Research Topics
Species | S L AndersenSummaryAffiliation: Harvard Medical School Country: USA Publications
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Detail Information
Publications
Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress modelMelanie P Leussis
Laboratory of Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, Belmont, Massachusetts 02478, USA
Synapse 62:22-30. 2008..However, adverse life events during development have greater impact on males. An animal model that incorporates behavioral and anatomical changes following adolescent stress is needed...- Pubertal changes in gonadal hormones do not underlie adolescent dopamine receptor overproductionSusan L Andersen
Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Psychoneuroendocrinology 27:683-91. 2002..The results of this study suggest that the endogenous rise in gonadal steroid hormones during puberty is not responsible for the overproduction of receptors in males or the lack of overproduction in females... - Sex differences in dopamine receptors and their relevance to ADHDS L Andersen
The Consolidated Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, MA 02178, USA
Neurosci Biobehav Rev 24:137-41. 2000..Differences in D1 receptor density in nucleus accumbens may have implications for increased substance abuse in males... - Maturational increases in c-fos expression in the ascending dopamine systemsS L Andersen
Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, Mailman Laboratories for Psychiatric Research, McLean Hospital, Belmont, Massachusetts 02478, USA
Synapse 41:345-50. 2001..Implications of these results are discussed for stimulant use in a pediatric population and the development of drug abuse... - Altered responsiveness to cocaine in rats exposed to methylphenidate during developmentSusan L Andersen
Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, Massachusetts 02478, USA
Nat Neurosci 5:13-4. 2002..Here we show in rats that exposure to MPH during pre-adolescence causes behavioral and neurobiological adaptations that endure into adulthood, and that are consistent with increased sensitivity to the aversive effects of cocaine... - Changes in the second messenger cyclic AMP during development may underlie motoric symptoms in attention deficit/hyperactivity disorder (ADHD)Susan L Andersen
Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA
Behav Brain Res 130:197-201. 2002..The maturational decline in cAMP activity may explain why this disorder recedes, while, simultaneously cAMP becomes more responsive to D1 and D2 receptor stimulation in adulthood... - Delayed effects of early stress on hippocampal developmentSusan L Andersen
Developmental Psychopharmacology Laboratory, Department of Psychiatry, Harvard Medical School, Belmont, MA, USA
Neuropsychopharmacology 29:1988-93. 2004..Overall, these results suggest that early maternal separation produced a regionally specific delayed effect on the structure of the hippocampus by attenuating rates of synaptic development... 
Juvenile methylphenidate modulates reward-related behaviors and cerebral blood flow by decreasing cortical D3 receptorsSusan L Andersen
Laboratory for Developmental Neuropsychopharmacology, Harvard Medical School, McLean Hospital, Boston, MA, USA
Eur J Neurosci 27:2962-72. 2008..These data provide evidence for a postnatal sensitive period when juvenile MPH exposure is able to alter cortical development...- Altering the course of neurodevelopment: a framework for understanding the enduring effects of psychotropic drugsSusan L Andersen
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Int J Dev Neurosci 22:423-40. 2004..We conclude with a discussion of the current status of preclinical studies on juvenile stimulant exposure... 
Enhancing the salience of dullness: behavioral and pharmacological strategies to facilitate extinction of drug-cue associations in adolescent ratsH C Brenhouse
Laboratory for Developmental Neuropharmacology, Department of Psychiatry, McLean Hospital, Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neuroscience 169:628-36. 2010..Furthermore, pharmacological intervention attenuated subsequent drug-primed reinstatement of cocaine-conditioned preferences. We establish a potential direction for distinct strategies to treat this vulnerable population...- Dopamine receptor pruning during the peripubertal period is not attenuated by NMDA receptor antagonism in ratM H Teicher
Developmental Psychopharmacology Laboratory, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Lett 339:169-71. 2003..3) or at P120 (P>0.7). These data suggest that the normal 40% reduction in striatal dopamine receptor density that occurs between puberty and adulthood is not dependent on post-pubertal glutamatergic transmission through NMDA receptors... - Lack of effect of chronic clorgyline or selegiline on dopamine and serotonin transporters in rat caudate-putamen or nucleus accumbens septiS K Yeghiayan
Consolidated Department of Psychiatry and Neuroscience Program, Harvard Medical School, Boston, MA, USA
Neurosci Lett 236:147-50. 1997..These results support the impression that transporter proteins for these monoamines are not regulated by increased ligand abundance... - Enduring behavioral effects of early exposure to methylphenidate in ratsWilliam A Carlezon
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 54:1330-7. 2003..The effects of MPH on cocaine-related behaviors may be a general consequence of early stimulant exposure... - Differences in behavior and monoamine laterality following neonatal clomipramine treatmentSusan L Andersen
Department of Psychiatry, Harvard Medical School, Laboratory of Developmental Psychopharmacology, McLean Hospital, Belmont, MA 02478, USA
Dev Psychobiol 41:50-7. 2002..This decline in monoaminergic content is consistent with clinical studies demonstrating decrements in serotonin as well as alterations in the lateralization of function in individuals with major depressive order... - Delayed extinction and stronger reinstatement of cocaine conditioned place preference in adolescent rats, compared to adultsHeather C Brenhouse
McLean Hospital, Harvard Medical School, Belmont, MA 02144, USA
Behav Neurosci 122:460-5. 2008..Therefore, drug-addicted adolescents may have a higher risk of relapse than adults, leading to greater prevalence of addiction in this population... - The enduring effects of an adolescent social stressor on synaptic density, part II: Poststress reversal of synaptic loss in the cortex by adinazolam and MK-801Melanie P Leussis
Laboratory for Developmental Neuropharmacology, Department of Psychiatry, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Synapse 62:185-92. 2008..These cortical changes can be reversed through a reduction of glutamatergic activity, but not serotonin augmentation... - Transient dopamine synthesis modulation in prefrontal cortex: in vitro studiesNathalie L Dumont
Department of Psychiatry, Harvard Medical School, McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA
Brain Res Dev Brain Res 150:163-6. 2004..The inhibitory effects of both agonists were antagonized by pre-incubation with the D1 antagonist SCH-23390 in cortex, but not in striatum... - Early developmental exposure to methylphenidate reduces cocaine-induced potentiation of brain stimulation reward in ratsStephen D Mague
Department of Psychiatry, Harvard Medical School, McLean Hospital, Belmont, Massachusetts 02478, USA
Biol Psychiatry 57:120-5. 2005..Reduced sensitivity to these various types of reward may reflect general dysfunctions of brain reward systems... - Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imagingYin-Ching I Chen
Athinoula A. Martinos Center for Biomedical Imaging and MGH-NMR Center, Department of Radiology Massachusetts General Hospital, Charlestown, MA 02129, USA
Psychopharmacology (Berl) 180:705-15. 2005..CONCLUSIONS: These results suggest that phMRI may potentially prove useful to map DAR function non-invasively in multiple brain regions simultaneously... - Rate dependency revisited: understanding the effects of methylphenidate in children with attention deficit hyperactivity disorderMartin H Teicher
Department of Psychiatry, Harvard Medical School, Boston, MA, USA
J Child Adolesc Psychopharmacol 13:41-51. 2003..These findings illustrate a clear inverse association between symptom severity and degree of therapeutic response that is crucial for our understanding of stimulant effects and effective clinical treatment of ADHD... - Trajectories of brain development: point of vulnerability or window of opportunity?Susan L Andersen
Laboratory of Development Psychopharmocology, Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Neurosci Biobehav Rev 27:3-18. 2003..This review endeavors to provide an overview of key components of mammalian brain development while simultaneously providing a framework for how perturbations during these changes uniquely impinge on the final outcome... - The neurobiological consequences of early stress and childhood maltreatmentMartin H Teicher
Department of Psychiatry, Harvard Medical School, and Developmental Biopsychiatry Research Program, McLean Hospital, Belmont, MA 02478, USA
Neurosci Biobehav Rev 27:33-44. 2003..There are also gender differences in vulnerability and functional consequences. The neurobiological sequelae of early stress and maltreatment may play a significant role in the emergence of psychiatric disorders during development... - Transient D1 dopamine receptor expression on prefrontal cortex projection neurons: relationship to enhanced motivational salience of drug cues in adolescenceHeather C Brenhouse
McLean Hospital, Belmont, Massachusetts 02478, USA
J Neurosci 28:2375-82. 2008.... - Stress, sensitive periods and maturational events in adolescent depressionSusan L Andersen
Department of Psychiatry, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Trends Neurosci 31:183-91. 2008..Adolescent depression is a serious recurrent brain-based disorder. Understanding the genesis and neurobiological basis is important in the development of more effective intervention strategies to treat or prevent the disorder... - Regulation of working memory by dopamine D4 receptor in ratsKehong Zhang
Mailman Research Center, McLean Division of Massachusetts General Hospital, Belmont, MA 02478, USA
Neuropsychopharmacology 29:1648-55. 2004..The present findings indicate a significant role of the D4 receptor in working memory, and suggest innovative, D4-based, treatment of cognitive deficits associated with neuropsychiatric disorders... - Stimulants and the developing brainSusan L Andersen
Laboratory of Developmental Neuropharmacology, McLean Hospital and Harvard Medical School, 115 Mill Street, Belmont, MA 02478, USA
Trends Pharmacol Sci 26:237-43. 2005..Preclinical studies of the effects of stimulant exposure provide increased understanding about the impact of stimulant drugs on brain development and provide insight into new treatment options for ADHD and other disorders of childhood...