M S Albert

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Biomedical imaging using hyperpolarized noble gas MRI: pulse sequence considerations
    L Zhao
    Department of Radiology, Harvard Medical School, Boston, MA 02115, USA
    Nucl Instrum Methods Phys Res A 402:454-60. 1998
  2. ncbi request reprint T(1) of (129)Xe in blood and the role of oxygenation
    M S Albert
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson 140:264-73. 1999
  3. ncbi request reprint Hyperpolarized (129)Xe T (1) in oxygenated and deoxygenated blood
    M S Albert
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    NMR Biomed 13:407-14. 2000
  4. ncbi request reprint Development of hyperpolarized noble gas MRI
    M S Albert
    Department of Radiology MRI, Harvard Medical School, Boston, MA 02115, USA
    Nucl Instrum Methods Phys Res A 402:441-53. 1998
  5. pmc Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease
    R S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    AJNR Am J Neuroradiol 30:532-8. 2009
  6. ncbi request reprint Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    B C Dickerson
    Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:404-11. 2005
  7. ncbi request reprint Encoding novel face-name associations: a functional MRI study
    R A Sperling
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 14:129-39. 2001
  8. pmc Semiautomatic segmentation of ventilated airspaces in healthy and asthmatic subjects using hyperpolarized 3He MRI
    J K Lui
    Boston University, School of Medicine, Boston, MA 02118, USA
    Comput Math Methods Med 2013:624683. 2013
  9. pmc fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
    R A Sperling
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Neurol Neurosurg Psychiatry 74:44-50. 2003
  10. pmc Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults
    B C Dickerson
    Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
    Neurology 76:1395-402. 2011

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Biomedical imaging using hyperpolarized noble gas MRI: pulse sequence considerations
    L Zhao
    Department of Radiology, Harvard Medical School, Boston, MA 02115, USA
    Nucl Instrum Methods Phys Res A 402:454-60. 1998
    ..Pulse sequences can be optimized to effectively utilize the non-renewable hyperpolarization, to enhance the SNR, and to eliminate image artifacts. Hyperpolarized noble gas MRI is concluded to be quite feasible...
  2. ncbi request reprint T(1) of (129)Xe in blood and the role of oxygenation
    M S Albert
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
    J Magn Reson 140:264-73. 1999
    ..Oxygenation was found to markedly increase the T(1) of (129)Xe in blood, as originally measured, and it shifts the RBC resonance to a higher frequency. Carbon monoxide has a similar but somewhat stronger effect...
  3. ncbi request reprint Hyperpolarized (129)Xe T (1) in oxygenated and deoxygenated blood
    M S Albert
    Department of Radiology, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    NMR Biomed 13:407-14. 2000
    ....
  4. ncbi request reprint Development of hyperpolarized noble gas MRI
    M S Albert
    Department of Radiology MRI, Harvard Medical School, Boston, MA 02115, USA
    Nucl Instrum Methods Phys Res A 402:441-53. 1998
    ..Cortical brain function is one perfusion-dependent phenomena that may be explored with hyperpolarized 129Xe MR. This leads to the exciting possibility of conducting hyperpolarized 129Xe functional MRI (HypX-fMRI) studies...
  5. pmc Temporoparietal MR imaging measures of atrophy in subjects with mild cognitive impairment that predict subsequent diagnosis of Alzheimer disease
    R S Desikan
    Department of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    AJNR Am J Neuroradiol 30:532-8. 2009
    ..Mild cognitive impairment (MCI) represents a transitional state between normal aging and Alzheimer disease (AD). Our goal was to determine if specific temporoparietal regions can predict the time to progress from MCI to AD...
  6. ncbi request reprint Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD
    B C Dickerson
    Department of Neurology, The Athinoula A Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Neurology 65:404-11. 2005
    ..To use fMRI to investigate whether hippocampal and entorhinal activation during learning is altered in the earliest phase of mild cognitive impairment (MCI)...
  7. ncbi request reprint Encoding novel face-name associations: a functional MRI study
    R A Sperling
    Department of Neurology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Hum Brain Mapp 14:129-39. 2001
    ..These data suggest that the process of forming new face-name associations is supported by a distributed network of brain regions, and provide additional evidence for the essential role of the hippocampus in associative memory processes...
  8. pmc Semiautomatic segmentation of ventilated airspaces in healthy and asthmatic subjects using hyperpolarized 3He MRI
    J K Lui
    Boston University, School of Medicine, Boston, MA 02118, USA
    Comput Math Methods Med 2013:624683. 2013
    ..95; P < 0.0001). The technique may open new pathways toward advancing more quantitative characterization of ventilation for routine clinical assessment for asthma severity as well as a number of other respiratory diseases...
  9. pmc fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease
    R A Sperling
    Memory Disorders Unit, Department of Neurology, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Neurol Neurosurg Psychiatry 74:44-50. 2003
    ..To examine alterations in patterns of brain activation seen in normal aging and in mild Alzheimer's disease by functional magnetic resonance imaging (fMRI) during an associative encoding task...
  10. pmc Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults
    B C Dickerson
    Department of Neurology, Massachusetts Alzheimer s Disease Research Center, Massachusetts General Hospital, MA, USA
    Neurology 76:1395-402. 2011
    ....
  11. ncbi request reprint Presenilin-1-associated abnormalities in regional cerebral perfusion
    K A Johnson
    Radiology and Neurology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Neurology 56:1545-51. 2001
    ..The subjects were members of a large pedigree from Colombia, South America, many of whom carry a PS-1 mutation for early-onset AD...
  12. ncbi request reprint Neuropsychological function in patients with chronic fatigue syndrome, multiple sclerosis, and depression
    E Daly
    Department of Psychiatry, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA
    Appl Neuropsychol 8:12-22. 2001
    ..The findings support the view that the cognitive deficits found in CFS cannot be attributed solely to the presence of depressive symptomatology in the patients...
  13. ncbi request reprint Recall and recognition memory in obsessive-compulsive disorder
    C R Savage
    Department of Psychiatry, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts 02129 2060, USA
    J Neuropsychiatry Clin Neurosci 8:99-103. 1996
    ..These results are interpreted as providing preliminary evidence of a nonverbal memory retrieval deficit consistent with proposed corticostriatal system dysfunction in OCD...
  14. doi request reprint Hyperpolarized 3He MR imaging of the lung: normal range of ventilation defects and PFT correlation in young adults
    Edward Y Lee
    Department of Radiology, Children s Hospital Boston, Boston, MA, USA
    J Thorac Imaging 24:110-4. 2009
    ....
  15. ncbi request reprint Quantification of water diffusion and relaxation times of human U87 tumors in a mouse model
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Boston, MA 02115, USA
    NMR Biomed 17:399-404. 2004
    ..64 +/- 0.06 s. The mean T(2) in tumor was 0.062 +/- 0.002 s and in normal brain tissue was 0.048 +/- 0.001 s. The mean ADC, T1 and T2 of the tumor compared to normal tissue were significantly different (p < 0.005)...
  16. ncbi request reprint Signal-to-noise ratio comparison of encoding methods for hyperpolarized noble gas MRI
    L Zhao
    Department of Radiology, Harvard Medical School, Brigham and Women's Hospital, 75 Francis Street, Boston, Massachusetts 02115, USA
    J Magn Reson 148:314-26. 2001
    ..Theoretical results are confirmed with hyperpolarized noble gas MRI experiments...
  17. ncbi request reprint Perfusion abnormalities in prodromal AD
    K A Johnson
    Departments of Neurology and Radiology, Brigham and Women s Hospital, 75 Francis Street, Boston, MA, USA
    Neurobiol Aging 21:289-92. 2000
    ..These perfusion abnormalities may also shed light on how AD progresses during the prodromal phase of disease and may ultimately lead to improved diagnosis or methods of monitoring response to treatment...
  18. ncbi request reprint Volume reconstruction techniques improve the correlation between histological and in vivo tumor volume measurements in mouse models of human gliomas
    Karl F Schmidt
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    J Neurooncol 68:207-15. 2004
    ....
  19. ncbi request reprint Preclinical prediction of AD using neuropsychological tests
    M S Albert
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Charlestown 02129, USA
    J Int Neuropsychol Soc 7:631-9. 2001
    ....
  20. ncbi request reprint Reinvestigating hyperpolarized (129)Xe longitudinal relaxation time in the rat brain with noise considerations
    X Zhou
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    NMR Biomed 21:217-25. 2008
    ..3 +/- 1.2 and 16.2 +/- 0.9 s, suggesting that the low SNR might be a key reason for the wide range of T(1) values published in the literature, a problem that might be easily alleviated by taking SNR levels into account...
  21. pmc MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD
    R S Desikan
    Dept of Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA 02118, USA
    Neurology 71:819-25. 2008
    ..The current study was designed to determine whether a broader set of temporoparietal regions show differential rates of atrophy during the evolution of AD...
  22. pmc Detection of cortical thickness correlates of cognitive performance: Reliability across MRI scan sessions, scanners, and field strengths
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
    Neuroimage 39:10-8. 2008
    ....
  23. pmc Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study
    B C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Hippocampus 17:1060-70. 2007
    ..These fronto-temporal brain regions act together as a large-scale memory-related network, the components of which make distinct yet interacting contributions during encoding that predict subsequent successful free recall performance...
  24. ncbi request reprint Extrapyramidal signs and other neurologic findings in clinically diagnosed Alzheimer's disease. A community-based study
    H H Funkenstein
    Department of Neurology, Harvard Medical School, Boston, Mass
    Arch Neurol 50:51-6. 1993
    ..These increased relative odds were not markedly affected by excluding from the analysis cases with severe cognitive impairment. The results suggest that involvement of the extrapyramidal system is a common finding in Alzheimer's disease...
  25. pmc Single photon emission computed tomography perfusion differences in mild cognitive impairment
    K A Johnson
    Department of Radiology, Massachusetts General Hospital, Fruit Street, Boston, MA 02114, USA
    J Neurol Neurosurg Psychiatry 78:240-7. 2007
    ..To relate cerebral perfusion abnormalities to subsequent changes in clinical status among patients with mild cognitive impairment (MCI)...
  26. ncbi request reprint Early Abeta accumulation and progressive synaptic loss, gliosis, and tangle formation in AD brain
    M Ingelsson
    Harvard Medical School, Massachusetts General Hospital, Boston
    Neurology 62:925-31. 2004
    ..Pathologic changes in the Alzheimer disease (AD) brain occur in a hierarchical neuroanatomical pattern affecting cortical, subcortical, and limbic regions...
  27. ncbi request reprint Efficacy of a rapamycin analog (CCI-779) and IFN-gamma in tuberous sclerosis mouse models
    Laifong Lee
    Division of Hematology, Brigham and Women s Hospital, Boston, MA 02115, USA
    Genes Chromosomes Cancer 42:213-27. 2005
    ..These results constitute definitive preclinical data that justify proceeding with clinical trials using these agents in selected patients with TSC and related disorders...
  28. doi request reprint Hyperpolarized gas MR Imaging of the lung: current status as a research tool
    Shin Matsuoka
    Department of Radiology, Center for Pulmonary Functional Imaging, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Thorac Imaging 24:181-8. 2009
    ..This study reviews the role of hyperpolarized 3-helium and 129-xenon magnetic resonance imaging in this research...
  29. pmc Marked pericardial inhomogeneity of specific ventilation at total lung capacity and beyond
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, United States
    Respir Physiol Neurobiol 169:44-9. 2009
    ....
  30. ncbi request reprint Knowledge of and attitudes about Alzheimer disease genetics: report of a pilot survey and two focus groups
    T J Moscarillo
    Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, Mass, USA
    Community Genet 10:97-102. 2007
    ....
  31. ncbi request reprint Magnetic resonance imaging assessment of a murine model of recessive polycystic kidney disease
    Yanping Sun
    Department of Radiology, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Comp Med 52:433-8. 2002
    ..To study the onset and degree of cyst formation in PKD mouse models without requiring sacrifice of these animals, we have initiated magnetic resonance imaging (MRI) studies of the juvenile cystic kidney (jck) mouse model...
  32. ncbi request reprint Hyperpolarized 129Xe MRI using gas-filled liposomes
    Arvind K Venkatesh
    Department of Radiology MRI, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Acad Radiol 9:S270-4. 2002
  33. pmc Quantification of airway diameters and 3D airway tree rendering from dynamic hyperpolarized 3He magnetic resonance imaging
    Tina A Lewis
    Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Magn Reson Med 53:474-8. 2005
    ..Work is being done to address the uncertainties of the manually intensive methods we have developed...