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Genomes and Genes | Omid AkbariSummaryAffiliation: Harvard University Country: USA Publications
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Publications
ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survivalOmid Akbari
Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
J Immunol 180:5448-56. 2008..These results indicate that ICOS costimulation plays a major role in induction of AHR by iNKT cells and is required for CD4(+) iNKT cell function, homeostasis, and survival in the periphery...
Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient miceYoungil I Koh
Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 181:4560-9. 2008....- CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthmaOmid Akbari
Division of Immunology, Children's Hospital Boston, Boston, MA 02115, USA
N Engl J Med 354:1117-29. 2006.... - Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cellsEverett H Meyer
Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
Proc Natl Acad Sci U S A 103:2782-7. 2006.... - Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loopMark A Exley
Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Eur J Immunol 38:1756-66. 2008..Specifically, an anti-Valpha24Jalpha18 CDR3 loop clonotypic TCR mAb is available for the enumeration and therapeutic manipulation of human and non-human primate iNKT populations... - Recent advances in the role of NKT cells in allergic diseases and asthmaPhilippe Stock
Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
Curr Allergy Asthma Rep 8:165-70. 2008..Moreover, in patients with chronic asthma, NKT cells can be found in bronchoalveolar lavage fluids in significant amounts. These data strongly suggest that NKT cells play an important role in asthma pathogenesis... - TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cellsLee A Albacker
Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
J Immunol 185:6839-49. 2010.... - Respiratory tolerance is inhibited by the administration of corticosteroidsPhilippe Stock
Division of Immunology, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
J Immunol 175:7380-7. 2005.... - Invariant natural killer T cells in obstructive pulmonary diseasesOmid Akbari
N Engl J Med 357:193-4; author reply 194-5. 2007 - TIM-1 induces T cell activation and inhibits the development of peripheral toleranceSarah E Umetsu
Department of Pediatrics, Stanford University, Stanford, California 94305, USA
Nat Immunol 6:447-54. 2005..Our studies suggest that immunotherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases... - Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivityOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA
Nat Med 8:1024-32. 2002..These studies demonstrate that T(R) cells and the ICOS-ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma... - CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammationJae-Won Oh
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
J Allergy Clin Immunol 110:460-8. 2002.... - Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivityOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
Nat Med 9:582-8. 2003..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma... - Regulatory T cells control the development of allergic disease and asthmaDale T Umetsu
Division of Immunology and Allergy, Department of Pediatrics, Room G309, Stanford University, Stanford, CA 94305-5208, USA
J Allergy Clin Immunol 112:480-7; quiz 488. 2003..A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review... - Asthma: an epidemic of dysregulated immunityDale T Umetsu
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Nat Immunol 3:715-20. 2002..In the absence of such infections, T(H)2 cells--which are developmentally related to T(R) cells--develop instead and coordinate the development of asthmatic inflammation... - Mucosal tolerance and immunity: regulating the development of allergic disease and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA
Int Arch Allergy Immunol 130:108-18. 2003.... - Role of regulatory T cells in allergy and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305-5208, USA
Curr Opin Immunol 15:627-33. 2003..A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets... - CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammationPhilippe Stock
Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
Eur J Immunol 34:1817-27. 2004..These data demonstrate protective effects of CD8(+)T cells against the induction of immune responses and show a functional diversity of CD8(+) T cells in different compartments of sensitized mice... - Role of regulatory dendritic cells in allergy and asthmaOmid Akbari
Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305-5208, USA
Curr Opin Allergy Clin Immunol 4:533-8. 2004..SUMMARY: Subsets of dendritic cells regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing antiinflammatory responses and protective immunity... - Role of regulatory dendritic cells in allergy and asthmaOmid Akbari
Department of Pediatrics, Stanford University, Rm G309, 300 Pasteur Drive, Stanford, CA 94305-5208, USA
Curr Allergy Asthma Rep 5:56-61. 2005..Subsets of DCs regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing anti-inflammatory responses and protective immunity...