y Chang
  • Kellsey P A Johannes
  • Anthony K Shum
  • Mickie H Cheng
  • Jason DeVoss
  • Angela Chang
  • Erich C Strauss
  • Matthias Wabl
  • Hamish S Scott
  • B Matija Peterlin
  • Ying X Tan
  • Gabriele Beck-Engeser
  • Cecilia Austin
  • Xuyu Zhou
  • John L Rinn
  • Irena Oven
  • Norbert P Leclair
  • David J Wong
  • James Gardner
  • Peter Wang
  • Huimin Jiang
  • Karen Giang
  • Ting Yang
  • Rachel S Friedman
  • Anna K Krawisz
  • Clifford L Wang
  • Kellsey P Johannes
  • Matthew F Krummel
  • Kristina Zumer
  • Paula Bubulya
  • Lindsie Goss
  • Lawrence Fong
  • Howard Chang
  • Rachel Caspi
  • Yafei Hou
  • Kellsey Johannes
  • John Rinn
  • Rachel R Caspi
  • Gregory I Liou

Detail Information

Publications12

  1. ncbi request reprint Autoimmune endocrine disease
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Harvard Medical School, Boston, Massachusetts 02215, USA
    Curr Opin Immunol 14:760-4. 2002
    ..Finally, the recent cloning of the causative gene for autoimmune polyglandular syndrome type I, called AIRE, has brought central tolerance back into focus as an important mechanism in these endocrine diseases...
  2. ncbi request reprint The cellular mechanism of Aire control of T cell tolerance
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02215, USA
    Immunity 23:227-39. 2005
    ..In Aire's absence, autoimmunity and ultimately overt autoimmune disease develops...
  3. pmc Modifier loci condition autoimmunity provoked by Aire deficiency
    Wenyu Jiang
    Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02215, USA
    J Exp Med 202:805-15. 2005
    ....
  4. ncbi request reprint Projection of an immunological self shadow within the thymus by the aire protein
    Mark S Anderson
    Section on Immunology and Immunogenetics, Joslin Diabetes Center Department of Medicine, Brigham and Women s Hospital Harvard Medical School, 1 Joslin Place, Boston, MA 02215, USA
    Science 298:1395-401. 2002
    ..These findings highlight the importance of thymically imposed "central" tolerance in controlling autoimmunity...
  5. pmc Deletional tolerance mediated by extrathymic Aire-expressing cells
    James M Gardner
    Diabetes Center, University of California San Francisco UCSF, San Francisco, CA 94122, USA
    Science 321:843-7. 2008
    ..We propose that such a secondary network of self-antigen-expressing stromal cells may help reinforce immune tolerance by preventing the maturation of autoreactive T cells that escape thymic negative selection...
  6. pmc Mechanisms of an autoimmunity syndrome in mice caused by a dominant mutation in Aire
    Maureen A Su
    Diabetes Center, Department of Pediatric, UCSF, San Francisco, California 94143, USA
    J Clin Invest 118:1712-26. 2008
    ..Together, these results may demonstrate a mechanism by which autoimmune predisposition to phenotypes distinct from APS 1 can be mediated in a dominant-negative fashion by Aire...
  7. ncbi request reprint Expression of Aire and the early wave of apoptosis in spermatogenesis
    Claudia E Schaller
    Department of Microbiology and Immunology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    J Immunol 180:1338-43. 2008
    ..We suggest that there is a link between the scheduled and sporadic apoptotic processes and propose that scheduled apoptosis provides a counterselection mechanism that keeps the germline stable...
  8. ncbi request reprint What's new in the Aire?
    Mickie H Cheng
    Diabetes Center, University of California San Francisco, San Francisco, CA 94143, USA
    Trends Immunol 28:321-7. 2007
    ..Recent characterization of Aire-targeted antigens continues to bear this out. Here, we review the current progress surrounding the role of Aire in central tolerance from a molecular, genetic and developmental basis...
  9. ncbi request reprint Lessons on immune tolerance from the monogenic disease APS1
    Jason J DeVoss
    University of California San Francisco Diabetes Center, HSW1102, San Francisco, CA 94143 0540, USA
    Curr Opin Genet Dev 17:193-200. 2007
    ..Recent work on the monogenic autoimmune disease 'autoimmune polyglandular syndrome type 1' (APS1) and on the causal gene of this disorder--autoimmune regulator (AIRE)--is providing new lessons on how immune tolerance is maintained...
  10. pmc Spontaneous autoimmunity prevented by thymic expression of a single self-antigen
    Jason DeVoss
    Diabetes Center and Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 203:2727-35. 2006
    ..These results suggest that failure of thymic expression of selective single self-antigens can be sufficient to cause organ-specific autoimmune disease, even in otherwise self-tolerant individuals...
  11. ncbi request reprint Aire: an update
    Maureen A Su
    Diabetes Center, University of California, San Francisco, Box 0540, 513 Parnassus Avenue, San Francisco, California 94143, USA
    Curr Opin Immunol 16:746-52. 2004
    ..Although these molecular details await further characterization, the association of Aire with the prevention of autoimmunity highlights the importance of thymic mechanisms in the maintenance of tolerance...
  12. pmc Effector mechanisms of the autoimmune syndrome in the murine model of autoimmune polyglandular syndrome type 1
    Jason J DeVoss
    Diabetes Center, University of California, San Francisco, CA 94143, USA
    J Immunol 181:4072-9. 2008
    ..Depletion of CD4(+) T cells using a neutralizing Ab ameliorated the disease process. Thus, therapies targeted specifically at the CD4(+) T cell subset may help control autoimmune disease in patients with APS1...