Stacey E Alexeeff

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study
    Cizao Ren
    Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Occup Environ Med 68:562-9. 2011
  2. pmc Statin use reduces decline in lung function: VA Normative Aging Study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, Landmark Center West, 415, 401 Park Drive, Boston, MA 02215, USA
    Am J Respir Crit Care Med 176:742-7. 2007
  3. ncbi request reprint Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, MA 02215, USA
    Chest 132:1890-7. 2007
  4. pmc Air pollution, obesity, genes and cellular adhesion molecules
    Jaime Madrigano
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 67:312-7. 2010
  5. pmc Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 118:1564-70. 2010
  6. pmc Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Environ Health 12:16. 2013
  7. pmc Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study
    Joel Schwartz
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Occup Environ Med 69:422-7. 2012
  8. pmc Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Environ Health 10:45. 2011
  9. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
  10. pmc Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    Circulation 117:1802-9. 2008

Detail Information

Publications33

  1. pmc Urinary 8-hydroxy-2'-deoxyguanosine as a biomarker of oxidative DNA damage induced by ambient pollution in the Normative Aging Study
    Cizao Ren
    Department of Environmental Health, Exposure, Epidemiology and Risk Program, Harvard School of Public Health, Boston, MA 02215, USA
    Occup Environ Med 68:562-9. 2011
    ..Studies show that exposure to air pollution damages human health, but the mechanisms are not fully understood. One suggested pathway is via oxidative stress...
  2. pmc Statin use reduces decline in lung function: VA Normative Aging Study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, Landmark Center West, 415, 401 Park Drive, Boston, MA 02215, USA
    Am J Respir Crit Care Med 176:742-7. 2007
    ..Decreased lung function has been linked to increased inflammation and oxidative stress. Statins have demonstrated antiinflammatory and antioxidant properties...
  3. ncbi request reprint Ozone exposure and lung function: effect modified by obesity and airways hyperresponsiveness in the VA normative aging study
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Landmark Center West, 415, 401 Park Dr, Boston, MA 02215, USA
    Chest 132:1890-7. 2007
    ..Ozone has heterogeneous effects on lung function. We investigated whether obesity and airways hyperresponsiveness (AHR) modify the acute effects of ozone on lung function in the elderly...
  4. pmc Air pollution, obesity, genes and cellular adhesion molecules
    Jaime Madrigano
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Occup Environ Med 67:312-7. 2010
    ..We examined the association between particulate matter and cell adhesion molecules. We also investigated the modifying effect of genotype and phenotype variation to gain insight into the relevant biological pathways for this association...
  5. pmc Annual ambient black carbon associated with shorter telomeres in elderly men: Veterans Affairs Normative Aging Study
    John McCracken
    Department of Environmental Health, Harvard School of Public Health, Landmark Building, 415 West, 401 Park Dr, Boston, MA 02215, USA
    Environ Health Perspect 118:1564-70. 2010
    ..Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown...
  6. pmc Modification by hemochromatosis gene polymorphisms of the association between traffic-related air pollution and cognition in older men: a cohort study
    Melinda C Power
    Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA
    Environ Health 12:16. 2013
    ....
  7. pmc Association between long-term exposure to traffic particles and blood pressure in the Veterans Administration Normative Aging Study
    Joel Schwartz
    Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Occup Environ Med 69:422-7. 2012
    ..The main objective was to assess the relationship between long-term exposure to traffic-related air pollution and blood pressure (BP)...
  8. pmc Ambient pollutants, polymorphisms associated with microRNA processing and adhesion molecules: the Normative Aging Study
    Elissa H Wilker
    Cardiovascular Epidemiology Research Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Environ Health 10:45. 2011
    ..We also investigated whether single nucleotide polymorphisms (SNPs) in miRNA-processing genes modify these associations...
  9. pmc Particulate air pollution, oxidative stress genes, and heart rate variability in an elderly cohort
    Teresa Chahine
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 115:1617-22. 2007
    ..We have extended this to include a longitudinal analysis with more subjects and examination of the GT short tandem repeat polymorphism in the heme oxygenase-1 (HMOX-1) promoter...
  10. pmc Cardiac autonomic dysfunction: effects from particulate air pollution and protection by dietary methyl nutrients and metabolic polymorphisms
    Andrea Baccarelli
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass 02215, USA
    Circulation 117:1802-9. 2008
    ....
  11. pmc Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease
    Kai Jen Chuang
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, USA
    Circulation 118:1314-20. 2008
    ..The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes...
  12. pmc Black carbon exposures, blood pressure, and interactions with single nucleotide polymorphisms in MicroRNA processing genes
    Elissa H Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 118:943-8. 2010
    ..MicroRNAs (miRNAs) are emerging as key regulators of gene expression, but whether polymorphisms in genes involved in processing of miRNAs to maturity influence susceptibility to BC has not been elucidated...
  13. pmc Postural changes in blood pressure associated with interactions between candidate genes for chronic respiratory diseases and exposure to particulate matter
    Elissa Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 117:935-40. 2009
    ..Fine particulate matter [aerodynamic diameter </= 2.5 mum (PM(2.5))] has been associated with autonomic dysregulation...
  14. pmc Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions
    Cizao Ren
    Exposure, Epidemiology, and Risk Program, Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Environ Health 9:78. 2010
    ..One suggested pathway is that pollution causes oxidative stress. If so, oxidative stress-related genotypes may modify the oxidative response defenses to pollution exposure...
  15. ncbi request reprint Focused exposures to airborne traffic particles and heart rate variability in the elderly
    Sara Dubowsky Adar
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Epidemiology 18:95-103. 2007
    ..Because these risks may be particularly great for traffic-related particles, we examined associations between particles and heart rate variability as 44 subjects participated in 4 repeated trips aboard a diesel bus...
  16. pmc Residential black carbon exposure and circulating markers of systemic inflammation in elderly males: the normative aging study
    Shona C Fang
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 120:674-80. 2012
    ..Traffic-related particles (TRPs) are associated with adverse cardiovascular events. The exact mechanisms are unclear, but systemic inflammatory responses likely play a role...
  17. ncbi request reprint HFE genotype, particulate air pollution, and heart rate variability: a gene-environment interaction
    Sung Kyun Park
    Department of Environmental Health, Harvard School of Public Health, Boston, Mass, USA
    Circulation 114:2798-805. 2006
    ..Two HFE polymorphisms (C282Y and H63D) associated with increased iron uptake may modify the effect of metal-rich particles on the cardiovascular system...
  18. pmc Medium-term exposure to traffic-related air pollution and markers of inflammation and endothelial function
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:481-6. 2011
    ..Exposure to traffic-related air pollution (TRAP) contributes to increased cardiovascular risk. Land-use regression models can improve exposure assessment for TRAP...
  19. pmc Association between blood pressure and DNA methylation of retrotransposons and pro-inflammatory genes
    Stacey E Alexeeff
    Department of Environmental Health, Harvard School of Public Health, Boston MA 02215, USA
    Int J Epidemiol 42:270-80. 2013
    ..We examined the relation of BP to the methylation of retrotransposon sequences of DNA and of selected candidate genes...
  20. pmc Diabetes, obesity, and hypertension may enhance associations between air pollution and markers of systemic inflammation
    Sara D Dubowsky
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts, USA
    Environ Health Perspect 114:992-8. 2006
    ..We found modest positive associations between PM2.5 and indicators of systemic inflammation, with larger associations suggested for individuals with diabetes, obesity, hypertension, and elevated mean inflammatory markers...
  21. pmc Candidate genes for respiratory disease associated with markers of inflammation and endothelial dysfunction in elderly men
    Elissa H Wilker
    Department of Environmental Health, Harvard School of Public Health, Boston, MA 02215, United States
    Atherosclerosis 206:480-5. 2009
    ..We hypothesized that candidate genes selected for a study of asthma and chronic obstructive pulmonary disorder (COPD) are associated with markers of systemic inflammation and endothelial dysfunction in an aging population...
  22. ncbi request reprint Ambient pollution and blood pressure in cardiac rehabilitation patients
    Antonella Zanobetti
    Department of Environmental Health, Exposure Epidemiology and Risk Program, Harvard School of Public Health, 401 Park Dr, Landmark Center, Suite 415, PO Box 15698, Boston, Mass 02215, USA
    Circulation 110:2184-9. 2004
    ..We investigated the associations between fine particulate pollution (PM2.5) and blood pressure during 631 repeated visits for cardiac rehabilitation in 62 Boston residents with cardiovascular disease...
  23. pmc Traffic-related air pollution and cognitive function in a cohort of older men
    Melinda C Power
    Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02215, USA
    Environ Health Perspect 119:682-7. 2011
    ..Traffic-related particles induce oxidative stress and may exert adverse effects on central nervous system function, which could manifest as cognitive impairment...
  24. pmc Air pollution and ST-segment depression in elderly subjects
    Diane R Gold
    Channing Laboratory, Brigham and Women s Hospital, Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Environ Health Perspect 113:883-7. 2005
    ..Carbon monoxide was not a confounder of this association. ST-segment depression, possibly representing myocardial ischemia or inflammation, is associated with increased exposure to particles whose predominant source is traffic...
  25. ncbi request reprint Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods
    Cathryn Tonne
    Department of Environmental Health, Harvard School of Public Health, Boston, MA, USA
    Circulation 111:3063-70. 2005
    ....
  26. pmc Traffic-related particles are associated with elevated homocysteine: the VA normative aging study
    Sung Kyun Park
    Department of Environmental Health Sciences, University of Michigan School of Public Health, 109 S Observatory Street, SPH II M6240, Ann Arbor, MI 48109, USA
    Am J Respir Crit Care Med 178:283-9. 2008
    ..Particulate air pollution has been related to cardiovascular death and hospital admission, but the underlying mechanisms are not fully elucidated...
  27. pmc Ambient and microenvironmental particles and exhaled nitric oxide before and after a group bus trip
    Sara Dubowsky Adar
    Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA
    Environ Health Perspect 115:507-12. 2007
    ....
  28. ncbi request reprint Air quality measurements for the aerosol research and inhalation epidemiology study
    D Alan Hansen
    Electric Power Research Institute, Palo Alto, CA 94304, USA
    J Air Waste Manag Assoc 56:1445-58. 2006
    ..To date, 13-, 25-, and 53-month air quality datasets have been used in epidemiologic analyses...
  29. pmc Workgroup report: workshop on source apportionment of particulate matter health effects--intercomparison of results and implications
    George D Thurston
    Nelson Institute of Environmental Medicine, New York University School of Medicine, Tuxedo Park, New York 10987, USA
    Environ Health Perspect 113:1768-74. 2005
    ..These results provide supportive evidence that existing PM2.5 source apportionment methods can be used to derive reliable insights into the source components that contribute to PM2.5 health effects...
  30. pmc The U.S. Environmental Protection Agency Particulate Matter Health Effects Research Centers Program: a midcourse report of status, progress, and plans
    Morton Lippmann
    New York University School of Medicine, New York, New York, USA
    Environ Health Perspect 111:1074-92. 2003
    ..5 years) and longer-term goals. It consists of six sections: biological mechanisms, acute effects, chronic effects, dosimetry, exposure assessment, and the specific attributes of a coordinated PM centers program...
  31. pmc Chronic particulate exposure, mortality, and coronary heart disease in the nurses' health study
    ROBIN C PUETT
    Department of Environmental Health Sciences, University of South Carolina, 2221 Devine Street, Columbia, SC 29208, USA
    Am J Epidemiol 168:1161-8. 2008
    ..In this population, increases in such exposures were associated with increases in all-cause and CHD mortality. Never smokers with higher body mass indexes were at greatest risk of fatal CHD...
  32. ncbi request reprint PM source apportionment and health effects: 1. Intercomparison of source apportionment results
    Philip K Hopke
    Center for Air Resources Engineering and Science, Clarkson University, Potsdam, NY 13699 5708, USA
    J Expo Sci Environ Epidemiol 16:275-86. 2006
    ..5) mass source apportionment results are consistent across users and methods, and that today's source apportionment methods are robust enough for application to PM(2.5) health effects assessments...
  33. ncbi request reprint Lung inflammation induced by concentrated ambient air particles is related to particle composition
    Paulo H N Saldiva
    Department of Pathology, School of Medicine, University of Sao Paulo, Brazil
    Am J Respir Crit Care Med 165:1610-7. 2002
    ..Results demonstrate that short-term exposures to CAPs from Boston induce a significant inflammatory reaction in rat lungs, with this reaction influenced by particle composition...