Md Ruhul Abid

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 282:35373-85. 2007
  2. ncbi request reprint Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:44030-8. 2004
  3. pmc Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Division Molecular and Vascular Medicine, Center for Vascular Biology Research, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arterioscler Thromb Vasc Biol 28:2042-8. 2008
  4. ncbi request reprint A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, the Division of Molecular, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:35544-53. 2006
  5. ncbi request reprint Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Beth Israel Deaconess Medical Center, RW 663, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 24:294-300. 2004
  6. ncbi request reprint Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell
    Youichiro Wada
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA
    FASEB J 19:1914-6. 2005
  7. ncbi request reprint The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    Carsten Skurk
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1513-25. 2004
  8. doi request reprint Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells
    Chantal Séguin
    Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biomed Pharmacother 62:395-400. 2008
  9. ncbi request reprint Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:29864-73. 2005
  10. pmc Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species
    Jun Feng
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1703-10. 2010

Detail Information

Publications15

  1. ncbi request reprint NADPH oxidase activity selectively modulates vascular endothelial growth factor signaling pathways
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 282:35373-85. 2007
    ..Taken together, these findings suggest that NADPH oxidase-derived ROS selectively modulate some but not all the effects of VEGF on endothelial cell phenotypes...
  2. ncbi request reprint Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB
    Md Ruhul Abid
    Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 279:44030-8. 2004
    ....
  3. pmc Hepatocyte growth factor inhibits VEGF-forkhead-dependent gene expression in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Division Molecular and Vascular Medicine, Center for Vascular Biology Research, Harvard Medical School, Boston, Massachusetts 02215, USA
    Arterioscler Thromb Vasc Biol 28:2042-8. 2008
    ..Here, we tested the hypothesis that hepatocyte growth factor (HGF), a potent activator of PI3K-Akt in endothelial cells, is capable of depleting the nucleus of FKHR/FOXO1 and thus inhibiting VEGF induction of this class of genes...
  4. ncbi request reprint A novel class of vascular endothelial growth factor-responsive genes that require forkhead activity for expression
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, the Division of Molecular, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 281:35544-53. 2006
    ..Together, these findings suggest that the VEGF-forkhead signaling axis plays an important functional role in ECs beyond the regulation of cell survival/apoptosis and cell cycle...
  5. ncbi request reprint Vascular endothelial growth factor activates PI3K/Akt/forkhead signaling in endothelial cells
    Md Ruhul Abid
    Department of Medicine, Beth Israel Deaconess Medical Center, RW 663, Boston, MA 02215, USA
    Arterioscler Thromb Vasc Biol 24:294-300. 2004
    ..In this study, we examined whether VEGF is coupled to phosphatidyl inositol 3-kinase (PI3K)/Akt/forkhead in ECs...
  6. ncbi request reprint Preconditioning of primary human endothelial cells with inflammatory mediators alters the "set point" of the cell
    Youichiro Wada
    The Center for Vascular Biology Research and Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center, Boston MA 02215, USA
    FASEB J 19:1914-6. 2005
    ..Taken together, these data suggest that inflammatory mediators prime endothelial cells to modulate subsequent thrombin response...
  7. ncbi request reprint The Akt-regulated forkhead transcription factor FOXO3a controls endothelial cell viability through modulation of the caspase-8 inhibitor FLIP
    Carsten Skurk
    Molecular Cardiology Whitaker Cardiovascular Institute, Boston University School of Medicine, Boston, Massachusetts 02118, USA
    J Biol Chem 279:1513-25. 2004
    ..These data suggest that FOXO3a is a downstream target of Akt in endothelial cells that can promote apoptosis via FLIP down-regulation and activation of the extrinsic apoptotic pathway...
  8. doi request reprint Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells
    Chantal Séguin
    Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
    Biomed Pharmacother 62:395-400. 2008
    ..Together, these findings suggest that Hcy sensitizes HUVEC to the effect of inflammatory mediators thrombin and LPS, at least in part through VCAM-1 expression and function...
  9. ncbi request reprint Forkhead transcription factors inhibit vascular smooth muscle cell proliferation and neointimal hyperplasia
    Md Ruhul Abid
    Center for Vascular Biology Research, Department of Medicine, Division of Molecular and Vascular Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 280:29864-73. 2005
    ..These data suggest that FoxO activity inhibits VSMC proliferation and activation and that this signaling axis may represent a therapeutic target in vasculopathic disease states...
  10. pmc Endothelium-dependent coronary vasodilatation requires NADPH oxidase-derived reactive oxygen species
    Jun Feng
    Department of Surgery, Beth Israel Deaconess Medical Center, Boston, Mass, USA
    Arterioscler Thromb Vasc Biol 30:1703-10. 2010
    ..To determine the functional significance of physiological reactive oxygen species (ROS) levels in endothelium-dependent nitric oxide (NO)-mediated coronary vasodilatation...
  11. ncbi request reprint Vascular endocan is preferentially expressed in tumor endothelium
    Md Ruhul Abid
    Center for Vascular Biology Research, and the Division of Vascular and Molecular Medicine, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, RW 663, Boston, MA 02215, USA
    Microvasc Res 72:136-45. 2006
    ..The results suggest that endocan is preferentially expressed in tumor endothelium in vivo and that its expression is regulated by tumor-derived factors...
  12. ncbi request reprint Thrombin downregulates thrombomodulin expression and activity in primary human endothelial cells
    Chantal Séguin
    Division of Molecular and Vascular Medicine and The Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA mcgill ca
    Endothelium 15:143-8. 2008
    ..These results suggest that activation of the coagulation cascade may result in a positive-feedback loop consisting of thrombin-mediated repression of TM-dependent protein C activation...
  13. doi request reprint Intracellular Ca2+ can compensate for the lack of NADPH oxidase-derived ROS in endothelial cells
    Monica Lee
    The Center for Vascular Biology Research, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
    FEBS Lett 584:3131-6. 2010
    ..These results suggest an essential role for Ca(2+) in redox-dependent selective activation of c-Src-PI3K-Akt and endothelial cell proliferation...
  14. ncbi request reprint Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways
    Takashi Minami
    Department of Molecular Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA
    J Biol Chem 278:6976-84. 2003
    ..Taken together, these data suggest that the endothelial cell-specific effect of thrombin on VCAM-1 expression involves the coordinate activity of PKC-delta-NF-kappaB and PKC-zeta-GATA signaling pathways...
  15. ncbi request reprint Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis
    Takashi Minami
    The Research Center for Advanced Science and Technology, The University of Tokyo, Tokyo 153 8904, Japan
    J Biol Chem 279:50537-54. 2004
    ..As a natural brake in the angiogenic process, this negative pathway may lend itself to therapeutic manipulation in pathological states...