Research Topics
| M P AlexanderSummaryAffiliation: Harvard University Country: USA Publications
Research Grants
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Detail Information
Publications
Cognitive impairments due to focal cerebellar injuries in adultsMichael P Alexander
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Cortex 48:980-90. 2012..This investigation was designed to assess whether focal cerebellar injuries in adults would cause impairment on tasks previously demonstrated to be sensitive to prefrontal lesions...- Cognitive and functional outcome after out of hospital cardiac arrestMichael P Alexander
Cognitive Neurology Unit, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
J Int Neuropsychol Soc 17:364-8. 2011..Coma duration was associated with group. Neither group had a high prevalence of depression. For most patients within the "middle range" of acute severity of OHCA, cognitive and functional outcomes at 3 months were encouraging... 
Impaired concentration due to frontal lobe damage from two distinct lesion sitesM P Alexander
Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Neurology 65:572-9. 2005..Some form of impairment in attention is often asserted to cause the revealed deficits...- Regional frontal injuries cause distinct impairments in cognitive controlM P Alexander
Behavioral Neurology, Beth Israel Deaconess Medical Center, and Harvard Medical School, Boston, MA, USA
Neurology 68:1515-23. 2007..Lesions of the frontal lobes may impair the capacity of patients to control otherwise intact cognitive operations in the face of ambiguous sensory input or conflicting possible responses... - Impairments of procedures for implementing complex language are due to disruption of frontal attention processesMichael P Alexander
Harvard Medical School, Behavioral Neurology Unit, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
J Int Neuropsychol Soc 12:236-47. 2006.... - Age-related differences in movement representationS Hutchinson
Neuroimaging Laboratory, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
Neuroimage 17:1720-8. 2002..This study has important implications for functional imaging experiments of neurological disorders in older subjects... - The neurological and cognitive sequelae of cardiac arrestC Lim
Behavioral Neurology Unit KS 2, Department of Neurology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA
Neurology 63:1774-8. 2004..Although cardiac arrest (CA) is commonly cited as a cause of amnesia, patients referred to the authors' center with a diagnosis of "amnesia" after CA rarely have isolated memory deficits... - California Verbal Learning Test: performance by patients with focal frontal and non-frontal lesionsM P Alexander
Rotman Research Institute of Baycrest Centre for Geriatric Care, University of Toronto, Toronto, ON, Canada
Brain 126:1493-503. 2003..This study has demonstrated even finer differentiations within the frontal region than previously known... - Central neurogenic hyperventilation: a case report and discussion of pathophysiologyAndrew W Tarulli
Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Arch Neurol 62:1632-4. 2005..Central neurogenic hyperventilation is a rare condition with poorly understood pathophysiology... - Stroke and episodic memory disordersChun Lim
The Cognitive Neurology Unit, Department of Neurology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Neuropsychologia 47:3045-58. 2009.... - Chronic akinetic mutism after mesencephalic-diencephalic infarction: remediated with dopaminergic medicationsM P Alexander
Memory Disorders Research Center, Boston University, Department of Neurology, Massachusetts, USA
Neurorehabil Neural Repair 15:151-6. 2001..The mechanism of abulia is more complex than simply a partial dopaminergic deficiency state and may persist even when AKM is treated and frontal cognitive functions are normal... - Lesion site patterns in severe, nonverbal aphasia to predict outcome with a computer-assisted treatment programM A Naeser
Department of Neurology, Boston University School of Medicine and the Harold Goodglass Aphasia Research Center at the Department of Veterans Affairs Medical Center, Mass, USA
Arch Neurol 55:1438-48. 1998.... 
Triangular backgrounds shift the bias of line bisection performance in hemispatial neglectM B Shulman
Department of Neurology, New York University Medical Center, New York, USA
J Neurol Neurosurg Psychiatry 72:68-72. 2002..This effect is strong enough to eliminate neglect on a bisection task. The mechanism of this effect is expressed through preattentive visual capacities...- Elevated false recognition in patients with frontal lobe damage is neither a general nor a unitary phenomenonMieke Verfaellie
Boston University School of Medicine, Memory Disorders Research Center, Boston Veterans Affairs Health Care System, Boston, MA, USA
Neuropsychology 18:94-103. 2004..These patients exhibited impaired monitoring and verification processes. The findings demonstrate that elevated false recognition is not characteristic of all frontal patients and may result from more than 1 underlying mechanism... - Impaired list learning is not a general property of frontal lesionsMichael P Alexander
Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
J Cogn Neurosci 21:1422-34. 2009..Small sample sizes, confounding anomia, and incomplete representation of all frontal regions have prevented consistent demonstration of distinct regional frontal effects on this task... - The evidence for brain injury in whiplash injuriesMichael P Alexander
Harvard Medical School, Boston, Massachusetts, USA
Pain Res Manag 8:19-23. 2003 - A role for right medial prefontal cortex in accurate feeling-of-knowing judgements: evidence from patients with lesions to frontal cortexDavid M Schnyer
Memory Disorders Research Center, Boston VA Healthcare System and Boston University School of Medicine 151A, 150 South Huntington Avenue, Boston, MA 02130 4817, USA
Neuropsychologia 42:957-66. 2004..These findings provide functional and anatomical evidence for a dissociation between recall confidence and prospective memory monitoring and are discussed in terms of familiarity and access theories of FOK predictions... - Dissociations within the anterior attentional system: effects of task complexity and irrelevant information on reaction time speed and accuracyDonald T Stuss
The Rotman Research Institute, Baycrest Centre for Geriatric Care, Toronto, Ontario, Canada
Neuropsychology 16:500-13. 2002..The frontal lobes, particularly right dorsolateral, were required to inhibit an incorrect response. There are at least 3 functionally and anatomically separable anterior attentional processes... - Multiple frontal systems controlling response speedDonald T Stuss
The Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Neuropsychologia 43:396-417. 2005..Monitoring of stimulus occurrence and response behaviour in order to enhance the speed of response to upcoming stimuli is sensitive to RL lesions... - Staying on the job: the frontal lobes control individual performance variabilityDonald T Stuss
Rotman Research Institute, Baycrest Centre for Geriatric Care and University of Toronto, Ontario, Canada
Brain 126:2363-80. 2003..Damage to different frontal regions causes different profiles of abnormal variability. Fluctuations in performance of a task may underlie some of the reported difficulties in daily tasks reported by patients with frontal injuries... - The multiple dimensions of sustained attentionTim Shallice
SISSA, Trieste, Italy
Cortex 44:794-805. 2008..1995). The most plausible interpretation is in terms of energising processes which involve the SM frontal cortex and monitoring processes which involve the RL frontal cortex... - Rehabilitation of executive functioning after focal damage to the cerebellumTom A Schweizer
Rotman Research Institute, Baycrest, Toronto, ON, Canada
Neurorehabil Neural Repair 22:72-7. 2008..This is the first report on the rehabilitation of impaired executive functioning following focal damage to the cerebellum and in the presence of intact frontal cortex... - Fast and efficient visuotemporal attention requires the cerebellumTom A Schweizer
Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ont M6A 2E1, Canada
Neuropsychologia 45:3068-74. 2007..These data provide evidence implicating the cerebellum as a critical node in the neuroanatomical network underlying visuotemporal attention and provide further evidence for the role of the cerebellum in non-motor behaviors... - Is there a dysexecutive syndrome?Donald T Stuss
Rotman Research Institute, Baycrest, 3560 Bathurst Street, Toronto, Ontario, Canada M6A 2E1
Philos Trans R Soc Lond B Biol Sci 362:901-15. 2007..Although distinct, these processes are flexibly assembled in response to context, complexity and intention over real time into different networks within the frontal regions and between frontal and posterior regions... - Keeping time: effects of focal frontal lesionsTerence W Picton
The Rotman Research Institute, Baycrest Centre for Geriatric Care, 3560 Bathurst Street, Toronto, Ont, Canada M6A 2E1
Neuropsychologia 44:1195-209. 2006..In contrast, the superior medial regions of the frontal lobe are necessary to maintain consistent timing performance over prolonged periods of time... - Effects of focal frontal lesions on response inhibitionTerence W Picton
Rotman Research Institute at Baycrest, Toronto, Ontario M6A 2E1, Canada
Cereb Cortex 17:826-38. 2007..Lesions to the right ventrolateral prefrontal cortex (Brodmann areas 44, 45, 47) also increased the variability of response, perhaps by disrupting monitoring performance... - Cognitive rehabilitation in the elderly: a randomized trial to evaluate a new protocolDonald T Stuss
Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
J Int Neuropsychol Soc 13:120-31. 2007..The results for each functional domain are reported in separate papers in this series... - Triangular backgrounds shift line bisection performance in hemispatial neglect: the critical pointMichael Esterman
Geriatric Neuropsychology Laboratory, Geriatric Research, Education and Clinical Center, VA Boston Healthcare System, Massachusetts 02130, USA
J Int Neuropsychol Soc 8:721-6. 2002..Similar geometric illusions that are also intact in neglect, along with these results, suggest that preattentive, implicit visual processing is preserved in neglect and drives these illusions... - The cerebellum mediates conflict resolutionTom A Schweizer
Rotman Research Institute, Baycrest, Toronto, Ontario, Canada
J Cogn Neurosci 19:1974-82. 2007..These results are the first demonstration of impaired conflict resolution following cerebellar lesions in the presence of an intact prefrontal cortex... - Outpatient rehabilitation of patients with chronic cognitive impairments after ruptured anterior communicating artery aneurysms reduces the burden of care: a pilot studyVirginia M Mills
Community Rehab Care, Inc, Newton, MA 02458, USA
Brain Inj 20:1183-8. 2006..To describe the functional outcome of 19 patients with anterior communicating artery aneurysm following the completion of an inter-disciplinary out-patient rehabilitation programme... - Recovery of ambulation after traumatic brain injuryDouglas I Katz
HealthSouth Braintree Rehabilitation Hospital, 250 Pond Street, Braintree, MA 02184, USA
Arch Phys Med Rehabil 85:865-9. 2004..To identify variables that are predictive of independent ambulation after traumatic brain injury (TBI) and to define the time course of recovery...
Research Grants
- Cognition and Functional Recovery after Cardiac ArrestMichael Alexander; Fiscal Year: 2007....