Ana C Anderson

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 20:101-23. 2002
  2. ncbi request reprint The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
  3. pmc A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 188:2084-92. 2012
  4. doi request reprint Tim-3, a negative regulator of anti-tumor immunity
    Ana Carrizosa Anderson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Immunol 24:213-6. 2012
  5. ncbi request reprint The Notch regulator Numb links the Notch and TCR signaling pathways
    Ana C Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 174:890-7. 2005
  6. pmc Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:7449-52. 2008
  7. pmc Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1383-92. 2010
  8. pmc Emerging Tim-3 functions in antimicrobial and tumor immunity
    Kaori Sakuishi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Immunol 32:345-9. 2011
  9. pmc T-bet, a Th1 transcription factor regulates the expression of Tim-3
    Ana C Anderson
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Eur J Immunol 40:859-66. 2010
  10. pmc T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:8706-11. 2010

Research Grants

Collaborators

Detail Information

Publications33

  1. ncbi request reprint T cell response in experimental autoimmune encephalomyelitis (EAE): role of self and cross-reactive antigens in shaping, tuning, and regulating the autopathogenic T cell repertoire
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Annu Rev Immunol 20:101-23. 2002
    ..This provides a mechanism by which the fidelity and specificity of the immune system against foreign antigens is improved without increasing the potential for developing an autoimmune disease...
  2. ncbi request reprint The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Nat Immunol 6:1245-52. 2005
    ..These data suggest that the Tim-3-galectin-9 pathway may have evolved to ensure effective termination of effector T(H)1 cells...
  3. pmc A transgenic model of central nervous system autoimmunity mediated by CD4+ and CD8+ T and B cells
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 188:2084-92. 2012
    ....
  4. doi request reprint Tim-3, a negative regulator of anti-tumor immunity
    Ana Carrizosa Anderson
    Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Immunol 24:213-6. 2012
    ..In addition to its role in exhausted T cells, recent data suggest that Tim-3 can further influence cancer outcome through its action on myeloid cells and cancer stem cells...
  5. ncbi request reprint The Notch regulator Numb links the Notch and TCR signaling pathways
    Ana C Anderson
    Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA
    J Immunol 174:890-7. 2005
    ..Together our data suggest that Notch and TCR signals may be integrated at the cell membrane, and that Numb may be an important adapter in this process...
  6. pmc Cutting edge: the Idd3 genetic interval determines regulatory T cell function through CD11b+CD11c- APC
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:7449-52. 2008
    ....
  7. pmc Tim-3/galectin-9 pathway: regulation of Th1 immunity through promotion of CD11b+Ly-6G+ myeloid cells
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 185:1383-92. 2010
    ..Our data uncover a novel mechanism by which the Tim-3/Gal-9 pathway regulates immune responses and identifies this pathway as a therapeutic target in diseases where myeloid-derived suppressor cells are disadvantageous...
  8. pmc Emerging Tim-3 functions in antimicrobial and tumor immunity
    Kaori Sakuishi
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Trends Immunol 32:345-9. 2011
    ..In contrast to this inhibitory effect on T cells, Tim-3-Gal-9 interaction promotes macrophage clearance of intracellular pathogens. Here, we focus on the emerging role for Tim-3 in tumor and antimicrobial immunity...
  9. pmc T-bet, a Th1 transcription factor regulates the expression of Tim-3
    Ana C Anderson
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA, USA
    Eur J Immunol 40:859-66. 2010
    ....
  10. pmc T and B cell hyperactivity and autoimmunity associated with niche-specific defects in apoptotic body clearance in TIM-4-deficient mice
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Harvard Institutes of Medicine, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 107:8706-11. 2010
    ....
  11. pmc Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion
    Manu Rangachari
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 18:1394-400. 2012
    ..These data indicate that Bat3 acts as an inhibitor of Tim-3–dependent exhaustion and cell death. Bat3 may thus represent a viable therapeutic target in autoimmune disorders, chronic infections and cancers...
  12. ncbi request reprint Modulation of CD4 co-receptor limits spontaneous autoimmunity when high-affinity transgenic TCR specific for self-antigen is expressed on a genetically resistant background
    Zsolt Illes
    Center for Neurologic Diseases, Harvard Institute of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Int Immunol 19:1235-48. 2007
    ....
  13. pmc Differential engagement of Tim-1 during activation can positively or negatively costimulate T cell expansion and effector function
    Sheng Xiao
    Center for Neurologic Diseases, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 204:1691-702. 2007
    ..These data indicate that Tim-1 regulates T cell responses and that Tim-1 engagement can alter T cell function depending on the affinity/avidity with which it is engaged...
  14. ncbi request reprint CD11b+Ly-6C(hi) suppressive monocytes in experimental autoimmune encephalomyelitis
    Bing Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:5228-37. 2007
    ..Further understanding of suppressive monocytes in autoimmune disease models may have important clinical implications for human autoimmune diseases...
  15. ncbi request reprint Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells
    Ana C Anderson
    Division of Molecular Immunology, Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Science 318:1141-3. 2007
    ..Thus, by virtue of differential expression on innate versus adaptive immune cells, Tim-3 can either promote or terminate TH1 immunity and may be able to influence a range of inflammatory conditions...
  16. pmc Tim3 binding to galectin-9 stimulates antimicrobial immunity
    Pushpa Jayaraman
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 207:2343-54. 2010
    ..We propose that the T(H)1 cell surface molecule Tim3 has evolved to inhibit growth of intracellular pathogens via its ligand Gal9, which in turn inhibits expansion of effector T(H)1 cells to prevent further tissue inflammation...
  17. ncbi request reprint Impairment of thymocyte development by dominant-negative Kuzbanian (ADAM-10) is rescued by the Notch ligand, delta-1
    Jennifer O Manilay
    Division of Immunology, Department of Molecular and Cell Biology, University of California, Berkeley, 94720, USA
    J Immunol 174:6732-41. 2005
    ..Our data suggest that multiple Notch-dependent steps in early thymocyte development require Kuzbanian, but differ in the involvement of other Notch signaling components...
  18. pmc TIM-4 expressed on APCs induces T cell expansion and survival
    ROSELYNN RODRIGUEZ-MANZANET
    Department of Neurology, Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 180:4706-13. 2008
    ..Tim-4 also induces the phosphorylation of signaling molecules LAT, Akt, and ERK1/2 in T cells. Tim-4, expressed on APCs, is a costimulatory molecule that promotes T cell expansion and survival by cross-linking Tim-1 on T cells...
  19. pmc Role of Th1 and Th17 cells in organ-specific autoimmunity
    Valerie Dardalhon
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Cambridge, MA 02139, USA
    J Autoimmun 31:252-6. 2008
    ..This review will discuss the respective roles of the Th1 and Th17 subsets in organ-specific autoimmunity...
  20. doi request reprint New roles for TIM family members in immune regulation
    Vijay K Kuchroo
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
    Nat Rev Immunol 8:577-80. 2008
    ..However, the recent discovery that antigen-presenting cells also express TIM molecules and the identification of new TIM-protein ligands has expanded the known roles of the TIM proteins in immune regulation...
  21. pmc IL-1β promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation
    Pushpa Jayaraman
    Division of Rheumatology, Immunology, and Allergy, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 190:4196-204. 2013
    ..Thus, IL-1β and downstream TNF production lead to caspase-dependent restriction of intracellular M. tuberculosis growth...
  22. ncbi request reprint IL-10 plays an important role in the homeostatic regulation of the autoreactive repertoire in naive mice
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 173:828-34. 2004
    ..EAE could be inhibited by prior tolerization of the mice with soluble PLP(139-151) peptide. These findings indicate that IL-10 may contribute to the regulation of the endogenous autoimmune repertoire...
  23. doi request reprint TIM-3 and its regulatory role in immune responses
    Chen Zhu
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA, 02115, USA
    Curr Top Microbiol Immunol 350:1-15. 2011
    ....
  24. pmc Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice
    Sue M Liu
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 121:4303-10. 2011
    ..Thus, we believe APCs provide a new candidate for therapeutic intervention in autoimmune diseases...
  25. ncbi request reprint TIM-3 in autoimmunity
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Curr Opin Immunol 18:665-9. 2006
    ..Most importantly, recent data suggest a novel paradigm in which dysregulation of the TIM-3-galectin-9 pathway could underlie chronic autoimmune disease states, such as multiple sclerosis...
  26. pmc The dynamics of effector T cells and Foxp3+ regulatory T cells in the promotion and regulation of autoimmune encephalomyelitis
    Thomas Korn
    Brigham and Women s Hospital, Center for Neurologic Diseases, Harvard Medical School, Boston, MA 02115, USA
    J Neuroimmunol 191:51-60. 2007
    ....
  27. ncbi request reprint Up-regulation of gene related to anergy in lymphocytes is associated with Notch-mediated human T cell suppression
    Alex M Kostianovsky
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Immunol 178:6158-63. 2007
    ....
  28. pmc Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity
    Kaori Sakuishi
    Center for Neurological Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 207:2187-94. 2010
    ..We further find that combined targeting of the Tim-3 and PD-1 pathways is more effective in controlling tumor growth than targeting either pathway alone...
  29. pmc Expression of self-antigen in the thymus: a little goes a long way
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Exp Med 198:1627-9. 2003
  30. ncbi request reprint Tim protein structures reveal a unique face for ligand binding
    Ana C Anderson
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Immunity 26:273-5. 2007
    ..In this issue of Immunity, Santiago et al. (2007) and Cao et al. (2007) report the crystal structures of several Tims and provide insights into the structure-function relationship of these molecules...
  31. pmc PD-1 and Tim-3 regulate the expansion of tumor antigen-specific CD8⁺ T cells induced by melanoma vaccines
    Julien Fourcade
    Authors Affiliations Division of Hematology Oncology, Department of Medicine Departments of Immunology and Biostatistics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Pfizer, Cambridge and Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts and Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland
    Cancer Res 74:1045-55. 2014
    ..Collectively, our findings support the use of PD-1 and Tim-3 blockades with cancer vaccines to stimulate potent antitumor T-cell responses and increase the likelihood of clinical responses in patients with advanced melanoma...
  32. pmc Immune checkpoints in central nervous system autoimmunity
    Nicole Joller
    Center for Neurologic Diseases, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115 5817, USA
    Immunol Rev 248:122-39. 2012
    ..Therefore, we propose that only the concerted action of a combination of inhibitory receptors is able to maintain peripheral tolerance and prevent autoimmunity...

Research Grants2

  1. Genetic Elements that Influence Susceptibility to CNS Autoimmunity
    ANA ANDERSON; Fiscal Year: 2007
    ..These studies will complement ongoing studies of the effects of Idd loci on the development of Type I diabetes in the NOD mouse and will accelerate the analysis of the genes affecting the development of CNS autoimmunity. ..