Omid Akbari

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
    Omid Akbari
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Immunol 180:5448-56. 2008
  2. ncbi request reprint Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice
    Youngil I Koh
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:4560-9. 2008
  3. ncbi request reprint CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    Omid Akbari
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 354:1117-29. 2006
  4. pmc Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
    Everett H Meyer
    Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2782-7. 2006
  5. pmc Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop
    Mark A Exley
    Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Immunol 38:1756-66. 2008
  6. ncbi request reprint Recent advances in the role of NKT cells in allergic diseases and asthma
    Philippe Stock
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 8:165-70. 2008
  7. pmc TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells
    Lee A Albacker
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    J Immunol 185:6839-49. 2010
  8. ncbi request reprint Respiratory tolerance is inhibited by the administration of corticosteroids
    Philippe Stock
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:7380-7. 2005
  9. ncbi request reprint Invariant natural killer T cells in obstructive pulmonary diseases
    Omid Akbari
    N Engl J Med 357:193-4; author reply 194-5. 2007
  10. ncbi request reprint TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
    Sarah E Umetsu
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:447-54. 2005

Detail Information

Publications20

  1. pmc ICOS/ICOSL interaction is required for CD4+ invariant NKT cell function and homeostatic survival
    Omid Akbari
    Division of Immunology, Children s Hospital, Harvard Medical School, Boston, MA, 02115, USA
    J Immunol 180:5448-56. 2008
    ..These results indicate that ICOS costimulation plays a major role in induction of AHR by iNKT cells and is required for CD4(+) iNKT cell function, homeostasis, and survival in the periphery...
  2. ncbi request reprint Activation of nonclassical CD1d-restricted NK T cells induces airway hyperreactivity in beta 2-microglobulin-deficient mice
    Youngil I Koh
    Division of Immunology and Allergy, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 181:4560-9. 2008
    ....
  3. ncbi request reprint CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
    Omid Akbari
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    N Engl J Med 354:1117-29. 2006
    ..Because mouse models of allergic asthma indicate that natural killer T cells are required for the development of allergen-induced airway hyperreactivity, we hypothesized that natural killer T cells play an important role in human asthma...
  4. pmc Glycolipid activation of invariant T cell receptor+ NK T cells is sufficient to induce airway hyperreactivity independent of conventional CD4+ T cells
    Everett H Meyer
    Division of Immunology, Children s Hospital, Harvard Medical School, One Blackfan Circle, Boston, MA 02115, USA
    Proc Natl Acad Sci U S A 103:2782-7. 2006
    ....
  5. pmc Selective activation, expansion, and monitoring of human iNKT cells with a monoclonal antibody specific for the TCR alpha-chain CDR3 loop
    Mark A Exley
    Hematology Oncology, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Eur J Immunol 38:1756-66. 2008
    ..Specifically, an anti-Valpha24Jalpha18 CDR3 loop clonotypic TCR mAb is available for the enumeration and therapeutic manipulation of human and non-human primate iNKT populations...
  6. ncbi request reprint Recent advances in the role of NKT cells in allergic diseases and asthma
    Philippe Stock
    Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Allergy Asthma Rep 8:165-70. 2008
    ..Moreover, in patients with chronic asthma, NKT cells can be found in bronchoalveolar lavage fluids in significant amounts. These data strongly suggest that NKT cells play an important role in asthma pathogenesis...
  7. pmc TIM-4, a receptor for phosphatidylserine, controls adaptive immunity by regulating the removal of antigen-specific T cells
    Lee A Albacker
    Division of Immunology, Children s Hospital Boston, Boston, MA 02115, USA
    J Immunol 185:6839-49. 2010
    ....
  8. ncbi request reprint Respiratory tolerance is inhibited by the administration of corticosteroids
    Philippe Stock
    Division of Immunology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 175:7380-7. 2005
    ....
  9. ncbi request reprint Invariant natural killer T cells in obstructive pulmonary diseases
    Omid Akbari
    N Engl J Med 357:193-4; author reply 194-5. 2007
  10. ncbi request reprint TIM-1 induces T cell activation and inhibits the development of peripheral tolerance
    Sarah E Umetsu
    Department of Pediatrics, Stanford University, Stanford, California 94305, USA
    Nat Immunol 6:447-54. 2005
    ..Our studies suggest that immunotherapies that regulate TIM-1 function may downmodulate allergic inflammatory diseases...
  11. ncbi request reprint Antigen-specific regulatory T cells develop via the ICOS-ICOS-ligand pathway and inhibit allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, School of Medicine, Stanford University, Stanford, California, USA
    Nat Med 8:1024-32. 2002
    ..These studies demonstrate that T(R) cells and the ICOS-ICOS-ligand signaling pathway are critically involved in respiratory tolerance and in downregulating pulmonary inflammation in asthma...
  12. ncbi request reprint CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation
    Jae Won Oh
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, CA 94305, USA
    J Allergy Clin Immunol 110:460-8. 2002
    ..T(H)2 cells play a critical role in the pathogenesis of asthma, but the precise immunologic mechanisms that inhibit T(H)2 cell function in vivo are not well understood...
  13. ncbi request reprint Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California, USA
    Nat Med 9:582-8. 2003
    ..Therapies that target V(alpha)14i NKT cells may be clinically effective in limiting the development of AHR and asthma...
  14. ncbi request reprint Regulatory T cells control the development of allergic disease and asthma
    Dale T Umetsu
    Division of Immunology and Allergy, Department of Pediatrics, Room G309, Stanford University, Stanford, CA 94305 5208, USA
    J Allergy Clin Immunol 112:480-7; quiz 488. 2003
    ..A spectrum of CD4+ T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25+ T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review...
  15. ncbi request reprint Asthma: an epidemic of dysregulated immunity
    Dale T Umetsu
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Nat Immunol 3:715-20. 2002
    ..In the absence of such infections, T(H)2 cells--which are developmentally related to T(R) cells--develop instead and coordinate the development of asthmatic inflammation...
  16. ncbi request reprint Mucosal tolerance and immunity: regulating the development of allergic disease and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Int Arch Allergy Immunol 130:108-18. 2003
    ....
  17. ncbi request reprint Role of regulatory T cells in allergy and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Curr Opin Immunol 15:627-33. 2003
    ..A better understanding of the role of regulatory cells in allergic diseases may lead to the identification of novel therapeutic targets...
  18. ncbi request reprint CD8(+) T cells regulate immune responses in a murine model of allergen-induced sensitization and airway inflammation
    Philippe Stock
    Department of Pediatrics, Stanford University, Stanford, CA 94305 5208, USA
    Eur J Immunol 34:1817-27. 2004
    ..These data demonstrate protective effects of CD8(+)T cells against the induction of immune responses and show a functional diversity of CD8(+) T cells in different compartments of sensitized mice...
  19. ncbi request reprint Role of regulatory dendritic cells in allergy and asthma
    Omid Akbari
    Division of Immunology and Allergy, Department of Pediatrics, Stanford University, Stanford, California 94305 5208, USA
    Curr Opin Allergy Clin Immunol 4:533-8. 2004
    ..In particular we summarize recent data regarding the relationship between dendritic cell subsets and Th1, Th2 and regulatory T (TReg) cells...
  20. ncbi request reprint Role of regulatory dendritic cells in allergy and asthma
    Omid Akbari
    Department of Pediatrics, Stanford University, Rm G309, 300 Pasteur Drive, Stanford, CA 94305 5208, USA
    Curr Allergy Asthma Rep 5:56-61. 2005
    ..Subsets of DCs regulate the induction of a variety of T-cell subtypes, which suppress the development of allergy and asthma, thus providing anti-inflammatory responses and protective immunity...