Research Topics
Species | Susan L AndersenSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Desperately driven and no brakes: developmental stress exposure and subsequent risk for substance abuseSusan L Andersen
Developmental Biopsychiatry Research Program, McLean Hospital Harvard Medical School, Belmont, MA 02478, USA
Neurosci Biobehav Rev 33:516-24. 2009..Together, these factors may explain why exposure to early adversity increases risk to abuse substances during adolescence...- Annual Research Review: New frontiers in developmental neuropharmacology: can long-term therapeutic effects of drugs be optimized through carefully timed early intervention?Susan L Andersen
Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA
J Child Psychol Psychiatry 52:476-503. 2011..We endeavor to provocatively set the stage for altering treatment approaches for improving mental health in non-adult populations... 
A novel, multiple symptom model of obsessive-compulsive-like behaviors in animalsSusan L Andersen
Laboratory of Developmental Neuropharmacology, McLean Hospital Harvard Medical School, Belmont, Massachusetts 02478, USA
Biol Psychiatry 68:741-7. 2010..None of these current models demonstrate multiple OCD-like behaviors...- Stress, sensitive periods and maturational events in adolescent depressionSusan L Andersen
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Trends Neurosci 31:183-91. 2008..Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder... 
Trajectories of brain development: point of vulnerability or window of opportunity?Susan L Andersen
Laboratory of Development Psychopharmocology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 27:3-18. 2003..This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome...- Stimulants and the developing brainSusan L Andersen
Laboratory of Developmental Neuropharmacology, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Trends Pharmacol Sci 26:237-43. 2005..Preclinical studies of the effects of stimulant exposure provide increased understanding about the impact of stimulant drugs on brain development and provide insight into new treatment options for ADHD and other disorders of childhood... - Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptorsSusan L Andersen
Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
Eur J Neurosci 27:2962-72. 2008..These data provide evidence for a postnatal sensitive period when juvenile MPH exposure is able to alter cortical development... - Juvenile methylphenidate exposure and factors that influence incentive processingHeather C Brenhouse
Laboratory for Developmental Neuropsychopharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Dev Neurosci 31:95-106. 2009..These observations add to the growing literature on the enduring effects of MPH exposure, and highlight the need for more research in females... - The neurobiological consequences of early stress and childhood maltreatmentMartin H Teicher
Department of Psychiatry, Harvard Medical School, and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
Neurosci Biobehav Rev 27:33-44. 2003..There are also gender differences in vulnerability and functional consequences. The neurobiological sequelae of early stress and maltreatment may play a significant role in the emergence of psychiatric disorders during development... - Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adultsHeather C Brenhouse
McLean Hospital, Harvard Medical School, Belmont, MA 02144, USA
Behav Neurosci 122:460-5. 2008..Therefore, drug-addicted adolescents may have a higher risk of relapse than adults, leading to greater prevalence of addiction in this population... - Pharmacologic neuroimaging of the ontogeny of dopamine receptor functionY Iris Chen
Athinoula A Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA
Dev Neurosci 32:125-38. 2010..These data suggest a predominance of D2-like over D1-like function between 20 and 30 days of age. These combined results suggested that the dopamine D1 receptor is functionally inhibited at young age... - Depressive-like behavior in adolescents after maternal separation: sex differences, controllability, and GABAMelanie P Leussis
Laboratory of Developmental Psychopharmacology, Department of Psychiatry, McLean Hospital and Harvard Medical School, Belmont, MA 02478, USA
Dev Neurosci 34:210-7. 2012..Understanding the risk factors for depression, the nature of depressive-like behaviors, and their unique sex dependency may ultimately provide insight into improved treatments... - Childhood neglect is associated with reduced corpus callosum areaMartin H Teicher
Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 56:80-5. 2004..CONCLUSIONS: These data are consistent with animal research that demonstrated reduced CC size in nursery-reared compared with semi-naturally reared primates. Early experience might also affect the development of the human CC... - Transient dopamine synthesis modulation in prefrontal cortex: in vitro studiesNathalie L Dumont
Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Brain Res Dev Brain Res 150:163-6. 2004..The inhibitory effects of both agonists were antagonized by pre-incubation with the D1 antagonist SCH-23390 in cortex, but not in striatum... - Enduring behavioral effects of early exposure to methylphenidate in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 54:1330-7. 2003..The effects of MPH on cocaine-related behaviors may be a general consequence of early stimulant exposure... - The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK-801Melanie P Leussis
Laboratory for Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Synapse 62:185-92. 2008..These cortical changes can be reversed through a reduction of glutamatergic activity, but not serotonin augmentation... - Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in ratsStephen D Mague
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 57:120-5. 2005..Reduced sensitivity to these various types of reward may reflect general dysfunctions of brain reward systems... - Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorderMartin H Teicher
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Child Adolesc Psychopharmacol 13:41-51. 2003..These findings illustrate a clear inverse association between symptom severity and degree of therapeutic response that is crucial for our understanding of stimulant effects and effective clinical treatment of ADHD... - Developmental neurobiology of childhood stress and traumaMartin H Teicher
Department of Psychiatry, Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA
Psychiatr Clin North Am 25:397-426, vii-viii. 2002.... - Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress modelMelanie P Leussis
Laboratory of Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Synapse 62:22-30. 2008..However, adverse life events during development have greater impact on males. An animal model that incorporates behavioral and anatomical changes following adolescent stress is needed... - Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable?Martin H Teicher
Developmental Biopsychiatry Research Program, McLean Hospital, 115 Mill Street Belmont, MA 02478, USA
Ann N Y Acad Sci 1071:313-23. 2006..To date, preclinical studies have guided clinical investigations and will continue to provide important insight into studies on molecular mechanisms and gene-environment interactions... - Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugsSusan L Andersen
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Int J Dev Neurosci 22:423-40. 2004..We conclude with a discussion of the current status of preclinical studies on juvenile stimulant exposure... - Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescenceHeather C Brenhouse
McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 28:2375-82. 2008.... - Nonsteroidal anti-inflammatory treatment prevents delayed effects of early life stress in ratsHeather C Brenhouse
Laboratory for Developmental Neuropharmacology, McLean Hospital, Department of Psychiatry, Harvard Medical School, Belmont, Massachusetts, USA
Biol Psychiatry 70:434-40. 2011..Here, we investigated whether the developmental trajectories of PVB expression and COX-2 induction in the prelimbic region of the prefrontal cortex are altered after maternal separation stress in male rats... - Preliminary evidence for sensitive periods in the effect of childhood sexual abuse on regional brain developmentSusan L Andersen
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
J Neuropsychiatry Clin Neurosci 20:292-301. 2008..Brain regions have unique windows of vulnerability to the effects of traumatic stress... - Developmental trajectories during adolescence in males and females: a cross-species understanding of underlying brain changesHeather C Brenhouse
Laboratory of Developmental Neuropharmacology, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 35:1687-703. 2011..We draw upon clinical and preclinical studies to provide a neural framework for defining adolescence and its role in the transition to adulthood... - Gene expression profiling of substantia nigra dopamine neurons: further insights into Parkinson's disease pathologyFilip Simunovic
Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA 02478, USA
Brain 132:1795-809. 2009..Our data provide a 'molecular fingerprint identity' of late-stage Parkinson's disease DA neurons that will advance our understanding of the molecular pathology of this disease... - Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)Susan L Andersen
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 130:197-201. 2002..The maturational decline in cAMP activity may explain why this disorder recedes, while, simultaneously cAMP becomes more responsive to D1 and D2 receptor stimulation in adulthood... - Altered responsiveness to cocaine in rats exposed to methylphenidate during developmentSusan L Andersen
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Nat Neurosci 5:13-4. 2002..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine... - Regulation of working memory by dopamine D4 receptor in ratsKehong Zhang
Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 29:1648-55. 2004..The present findings indicate a significant role of the D4 receptor in working memory, and suggest innovative, D4-based, treatment of cognitive deficits associated with neuropsychiatric disorders... - Differences in behavior and monoamine laterality following neonatal clomipramine treatmentSusan L Andersen
Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, McLean Hospital, Belmont, MA 02478, USA
Dev Psychobiol 41:50-7. 2002..This decline in monoaminergic content is consistent with clinical studies demonstrating decrements in serotonin as well as alterations in the lateralization of function in individuals with major depressive order... - Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproductionSusan L Andersen
Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychoneuroendocrinology 27:683-91. 2002..The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females... - Delayed effects of early stress on hippocampal developmentSusan L Andersen
Developmental Psychopharmacology Laboratory, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
Neuropsychopharmacology 29:1988-93. 2004..Overall, these results suggest that early maternal separation produced a regionally specific delayed effect on the structure of the hippocampus by attenuating rates of synaptic development... - Length of time between onset of childhood sexual abuse and emergence of depression in a young adult sample: a retrospective clinical reportMartin H Teicher
Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
J Clin Psychiatry 70:684-91. 2009..Depression is the most common adult outcome of exposure to childhood sexual abuse (CSA). In this study, we retrospectively assessed the length of time from initial abuse exposure to onset of a major depressive episode... - Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imagingYin-Ching I Chen
Athinoula A. Martinos Center for Biomedical Imaging and MGH-NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
Psychopharmacology (Berl) 180:705-15. 2005..CONCLUSIONS: These results suggest that phMRI may potentially prove useful to map DAR function non-invasively in multiple brain regions simultaneously...
Research Grants
- Early Drug Exposure and Drug Reward MechanismsSusan L Andersen; Fiscal Year: 2010....
- Translational Imaging of Methylphenidate ExposureSusan Andersen; Fiscal Year: 2003..These important pilot data will then serve as the basis for an R01 application that will determine the nature and mechanism by which early drug exposure imprints on brain activity in rats and humans. ..
- Early Drug Exposure and Drug Reward MechanismsSusan Andersen; Fiscal Year: 2007..abstract_text> ..