WILLIAM AIRD

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Elevated levels of placental growth factor represent an adaptive host response in sepsis
    Kiichiro Yano
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 205:2623-31. 2008
  2. pmc Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    Kiichiro Yano
    Center for Vascular Biology Research, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 203:1447-58. 2006
  3. pmc Endothelial cell heterogeneity
    William C Aird
    Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cold Spring Harb Perspect Med 2:a006429. 2012
  4. pmc Sepsis and the broken endothelium
    Nathan I Shapiro
    Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care 15:135. 2011
  5. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
  6. pmc Endothelial cells present antigens in vivo
    Annette L Rothermel
    Department of Pathology, Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    BMC Immunol 5:5. 2004
  7. ncbi request reprint Endothelium and allotransplantation
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Transplantation 82:S6-8. 2006
  8. ncbi request reprint Sepsis and coagulation
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, RW 663, Boston, MA 02215, USA
    Crit Care Clin 21:417-31. 2005
  9. ncbi request reprint Spatial and temporal dynamics of the endothelium
    W C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 3:1392-406. 2005
  10. ncbi request reprint Endothelium as a therapeutic target in sepsis
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Drug Targets 8:501-7. 2007

Research Grants

  1. Forkhead Signaling in the Endothelium
    William C Aird; Fiscal Year: 2010
  2. VEGF, Transcriptional Networks and Vascular Inflammation
    William C Aird; Fiscal Year: 2010
  3. Role of VEGF and PlGF signaling in sepsis
    William C Aird; Fiscal Year: 2010
  4. TRANSCRIPTIONAL CONTROL OF CARDIAC-SPECIFIC HEMOSTASIS
    WILLIAM AIRD; Fiscal Year: 2004
  5. VASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENE
    WILLIAM AIRD; Fiscal Year: 2001
  6. Forkhead Signaling in the Endothelium
    WILLIAM AIRD; Fiscal Year: 2005

Collaborators

Detail Information

Publications70

  1. pmc Elevated levels of placental growth factor represent an adaptive host response in sepsis
    Kiichiro Yano
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 205:2623-31. 2008
    ..Collectively, these data suggest that up-regulation of PlGF in sepsis is an adaptive host response that exerts its benefit, at least in part, by attenuating VEGF signaling...
  2. pmc Vascular endothelial growth factor is an important determinant of sepsis morbidity and mortality
    Kiichiro Yano
    Center for Vascular Biology Research, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 203:1447-58. 2006
    ..Adenovirus-mediated overexpression of VEGF but not PlGF exacerbated the lipopolysaccharide-mediated toxic effects. Together, these data support a pathophysiological role for VEGF in mediating the sepsis phenotype...
  3. pmc Endothelial cell heterogeneity
    William C Aird
    Department of Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    Cold Spring Harb Perspect Med 2:a006429. 2012
    ..Second, we apply these principles, together with their therapeutic implications, to a representative vascular bed in disease, namely, tumor endothelium...
  4. pmc Sepsis and the broken endothelium
    Nathan I Shapiro
    Department of Emergency Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care 15:135. 2011
    ....
  5. pmc The association of endothelial cell signaling, severity of illness, and organ dysfunction in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, 1 Deaconess Road CC2 W, Boston, MA 02215, USA
    Crit Care 14:R182. 2010
    ..We investigated the association between biomarkers of endothelial cell activation and sepsis severity, organ dysfunction sequential organ failure assessment (SOFA) score, and death...
  6. pmc Endothelial cells present antigens in vivo
    Annette L Rothermel
    Department of Pathology, Interdepartmental Program in Vascular Biology and Transplantation, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06510, USA
    BMC Immunol 5:5. 2004
    ..coli beta-galactosidase (beta-gal) in two lines of transgenic mice that express beta-gal exclusively in their EC. TIE2-lacZ mice express beta-gal in all EC and VWF-lacZ mice express beta-gal in heart and brain microvascular EC...
  7. ncbi request reprint Endothelium and allotransplantation
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Transplantation 82:S6-8. 2006
    ..The goal of this review is to provide a conceptual framework for approaching the endothelium in allotransplantation...
  8. ncbi request reprint Sepsis and coagulation
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 330 Brookline Avenue, RW 663, Boston, MA 02215, USA
    Crit Care Clin 21:417-31. 2005
    ..This article describes sepsis-associated changes in coagulation, discusses the putative role for these changes in pathogenesis of the sepsis syndrome, and outlines current diagnostic and therapeutic strategies...
  9. ncbi request reprint Spatial and temporal dynamics of the endothelium
    W C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 3:1392-406. 2005
    ..Finally, these themes will be applied to an understanding of vascular bed-specific hemostasis...
  10. ncbi request reprint Endothelium as a therapeutic target in sepsis
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    Curr Drug Targets 8:501-7. 2007
    ..An important goal is to develop novel therapies that reverse endothelial dysfunction in sepsis. This review will consider the role of the endothelium in sepsis and will highlight its untapped therapeutic potential...
  11. ncbi request reprint Endothelium in health and disease
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Pharmacol Rep 60:139-43. 2008
    ..Endothelial cell phenotypes vary in structure and function, in space and time, and in health and disease. The goal of this review is to underscore the importance of phenotypic heterogeneity as a core property of the endothelium...
  12. ncbi request reprint Natural anticoagulant inhibitors: activated Protein C
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RW 663, Boston, MA 02215, USA
    Best Pract Res Clin Haematol 17:161-82. 2004
    ....
  13. ncbi request reprint Endothelium as an organ system
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Crit Care Med 32:S271-9. 2004
    ..The overall goal of this review is to bring the endothelium "to life" and to argue that future breakthroughs in biomedicine are contingent on acceptance of the endothelium as a bona fide organ system...
  14. doi request reprint Molecular heterogeneity of tumor endothelium
    William C Aird
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center Harvard Medical School, RW 663, 330 Brookline Avenue, Boston, MA 02215, USA
    Cell Tissue Res 335:271-81. 2009
    ....
  15. ncbi request reprint Endothelial cell heterogeneity and atherosclerosis
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Curr Atheroscler Rep 8:69-75. 2006
    ..The goal of this review is to highlight concepts of endothelial cell heterogeneity and to apply these principles to an understanding of the pathogenesis, diagnosis, and treatment of atherosclerosis...
  16. pmc Vascular bed-specific expression of an endothelial cell gene is programmed by the tissue microenvironment
    W C Aird
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02119, USA
    J Cell Biol 138:1117-24. 1997
    ..Taken together, the results suggest that the vWF gene is regulated by vascular bed-specific pathways in response to signals derived from the local microenvironment...
  17. doi request reprint Discovery of the cardiovascular system: from Galen to William Harvey
    W C Aird
    The Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    J Thromb Haemost 9:118-29. 2011
    ..The mechanical force of the heart replaced Galen's elusive attractive powers. Ultimately, Galenism would collapse under the weight of Harvey's evidence, and a new paradigm of blood circulation would prevail...
  18. doi request reprint Proximate and evolutionary causation of endothelial heterogeneity
    William C Aird
    Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Semin Thromb Hemost 36:276-85. 2010
    ..Mismatch between the genome and/or epigenome and the environment is an important determinant of human vascular disease...
  19. ncbi request reprint The hematologic system as a marker of organ dysfunction in sepsis
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass 02215, USA
    Mayo Clin Proc 78:869-81. 2003
    ..A thorough clinical evaluation and panel of laboratory tests that relate to this organ system should be as much a part of the work-up as taking the patient's blood pressure, monitoring renal function, or measuring liver enzymes...
  20. ncbi request reprint Phenotypic heterogeneity of the endothelium: II. Representative vascular beds
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circ Res 100:174-90. 2007
    ....
  21. ncbi request reprint Vascular bed-specific thrombosis
    W C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    J Thromb Haemost 5:283-91. 2007
    ..The vast majority of hypercoagulable states are associated with local thrombus formation. The goal of this review is to discuss the mechanisms underlying site-specific thrombosis...
  22. ncbi request reprint Phenotypic heterogeneity of the endothelium: I. Structure, function, and mechanisms
    William C Aird
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Mass 02215, USA
    Circ Res 100:158-73. 2007
    ..The overall goal is to underscore the importance of phenotypic heterogeneity as a core property of the endothelium...
  23. ncbi request reprint Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Beth Israel Deaconess Medical Center, RW 663, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 24:294-300. 2004
    ..In this study, we examined whether VEGF is coupled to phosphatidyl inositol 3-kinase (PI3K)/Akt/forkhead in ECs...
  24. ncbi request reprint Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell
    Youichiro Wada
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA
    FASEB J 19:1914-6. 2005
    ..Taken together, these data suggest that inflammatory mediators prime endothelial cells to modulate subsequent thrombin response...
  25. doi request reprint Antiinflammatory effects of the ETS factor ERG in endothelial cells are mediated through transcriptional repression of the interleukin-8 gene
    Lei Yuan
    Division of Cardiology, Department of Medicine, and the Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Circ Res 104:1049-57. 2009
    ..In summary, our findings support a role for ERG in promoting antiinflammatory effects in ECs through repression of inflammatory genes such as IL-8...
  26. ncbi request reprint The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    Carsten Skurk
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1513-25. 2004
    ..These data suggest that FOXO3a is a downstream target of Akt in endothelial cells that can promote apoptosis via FLIP down-regulation and activation of the extrinsic apoptotic pathway...
  27. pmc Differential roles for ETS, CREB, and EGR binding sites in mediating VEGF receptor 1 expression in vivo
    Enjing Jin
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Blood 114:5557-66. 2009
    ..In contrast, mutation of the -39 ETS site resulted in increased LacZ staining in multiple vascular beds. Together, these results provide new insights into the transcriptional regulatory mechanisms of VEGFR1...
  28. ncbi request reprint A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, the Division of Molecular, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:35544-53. 2006
    ..Together, these findings suggest that the VEGF-forkhead signaling axis plays an important functional role in ECs beyond the regulation of cell survival/apoptosis and cell cycle...
  29. ncbi request reprint NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 282:35373-85. 2007
    ..Taken together, these findings suggest that NADPH oxidase-derived ROS selectively modulate some but not all the effects of VEGF on endothelial cell phenotypes...
  30. doi request reprint Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells
    Chantal Séguin
    Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biomed Pharmacother 62:395-400. 2008
    ..Together, these findings suggest that Hcy sensitizes HUVEC to the effect of inflammatory mediators thrombin and LPS, at least in part through VCAM-1 expression and function...
  31. doi request reprint Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells
    Chantal Séguin
    Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA mcgill ca
    Endothelium 15:143-8. 2008
    ..These results suggest that activation of the coagulation cascade may result in a positive-feedback loop consisting of thrombin-mediated repression of TM-dependent protein C activation...
  32. pmc A20 inhibits post-angioplasty restenosis by blocking macrophage trafficking and decreasing adventitial neovascularization
    Scott M Damrauer
    The Division of Vascular Surgery, Department of Surgery and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Atherosclerosis 211:404-8. 2010
    ....
  33. ncbi request reprint Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  34. ncbi request reprint Endothelial cell heterogeneity
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care Med 31:S221-30. 2003
    ..To review recent advances in the field of endothelial cell heterogeneity, and to apply this knowledge to an understanding of site-specific vasculopathy, including acute lung injury...
  35. ncbi request reprint Differential regulation of the von Willebrand factor and Flt-1 promoters in the endothelium of hypoxanthine phosphoribosyltransferase-targeted mice
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 100:4019-25. 2002
    ....
  36. doi request reprint Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
    Monica Lee
    The Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 584:3131-6. 2010
    ..These results suggest an essential role for Ca(2+) in redox-dependent selective activation of c-Src-PI3K-Akt and endothelial cell proliferation...
  37. ncbi request reprint Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:44030-8. 2004
    ....
  38. doi request reprint Skin biopsies demonstrate site-specific endothelial activation in mouse models of sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Res 46:495-502. 2009
    ..Skin biopsies allow for direct phenotyping of the endothelium in clinical settings...
  39. pmc Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Division Molecular and Vascular Medicine, Center for Vascular Biology Research, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arterioscler Thromb Vasc Biol 28:2042-8. 2008
    ..Here, we tested the hypothesis that hepatocyte growth factor (HGF), a potent activator of PI3K-Akt in endothelial cells, is capable of depleting the nucleus of FKHR/FOXO1 and thus inhibiting VEGF induction of this class of genes...
  40. ncbi request reprint The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Blood 101:3765-77. 2003
    ....
  41. ncbi request reprint A prospective, observational study of soluble FLT-1 and vascular endothelial growth factor in sepsis
    Nathan I Shapiro
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Masachusetts 02215, USA
    Shock 29:452-7. 2008
    ..Vascular endothelial cell growth factor and its signaling axis are important in the endothelial cell response to sepsis, and further elucidation of these mechanisms may lead to advances in future diagnostic and therapeutic opportunities...
  42. ncbi request reprint Endothelial cell dynamics and complexity theory
    William C Aird
    Harvard Medical School and Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Crit Care Med 30:S180-5. 2002
    ..To apply complexity theory to understanding endothelial cell function in health and disease...
  43. ncbi request reprint Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:29864-73. 2005
    ..These data suggest that FoxO activity inhibits VSMC proliferation and activation and that this signaling axis may represent a therapeutic target in vasculopathic disease states...
  44. ncbi request reprint Cloning and characterization of the human lung endothelial-cell-specific molecule-1 promoter
    Jo C Tsai
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Mass 02215, USA
    J Vasc Res 39:148-59. 2002
    ..Taken together, these results provide an important foundation for studying endothelial-cell-subtype-specific gene regulation...
  45. ncbi request reprint Phenotypic heterogeneity is an evolutionarily conserved feature of the endothelium
    Kiichiro Yano
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, RW 663, 330 Brookline Ave, Department of Pathology, Harvard Medical School, Boston, MA 02215, USA
    Blood 109:613-5. 2007
    ..Together, these data suggest that structural, molecular, and functional heterogeneity of the endothelium evolved as an early feature of this cell lineage...
  46. ncbi request reprint Vascular endocan is preferentially expressed in tumor endothelium
    Md Ruhul Abid
    Center for Vascular Biology Research, and the Division of Vascular and Molecular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RW 663, Boston, MA 02215, USA
    Microvasc Res 72:136-45. 2006
    ..The results suggest that endocan is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors...
  47. pmc Overexpression of MyrAkt1 in endothelial cells leads to erythropoietin- and BMP4-independent splenic erythropoiesis in mice
    Rebekah K O'Donnell
    Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, USA
    PLoS ONE 8:e55095. 2013
    ..Together, these data suggest that endothelial cell hyperactivation is a potentially novel pathway of inducing red cell production under stress...
  48. ncbi request reprint Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells
    Sheng Qian Wu
    Division of Molecular and Vascular Medicine, Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, RW 663, 330 Brookline Ave, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 289:H873-85. 2005
    ..The data support the notion that endothelial cell activation is not an all-or-nothing phenomenon but rather is dependent on the nature of the extracellular mediator...
  49. ncbi request reprint A three-kilobase fragment of the human Robo4 promoter directs cell type-specific expression in endothelium
    Yoshiaki Okada
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Circ Res 100:1712-22. 2007
    ..Together, these data suggest that 3-kb upstream promoter of human Robo4 contains information for cell type-specific expression in the intact endothelium...
  50. ncbi request reprint Endothelial biomedicine: its status as an interdisciplinary field, its progress as a basic science, and its translational bench-to-bedside gap
    Charlotte Hwa
    Division of Molecular and Vascular Medicine, Department of Medicine, and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 023215, USA
    Endothelium 12:139-51. 2005
    ..Until the bench-to-bedside gap closes, the enormous potential of the endothelium as a diagnostic, preventive, and therapeutic target will remain largely untapped...
  51. ncbi request reprint Coagulation
    William C Aird
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Crit Care Med 33:S485-7. 2005
  52. pmc Diabetes is not associated with increased mortality in emergency department patients with sepsis
    Philipp Schuetz
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA
    Ann Emerg Med 58:438-44. 2011
    ..Our aim is to investigate the association of diabetes and initial glucose level with mortality in patients with suspected infection from the ED...
  53. ncbi request reprint The proximal serum response element in the Egr-1 promoter mediates response to thrombin in primary human endothelial cells
    Sheng Qian Wu
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 100:4454-61. 2002
    ..Taken together, these data suggest that thrombin induces Egr-1 expression in endothelial cells by a MAPK-dependent mechanism that involves an interaction between SRF and SRE-1...
  54. ncbi request reprint CpG oligodeoxynucleotide protection in polymicrobial sepsis is dependent on interleukin-17
    Lauren Rice
    Department of Emergency Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02215, USA
    J Infect Dis 191:1368-76. 2005
    ..Anti-IL-17 antibody inhibited the CpG-mediated prevention of mortality. These data suggest that IL-17 may mediate CpG-inducible host defenses during intraabdominal sepsis...
  55. pmc A GABP-binding element in the Robo4 promoter is necessary for endothelial expression in vivo
    Yoshiaki Okada
    Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Blood 112:2336-9. 2008
    ..Together, these data provide strong support for the role of the GABP-binding motif in mediating Robo4 expression in the intact endothelium...
  56. ncbi request reprint Vascular bed-specific endothelium-dependent vasomomotor relaxation in the hagfish, Myxine glutinosa
    Jun Feng
    The Center for Vascular Biology Research, Department of Surgery, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Regul Integr Comp Physiol 293:R894-900. 2007
    ..Together, these data suggest that site-specific endothelium-dependent vasorelaxation is an evolutionarily conserved property of this cell lineage...
  57. ncbi request reprint Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 15-200. A 53-year-old man with a myocardial infarct and thromboses after coronary-artery bypass grafting
    William C Aird
    N Engl J Med 346:1562-70. 2002
  58. ncbi request reprint Thrombin and phenotypic modulation of the endothelium
    Takashi Minami
    Research Center for Advanced Science and Technology, University of Tokyo, Tokyo, Japan
    Arterioscler Thromb Vasc Biol 24:41-53. 2004
    ....
  59. ncbi request reprint Histone deacetylase inhibitor reduces monocyte adhesion to endothelium through the suppression of vascular cell adhesion molecule-1 expression
    Kenji Inoue
    Laboratory for Systems Biology and Medicine, Research Center for Advanced Science and Technology, The University of Tokyo, 4 6 1, Komaba, Meguro, Tokyo, 153 8904, Japan
    Arterioscler Thromb Vasc Biol 26:2652-9. 2006
    ..We hypothesized that TNF-alpha-mediated gene induction involves multiple signaling pathways, and that inhibition of one or more of these pathways may selectively target subsets of TNF-alpha-responsive genes and functions...
  60. ncbi request reprint Interaction between hex and GATA transcription factors in vascular endothelial cells inhibits flk-1/KDR-mediated vascular endothelial growth factor signaling
    Takashi Minami
    Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1 Komaba, Meguro, Tokyo 153 8904, Japan
    J Biol Chem 279:20626-35. 2004
    ....
  61. ncbi request reprint Endothelial cell gene regulation
    Takashi Minami
    The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153 8904, Japan
    Trends Cardiovasc Med 15:174-84. 2005
    ..Finally, we draw on both the in vitro and in vivo results to propose a model of gene regulation that emphasizes the importance of the extracellular environment in controlling site- and time-specific vascular gene expression...
  62. pmc G protein-coupled receptor Ca2+-linked mitochondrial reactive oxygen species are essential for endothelial/leukocyte adherence
    Brian J Hawkins
    Institute for Environmental Medicine, University of Pennsylvania, Philadelphia, PA 19104 6068, USA
    Mol Cell Biol 27:7582-93. 2007
    ..These results demonstrate that mROS is the downstream effector molecule that translates receptor-mediated Ca(2+) signals into proinflammatory signaling and leukocyte/EC firm adhesion...
  63. ncbi request reprint Thrombin-induced autoinhibitory factor, Down syndrome critical region-1, attenuates NFAT-dependent vascular cell adhesion molecule-1 expression and inflammation in the endothelium
    Takashi Minami
    Research Center for Advanced Science and Technology, University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 281:20503-20. 2006
    ..As natural brakes in the inflammatory process, DSCR-1 and I-kappaB may lend themselves to therapeutic manipulation in vasculopathic disease states...
  64. doi request reprint Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle c
    Chiang Wen Lee
    Department of Physiology and Pharmacology, Chang Gung University, 259 Wen Hwa 1st Road, Kwei San, Tao Yuan, Taiwan
    Mol Pharmacol 73:1454-64. 2008
    ..Blockade of these pathways may be selectively targeted to reduce neutrophil adhesion via VCAM-1 suppression and attenuation of the inflammatory responses in airway diseases...
  65. ncbi request reprint Mechanisms of endothelial cell heterogeneity in health and disease
    William C Aird
    Circ Res 98:159-62. 2006
  66. ncbi request reprint Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis
    Takashi Minami
    The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 279:50537-54. 2004
    ..As a natural brake in the angiogenic process, this negative pathway may lend itself to therapeutic manipulation in pathological states...
  67. ncbi request reprint Regulation of tissue factor and inflammatory mediators by Egr-1 in a mouse endotoxemia model
    Rafal Pawlinski
    Department of Immunology, The Scripps Research Institute, La Jolla, CA, USA
    Blood 101:3940-7. 2003
    ..However, Egr-1 does contribute to the sustained expression of inflammatory mediators and to the maximal expression of TF at 8 hours in the kidneys and lungs...
  68. ncbi request reprint Ets motifs are necessary for endothelial cell-specific expression of a 723-bp Tie-2 promoter/enhancer in Hprt targeted transgenic mice
    Takashi Minami
    Research Center for Advanced Science and Technology, University of Tokyo, 4 6 1 Komaba, Meguro Tokyo, 153 8904
    Arterioscler Thromb Vasc Biol 23:2041-7. 2003
    ..Our goal was to characterize Tie-2 promoter function as a means of providing insight into the mechanisms of endothelial cell-specific gene regulation...
  69. ncbi request reprint The history of the capillary wall: doctors, discoveries, and debates
    Charlotte Hwa
    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    Am J Physiol Heart Circ Physiol 293:H2667-79. 2007
    ....
  70. doi request reprint Ligand-independent assembly of purified soluble magic roundabout (Robo4), a tumor-specific endothelial marker
    Mai Yoshikawa
    Department of Biotechnology and Therapeutics, Graduate School of Pharmaceutical Sciences, Osaka University, 1 6 Yamadaoka, Suita, Osaka 565 0871, Japan
    Protein Expr Purif 61:78-82. 2008
    ..The results of these studies will help to elucidate the role of Robo4 in angiogenesis and perhaps eventually contribute to the development of novel vessel-targeting therapies...

Research Grants18

  1. Forkhead Signaling in the Endothelium
    William C Aird; Fiscal Year: 2010
    ..PUBLIC HEALTH RELEVANCE: The proposal is significant in that it will provide important insights into the mechanisms (hence therapeutic potential) of FOXO1-mediated EC signal transduction. ..
  2. VEGF, Transcriptional Networks and Vascular Inflammation
    William C Aird; Fiscal Year: 2010
    ..abstract_text> ..
  3. Role of VEGF and PlGF signaling in sepsis
    William C Aird; Fiscal Year: 2010
    ..Aim 2 is to delineate the role of PlGF in the host response to infection. In the revised application, Aim 2 focuses specifically on the role of VEGFR1 and PlGF-VEGF heterodimers in sepsis. ..
  4. TRANSCRIPTIONAL CONTROL OF CARDIAC-SPECIFIC HEMOSTASIS
    WILLIAM AIRD; Fiscal Year: 2004
    ..Dr. Housman is an acknowledged expert in human genomics. Taken together, the individual projects and the collaborative efforts promise to provide important insight into the molecular basis of cardiac hemostasis. ..
  5. VASCULAR BED SPECIFIC EXPRESSION OF A VWF TRANSGENE
    WILLIAM AIRD; Fiscal Year: 2001
    ..Taken together, these studies should provide important information about the mechanisms of endothelial cell heterogeneity and vascular diversity. ..
  6. Forkhead Signaling in the Endothelium
    WILLIAM AIRD; Fiscal Year: 2005
    ..A more complete understanding of these mechanisms should provide a framework for tailoring and fine tuning therapeutic modalities in vascular disease states. ..