R Abdi

Summary

Affiliation: Harvard University
Country: USA

Publications

  1. ncbi request reprint Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension
    R Abdi
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Transplantation 72:726-9. 2001
  2. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
  3. ncbi request reprint The inception and formation of the theory of hyperfiltration through the ages
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Iran J Kidney Dis 6:94-7. 2012
  4. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
  5. ncbi request reprint Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02120, USA
    J Immunol 172:767-75. 2004
  6. ncbi request reprint Correlation between glomerular size and long-term renal function in patients with substantial loss of renal mass
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Urol 170:42-4. 2003
  7. ncbi request reprint Chemokines in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Diabetes Metab Res Rev 19:186-90. 2003
  8. doi request reprint Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†)
    M Jurewicz
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA, USA
    Am J Transplant 11:348-55. 2011
  9. pmc Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes
    Mollie Jurewicz
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:3139-47. 2010
  10. ncbi request reprint Role of CXC chemokine receptor 3 pathway in renal ischemic injury
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:716-23. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Angiotensin gene polymorphism as a determinant of posttransplantation renal dysfunction and hypertension
    R Abdi
    Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Transplantation 72:726-9. 2001
    ....
  2. pmc The novel therapeutic effect of phosphoinositide 3-kinase-γ inhibitor AS605240 in autoimmune diabetes
    Jamil Azzi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital and Children s Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 61:1509-18. 2012
    ..These studies demonstrate the key role of the PI3Kγ pathway in determining the balance of Tregs and autoreactive cells regulating autoimmune diabetes...
  3. ncbi request reprint The inception and formation of the theory of hyperfiltration through the ages
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Iran J Kidney Dis 6:94-7. 2012
    ..This review focuses on the major discoveries of the leading thinkers who with their paradigm shifting ideas and skepticism pushed the boundaries of our knowledge and shaped the theory of hyperfiltration...
  4. pmc Immunomodulation by mesenchymal stem cells: a potential therapeutic strategy for type 1 diabetes
    Reza Abdi
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 57:1759-67. 2008
    ....
  5. ncbi request reprint Differential role of CCR2 in islet and heart allograft rejection: tissue specificity of chemokine/chemokine receptor function in vivo
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, 75 Francis Street, Boston, MA 02120, USA
    J Immunol 172:767-75. 2004
    ..This study demonstrates the important role for CCR2 in early islet allograft rejection and highlights the tissue specificity of the chemokine/chemokine receptor system in vivo in regulating allograft rejection...
  6. ncbi request reprint Correlation between glomerular size and long-term renal function in patients with substantial loss of renal mass
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    J Urol 170:42-4. 2003
    ..Studies also have shown that a strong correlation exists between higher glomerular size and the degree of glomerular sclerosis that develops following loss of functioning nephrons...
  7. ncbi request reprint Chemokines in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Diabetes Metab Res Rev 19:186-90. 2003
    ..Hence, each organ or tissue may require a unique set of chemokines to generate acute rejection. Targeting the appropriate chemokine receptors may provide a clinically useful strategy to prevent islet allograft rejection...
  8. doi request reprint Donor antioxidant strategy prolongs cardiac allograft survival by attenuating tissue dendritic cell immunogenicity(†)
    M Jurewicz
    Transplantation Research Center, Brigham and Women s Hospital and Children s Hospital, Boston, MA, USA
    Am J Transplant 11:348-55. 2011
    ..These data for the first time establish a basis for donor anti-ischemic strategies, which in the ever-expanding marginal donor pools, can be instituted to promote engraftment...
  9. pmc Congenic mesenchymal stem cell therapy reverses hyperglycemia in experimental type 1 diabetes
    Mollie Jurewicz
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Diabetes 59:3139-47. 2010
    ..Here, we examine this question by testing the ability of congenic MSCs, obtained from the NOR mouse strain, to reverse recent-onset type 1 diabetes in NOD mice, as well as determine the immunomodulatory effects of NOR MSCs in vivo...
  10. ncbi request reprint Role of CXC chemokine receptor 3 pathway in renal ischemic injury
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital, Harvard Medical School, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 17:716-23. 2006
    ..It is concluded that CXCR3 plays an important role in orchestrating the recruitment of Th1 cells to the ischemic kidney and in mediating I/R injury and therefore may serve as a novel target for the therapy of I/R injury...
  11. ncbi request reprint Chemokine receptor polymorphism and risk of acute rejection in human renal transplantation
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Boston, Massachesetts, USA
    J Am Soc Nephrol 13:754-8. 2002
    ..20; P = 0.032) and homozygosity for the 59029-A allele (OR, 0.26; P = 0.027). It was concluded that the risk of acute rejection in renal transplantation is associated with genetic variation in the chemokine receptors CCR2 and CCR5...
  12. ncbi request reprint The role of CC chemokine receptor 5 (CCR5) in islet allograft rejection
    Reza Abdi
    Laboratory of Immunogenetics and Transplantation, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:2489-95. 2002
    ..Targeting this chemokine receptor, therefore, may provide a clinically useful strategy to prevent islet allograft rejection...
  13. doi request reprint Phenotypic and functional differences between wild-type and CCR2-/- dendritic cells: implications for islet transplantation
    Paolo Fiorina
    Transplantation Research Center, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Transplantation 85:1030-8. 2008
    ..Here, we provide evidence that lack of CCR2 could lead to the generation of functionally and phenotypically different DC, which in part could explain the benefits observed in transplanting islets in CCR2 recipients...
  14. ncbi request reprint Importance of donor- and recipient-derived selectins in cardiac allograft rejection
    Atsushi Izawa
    Transplantation Research Center, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 18:2929-36. 2007
    ..In conclusion, donor-derived selectins contribute to the development of both acute and chronic cardiac allograft rejection, and targeting donor selectins may open novel therapeutic approaches in clinical transplantation...
  15. ncbi request reprint Role of beta3 integrin in acute renal allograft rejection in humans
    Arun Chandrakantan
    Division of Nephrology, University of Alabama at Birmingham, Birmingham, Alabama, USA
    Clin J Am Soc Nephrol 2:1268-73. 2007
    ..Beta3 Integrin may play a role in the process of acute rejection by increasing leukocyte adhesion to the endothelium, cytotoxic T lymphocyte activation, and platelet aggregation...
  16. ncbi request reprint Chemokines and chronic heart allograft rejection
    R Neal Smith
    Transplantation 84:442-4. 2007
  17. ncbi request reprint Impact of renin angiotensin system blockade on renal function in health and disease: an end or a beginning?
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Boston, MA 02115 6392, USA
    Semin Nephrol 24:141-6. 2004
    ..Numerous animal studies as well as recent clinical trials indicate that blockade of the renin angiotensin system effectively retards progression of nephropathy from diverse origins...
  18. ncbi request reprint Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation
    Mollie Jurewicz
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, 221 Longwood Avenue, Boston, MA 02115, USA
    J Am Soc Nephrol 18:1093-102. 2007
    ..Because their chemotaxis is enhanced by AngII, this creates a potential inflammatory amplification system...
  19. ncbi request reprint Characterization of donor dendritic cells and enhancement of dendritic cell efflux with CC-chemokine ligand 21: a novel strategy to prolong islet allograft survival
    Paolo Fiorina
    Transplantation Research Center TRC, Children s Hospital and Brigham and Women s Hospital, Harvard Medical School, 221 Longwood Ave, Boston, MA 02115, USA
    Diabetes 56:912-20. 2007
    ..This study introduces dDCs and rDCs as two distinct types of DCs and provides novel data with clinical implications to use chemokine-based DC-depleting strategies to prolong islet allograft survival...
  20. ncbi request reprint Allorecognition and effector pathways of islet allograft rejection in normal versus nonobese diabetic mice
    Leila Makhlouf
    Laboratory of Immunogenetics and Transplantation, Renal Division, Department of Medicine, Brigham and Women s Hospital, Boston, Massachusetts, USA
    J Am Soc Nephrol 14:2168-75. 2003
    ..These data shed light on the mechanisms of islet allograft rejection in different responder strains, including those with autoimmunity...
  21. ncbi request reprint Emerging immunomodulatory therapies targeting the co-stimulatory pathways for the prevention of transplant rejection
    Mohammed J I Ansari
    Brigham and Women s Hospital, Laboratory of Immunogenetics and Transplantation, 75 Francis Street, Boston, MA 02115, USA
    IDrugs 6:964-9. 2003
    ..These novel immunomodulatory strategies have the potential to bring us a step closer to achieving transplantation tolerance...
  22. ncbi request reprint The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade
    Leila Makhlouf
    Laboratory of Immunogenetics and Transplantation, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Diabetes 51:3202-10. 2002
    ..Our results may have implications for the design of future clinical trials in islet transplantation...
  23. ncbi request reprint Chemokines and diseases
    Victor M Dong
    Clinical Operations and Medical Affairs, Solvay Pharmaceuticals, Inc, 901 Sawyer Road, Marietta, GA 30062, USA
    Eur J Dermatol 13:224-30. 2003
    ..This review focuses on the physiology of chemokines and their significant roles in the pathogenesis and progression of major diseases...
  24. ncbi request reprint A novel alloantigen-specific CD8+PD1+ regulatory T cell induced by ICOS-B7h blockade in vivo
    Atsushi Izawa
    Transplantation Research Center, Renal Division, Brigham and Women s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Immunol 179:786-96. 2007
    ..These results describe a novel allospecific regulatory CD8(+)PD1(+) T cell induced by ICOS-B7h blockade in vivo...
  25. ncbi request reprint Metabolic and immunological features of the failing islet-transplanted patient
    Paolo Fiorina
    Department of Medicine, San Raffaele Scientific Institute, Milan, Italy
    Diabetes Care 31:436-8. 2008
    ..This retrospective study was designed to identify metabolic and immune predictors of early islet allograft failure...
  26. ncbi request reprint Angiotensin II receptor blocker-associated angioedema: on the heels of ACE inhibitor angioedema
    Reza Abdi
    Renal Division, Brigham and Women s Hospital, Boston, Massachusetts 02115, USA
    Pharmacotherapy 22:1173-5. 2002
    ..Clinicians should exercise caution when using ARBs in patients with a history of angioedema secondary to ACE inhibitors...
  27. ncbi request reprint Cutaneous neoplasms in renal transplant recipients
    Jeffrey Rand Rubel
    Renal Division, MRB 4, Brigham and Women s Hospital, 75 Francis Street, Boston, MA 02115, USA
    Eur J Dermatol 12:532-5. 2002
    ..Treatment options include reduction in immunosuppression, but preventive maintenance remains the primary focus of efforts to limit these malignancies...