Research Topics
Genomes and Genes
Species | Stacey E AlexeeffSummaryAffiliation: Harvard University Country: USA Publications
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Detail Information
Publications
Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging StudyCizao Ren
Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
Occup Environ Med 68:562-9. 2011..Studies show that exposure to air pollution damages human health, but the mechanisms are not fully understood. One suggested pathway is via oxidative stress...
Statin use reduces decline in lung function: VA Normative Aging StudyStacey E Alexeeff
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, Landmark Center West, 415, 401 Park Drive, Boston, MA 02215, USA
Am J Respir Crit Care Med 176:742-7. 2007..Decreased lung function has been linked to increased inflammation and oxidative stress. Statins have demonstrated antiinflammatory and antioxidant properties...
Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging studyStacey E Alexeeff
Department of Environmental Health, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, MA 02215, USA
Chest 132:1890-7. 2007..Ozone has heterogeneous effects on lung function. We investigated whether obesity and airways hyperresponsiveness (AHR) modify the acute effects of ozone on lung function in the elderly...- Air pollution, obesity, genes and cellular adhesion moleculesJaime Madrigano
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Occup Environ Med 67:312-7. 2010..We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association... - Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging StudyJohn McCracken
Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr, Boston, MA 02215, USA
Environ Health Perspect 118:1564-70. 2010..Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown... - Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging StudyJoel Schwartz
Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Occup Environ Med 69:422-7. 2012..The main objective was to assess the relationship between long-term exposure to traffic-related air pollution and blood pressure (BP)... - Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging StudyElissa H Wilker
Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
Environ Health 10:45. 2011..We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations... - Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohortTeresa Chahine
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 115:1617-22. 2007..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter... - Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genesElissa H Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 118:943-8. 2010..MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated... - Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matterElissa Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 117:935-40. 2009..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation... - Focused exposures to airborne traffic particles and heart rate variability in the elderlySara Dubowsky Adar
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Epidemiology 18:95-103. 2007..Because these risks may be particularly great for traffic-related particles, we examined associations between particles and heart rate variability as 44 subjects participated in 4 repeated trips aboard a diesel bus... - Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactionsCizao Ren
Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Environ Health 9:78. 2010..One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure... - Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery diseaseKai Jen Chuang
Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
Circulation 118:1314-20. 2008..The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes... - Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphismsAndrea Baccarelli
Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
Circulation 117:1802-9. 2008.... - Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging studyShona C Fang
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 120:674-80. 2012..Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role... - HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interactionSung Kyun Park
Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
Circulation 114:2798-805. 2006..Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system... - Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial functionStacey E Alexeeff
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 119:481-6. 2011..Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP... - Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort studyMelinda C Power
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
Environ Health 12:16. 2013.... - Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammationSara D Dubowsky
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
Environ Health Perspect 114:992-8. 2006..We found modest positive associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers... - Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly menElissa H Wilker
Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, United States
Atherosclerosis 206:480-5. 2009..We hypothesized that candidate genes selected for a study of asthma and chronic obstructive pulmonary disorder (COPD) are associated with markers of systemic inflammation and endothelial dysfunction in an aging population... - Ambient pollution and blood pressure in cardiac rehabilitation patientsAntonella Zanobetti
Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Dr, Landmark Center, Suite 415, PO Box 15698, Boston, Mass 02215, USA
Circulation 110:2184-9. 2004..We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease... - Traffic-related air pollution and cognitive function in a cohort of older menMelinda C Power
Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
Environ Health Perspect 119:682-7. 2011..Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment... - Air pollution and ST-segment depression in elderly subjectsDiane R Gold
Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
Environ Health Perspect 113:883-7. 2005..Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic... - Long-term survival after acute myocardial infarction is lower in more deprived neighborhoodsCathryn Tonne
Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
Circulation 111:3063-70. 2005.... - Traffic-related particles are associated with elevated homocysteine: the VA normative aging studySung Kyun Park
Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory Street, SPH II M6240, Ann Arbor, MI 48109, USA
Am J Respir Crit Care Med 178:283-9. 2008..Particulate air pollution has been related to cardiovascular death and hospital admission, but the underlying mechanisms are not fully elucidated... - Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus tripSara Dubowsky Adar
Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
Environ Health Perspect 115:507-12. 2007.... - Air quality measurements for the aerosol research and inhalation epidemiology studyD Alan Hansen
Electric Power Research Institute, Palo Alto, CA 94304, USA
J Air Waste Manag Assoc 56:1445-58. 2006..To date, 13-, 25-, and 53-month air quality datasets have been used in epidemiologic analyses... - Workgroup report: workshop on source apportionment of particulate matter health effects--intercomparison of results and implicationsGeorge D Thurston
Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
Environ Health Perspect 113:1768-74. 2005..These results provide supportive evidence that existing PM2.5 source apportionment methods can be used to derive reliable insights into the source components that contribute to PM2.5 health effects... - The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plansMorton Lippmann
New York University School of Medicine, New York, New York, USA
Environ Health Perspect 111:1074-92. 2003..5 years) and longer-term goals. It consists of six sections: biological mechanisms, acute effects, chronic effects, dosimetry, exposure assessment, and the specific attributes of a coordinated PM centers program... - Chronic particulate exposure, mortality, and coronary heart disease in the nurses' health studyROBIN C PUETT
Department of Environmental Health Sciences, University of South Carolina, 2221 Devine Street, Columbia, SC 29208, USA
Am J Epidemiol 168:1161-8. 2008..In this population, increases in such exposures were associated with increases in all-cause and CHD mortality. Never smokers with higher body mass indexes were at greatest risk of fatal CHD... - PM source apportionment and health effects: 1. Intercomparison of source apportionment resultsPhilip K Hopke
Center for Air Resources Engineering and Science, Clarkson University, Potsdam, NY 13699 5708, USA
J Expo Sci Environ Epidemiol 16:275-86. 2006..5) mass source apportionment results are consistent across users and methods, and that today's source apportionment methods are robust enough for application to PM(2.5) health effects assessments... - Lung inflammation induced by concentrated ambient air particles is related to particle compositionPaulo H N Saldiva
Department of Pathology, School of Medicine, , Brazil
Am J Respir Crit Care Med 165:1610-7. 2002..Results demonstrate that short-term exposures to CAPs from Boston induce a significant inflammatory reaction in rat lungs, with this reaction influenced by particle composition...