E D Abel

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. pmc Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    E D Abel
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 104:1703-14. 1999
  2. ncbi Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    E D Abel
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 409:729-33. 2001
  3. ncbi Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis
    R Tian
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:2961-6. 2001
  4. ncbi Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis
    J Pachucki
    Thyroid Division, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 142:13-20. 2001
  5. ncbi Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    A Zisman
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 6:924-8. 2000
  6. ncbi Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor
    C Pazos-Moura
    Thyroid Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Circ Res 86:700-6. 2000
  7. ncbi Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements
    M Ito
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 47:1464-71. 1998
  8. ncbi Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density
    Alfred P McQueen
    Division of Cardiology, The University of Utah, Salt Lake City, UT, USA
    J Mol Cell Cardiol 39:882-92. 2005

Collaborators

Detail Information

Publications8

  1. pmc Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    E D Abel
    Division of Endocrinology and Metabolism, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    J Clin Invest 104:1703-14. 1999
    ..Basal and isoproterenol-stimulated isovolumic contractile performance was preserved. Thus, selective ablation of GLUT4 in the heart initiates a series of events that results in compensated cardiac hypertrophy...
  2. ncbi Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
    E D Abel
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Nature 409:729-33. 2001
    ..G4A-/- mice develop glucose intolerance and hyperinsulinaemia. Thus, downregulation of GLUT4 and glucose transport selectively in adipose tissue can cause insulin resistance and thereby increase the risk of developing diabetes...
  3. ncbi Responses of GLUT4-deficient hearts to ischemia underscore the importance of glycolysis
    R Tian
    NMR Laboratory for Physiological Chemistry, Division of Cardiovascular Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Circulation 103:2961-6. 2001
    ..Myocardial ischemia results in the translocation of the glucose transporter proteins GLUT1 and GLUT4 to the sarcolemma. The increased glucose entry via these transporters contributes to enhanced glycolysis during ischemia...
  4. ncbi Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis
    J Pachucki
    Thyroid Division, Brigham and Women's Hospital, Harvard Institute of Medicine, Boston, Massachusetts 02115, USA
    Endocrinology 142:13-20. 2001
    ....
  5. ncbi Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    A Zisman
    Research Division, Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02215, USA
    Nat Med 6:924-8. 2000
    ..These mice showed severe insulin resistance and glucose intolerance from an early age. Thus, GLUT4-mediated glucose transport in muscle is essential to the maintenance of normal glucose homeostasis...
  6. ncbi Cardiac dysfunction caused by myocardium-specific expression of a mutant thyroid hormone receptor
    C Pazos-Moura
    Thyroid Unit, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA
    Circ Res 86:700-6. 2000
    ..This is the first demonstration indicating that isolated cardiac hypothyroidism causes cardiac dysfunction in the absence of changes in the adrenergic or peripheral vascular system...
  7. ncbi Mice expressing human but not murine beta3-adrenergic receptors under the control of human gene regulatory elements
    M Ito
    Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215, USA
    Diabetes 47:1464-71. 1998
    ..These "humanized" mice should assist us in the development of drugs that may become effective anti-obesity agents in humans...
  8. ncbi Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density
    Alfred P McQueen
    Division of Cardiology, The University of Utah, Salt Lake City, UT, USA
    J Mol Cell Cardiol 39:882-92. 2005
    ..Thus, absence of insulin receptor signaling in the cardiac myocyte worsens catecholamine-mediated myocardial injury, at least in part, via mechanisms that tend to impair myocardial blood flow and increase ischemic injury...