PAUL DAVIS THOMPSON

Summary

Affiliation: Hartford Hospital
Country: USA

Publications

  1. doi request reprint A history of medical reports on the Boston Marathon: 112 years and still running
    Paul D Thompson
    Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 41:257-64. 2009
  2. doi request reprint A meta-analysis of aortic root size in elite athletes
    Aline Iskandar
    University of Connecticut School of Medicine, Department of Medicine, Farmington, CT, USA
    Circulation 127:791-8. 2013
  3. doi request reprint Effect of statins on skeletal muscle function
    Beth A Parker
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA
    Circulation 127:96-103. 2013
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
  5. pmc The metabolic syndrome and the immediate antihypertensive effects of aerobic exercise: a randomized control design
    Linda S Pescatello
    Department of Kinesiology, University of CT, Storrs, CT, USA
    BMC Cardiovasc Disord 8:12. 2008
  6. doi request reprint Cardiovascular risks of exercise: avoiding sudden death and myocardial infarction
    P D Thompson
    Division of Cardiology, Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 29:33-47. 2001
  7. ncbi request reprint Exercise rehabilitation for cardiac patients: a beneficial but underused therapy
    P D Thompson
    Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 29:69-75. 2001
  8. ncbi request reprint Aortic valvular disease in active patients: overcoming diagnostic and management challenges
    Paul D Thompson
    Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 30:19-35. 2002
  9. doi request reprint CHD risk equivalents and the metabolic syndrome. Trial evidence supports aggressive management
    Paul D Thompson
    Preventive Cardiology and Cardiovascular Research, Hartford Hospital, Hartford, CT 06102, USA
    Postgrad Med 114:22-30. 2003
  10. ncbi request reprint The acute versus the chronic response to exercise
    P D Thompson
    Preventive Cardiology, Division of Cardiology, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 33:S438-45; discussion S452-3. 2001

Research Grants

  1. The Effect of Statins on Skeletal Muscle Function
    Paul Thompson; Fiscal Year: 2007
  2. The Effect of Statins on Skeletal Muscle Function
    Paul Thompson; Fiscal Year: 2009
  3. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010

Detail Information

Publications96

  1. doi request reprint A history of medical reports on the Boston Marathon: 112 years and still running
    Paul D Thompson
    Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 41:257-64. 2009
    ..We performed a systematic search for medical reports on the Boston Marathon, run annually since April 19, 1897 and studied medically since 1899...
  2. doi request reprint A meta-analysis of aortic root size in elite athletes
    Aline Iskandar
    University of Connecticut School of Medicine, Department of Medicine, Farmington, CT, USA
    Circulation 127:791-8. 2013
    ..We performed a systematic literature review and meta-analysis to examine whethere athletes demonstrate increased aortic root dimensions compared with nonathlete controls...
  3. doi request reprint Effect of statins on skeletal muscle function
    Beth A Parker
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT, USA
    Circulation 127:96-103. 2013
    ..Many clinicians believe that statins cause muscle pain, but this has not been observed in clinical trials, and the effect of statins on muscle performance has not been carefully studied...
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
    ..We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome...
  5. pmc The metabolic syndrome and the immediate antihypertensive effects of aerobic exercise: a randomized control design
    Linda S Pescatello
    Department of Kinesiology, University of CT, Storrs, CT, USA
    BMC Cardiovasc Disord 8:12. 2008
    ..We examined the influence of the Msyn on the blood pressure (BP) response following low (LIGHT, 40% peak oxygen consumption, VO2peak) and moderate (MODERATE, 60% VO2peak) intensity, aerobic exercise...
  6. doi request reprint Cardiovascular risks of exercise: avoiding sudden death and myocardial infarction
    P D Thompson
    Division of Cardiology, Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 29:33-47. 2001
    ..Personnel involved with sports should be able to recognize cardiac symptoms and be certified in cardiopulmonary resuscitation...
  7. ncbi request reprint Exercise rehabilitation for cardiac patients: a beneficial but underused therapy
    P D Thompson
    Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 29:69-75. 2001
    ..Subsequent moderate exercise regimens can be done at home. All patients should engage in lifelong maintenance programs...
  8. ncbi request reprint Aortic valvular disease in active patients: overcoming diagnostic and management challenges
    Paul D Thompson
    Hartford Hospital, Hartford, CT, 06102, USA
    Phys Sportsmed 30:19-35. 2002
    ..Symptoms of severe aortic stenosis include exercise-induced syncope, angina, heart attack, and, rarely, sudden death; these athletes should not compete and should have aortic valve replacement...
  9. doi request reprint CHD risk equivalents and the metabolic syndrome. Trial evidence supports aggressive management
    Paul D Thompson
    Preventive Cardiology and Cardiovascular Research, Hartford Hospital, Hartford, CT 06102, USA
    Postgrad Med 114:22-30. 2003
    ..Drug therapy usually starts with an LDL-C-lowering agent, such as a statin. If LDL-C and non-high-density lipoprotein cholesterol goals are not achieved, statin therapy should be intensified or a fibrate or niacin should be added...
  10. ncbi request reprint The acute versus the chronic response to exercise
    P D Thompson
    Preventive Cardiology, Division of Cardiology, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 33:S438-45; discussion S452-3. 2001
    ..Such observations suggest that at least some of the effects on atherosclerotic cardiovascular disease (ASCVD) risk factors attributed to exercise training may be the result of recent exercise...
  11. doi request reprint A history of medical reports on the Boston Marathon: 112 years and still running
    Paul D Thompson
    Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 41:1341-8. 2009
    ..We performed a systematic search for medical reports on the Boston Marathon, run annually since April 19, 1897 and studied medically since 1899...
  12. ncbi request reprint Exercise prescription and proscription for patients with coronary artery disease
    Paul D Thompson
    The Cardiac Rehabilitation and Cardiovascular Research, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Circulation 112:2354-63. 2005
  13. ncbi request reprint Cardiovascular adaptations to marathon running : the marathoner's heart
    Paul D Thompson
    Division of Cardiology, University of Connecticut, Hartford Hospital, Hartford, Connecticut 06102, USA
    Sports Med 37:444-7. 2007
    ..Many of these findings were presented in the 1977 report on the marathon and have simply been better defined with subsequent studies...
  14. ncbi request reprint An assessment of statin safety by muscle experts
    Paul D Thompson
    Division of Cardiology, Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 97:69C-76C. 2006
    ..The panel was composed of a clinical cardiologist, an exercise physiologist and skeletal muscle expert, and an expert in preventive cardiology who also examined skeletal muscle complications of statin use...
  15. ncbi request reprint Functional polymorphisms associated with human muscle size and strength
    Paul D Thompson
    Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 36:1132-9. 2004
    ....
  16. doi request reprint A randomized clinical trial to assess the effect of statins on skeletal muscle function and performance: rationale and study design
    Paul D Thompson
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Prev Cardiol 13:104-11. 2010
    ..This study will determine the effect of statins on skeletal muscle strength, endurance, and aerobic exercise performance and may ultimately help clinicians better evaluate statin-related muscle and exercise complaints...
  17. ncbi request reprint Angiotensin-converting enzyme genotype and adherence to aerobic exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT 06102, USA
    Prev Cardiol 9:21-4. 2006
    ..These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen...
  18. ncbi request reprint Effect of intravenous testosterone on myocardial ischemia in men with coronary artery disease
    Paul D Thompson
    Division of Cardiology, Hartford Hospital, Hartford, Conn 06102 5037, USA
    Am Heart J 143:249-56. 2002
    ..Studies on the effect of estrogen on atherosclerotic coronary artery disease (CAD) risk in women have produced conflicting results. Similar confusion, but fewer data, exists on the effect of testosterone on CAD risk in men...
  19. ncbi request reprint D. Bruce Dill Historical lecture. Historical concepts of the athlete's heart
    Paul D Thompson
    Director of Preventive Cardiology and Cardiovascular Research, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 36:363-70. 2004
  20. ncbi request reprint The effects of hydroxy-methyl-glutaryl co-enzyme A reductase inhibitors on platelet thrombus formation
    Paul D Thompson
    Section of Preventive Cardiology, Division of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Atherosclerosis 161:301-6. 2002
    ....
  21. ncbi request reprint The cardiovascular risks of diving
    Paul D Thompson
    Section of Cardiology, Henry Low Heart Center, Hartford Hospital Hartford, Conn, USA
    Undersea Hyperb Med 38:271-7. 2011
    ....
  22. ncbi request reprint Statin-associated myopathy
    Paul D Thompson
    Preventive Cardiology and Cardiovascular Research, Division of Cardiology, Hartford Hospital, Hartford, Conn 06102, USA
    JAMA 289:1681-90. 2003
    ..How statins injure skeletal muscle is not clear, although recent evidence suggests that statins reduce the production of small regulatory proteins that are important for myocyte maintenance...
  23. ncbi request reprint Meta-analysis of results from eight randomized, placebo-controlled trials on the effect of cilostazol on patients with intermittent claudication
    Paul D Thompson
    Hartford Hospital, Hartford, Connecticut 06102, USA
    Am J Cardiol 90:1314-9. 2002
    ..8%, but there were no deleterious effects on any hematologic or serum markers. We conclude that cilostazol significantly increases walking distance and quality-of-life measures in patients with claudication without major adverse effects...
  24. doi request reprint The endothelial nitric oxide synthase -786 T>C polymorphism and the exercise-induced blood pressure and nitric oxide responses among men with elevated blood pressure
    Amanda L Augeri
    Department of Kinesiology, University of Connecticut, Storrs, CT 06269 1110, USA
    Atherosclerosis 204:e28-34. 2009
    ..We examined the influence of eNOS -786 T>C (rs2070744) on the BP and NO response to acute dynamic exercise...
  25. ncbi request reprint The alpha-adducin Gly460Trp polymorphism and the antihypertensive effects of exercise among men with high blood pressure
    Linda S Pescatello
    Department of Kinesiology, University of Connecticut, Storrs, CT, USA
    Clin Sci (Lond) 113:251-8. 2007
    ..Our findings indicate that the alpha-adducin Gly460Trp genotype may be useful in identifying men who have a reduced BP after lower intensity aerobic exercise...
  26. ncbi request reprint ACE ID genotype and the muscle strength and size response to unilateral resistance training
    Linda S Pescatello
    School of Allied Health, University of Connecticut, Storrs, CT 06269 2101, USA
    Med Sci Sports Exerc 38:1074-81. 2006
    ..wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms...
  27. doi request reprint The additive blood pressure lowering effects of exercise intensity on post-exercise hypotension
    John D Eicher
    University of Connecticut, Storrs, 06269 1110, USA
    Am Heart J 160:513-20. 2010
    ..We also examined clinical correlates of the BP response...
  28. doi request reprint Efficacy of rosuvastatin (5 mg and 10 mg) twice a week in patients intolerant to daily statins
    Mamatha Gadarla
    Preventive Cardiology, Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut, USA
    Am J Cardiol 101:1747-8. 2008
    ..In conclusion, rosuvastatin twice weekly reduced total cholesterol, low-density lipoprotein cholesterol, and triglycerides and was well tolerated, but determining long-term tolerability requires more prolonged treatment...
  29. ncbi request reprint Exercise intensity alters postexercise hypotension
    Linda S Pescatello
    University of Connecticut, School of Allied Health, Storrs, Connecticut 06269 2101, USA
    J Hypertens 22:1881-8. 2004
    ..g. postexercise hypotension (PEH). The optimal exercise intensity needed to evoke PEH has not been established. We examined the effect of light (LITE) and moderate (MOD) exercise intensity on PEH...
  30. ncbi request reprint Peak systolic blood pressure on a graded maximal exercise test and the blood pressure response to an acute bout of submaximal exercise
    Amy N Syme
    University of Connecticut, Storrs, Connecticut, USA
    Am J Cardiol 98:938-43. 2006
    ..In conclusion, the findings of this study suggest that peak systolic BP on a GEST may be used to characterize which men with hypertension will have decreased systolic BP after acute submaximal aerobic exercise...
  31. ncbi request reprint Physiogenomic association of statin-related myalgia to serotonin receptors
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
    Muscle Nerve 36:329-35. 2007
    ..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...
  32. ncbi request reprint RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension
    Bruce E Blanchard
    University of CT, Storrs, CT 06102, USA
    Eur J Appl Physiol 97:26-33. 2006
    ..In order to optimally prescribe exercise for its BP lowering benefits in those with hypertension, additional knowledge of how genetic variation affects the BP response to exercise is needed...
  33. doi request reprint The creatine kinase response to eccentric exercise with atorvastatin 10 mg or 80 mg
    Amy K Kearns
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, 87 Seymour Street, Hartford, CT 06102, USA
    Atherosclerosis 200:121-5. 2008
    ..This study examined the CK response to downhill walking in subjects treated with low and high dose of atorvastatin...
  34. ncbi request reprint Acute cardiovascular response to exercise and its implications for exercise testing
    Sachin M Navare
    Hartford Hospital, University of Connecticut School of Medicine, Farmington, CT, USA
    J Nucl Cardiol 10:521-8. 2003
  35. ncbi request reprint Postexercise hypotension differs between white and black women
    Linda S Pescatello
    Center for Health Promotion, University of Connecticut, School of Allied Health, Storrs, CT 06269 2101, USA
    Am Heart J 145:364-70. 2003
    ..Because data are lacking, we examined the acute effect of exercise on ambulatory blood pressure (BP) in premenopausal white women (n = 18) and black women (n = 15) with normal (n = 21) and high (n = 12) BP...
  36. pmc Interactive effects of APOE haplotype, sex, and exercise on postheparin plasma lipase activities
    Richard L Seip
    Preventive Cardiology JB704, Hartford Hospital, Hartford, CT 06102 5037, USA
    J Appl Physiol 110:1021-8. 2011
    ....
  37. ncbi request reprint Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Atherosclerosis 185:65-9. 2006
    ..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training...
  38. ncbi request reprint Use of prehospital electrocardiograms for the treatment of patients with ST-segment elevation myocardial infarction
    Marcin R Dada
    Chest Pain Center, Hartford Hospital, Hartford, CT 06102, USA
    Conn Med 73:69-72. 2009
    ..Use of prehospital electrocardiography combined with early catheterization laboratory mobilization allowed for timely STEMI reperfusion according to national guidelines, despite "off-hour" presentation...
  39. ncbi request reprint The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise
    Richard L Seip
    Cardiology Division, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    Atherosclerosis 188:126-33. 2006
    ..In conclusion, APOE variants influence the serum LDL subpopulation response to exercise training in normolipidemic subjects. Subjects homozygous for APOE3 experienced the most beneficial lipid effects from exercise training...
  40. ncbi request reprint The origins and development of the Cardiovascular Program at Hartford Hospital. 150th Anniversary of Hartford Hospital
    William E Boden
    Hartford Hospital, Hartford, 80 Seymour Street, Hartford, CT 06102, USA
    Conn Med 68:259-68. 2004
  41. ncbi request reprint Urban ethnic minority women's attendance at health clinic vs. church based exercise programs
    Ellen A Dornelas
    Preventive Cardiology, Henry Low Heart Center, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    J Cross Cult Gerontol 22:129-36. 2007
    ..Administrators who design exercise programs for urban-living women should consider age of the target population when selecting the most conducive setting...
  42. ncbi request reprint Randomized trial of hormone therapy in women after coronary bypass surgery. Evidence of differential effect of hormone therapy on angiographic progression of disease in saphenous vein grafts and native coronary arteries
    Pamela Ouyang
    Johns Hopkins University School of Medicine, John Hopkins Bayview Medical Center, Division of Cardiology, 4940 Eastern Avenue, Baltimore, MD 21224, USA
    Atherosclerosis 189:375-86. 2006
    ..This study suggests that hormone treatment may slow SVG disease progression while accelerating atherosclerosis in non-bypassed native coronary arteries...
  43. ncbi request reprint Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasis
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA
    Pharmacogenomics 6:865-72. 2005
    ....
  44. doi request reprint Myostatin and follistatin polymorphisms interact with muscle phenotypes and ethnicity
    Matthew A Kostek
    Department of Kinesiology, University of Connecticut, Storrs, CT 06269 2101, USA
    Med Sci Sports Exerc 41:1063-71. 2009
    ..We examined associations among myostatin (MSTN) 2379 A > G and 163 G > A and follistatin (FST) -5003 A > T and -833 G > T single nucleotide polymorphisms (SNP) on the muscle size and the strength response to resistance training (RT)...
  45. doi request reprint Managing statin myopathy
    Carmelo V Venero
    The Henry Low Heart Center, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Endocrinol Metab Clin North Am 38:121-36. 2009
    ..In patients with myopathic symptoms, their symptoms and CK levels determine whether statin therapy can be continued or must be stopped...
  46. doi request reprint The effects of statins on skeletal muscle strength and exercise performance
    Guru M Krishnan
    Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
    Curr Opin Lipidol 21:324-8. 2010
    ..We performed a literature search to examine these issues...
  47. ncbi request reprint Tendon rupture associated with simvastatin/ezetimibe therapy
    Raja C Pullatt
    Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
    Am J Cardiol 100:152-3. 2007
    ..Statins are known to inhibit MMPs. It was hypothesized that statins may increase the risk of tendon rupture by altering MMP activity. In conclusion, statins may increase the risk of tendon rupture by altering MMP activity...
  48. doi request reprint The genetics of statin-induced myopathy
    Abhijit Ghatak
    Department of Internal Medicine, University of Connecticut, Farmington, CT 06032, USA
    Atherosclerosis 210:337-43. 2010
    ..Our goal was to use genetic variants to identify factors contributing to the muscular side effects of statins...
  49. ncbi request reprint How do you treat patients with myalgia who take statins?
    Saadi A Siddiqi
    Division of Cardiology, Hartford Hospital, Hartford, CT 06102, USA
    Curr Atheroscler Rep 11:9-14. 2009
    ..These clinical events, plus other symptoms, constitute what is termed statin myopathy. This review summarizes current concepts of statin myopathy and presents strategies to minimize statin-associated myopathic complaints...
  50. ncbi request reprint Rhabdomyolysis associated with pomegranate juice consumption
    Alexey V Sorokin
    Section of Preventive Cardiology, Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut, USA
    Am J Cardiol 98:705-6. 2006
    ....
  51. ncbi request reprint Apolipoprotein E genotype and changes in serum lipids and maximal oxygen uptake with exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT, USA
    Metabolism 53:193-202. 2004
    ..Surprisingly, Apo E genotype also affected the increase in aerobic capacity produced by exercise training possibly via undefined effects on nerve and skeletal muscle function...
  52. ncbi request reprint What's new in lipid management?
    Paul D Thompson
    Department of Medicine, University of Connecticut, Farmingham, Connecticut, USA
    Pharmacotherapy 23:34S-40S. 2003
    ..Low-density lipoprotein cholesterol apheresis is another, nonpharmacologic option for patients with severe hyperlipidemia despite maximal medical therapy...
  53. ncbi request reprint Effectiveness of ezetimibe in clinical practice
    Javier Jurado
    University of Connecticut, Farmington, Connecticut, USA
    Am J Cardiol 93:641-3. 2004
    ..Ezetimibe was also effective in patients treated with this agent alone (-23%, n = 21), with a statin (-23%, n = 28), with a nonstatin (-21%, n = 18), and with both a statin and a nonstatin (-22%, n = 20)...
  54. ncbi request reprint Statin use in the metabolic syndrome
    Justin B Lundbye
    Cardiology, Hartford Hospital, Hartford, CT 06102 5037, USA
    Curr Atheroscler Rep 7:17-21. 2005
    ....
  55. ncbi request reprint The accuracy of aneroid sphygmomanometers in the ambulatory setting
    Timothy A Moore
    Division of Cardiology, Department of Medicine, Beth Israel Medical Center, New York, NY, USA
    Prev Cardiol 11:90-4. 2008
    ..Inaccurate readings of aneroid sphygmomanometers may result in a failure to diagnose and treat hypertension, thereby placing hypertensive patients at risk for end-organ damage and cardiovascular events...
  56. ncbi request reprint Premature atherosclerosis: a possible mechanism for symptoms in anomalous coronary arteries--report of a case
    Jose Raymond Mercado
    Internal Medicine, University of Connecticut, Farmington, USA
    Conn Med 74:91-2. 2010
    ..This case illustrates anomalous coronary artery origins may produce turbulent flow thereby accelerating atherosclerosis and producing abnormal endothelial function and coronary spasm...
  57. ncbi request reprint The effects of physical activity on serum C-reactive protein and inflammatory markers: a systematic review
    Christos Kasapis
    Department of Internal Medicine, University of Connecticut, Farmington, Connecticut, USA
    J Am Coll Cardiol 45:1563-9. 2005
    ..This anti-inflammatory response may contribute to the beneficial effects of habitual physical activity...
  58. ncbi request reprint Exercise-related spontaneous coronary artery dissection: case report and literature review
    Ravishankar V Kalaga
    Division of Cardiology, Henry Low Heart Center, Hartford Hospital, Hartford, CT 06102, USA
    Med Sci Sports Exerc 39:1218-20. 2007
    ..In summary, spontaneous coronary artery dissection should be considered in young individuals presenting with exercise-related acute ischemic cardiac events...
  59. ncbi request reprint The congenital long QT syndrome and implications for young athletes
    Athanasios Kapetanopoulos
    Hartford Hospital, University of Connecticut School of Medicine, Farmington, 06102, USA
    Med Sci Sports Exerc 38:816-25. 2006
    ..This article reviews the pathophysiology, clinical characteristics, and management of LQTS in the physically active and athletic population...
  60. doi request reprint Statins and interstitial lung disease: a systematic review of the literature and of food and drug administration adverse event reports
    Antonio B Fernandez
    Section of Cardiovascular Medicine, Yale University School of Medicine, New Haven, CT, USA
    Chest 134:824-30. 2008
    ..To systematically review all published case reports and the US Food and Drug Administration adverse event reporting (FDA-AER) database to examine the relationship between statins and interstitial lung disease (ILD)...
  61. ncbi request reprint Hypertrophic cardiomyopathy: who plays and who sits
    Asad A Rizvi
    Division of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Curr Sports Med Rep 1:93-9. 2002
    ..This article presents our current understanding and approach to evaluating and advising athletes with HCM...
  62. ncbi request reprint Statins provoking MELAS syndrome. A case report
    Joseph E Thomas
    Department of Internal Medicine, School of Medicine, University of Connecticut, Farmington, Conn, USA
    Eur Neurol 57:232-5. 2007
    ..Idiopathic or primary CoQ10 deficiencies have been known to cause mitochondrial encephalomyopathy...
  63. ncbi request reprint Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology
    Paul D Thompson
    Hartford Hospital, USA
    Circulation 115:2358-68. 2007
    ....
  64. ncbi request reprint The muscle strength and size response to upper arm, unilateral resistance training among adults who are overweight and obese
    Linda S Pescatello
    University of Connecticut, Storrs, Connecticut 06269, USA
    J Strength Cond Res 21:307-13. 2007
    ..These findings indicate the short-term relative and allometric muscle strength response to RT may be attenuated among adults who are overweight and obese...
  65. doi request reprint The definition of exertion-related cardiac events
    M Rai
    Director of Cardiology, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102, USA
    Br J Sports Med 45:130-1. 2011
    ..It is suggested, therefore, that the definition of an exertion-related cardiac event be established as a cardiac event in which symptoms started during or within 1 h of physical exertion...
  66. doi request reprint Atrial fibrillation in endurance-trained athletes
    A V Sorokin
    Cardiology, Hartford Hospital, 81 Seymour Street, Hartford, CT 06102, USA
    Br J Sports Med 45:185-8. 2011
    ..PubMed was searched from January 1960 through December 2008 to identify articles examining the relationship between endurance exercise training and AF...
  67. ncbi request reprint Decreasing LDL cholesterol and medication cost with every-other-day statin therapy
    Monika A Juszczyk
    Preventive Cardiology, Henry Low Heart Center, Division of Cardiology, Hartford Hospital, 86 Seymour Street, Hartford, CT 06102, USA
    Prev Cardiol 8:197-9. 2005
    ..o.d. (n=16; p<0.05 for all). We conclude that q.o.d. treatment with long-acting statins significantly improves serum lipid levels...
  68. ncbi request reprint Phytosterols and vascular disease
    Saji John
    Section of Preventive Cardiology, Division of Cardiology, The Henry Low Heart Center, Hartford Hospital, Hartford, Connecticut 06102, USA
    Curr Opin Lipidol 18:35-40. 2007
    ..This review evaluates the relationship between phytosterol and stanol supplementation and cardiovascular risk...
  69. ncbi request reprint Allometric scaling of biceps strength before and after resistance training in men
    Robert F Zoeller
    Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL 33314, and Division of Cardiology, Hartford Hospital, Hartford, CT, USA
    Med Sci Sports Exerc 39:1013-9. 2007
    ....
  70. ncbi request reprint Subcutaneous fat alterations resulting from an upper-body resistance training program
    Matthew A Kostek
    Department of Kinesiology, University of Connecticut, Storrs, CT 06269 2101, USA
    Med Sci Sports Exerc 39:1177-85. 2007
    ..To reexamine this concept, we compared subcutaneous fat measurements before and after resistance training among 104 subjects (45 men, 59 women)...
  71. ncbi request reprint Recommendations for physical activity and recreational sports participation for young patients with genetic cardiovascular diseases
    Barry J Maron
    Circulation 109:2807-16. 2004
    ....
  72. ncbi request reprint Task Force 6: coronary artery disease
    Paul D Thompson
    J Am Coll Cardiol 45:1348-53. 2005
  73. ncbi request reprint Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure: the CAMELOT study: a randomized controlled trial
    Steven E Nissen
    Department of Cardiovascular Medicine, Cleveland Clinic Lerner School of Medicine, Cleveland, Ohio, USA
    JAMA 292:2217-25. 2004
    ..The effect of antihypertensive drugs on cardiovascular events in patients with coronary artery disease (CAD) and normal blood pressure remains uncertain...
  74. ncbi request reprint Cardiac rehabilitation and secondary prevention of coronary heart disease: an American Heart Association scientific statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Cardiac Rehabilitation, and Prevention) and the Council on Nut
    Arthur S Leon
    Circulation 111:369-76. 2005
    ....
  75. ncbi request reprint Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical
    Paul D Thompson
    Circulation 107:3109-16. 2003
  76. ncbi request reprint Task Force 1: preparticipation screening and diagnosis of cardiovascular disease in athletes
    Barry J Maron
    J Am Coll Cardiol 45:1322-6. 2005
  77. ncbi request reprint Is there evidence for the evidence-based guidelines for cardiovascular disease prevention in women?
    Barbara H Roberts
    The Women s Cardiac Center at The Miriam Hospital, Providence, RI 02906, USA
    Gend Med 3:5-12. 2006
  78. ncbi request reprint Additional steps for cardiovascular health
    Paul D Thompson
    N Engl J Med 347:755-6. 2002
  79. ncbi request reprint ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women
    Priscilla M Clarkson
    Dept of Exercise Science, Univ of Massachusetts, Amherst, MA 01003, USA
    J Appl Physiol 99:154-63. 2005
    ..01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise...
  80. ncbi request reprint Recommendations and considerations related to preparticipation screening for cardiovascular abnormalities in competitive athletes: 2007 update: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabol
    Barry J Maron
    Minneapolis Heart Institute Foundation, USA
    Circulation 115:1643-455. 2007
  81. ncbi request reprint Dose-dependent effects of training and detraining on weight in 6406 runners during 7.4 years
    Paul T Williams
    Life Sciences Division, Lawrence Berkeley Laboratory, Donner Laboratory, Berkeley, CA 94720, USA
    Obesity (Silver Spring) 14:1975-84. 2006
    ..The objectives of this study were to determine whether exercise reduces body weight and to examine the dose-response relationships between changes in exercise and changes in total and regional adiposity...
  82. ncbi request reprint The acute effect of aerobic exercise on brachial artery endothelial function in renal transplant recipients
    Ludmila M Cosio-Lima
    Division of Health, Leisure and Exercise Science, University of West Florida, Pensacola, FL 32514 5750, USA
    Prev Cardiol 9:211-4. 2006
    ..The KT recipients had several coronary artery disease risk factors that may have adversely affected endothelial function...
  83. ncbi request reprint Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women
    Emidio E Pistilli
    Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 26506 9227, USA
    Obesity (Silver Spring) 15:392-402. 2007
    ..The objective of this study was to examine the effects of single nucleotide polymorphisms (SNPs) in the human RST gene on muscle, bone, and adipose tissue phenotypes and in response to resistance training (RT)...
  84. ncbi request reprint Statin myopathy: incidence, risk factors, and pathophysiology
    Kimberly A Sewright
    Department of Kinesiology, University of Massachusetts, Totman Building, 30 Eastman Lane, Amherst, MA 01002, USA
    Curr Atheroscler Rep 9:389-96. 2007
    ....
  85. ncbi request reprint Serum creatine kinase levels and renal function measures in exertional muscle damage
    Priscilla M Clarkson
    Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
    Med Sci Sports Exerc 38:623-7. 2006
    ..This study determined the magnitude of CK elevation and the effect on renal function produced by exercise in a large subject group...
  86. pmc Interleukin-15 and interleukin-15R alpha SNPs and associations with muscle, bone, and predictors of the metabolic syndrome
    Emidio E Pistilli
    Department of Physiology and Pennsylvania Muscle Institute, University of Pennsylvania, 3700 Hamilton Walk, A601 Richards Building, Philadelphia, PA 19140, USA
    Cytokine 43:45-53. 2008
    ..04), and baseline muscle quality (p=0.04). All associations were consistent in showing a potential involvement of the IL-15 pathway with muscle and bone phenotypes and predictors of metabolic syndrome...
  87. ncbi request reprint The genetics of left ventricular remodeling in competitive athletes
    Antonio Pelliccia
    National Institute of Sports Medicine, CONI, Rome, Italy
    J Cardiovasc Med (Hagerstown) 7:267-70. 2006
    ....
  88. ncbi request reprint Use of a treatment algorithm to achieve NCEP ATP III goals with atorvastatin
    James M McKenney
    National Clinical Research Inc, 2809 Emerywood Parkway, Ste 140, Richmond, VA 23294, USA
    J Cardiovasc Pharmacol 46:594-9. 2005
    ..Selecting the starting dose of atorvastatin using a treatment algorithm achieves NCEP ATP III LDL-cholesterol goals in the majority of patients and minimizes the need for dose titration...
  89. ncbi request reprint Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins
    Maria L Urso
    Department of Exercise Science, University of Massachusetts, Amherst, MA 01003, USA
    Arterioscler Thromb Vasc Biol 25:2560-6. 2005
    ..Statins are safe medications but have side effects including myalgia and rhabdomyolysis. How statins provoke muscle damage is not known, but this effect is exacerbated by exercise...
  90. pmc Apolipoprotein E genotype and sex influence C-reactive protein levels regardless of exercise training status
    Theodore J Angelopoulos
    Center for Lifestyle Medicine and Department of Health Professions, University of Central Florida, Orlando, FL 32826, USA
    Metabolism 57:1204-10. 2008
    ..How apo E genotype affects CRP is not known...
  91. doi request reprint Effectiveness and tolerability of every-other-day rosuvastatin dosing in patients with prior statin intolerance
    James M Backes
    Department of Pharmacy Practice, Schools of Pharmacy and Medicine, University of KansasKansas City, KS 66160, USA
    Ann Pharmacother 42:341-6. 2008
    ..Dosing a statin (rosuvastatin) every other day (EOD) may provide significant lipoprotein changes while avoiding common adverse effects in this statin-intolerant population...
  92. ncbi request reprint Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University, USA
    Circulation 116:1081-93. 2007
    ..i (a)]..
  93. ncbi request reprint The influence of short and long duration on the blood pressure response to an acute bout of dynamic exercise
    Margaux A Guidry
    University of CT, Storrs, CT 06269 2101, USA
    Am Heart J 151:1322.e5-12. 2006
    ..The minimum duration of exercise needed to acutely lower blood pressure (BP) has not been established. The purpose of this study is to compare the effects of short and long duration on the BP response to a session of aerobic exercise...
  94. ncbi request reprint Physical activity and public health: updated recommendation for adults from the American College of Sports Medicine and the American Heart Association
    William L Haskell
    Stanford University School of Medicine, Stanford, CA 94305 5705, USA
    Med Sci Sports Exerc 39:1423-34. 2007
    ..i (a)]...
  95. ncbi request reprint The Athlete's Heart 2007: diseases of the coronary circulation
    Aaron L Baggish
    Department of Cardiology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA
    Cardiol Clin 25:431-40, vi. 2007
    ..This article discusses diseases of the coronary circulation relevant to athletes...
  96. ncbi request reprint Variability in muscle size and strength gain after unilateral resistance training
    Monica J Hubal
    Department of Exercise Science, Totman Building, University of Massachusetts, Amherst, MA 01003, USA
    Med Sci Sports Exerc 37:964-72. 2005
    ..A secondary purpose was to assess sex differences in size and strength changes after training...

Research Grants4

  1. The Effect of Statins on Skeletal Muscle Function
    Paul Thompson; Fiscal Year: 2007
    ....
  2. The Effect of Statins on Skeletal Muscle Function
    Paul Thompson; Fiscal Year: 2009
    ....
  3. The Effect of Statins on Skeletal Muscle Function
    PAUL DAVIS THOMPSON; Fiscal Year: 2010
    ....