C A Alper

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E
    Viviana Romero
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Genet 8:14. 2007
  2. ncbi request reprint Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency
    Chester A Alper
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Immunol 23:297-305. 2003
  3. ncbi request reprint A history of complement genetics
    C A Alper
    The Center for Blood Research and the Department of Pediatrics, Harvard Medical School, Boston, Mass 02115, USA
    Exp Clin Immunogenet 15:203-12. 1998
  4. ncbi request reprint A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease
    C A Alper
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Exp Clin Immunogenet 17:138-47. 2000
  5. ncbi request reprint Incomplete penetrance of MHC susceptibility genes: prospective analysis of polygenic MHC-determined traits
    C A Alper
    The Center for Blood Research, Boston, Massachusetts 02115 6303, USA
    Tissue Antigens 56:199-206. 2000
  6. ncbi request reprint Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype
    C A Alper
    The Center for Blood Research, Boston, Massachusetts 02115 6303, USA
    Tissue Antigens 56:207-16. 2000
  7. ncbi request reprint The haplotype structure of the human major histocompatibility complex
    Chester A Alper
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Hum Immunol 67:73-84. 2006
  8. ncbi request reprint The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency
    B Calvo
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Immunol 20:216-20. 2000
  9. ncbi request reprint HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes
    C Pinto
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Hum Immunol 65:181-7. 2004
  10. ncbi request reprint HLA-DQ RFLP variants of five HLA-DQw2-bearing major histocompatibility complex extended haplotypes
    J J Yunis
    Division of Immunogenetics, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Immunogenetics 32:88-95. 1990

Collaborators

  • E J Yunis
  • Gunnar Sturfelt
  • Lennart Truedsson
  • D P Dubey
  • S J Brink
  • G S Eisenbarth
  • Alberto Pugliese
  • Z L Awdeh
  • Zaheed Husain
  • Charles E Larsen
  • Viviana Romero
  • C Pinto
  • C E Larsen
  • G P Uko
  • D A Fici
  • B Calvo
  • M Ann Kelly
  • Dolores A Fici
  • Tatiana Romero
  • Joaquin Zuniga
  • Lama El-Dahdah
  • Ingrid Almeciga
  • Olga P Clavijo
  • Jonathan S Duke-Cohan
  • Edward A Fox
  • Dennis R Alford
  • Irma Szymanski
  • Nichol Holodick
  • Caitlin Day
  • Z Husain
  • Z C Wang
  • J A Hansen
  • M Fernandez-Vina
  • A G Smith
  • B Nisperos
  • O P Clavijo
  • Nadeem M Mirza
  • Souhad Younes
  • Edward Levitan
  • P A Fraser
  • K D Crawford
  • D Marcus-Bagley
  • L Castano
  • J J Yunis
  • S J Lechin
  • S M Alosco
  • M Wescott

Detail Information

Publications18

  1. pmc Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E
    Viviana Romero
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA, USA
    BMC Genet 8:14. 2007
    ..The definition of human MHC class I haplotypes through association of HLA-A, HLA-Cw and HLA-B has been used to analyze ethnicity, population migrations and disease association...
  2. ncbi request reprint Immunoglobulin deficiencies and susceptibility to infection among homozygotes and heterozygotes for C2 deficiency
    Chester A Alper
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Immunol 23:297-305. 2003
    ....
  3. ncbi request reprint A history of complement genetics
    C A Alper
    The Center for Blood Research and the Department of Pediatrics, Harvard Medical School, Boston, Mass 02115, USA
    Exp Clin Immunogenet 15:203-12. 1998
    ..Finally, some recent work based on features in the DNA of the MHC-encoded complement genes is outlined that sheds some light on their evolution...
  4. ncbi request reprint A simple estimate of the general population frequency of the MHC susceptibility gene for autoimmune polygenic disease
    C A Alper
    Center for Blood Research, Harvard Medical School, Boston, MA 02115, USA
    Exp Clin Immunogenet 17:138-47. 2000
    ..The analysis is general, simple and provides a single estimate (not a range) of the MHC susceptibility gene frequency. This approach should be applicable to other MHC-determined polygenic diseases...
  5. ncbi request reprint Incomplete penetrance of MHC susceptibility genes: prospective analysis of polygenic MHC-determined traits
    C A Alper
    The Center for Blood Research, Boston, Massachusetts 02115 6303, USA
    Tissue Antigens 56:199-206. 2000
    ..0 were consistent with an intrinsic mechanism for baseline penetrance acting on the MHC susceptibility genes...
  6. ncbi request reprint Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype
    C A Alper
    The Center for Blood Research, Boston, Massachusetts 02115 6303, USA
    Tissue Antigens 56:207-16. 2000
    ....
  7. ncbi request reprint The haplotype structure of the human major histocompatibility complex
    Chester A Alper
    CBR Institute for Biomedical Research, and Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Hum Immunol 67:73-84. 2006
    ....
  8. ncbi request reprint The [HLA-B18, F1C30, DR3] conserved extended haplotype carries a susceptibility gene for IgD deficiency
    B Calvo
    The Center for Blood Research, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Clin Immunol 20:216-20. 2000
    ..The high frequency of IgD deficiency in both homozygotes and heterozygotes for (F1C30, DR3) suggests a partially penetrant dominant susceptibility gene for IgD deficiency on [HLA-B18, F1C30, DR3]...
  9. ncbi request reprint HLA-Cw*0409N is associated with HLA-A*2301 and HLA-B*4403-carrying haplotypes
    C Pinto
    Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Hum Immunol 65:181-7. 2004
    ..Our findings demonstrate the first example of three different HLA-Cw-determined subtypes of a common or CEH carrying a shared HLA-B allele, in this case HLA-B*4403...
  10. ncbi request reprint HLA-DQ RFLP variants of five HLA-DQw2-bearing major histocompatibility complex extended haplotypes
    J J Yunis
    Division of Immunogenetics, Dana Farber Cancer Institute, Boston, Massachusetts 02115
    Immunogenetics 32:88-95. 1990
    ..Our results show that the DNA in the DR/DQ region of extended haplotypes is relatively fixed and that different DQw2 subtypes characterize different DQw2-bearing extended haplotypes...
  11. ncbi request reprint Inheritable variable sizes of DNA stretches in the human MHC: conserved extended haplotypes and their fragments or blocks
    E J Yunis
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Boston, MA 02115, USA
    Tissue Antigens 62:1-20. 2003
    ..This knowledge could also be used for matching CEHs and their fragments for patients undergoing allotransplantation...
  12. ncbi request reprint Hepatitis B surface antigen- and tetanus toxoid-specific clonal expansion of CD4+ cells in vitro determined by TCRBV CDR3 length and nucleotide sequence
    G P Uko
    The Center for Blood Research and the Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Genes Immun 2:11-9. 2001
    ..The ability to induce monoclonal/ oligoclonal responses to HBsAg now permits motif identification studies for determining the T cell role in nonresponsiveness to the HBsAg vaccine...
  13. ncbi request reprint The genetics of HLA-associated disease
    Charles E Larsen
    The CBR Institute for Biomedical Research, 800 Huntington Avenue, Boston, MA 02115, USA
    Curr Opin Immunol 16:660-7. 2004
    ..Epigenetic mechanisms are probably involved in many MHC-associated phenomena, including autoimmunity, and appear to be the best explanation for incomplete penetrance...
  14. pmc Incomplete penetrance of susceptibility genes for MHC-determined immunoglobulin deficiencies in monozygotic twins discordant for type 1 diabetes
    Chester A Alper
    The CBR Institute for Biomedical Research, Harvard Medical School, 800 Huntington Avenue, Boston, MA 02115, USA edu
    J Autoimmun 27:89-95. 2006
    ..Because multiple different external triggers would be required to explain the results, differential environmental determinants appear unlikely...
  15. ncbi request reprint The MHC type 1 diabetes susceptibility gene is centromeric to HLA-DQB1
    Zaheed Husain
    Immune Disease Institute, 800 Huntington Avenue, Boston, MA 02115, USA
    J Autoimmun 30:266-72. 2008
    ....
  16. ncbi request reprint Mendelian inheritance of polygenic diseases: a hypothetical basis for increasing incidence
    Z L Awdeh
    The CBR Institute for Biomedical Research, 800 Huntington Avenue, Boston, MA 02115, USA
    Med Hypotheses 64:495-8. 2005
    ..The parents and patients would also be expected to give more evidence of ethnic or subethnic disparity than that observed in controls...
  17. ncbi request reprint HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells
    Zaheed Husain
    Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA
    J Clin Immunol 22:28-36. 2002
    ....
  18. ncbi request reprint Increased apoptosis of CD20+ IgA + B cells is the basis for IgA deficiency: the molecular mechanism for correction in vitro by IL-10 and CD40L
    Zaheed Husain
    The CBR Institute for Biomedical Research, Boston, Massachusetts 02115, USA
    J Clin Immunol 26:113-25. 2006
    ..The inability to detect secreted IgA in IgAd patients could result from the loss of IgA-committed B cells that express high levels of caspase-1...