Susan L Andersen

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. doi request reprint Stress, sensitive periods and maturational events in adolescent depression
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 31:183-91. 2008
  2. pmc Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse
    Susan L Andersen
    Developmental Biopsychiatry Research Program, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 33:516-24. 2009
  3. pmc Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?
    Susan L Andersen
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    J Child Psychol Psychiatry 52:476-503. 2011
  4. doi request reprint A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals
    Susan L Andersen
    Laboratory of Developmental Neuropharmacology, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 68:741-7. 2010
  5. ncbi request reprint Stimulants and the developing brain
    Susan L Andersen
    Laboratory of Developmental Neuropharmacology, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Pharmacol Sci 26:237-43. 2005
  6. ncbi request reprint Trajectories of brain development: point of vulnerability or window of opportunity?
    Susan L Andersen
    Laboratory of Development Psychopharmocology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:3-18. 2003
  7. doi request reprint Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors
    Susan L Andersen
    Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
    Eur J Neurosci 27:2962-72. 2008
  8. ncbi request reprint The neurobiological consequences of early stress and childhood maltreatment
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:33-44. 2003
  9. doi request reprint Juvenile methylphenidate exposure and factors that influence incentive processing
    Heather C Brenhouse
    Laboratory for Developmental Neuropsychopharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Dev Neurosci 31:95-106. 2009
  10. pmc Pharmacologic neuroimaging of the ontogeny of dopamine receptor function
    Y Iris Chen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Dev Neurosci 32:125-38. 2010

Research Grants

  1. Early Drug Exposure and Drug Reward Mechanisms
    Susan L Andersen; Fiscal Year: 2010
  2. Translational Imaging of Methylphenidate Exposure
    Susan Andersen; Fiscal Year: 2003
  3. Early Drug Exposure and Drug Reward Mechanisms
    Susan Andersen; Fiscal Year: 2007

Collaborators

Detail Information

Publications36

  1. doi request reprint Stress, sensitive periods and maturational events in adolescent depression
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 31:183-91. 2008
    ..Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder...
  2. pmc Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuse
    Susan L Andersen
    Developmental Biopsychiatry Research Program, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 33:516-24. 2009
    ..Together, these factors may explain why exposure to early adversity increases risk to abuse substances during adolescence...
  3. pmc Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?
    Susan L Andersen
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
    J Child Psychol Psychiatry 52:476-503. 2011
    ..We endeavor to provocatively set the stage for altering treatment approaches for improving mental health in non-adult populations...
  4. doi request reprint A novel, multiple symptom model of obsessive-compulsive-like behaviors in animals
    Susan L Andersen
    Laboratory of Developmental Neuropharmacology, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 68:741-7. 2010
    ..None of these current models demonstrate multiple OCD-like behaviors...
  5. ncbi request reprint Stimulants and the developing brain
    Susan L Andersen
    Laboratory of Developmental Neuropharmacology, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Pharmacol Sci 26:237-43. 2005
    ..Preclinical studies of the effects of stimulant exposure provide increased understanding about the impact of stimulant drugs on brain development and provide insight into new treatment options for ADHD and other disorders of childhood...
  6. ncbi request reprint Trajectories of brain development: point of vulnerability or window of opportunity?
    Susan L Andersen
    Laboratory of Development Psychopharmocology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:3-18. 2003
    ..This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome...
  7. doi request reprint Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors
    Susan L Andersen
    Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
    Eur J Neurosci 27:2962-72. 2008
    ..These data provide evidence for a postnatal sensitive period when juvenile MPH exposure is able to alter cortical development...
  8. ncbi request reprint The neurobiological consequences of early stress and childhood maltreatment
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:33-44. 2003
    ..There are also gender differences in vulnerability and functional consequences. The neurobiological sequelae of early stress and maltreatment may play a significant role in the emergence of psychiatric disorders during development...
  9. doi request reprint Juvenile methylphenidate exposure and factors that influence incentive processing
    Heather C Brenhouse
    Laboratory for Developmental Neuropsychopharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Dev Neurosci 31:95-106. 2009
    ..These observations add to the growing literature on the enduring effects of MPH exposure, and highlight the need for more research in females...
  10. pmc Pharmacologic neuroimaging of the ontogeny of dopamine receptor function
    Y Iris Chen
    Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
    Dev Neurosci 32:125-38. 2010
    ..These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age...
  11. doi request reprint Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults
    Heather C Brenhouse
    McLean Hospital, Harvard Medical School, Belmont, MA 02144, USA
    Behav Neurosci 122:460-5. 2008
    ..Therefore, drug-addicted adolescents may have a higher risk of relapse than adults, leading to greater prevalence of addiction in this population...
  12. ncbi request reprint Depressive-like behavior in adolescents after maternal separation: sex differences, controllability, and GABA
    Melanie P Leussis
    Laboratory of Developmental Psychopharmacology, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
    Dev Neurosci 34:210-7. 2012
    ..Understanding the risk factors for depression, the nature of depressive-like behaviors, and their unique sex dependency may ultimately provide insight into improved treatments...
  13. ncbi request reprint The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK-801
    Melanie P Leussis
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Synapse 62:185-92. 2008
    ..These cortical changes can be reversed through a reduction of glutamatergic activity, but not serotonin augmentation...
  14. ncbi request reprint Childhood neglect is associated with reduced corpus callosum area
    Martin H Teicher
    Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 56:80-5. 2004
    ..Childhood abuse has been associated with abnormalities in brain development, particularly corpus callosum (CC) morphology. The impact of neglect has not been assessed, though it is the most prevalent form of childhood maltreatment...
  15. ncbi request reprint Transient dopamine synthesis modulation in prefrontal cortex: in vitro studies
    Nathalie L Dumont
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res Dev Brain Res 150:163-6. 2004
    ..The inhibitory effects of both agonists were antagonized by pre-incubation with the D1 antagonist SCH-23390 in cortex, but not in striatum...
  16. ncbi request reprint Enduring behavioral effects of early exposure to methylphenidate in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:1330-7. 2003
    ..Stimulant drugs can cause enduring behavioral adaptations, including altered drug sensitivity, in laboratory animals. We examined how early developmental exposure to stimulants affects behavior in several rodent models...
  17. ncbi request reprint Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats
    Stephen D Mague
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 57:120-5. 2005
    ..Here we examined if early MPH exposure alters the ability of cocaine to potentiate the rewarding effects of electrical stimulation of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS)...
  18. ncbi request reprint Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Child Adolesc Psychopharmacol 13:41-51. 2003
    ..These findings illustrate a clear inverse association between symptom severity and degree of therapeutic response that is crucial for our understanding of stimulant effects and effective clinical treatment of ADHD...
  19. ncbi request reprint Developmental neurobiology of childhood stress and trauma
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
    Psychiatr Clin North Am 25:397-426, vii-viii. 2002
    ....
  20. ncbi request reprint Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model
    Melanie P Leussis
    Laboratory of Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 62:22-30. 2008
    ..However, adverse life events during development have greater impact on males. An animal model that incorporates behavioral and anatomical changes following adolescent stress is needed...
  21. ncbi request reprint Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Int J Dev Neurosci 22:423-40. 2004
    ..We conclude with a discussion of the current status of preclinical studies on juvenile stimulant exposure...
  22. ncbi request reprint Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable?
    Martin H Teicher
    Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill Street Belmont, MA 02478, USA
    Ann N Y Acad Sci 1071:313-23. 2006
    ..To date, preclinical studies have guided clinical investigations and will continue to provide important insight into studies on molecular mechanisms and gene-environment interactions...
  23. doi request reprint Viral over-expression of D1 dopamine receptors in the prefrontal cortex increase high-risk behaviors in adults: Comparison with adolescents
    Kai C Sonntag
    Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill St, Belmont, MA, 02478, USA
    Psychopharmacology (Berl) 231:1615-26. 2014
    ..We hypothesized that a constellation of risk-related behaviors is mediated by prefrontal output neuron expression of D1...
  24. doi request reprint Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence
    Heather C Brenhouse
    McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 28:2375-82. 2008
    ....
  25. doi request reprint Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain development
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    J Neuropsychiatry Clin Neurosci 20:292-301. 2008
    ..Brain regions have unique windows of vulnerability to the effects of traumatic stress...
  26. pmc Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathology
    Filip Simunovic
    Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
    Brain 132:1795-809. 2009
    ..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease...
  27. doi request reprint Nonsteroidal anti-inflammatory treatment prevents delayed effects of early life stress in rats
    Heather C Brenhouse
    Laboratory for Developmental Neuropharmacology, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
    Biol Psychiatry 70:434-40. 2011
    ..Here, we investigated whether the developmental trajectories of PVB expression and COX-2 induction in the prelimbic region of the prefrontal cortex are altered after maternal separation stress in male rats...
  28. pmc Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changes
    Heather C Brenhouse
    Laboratory of Developmental Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 35:1687-703. 2011
    ..We draw upon clinical and preclinical studies to provide a neural framework for defining adolescence and its role in the transition to adulthood...
  29. ncbi request reprint Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Behav Brain Res 130:197-201. 2002
    ..The maturational decline in cAMP activity may explain why this disorder recedes, while, simultaneously cAMP becomes more responsive to D1 and D2 receptor stimulation in adulthood...
  30. ncbi request reprint Altered responsiveness to cocaine in rats exposed to methylphenidate during development
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Nat Neurosci 5:13-4. 2002
    ..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine...
  31. ncbi request reprint Differences in behavior and monoamine laterality following neonatal clomipramine treatment
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, McLean Hospital, Belmont, MA 02478, USA
    Dev Psychobiol 41:50-7. 2002
    ..This decline in monoaminergic content is consistent with clinical studies demonstrating decrements in serotonin as well as alterations in the lateralization of function in individuals with major depressive order...
  32. ncbi request reprint Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:683-91. 2002
    ..The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females...
  33. ncbi request reprint Delayed effects of early stress on hippocampal development
    Susan L Andersen
    Developmental Psychopharmacology Laboratory, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:1988-93. 2004
    ..Overall, these results suggest that early maternal separation produced a regionally specific delayed effect on the structure of the hippocampus by attenuating rates of synaptic development...
  34. ncbi request reprint Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical report
    Martin H Teicher
    Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    J Clin Psychiatry 70:684-91. 2009
    ..Depression is the most common adult outcome of exposure to childhood sexual abuse (CSA). In this study, we retrospectively assessed the length of time from initial abuse exposure to onset of a major depressive episode...
  35. ncbi request reprint Regulation of working memory by dopamine D4 receptor in rats
    Kehong Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 29:1648-55. 2004
    ..The present findings indicate a significant role of the D4 receptor in working memory, and suggest innovative, D4-based, treatment of cognitive deficits associated with neuropsychiatric disorders...
  36. ncbi request reprint Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
    Yin Ching I Chen
    Athinoula A Martinos Center for Biomedical Imaging and MGH NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacology (Berl) 180:705-15. 2005
    ..We wished to show that pharmacological magnetic resonance imaging (phMRI) may prove useful for this purpose...

Research Grants7

  1. Early Drug Exposure and Drug Reward Mechanisms
    Susan L Andersen; Fiscal Year: 2010
    ....
  2. Translational Imaging of Methylphenidate Exposure
    Susan Andersen; Fiscal Year: 2003
    ..These important pilot data will then serve as the basis for an R01 application that will determine the nature and mechanism by which early drug exposure imprints on brain activity in rats and humans. ..
  3. Early Drug Exposure and Drug Reward Mechanisms
    Susan Andersen; Fiscal Year: 2007
    ..abstract_text> ..