Research Topics
Species | J C AdamsSummaryAffiliation: Harvard University Country: USA Publications
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Publications
Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stressJ C Adams
Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
Neuroscience 160:530-9. 2009....- Immunocytochemical traits of type IV fibrocytes and their possible relations to cochlear function and pathologyJoe C Adams
Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
J Assoc Res Otolaryngol 10:369-82. 2009..The lack of CTGF paracrine effects following noise-induced loss of type IV fibrocytes may account for previously unexplained hearing losses... - Differences in gene expression between the otic capsule and other bonesKonstantina M Stankovic
Eaton Peabody Laboratory and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Hear Res 265:83-9. 2010..Expression levels were high for opg and bmpr1b, and minimal for bmp3 within the otic capsule. We concluded that opg and bmpr1b likely play important roles in inhibition of remodeling within the otic capsule... 
Pathology and pathophysiology of idiopathic sudden sensorineural hearing lossSaumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
Otol Neurotol 26:151-60. 2005..The cause and pathogenesis of idiopathic sudden sensorineural hearing loss remain unknown. Proposed theories include vascular occlusion, membrane breaks, and viral cochleitis...- Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing lossAndreas F Zehnder
Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
Laryngoscope 116:201-6. 2006..We also tested the hearing in OPG knockout mice to determine whether OPG and its influence on surrounding bone is important for auditory function... - Polyester wax: a new embedding medium for the histopathologic study of human temporal bonesSaumil N Merchant
Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
Laryngoscope 116:245-9. 2006..Embedding in paraffin allows immunostaining to be performed, but preservation of cellular detail within the membranous labyrinth is relatively poor... - Sudden deafness: is it viral?Saumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008..Finally, we review our recently proposed theory that abnormal cellular stress responses within the cochlea may be responsible for ISSHL... - Effects of fixative and embedding medium on morphology and immunostaining of the cochleaJennifer T O'Malley
Massachusetts Eye and Ear Infirmary, Boston, Mass 02114, USA
Audiol Neurootol 14:78-87. 2009..These results suggest that celloidin may be the embedding medium of choice for both morphological and pathological studies, including immunostaining when morphology must be optimized... - Wolfram syndrome: a clinicopathologic correlationJustin B Hilson
Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
Acta Neuropathol 118:415-28. 2009..Our findings extend prior neuropathologic reports of Wolfram syndrome by providing contributions to our understanding of eye, inner ear and olivopontine pathology in this disease... - Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?Saumil N Merchant
Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
Otol Neurotol 26:74-81. 2005..If the central hypothesis were true, every case of Meniere's syndrome should have hydrops and every case of hydrops should show the typical symptoms... - Temporal bone histopathology in alport syndromeSaumil N Merchant
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
Laryngoscope 114:1609-18. 2004..To determine the histopathologic abnormalities within the cochlea in Alport syndrome... - Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerveStephane F Maison
Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
J Neurophysiol 90:2941-9. 2003..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery... - Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalizationStephane F Maison
Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
J Comp Neurol 455:406-16. 2003.... - Clinical implications of inflammatory cytokines in the cochlea: a technical noteJoe C Adams
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, U S A
Otol Neurotol 23:316-22. 2002..Establishing the presence of critical cellular stress response components in cochlear cells can contribute to a better understanding of cochlear cell biology and pathology... - Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsuleAndreas F Zehnder
Department of Otolaryngology, MA Eye and Ear Infirmary, and Harvard Medical School, Boston, MA, USA
Laryngoscope 115:172-7. 2005..By this means, the cochlear soft tissue may control the nature of the surrounding petrous bone... - Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner earKonstantina Stankovic
Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
J Neurosci 24:8651-61. 2004.... - Techniques of celloidin removal from temporal bone sectionsJennifer T O'Malley
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
Ann Otol Rhinol Laryngol 118:435-41. 2009..We sought to determine whether the technique of celloidin removal influences the results of immunostaining in celloidin-embedded cochleae... - Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner earK M Stankovic
Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Hear Res 114:21-34. 1997.... - Gap junction systems in the mammalian cochleaT Kikuchi
Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
Brain Res Brain Res Rev 32:163-6. 2000..Interruption of this recirculation, which may be caused by the mutation in connexin 26 gene, would deprive the stria vascularis of K(+) and result in hearing loss... - Histopathologic observations of the aging gerbil cochleaJ C Adams
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
Hear Res 104:101-11. 1997..Further light and electron microscopic analysis of other regions from these aged cochleas may provide more conclusive data... - Studies of otic capsule morphology and gene expression in the Mov13 mouse--an animal model of type I osteogenesis imperfectaKonstantina M Stankovic
Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass 02114 3096, USA
Audiol Neurootol 12:334-43. 2007.... - Isolation from cochlea of a novel human intronless gene with predominant fetal expressionBarbara L Resendes
Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
J Assoc Res Otolaryngol 5:185-202. 2004.... - CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cellsBenjamin D Medoff
Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA
Am J Respir Cell Mol Biol 40:286-94. 2009..In conclusion, these data demonstrate that LPA stimulates TSLP and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation...