J C Adams

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress
    J C Adams
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Neuroscience 160:530-9. 2009
  2. pmc Immunocytochemical traits of type IV fibrocytes and their possible relations to cochlear function and pathology
    Joe C Adams
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 10:369-82. 2009
  3. pmc Differences in gene expression between the otic capsule and other bones
    Konstantina M Stankovic
    Eaton Peabody Laboratory and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Hear Res 265:83-9. 2010
  4. ncbi request reprint Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 26:151-60. 2005
  5. pmc Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss
    Andreas F Zehnder
    Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Laryngoscope 116:201-6. 2006
  6. pmc Polyester wax: a new embedding medium for the histopathologic study of human temporal bones
    Saumil N Merchant
    Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 116:245-9. 2006
  7. pmc Sudden deafness: is it viral?
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008
  8. pmc Effects of fixative and embedding medium on morphology and immunostaining of the cochlea
    Jennifer T O'Malley
    Massachusetts Eye and Ear Infirmary, Boston, Mass 02114, USA
    Audiol Neurootol 14:78-87. 2009
  9. pmc Wolfram syndrome: a clinicopathologic correlation
    Justin B Hilson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Acta Neuropathol 118:415-28. 2009
  10. ncbi request reprint Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Otol Neurotol 26:74-81. 2005

Collaborators

Detail Information

Publications23

  1. pmc Selective activation of nuclear factor kappa B in the cochlea by sensory and inflammatory stress
    J C Adams
    Department of Otology and Laryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, 243 Charles Street, Boston, MA 02114, USA
    Neuroscience 160:530-9. 2009
    ....
  2. pmc Immunocytochemical traits of type IV fibrocytes and their possible relations to cochlear function and pathology
    Joe C Adams
    Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    J Assoc Res Otolaryngol 10:369-82. 2009
    ..The lack of CTGF paracrine effects following noise-induced loss of type IV fibrocytes may account for previously unexplained hearing losses...
  3. pmc Differences in gene expression between the otic capsule and other bones
    Konstantina M Stankovic
    Eaton Peabody Laboratory and Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Hear Res 265:83-9. 2010
    ..Expression levels were high for opg and bmpr1b, and minimal for bmp3 within the otic capsule. We concluded that opg and bmpr1b likely play important roles in inhibition of remodeling within the otic capsule...
  4. ncbi request reprint Pathology and pathophysiology of idiopathic sudden sensorineural hearing loss
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, Massachusetts, USA
    Otol Neurotol 26:151-60. 2005
    ..The cause and pathogenesis of idiopathic sudden sensorineural hearing loss remain unknown. Proposed theories include vascular occlusion, membrane breaks, and viral cochleitis...
  5. pmc Osteoprotegrin knockout mice demonstrate abnormal remodeling of the otic capsule and progressive hearing loss
    Andreas F Zehnder
    Department of Otology and Laryngology, Harvard Medical School, and the Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114 3096, USA
    Laryngoscope 116:201-6. 2006
    ..We also tested the hearing in OPG knockout mice to determine whether OPG and its influence on surrounding bone is important for auditory function...
  6. pmc Polyester wax: a new embedding medium for the histopathologic study of human temporal bones
    Saumil N Merchant
    Otopathology Laboratory and the Department of Otolaryngology, MA Eye and Ear Infirmary, and the Department of Otology and Laryngology, Harvard Medical School, Boston, Massachusetts 02114, USA
    Laryngoscope 116:245-9. 2006
    ..Embedding in paraffin allows immunostaining to be performed, but preservation of cellular detail within the membranous labyrinth is relatively poor...
  7. pmc Sudden deafness: is it viral?
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    ORL J Otorhinolaryngol Relat Spec 70:52-60; discussion 60-2. 2008
    ..Finally, we review our recently proposed theory that abnormal cellular stress responses within the cochlea may be responsible for ISSHL...
  8. pmc Effects of fixative and embedding medium on morphology and immunostaining of the cochlea
    Jennifer T O'Malley
    Massachusetts Eye and Ear Infirmary, Boston, Mass 02114, USA
    Audiol Neurootol 14:78-87. 2009
    ..These results suggest that celloidin may be the embedding medium of choice for both morphological and pathological studies, including immunostaining when morphology must be optimized...
  9. pmc Wolfram syndrome: a clinicopathologic correlation
    Justin B Hilson
    Department of Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Acta Neuropathol 118:415-28. 2009
    ..Our findings extend prior neuropathologic reports of Wolfram syndrome by providing contributions to our understanding of eye, inner ear and olivopontine pathology in this disease...
  10. ncbi request reprint Pathophysiology of Meniere's syndrome: are symptoms caused by endolymphatic hydrops?
    Saumil N Merchant
    Otopathology Laboratory, Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    Otol Neurotol 26:74-81. 2005
    ..However, this hypothesis of hydrops as being the final common pathway has not been proven conclusively...
  11. ncbi request reprint Temporal bone histopathology in alport syndrome
    Saumil N Merchant
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA
    Laryngoscope 114:1609-18. 2004
    ..To determine the histopathologic abnormalities within the cochlea in Alport syndrome...
  12. ncbi request reprint Loss of alpha CGRP reduces sound-evoked activity in the cochlear nerve
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    J Neurophysiol 90:2941-9. 2003
    ..This constitutes the most direct evidence to date for a functional role of the lateral OC system in the auditory periphery...
  13. pmc Olivocochlear innervation in the mouse: immunocytochemical maps, crossed versus uncrossed contributions, and transmitter colocalization
    Stephane F Maison
    Department of Otology and Laryngology, Harvard Medical School and Eaton Peabody Laboratory, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114 3096, USA
    J Comp Neurol 455:406-16. 2003
    ....
  14. ncbi request reprint Clinical implications of inflammatory cytokines in the cochlea: a technical note
    Joe C Adams
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA 02114, U S A
    Otol Neurotol 23:316-22. 2002
    ..Establishing the presence of critical cellular stress response components in cochlear cells can contribute to a better understanding of cochlear cell biology and pathology...
  15. ncbi request reprint Osteoprotegerin in the inner ear may inhibit bone remodeling in the otic capsule
    Andreas F Zehnder
    Department of Otolaryngology, MA Eye and Ear Infirmary, and Harvard Medical School, Boston, MA, USA
    Laryngoscope 115:172-7. 2005
    ..To elucidate factors that may be responsible for the inhibition of remodeling of bone within the otic capsule...
  16. ncbi request reprint Survival of adult spiral ganglion neurons requires erbB receptor signaling in the inner ear
    Konstantina Stankovic
    Division of Neuroscience, Children s Hospital, Boston, Massachusetts 02115, USA
    J Neurosci 24:8651-61. 2004
    ....
  17. pmc Techniques of celloidin removal from temporal bone sections
    Jennifer T O'Malley
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, 243 Charles St, Boston, MA 02114, USA
    Ann Otol Rhinol Laryngol 118:435-41. 2009
    ..We sought to determine whether the technique of celloidin removal influences the results of immunostaining in celloidin-embedded cochleae...
  18. ncbi request reprint Localization of pH regulating proteins H+ATPase and Cl-/HCO3- exchanger in the guinea pig inner ear
    K M Stankovic
    Harvard Massachusetts Institute of Technology Division of Health Sciences and Technology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Hear Res 114:21-34. 1997
    ....
  19. ncbi request reprint Gap junction systems in the mammalian cochlea
    T Kikuchi
    Department of Otolaryngology, Harvard Medical School and Massachusetts Eye and Ear Infirmary, Boston, MA 02114, USA
    Brain Res Brain Res Rev 32:163-6. 2000
    ..Interruption of this recirculation, which may be caused by the mutation in connexin 26 gene, would deprive the stria vascularis of K(+) and result in hearing loss...
  20. ncbi request reprint Histopathologic observations of the aging gerbil cochlea
    J C Adams
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston 02114, USA
    Hear Res 104:101-11. 1997
    ..Further light and electron microscopic analysis of other regions from these aged cochleas may provide more conclusive data...
  21. ncbi request reprint Studies of otic capsule morphology and gene expression in the Mov13 mouse--an animal model of type I osteogenesis imperfecta
    Konstantina M Stankovic
    Department of Otolaryngology, Massachusetts Eye and Ear Infirmary, Boston, Mass 02114 3096, USA
    Audiol Neurootol 12:334-43. 2007
    ....
  22. pmc Isolation from cochlea of a novel human intronless gene with predominant fetal expression
    Barbara L Resendes
    Department of Obstetrics, Gynecology and Reproductive Biology, Brigham and Women s Hospital, Boston, MA 02115, USA
    J Assoc Res Otolaryngol 5:185-202. 2004
    ....
  23. pmc CARMA3 mediates lysophosphatidic acid-stimulated cytokine secretion by bronchial epithelial cells
    Benjamin D Medoff
    Center for Computational and Integrative Biology, Massachusetts General Hospital, Simches Research Building, Room 7222, 185 Cambridge Street, Boston, MA 02114, USA
    Am J Respir Cell Mol Biol 40:286-94. 2009
    ..In conclusion, these data demonstrate that LPA stimulates TSLP and CCL20 expression in bronchial epithelial cells via CARMA3-mediated NF-kappaB activation...