M S Albert
Affiliation: Harvard University
- Biomedical imaging using hyperpolarized noble gas MRI: pulse sequence considerationsL Zhao
Department of Radiology, Harvard Medical School, Boston, MA 02115, USA
Nucl Instrum Methods Phys Res A 402:454-60. 1998..Pulse sequences can be optimized to effectively utilize the non-renewable hyperpolarization, to enhance the SNR, and to eliminate image artifacts. Hyperpolarized noble gas MRI is concluded to be quite feasible...
- Development of hyperpolarized noble gas MRIM S Albert
Department of Radiology MRI, Harvard Medical School, Boston, MA 02115, USA
Nucl Instrum Methods Phys Res A 402:441-53. 1998..Cortical brain function is one perfusion-dependent phenomena that may be explored with hyperpolarized 129Xe MR. This leads to the exciting possibility of conducting hyperpolarized 129Xe functional MRI (HypX-fMRI) studies...
- Hyperpolarized (129)Xe T (1) in oxygenated and deoxygenated bloodM S Albert
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
NMR Biomed 13:407-14. 2000....
- T(1) of (129)Xe in blood and the role of oxygenationM S Albert
Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
J Magn Reson 140:264-73. 1999..Oxygenation was found to markedly increase the T(1) of (129)Xe in blood, as originally measured, and it shifts the RBC resonance to a higher frequency. Carbon monoxide has a similar but somewhat stronger effect...
- Increased hippocampal activation in mild cognitive impairment compared to normal aging and ADB C Dickerson
Department of Neurology, The Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Neurology 65:404-11. 2005..CONCLUSIONS: The authors hypothesize that there is a phase of increased medial temporal lobe activation early in the course of prodromal Alzheimer disease followed by a subsequent decrease as the disease progresses...
- Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer diseaseR S Desikan
Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
AJNR Am J Neuroradiol 30:532-8. 2009..Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific temporoparietal regions can predict the time to progress from MCI to AD...
- Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI studyB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
Hippocampus 17:1060-70. 2007..These fronto-temporal brain regions act together as a large-scale memory-related network, the components of which make distinct yet interacting contributions during encoding that predict subsequent successful free recall performance...
- Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengthsB C Dickerson
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
Neuroimage 39:10-8. 2008....
- Encoding novel face-name associations: a functional MRI studyR A Sperling
Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Hum Brain Mapp 14:129-39. 2001..These data suggest that the process of forming new face-name associations is supported by a distributed network of brain regions, and provide additional evidence for the essential role of the hippocampus in associative memory processes...
- fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's diseaseR A Sperling
Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
J Neurol Neurosurg Psychiatry 74:44-50. 2003..To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer's disease by functional magnetic resonance imaging (fMRI) during an associative encoding task...
- Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adultsB C Dickerson
Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
Neurology 76:1395-402. 2011....
- Preclinical prediction of AD using neuropsychological testsM S Albert
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
J Int Neuropsychol Soc 7:631-9. 2001....
- Presenilin-1-associated abnormalities in regional cerebral perfusionK A Johnson
Radiology and Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
Neurology 56:1545-51. 2001..The subjects were members of a large pedigree from Colombia, South America, many of whom carry a PS-1 mutation for early-onset AD...
- Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depressionE Daly
Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
Appl Neuropsychol 8:12-22. 2001..The findings support the view that the cognitive deficits found in CFS cannot be attributed solely to the presence of depressive symptomatology in the patients...
- Perfusion abnormalities in prodromal ADK A Johnson
Departments of Neurology and Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
Neurobiol Aging 21:289-92. 2000..These perfusion abnormalities may also shed light on how AD progresses during the prodromal phase of disease and may ultimately lead to improved diagnosis or methods of monitoring response to treatment...
- Recall and recognition memory in obsessive-compulsive disorderC R Savage
Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
J Neuropsychiatry Clin Neurosci 8:99-103. 1996..These results are interpreted as providing preliminary evidence of a nonverbal memory retrieval deficit consistent with proposed corticostriatal system dysfunction in OCD...
- Hyperpolarized 3He MR imaging of the lung: normal range of ventilation defects and PFT correlation in young adultsEdward Y Lee
Department of Radiology, Children s Hospital Boston, Boston, MA, USA
J Thorac Imaging 24:110-4. 2009....
- Quantification of water diffusion and relaxation times of human U87 tumors in a mouse modelYanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
NMR Biomed 17:399-404. 2004..64 +/- 0.06 s. The mean T(2) in tumor was 0.062 +/- 0.002 s and in normal brain tissue was 0.048 +/- 0.001 s. The mean ADC, T1 and T2 of the tumor compared to normal tissue were significantly different (p < 0.005)...
- Volume reconstruction techniques improve the correlation between histological and in vivo tumor volume measurements in mouse models of human gliomasKarl F Schmidt
Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA
J Neurooncol 68:207-15. 2004....
- Reinvestigating hyperpolarized (129)Xe longitudinal relaxation time in the rat brain with noise considerationsX Zhou
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
NMR Biomed 21:217-25. 2008..3 +/- 1.2 and 16.2 +/- 0.9 s, suggesting that the low SNR might be a key reason for the wide range of T(1) values published in the literature, a problem that might be easily alleviated by taking SNR levels into account...
- Signal-to-noise ratio comparison of encoding methods for hyperpolarized noble gas MRIL Zhao
Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
J Magn Reson 148:314-26. 2001..Theoretical results are confirmed with hyperpolarized noble gas MRI experiments...
- MRI measures of temporoparietal regions show differential rates of atrophy during prodromal ADR S Desikan
Dept of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
Neurology 71:819-25. 2008..The current study was designed to determine whether a broader set of temporoparietal regions show differential rates of atrophy during the evolution of AD...
- Single photon emission computed tomography perfusion differences in mild cognitive impairmentK A Johnson
Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
J Neurol Neurosurg Psychiatry 78:240-7. 2007..To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI)...
- Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brainM Ingelsson
Harvard Medical School, Massachusetts General Hospital, Boston
Neurology 62:925-31. 2004....
- Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse modelsLaifong Lee
Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
Genes Chromosomes Cancer 42:213-27. 2005..These results constitute definitive preclinical data that justify proceeding with clinical trials using these agents in selected patients with TSC and related disorders...
- Hyperpolarized gas MR Imaging of the lung: current status as a research toolShin Matsuoka
Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
J Thorac Imaging 24:181-8. 2009..This study reviews the role of hyperpolarized 3-helium and 129-xenon magnetic resonance imaging in this research...
- Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyondYanping Sun
Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
Respir Physiol Neurobiol 169:44-9. 2009....
- Extrapyramidal signs and other neurologic findings in clinically diagnosed Alzheimer's disease. A community-based studyH H Funkenstein
Department of Neurology, Harvard Medical School, Boston, Mass
Arch Neurol 50:51-6. 1993..These increased relative odds were not markedly affected by excluding from the analysis cases with severe cognitive impairment. The results suggest that involvement of the extrapyramidal system is a common finding in Alzheimer's disease...
- Knowledge of and attitudes about Alzheimer disease genetics: report of a pilot survey and two focus groupsT J Moscarillo
Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
Community Genet 10:97-102. 2007....
- Hyperpolarized 129Xe MRI using gas-filled liposomesArvind K Venkatesh
Department of Radiology/MRI, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA
Acad Radiol 9:S270-4. 2002
- Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney diseaseYanping Sun
Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
Comp Med 52:433-8. 2002..To study the onset and degree of cyst formation in PKD mouse models without requiring sacrifice of these animals, we have initiated magnetic resonance imaging (MRI) studies of the juvenile cystic kidney (jck) mouse model...
- Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized 3He magnetic resonance imagingTina A Lewis
Brigham and Women's Hosp, Boston, MA
Magn Reson Med 53:474-8. 2005..Work is being done to address the uncertainties of the manually intensive methods we have developed...