S L Andersen

Summary

Affiliation: Harvard Medical School
Country: USA

Publications

  1. ncbi Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model
    Melanie P Leussis
    Laboratory of Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 62:22-30. 2008
  2. ncbi Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Int J Dev Neurosci 22:423-40. 2004
  3. doi Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors
    Susan L Andersen
    Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
    Eur J Neurosci 27:2962-72. 2008
  4. ncbi Delayed effects of early stress on hippocampal development
    Susan L Andersen
    Developmental Psychopharmacology Laboratory, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:1988-93. 2004
  5. ncbi Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:683-91. 2002
  6. ncbi Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Behav Brain Res 130:197-201. 2002
  7. ncbi Altered responsiveness to cocaine in rats exposed to methylphenidate during development
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Nat Neurosci 5:13-4. 2002
  8. ncbi Maturational increases in c-fos expression in the ascending dopamine systems
    S L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 41:345-50. 2001
  9. ncbi Sex differences in dopamine receptors and their relevance to ADHD
    S L Andersen
    The Consolidated Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
    Neurosci Biobehav Rev 24:137-41. 2000
  10. pmc Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent rats
    H C Brenhouse
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 169:628-36. 2010

Collaborators

Detail Information

Publications27

  1. ncbi Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model
    Melanie P Leussis
    Laboratory of Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 62:22-30. 2008
    ..However, adverse life events during development have greater impact on males. An animal model that incorporates behavioral and anatomical changes following adolescent stress is needed...
  2. ncbi Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugs
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Int J Dev Neurosci 22:423-40. 2004
    ..We conclude with a discussion of the current status of preclinical studies on juvenile stimulant exposure...
  3. doi Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptors
    Susan L Andersen
    Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
    Eur J Neurosci 27:2962-72. 2008
    ..These data provide evidence for a postnatal sensitive period when juvenile MPH exposure is able to alter cortical development...
  4. ncbi Delayed effects of early stress on hippocampal development
    Susan L Andersen
    Developmental Psychopharmacology Laboratory, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
    Neuropsychopharmacology 29:1988-93. 2004
    ..Overall, these results suggest that early maternal separation produced a regionally specific delayed effect on the structure of the hippocampus by attenuating rates of synaptic development...
  5. ncbi Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproduction
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Psychoneuroendocrinology 27:683-91. 2002
    ..The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females...
  6. ncbi Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
    Behav Brain Res 130:197-201. 2002
    ..The maturational decline in cAMP activity may explain why this disorder recedes, while, simultaneously cAMP becomes more responsive to D1 and D2 receptor stimulation in adulthood...
  7. ncbi Altered responsiveness to cocaine in rats exposed to methylphenidate during development
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
    Nat Neurosci 5:13-4. 2002
    ..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine...
  8. ncbi Maturational increases in c-fos expression in the ascending dopamine systems
    S L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, Belmont, Massachusetts 02478, USA
    Synapse 41:345-50. 2001
    ..Implications of these results are discussed for stimulant use in a pediatric population and the development of drug abuse...
  9. ncbi Sex differences in dopamine receptors and their relevance to ADHD
    S L Andersen
    The Consolidated Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
    Neurosci Biobehav Rev 24:137-41. 2000
    ..Differences in D1 receptor density in nucleus accumbens may have implications for increased substance abuse in males...
  10. pmc Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent rats
    H C Brenhouse
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neuroscience 169:628-36. 2010
    ..Furthermore, pharmacological intervention attenuated subsequent drug-primed reinstatement of cocaine-conditioned preferences. We establish a potential direction for distinct strategies to treat this vulnerable population...
  11. ncbi Dopamine receptor pruning during the peripubertal period is not attenuated by NMDA receptor antagonism in rat
    M H Teicher
    Developmental Psychopharmacology Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Lett 339:169-71. 2003
    ..3) or at P120 (P>0.7). These data suggest that the normal 40% reduction in striatal dopamine receptor density that occurs between puberty and adulthood is not dependent on post-pubertal glutamatergic transmission through NMDA receptors...
  12. doi Windows of vulnerability: maternal separation, age, and fluoxetine on adolescent depressive-like behavior in rats
    N Freund
    Laboratory of Developmental Neuropsychopharmacology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 0247, United States
    Neuroscience 249:88-97. 2013
    ....
  13. ncbi Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septi
    S K Yeghiayan
    Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
    Neurosci Lett 236:147-50. 1997
    ..These results support the impression that transporter proteins for these monoamines are not regulated by increased ligand abundance...
  14. ncbi Transient dopamine synthesis modulation in prefrontal cortex: in vitro studies
    Nathalie L Dumont
    Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Brain Res Dev Brain Res 150:163-6. 2004
    ..The inhibitory effects of both agonists were antagonized by pre-incubation with the D1 antagonist SCH-23390 in cortex, but not in striatum...
  15. ncbi Differences in behavior and monoamine laterality following neonatal clomipramine treatment
    Susan L Andersen
    Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, McLean Hospital, Belmont, MA 02478, USA
    Dev Psychobiol 41:50-7. 2002
    ..This decline in monoaminergic content is consistent with clinical studies demonstrating decrements in serotonin as well as alterations in the lateralization of function in individuals with major depressive order...
  16. doi Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adults
    Heather C Brenhouse
    McLean Hospital, Harvard Medical School, Belmont, MA 02144, USA
    Behav Neurosci 122:460-5. 2008
    ..Therefore, drug-addicted adolescents may have a higher risk of relapse than adults, leading to greater prevalence of addiction in this population...
  17. ncbi The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK-801
    Melanie P Leussis
    Laboratory for Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
    Synapse 62:185-92. 2008
    ..These cortical changes can be reversed through a reduction of glutamatergic activity, but not serotonin augmentation...
  18. ncbi Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in rats
    Stephen D Mague
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 57:120-5. 2005
    ..Here we examined if early MPH exposure alters the ability of cocaine to potentiate the rewarding effects of electrical stimulation of the medial forebrain bundle (MFB) using intracranial self-stimulation (ICSS)...
  19. ncbi Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging
    Yin Ching I Chen
    Athinoula A Martinos Center for Biomedical Imaging and MGH NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
    Psychopharmacology (Berl) 180:705-15. 2005
    ..We wished to show that pharmacological magnetic resonance imaging (phMRI) may prove useful for this purpose...
  20. ncbi Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorder
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, Boston, MA, USA
    J Child Adolesc Psychopharmacol 13:41-51. 2003
    ..These findings illustrate a clear inverse association between symptom severity and degree of therapeutic response that is crucial for our understanding of stimulant effects and effective clinical treatment of ADHD...
  21. ncbi Enduring behavioral effects of early exposure to methylphenidate in rats
    William A Carlezon
    Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
    Biol Psychiatry 54:1330-7. 2003
    ..Stimulant drugs can cause enduring behavioral adaptations, including altered drug sensitivity, in laboratory animals. We examined how early developmental exposure to stimulants affects behavior in several rodent models...
  22. ncbi Stimulants and the developing brain
    Susan L Andersen
    Laboratory of Developmental Neuropharmacology, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Pharmacol Sci 26:237-43. 2005
    ..Preclinical studies of the effects of stimulant exposure provide increased understanding about the impact of stimulant drugs on brain development and provide insight into new treatment options for ADHD and other disorders of childhood...
  23. ncbi The neurobiological consequences of early stress and childhood maltreatment
    Martin H Teicher
    Department of Psychiatry, Harvard Medical School, and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:33-44. 2003
    ..There are also gender differences in vulnerability and functional consequences. The neurobiological sequelae of early stress and maltreatment may play a significant role in the emergence of psychiatric disorders during development...
  24. doi Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescence
    Heather C Brenhouse
    McLean Hospital, Belmont, Massachusetts 02478, USA
    J Neurosci 28:2375-82. 2008
    ....
  25. doi Stress, sensitive periods and maturational events in adolescent depression
    Susan L Andersen
    Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Trends Neurosci 31:183-91. 2008
    ..Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder...
  26. ncbi Trajectories of brain development: point of vulnerability or window of opportunity?
    Susan L Andersen
    Laboratory of Development Psychopharmocology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
    Neurosci Biobehav Rev 27:3-18. 2003
    ..This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome...
  27. ncbi Regulation of working memory by dopamine D4 receptor in rats
    Kehong Zhang
    Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
    Neuropsychopharmacology 29:1648-55. 2004
    ..The present findings indicate a significant role of the D4 receptor in working memory, and suggest innovative, D4-based, treatment of cognitive deficits associated with neuropsychiatric disorders...