M Aikawa

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Dietary lipid lowering reduces tissue factor expression in rabbit atheroma
    M Aikawa
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 100:1215-22. 1999
  2. ncbi request reprint Lipid lowering reduces proteolytic and prothrombotic potential in rabbit atheroma
    M Aikawa
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 902:140-52. 2000
  3. ncbi request reprint An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    M Aikawa
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 103:276-83. 2001
  4. ncbi request reprint Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits
    Y Fukumoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:993-9. 2001
  5. ncbi request reprint MRI of rabbit atherosclerosis in response to dietary cholesterol lowering
    M V McConnell
    Noninvasive Laboratory, Vascular Medicine, Atherosclerosis Unit, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1956-9. 1999
  6. ncbi request reprint Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy
    K Shimizu
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 7:738-41. 2001
  7. ncbi request reprint Macrophages and atherosclerotic plaque stability
    P Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Lipidol 7:330-5. 1996
  8. ncbi request reprint Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension
    H Sakamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:109-14. 2001
  9. ncbi request reprint Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    E Rabkin
    Department of Pathology, Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:2525-32. 2001
  10. ncbi request reprint Lipid lowering improves endothelial functions
    P Libby
    Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, LMRC 307, Boston, MA 02115, USA
    Int J Cardiol 74:S3-S10. 2000

Collaborators

Detail Information

Publications11

  1. ncbi request reprint Dietary lipid lowering reduces tissue factor expression in rabbit atheroma
    M Aikawa
    Vascular Medicine and Atherosclerosis Unit, Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 100:1215-22. 1999
    ..Tissue factor (TF) overexpressed in atheroma may accelerate thrombus formation at the sites of plaque disruption. A cell surface cytokine CD40 ligand (CD40L) enhances TF expression in vitro...
  2. ncbi request reprint Lipid lowering reduces proteolytic and prothrombotic potential in rabbit atheroma
    M Aikawa
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Ann N Y Acad Sci 902:140-52. 2000
    ..These results suggest potential mechanisms by which lipid lowering reduces acute coronary events in patients by decreasing proteolytic and prothrombotic activity within the atheroma...
  3. ncbi request reprint An HMG-CoA reductase inhibitor, cerivastatin, suppresses growth of macrophages expressing matrix metalloproteinases and tissue factor in vivo and in vitro
    M Aikawa
    Cardiovascular Division, Department of Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
    Circulation 103:276-83. 2001
    ..Lipid lowering with HMG-CoA reductase inhibitors reduces acute coronary events...
  4. ncbi request reprint Statins alter smooth muscle cell accumulation and collagen content in established atheroma of watanabe heritable hyperlipidemic rabbits
    Y Fukumoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:993-9. 2001
    ..CONCLUSIONS: This study showed that statins can reduce MMP expression in atheroma and that cell-permeant statins can decrease SMC number and collagen gene expression in vivo...
  5. ncbi request reprint MRI of rabbit atherosclerosis in response to dietary cholesterol lowering
    M V McConnell
    Noninvasive Laboratory, Vascular Medicine, Atherosclerosis Unit, Brigham and Women s Hospital, Boston, MA 02115, USA
    Arterioscler Thromb Vasc Biol 19:1956-9. 1999
    ..Plaque progression was seen with maintenance of high-cholesterol diet. MRI is a promising noninvasive technology for directly imaging atherosclerosis and its response to therapeutic interventions...
  6. ncbi request reprint Host bone-marrow cells are a source of donor intimal smooth- muscle-like cells in murine aortic transplant arteriopathy
    K Shimizu
    Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Nat Med 7:738-41. 2001
    ..Thus, smooth-muscle--like cells in GAD lesions can originate from circulating bone--marrow-derived precursors...
  7. ncbi request reprint Macrophages and atherosclerotic plaque stability
    P Libby
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    Curr Opin Lipidol 7:330-5. 1996
    ..We hypothesize that lipid-lowering reduces clinical events, as shown in recent trials, by stabilizing lesions in part by reversing some of the maladaptive functions of macrophages described above...
  8. ncbi request reprint Biomechanical strain induces class a scavenger receptor expression in human monocyte/macrophages and THP-1 cells: a potential mechanism of increased atherosclerosis in hypertension
    H Sakamoto
    Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:109-14. 2001
    ..7+/-4.7% for animals on standard chow; P<0.001). CONCLUSIONS: Biomechanical strain induces SRA expression by monocyte/macrophages, suggesting a novel mechanism for promotion of atherosclerosis in hypertensive patients...
  9. ncbi request reprint Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves
    E Rabkin
    Department of Pathology, Leducq Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Circulation 104:2525-32. 2001
    ..We conclude that valvular interstitial cells regulate matrix degradation and remodeling in myxomatous mitral valve degeneration...
  10. ncbi request reprint Lipid lowering improves endothelial functions
    P Libby
    Brigham and Women s Hospital and Harvard Medical School, 221 Longwood Avenue, LMRC 307, Boston, MA 02115, USA
    Int J Cardiol 74:S3-S10. 2000
    ..Continued probing of the basic mechanisms of endothelial dysfunction and its treatment may lead to new therapies that offer clinical benefits in patients with atherosclerosis, including reductions in coronary events...
  11. pmc Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    A Ducharme
    Cardiovascular Division, Department of Medicine, and Department of Pathology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Clin Invest 106:55-62. 2000
    ..The decrease in collagen accumulation and the enhanced expression of other MMPs suggest that MMP-9 plays a prominent role in extracellular matrix remodeling after MI...