Richard L Seip

Summary

Affiliation: Hartford Hospital
Country: USA

Publications

  1. ncbi request reprint Apolipoprotein E genotype and changes in serum lipids and maximal oxygen uptake with exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT, USA
    Metabolism 53:193-202. 2004
  2. ncbi request reprint The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise
    Richard L Seip
    Cardiology Division, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    Atherosclerosis 188:126-33. 2006
  3. pmc Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial
    Kevin D Ballard
    Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT 06269, USA
    Nutr J 8:34. 2009
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
  5. pmc INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 9:117. 2008
  6. pmc Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
    Richard L Seip
    Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
    Nutr Metab (Lond) 5:4. 2008
  7. pmc Interactive effects of APOE haplotype, sex, and exercise on postheparin plasma lipase activities
    Richard L Seip
    Preventive Cardiology JB704, Hartford Hospital, Hartford, CT 06102 5037, USA
    J Appl Physiol 110:1021-8. 2011
  8. pmc Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Pharmacogenomics 11:959-71. 2010
  9. ncbi request reprint Angiotensin-converting enzyme genotype and adherence to aerobic exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT 06102, USA
    Prev Cardiol 9:21-4. 2006
  10. pmc Mechanisms of statin-induced myalgia assessed by physiogenomic associations
    GUALBERTO RUANO
    Genetics Research Center, Hartford Hospital, Hartford, CT, USA
    Atherosclerosis 218:451-6. 2011

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Apolipoprotein E genotype and changes in serum lipids and maximal oxygen uptake with exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT, USA
    Metabolism 53:193-202. 2004
    ..Surprisingly, Apo E genotype also affected the increase in aerobic capacity produced by exercise training possibly via undefined effects on nerve and skeletal muscle function...
  2. ncbi request reprint The effect of apolipoprotein E genotype on serum lipoprotein particle response to exercise
    Richard L Seip
    Cardiology Division, Hartford Hospital, 80 Seymour Street, Hartford, CT 06102 5037, USA
    Atherosclerosis 188:126-33. 2006
    ..In conclusion, APOE variants influence the serum LDL subpopulation response to exercise training in normolipidemic subjects. Subjects homozygous for APOE3 experienced the most beneficial lipid effects from exercise training...
  3. pmc Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial
    Kevin D Ballard
    Department of Kinesiology, University of Connecticut, 2095 Hillside Road, Unit 1110, Storrs, CT 06269, USA
    Nutr J 8:34. 2009
    ..Based on findings from in vitro experiments indicating a novel whey derived peptide (NOP-47) increased endothelial nitric oxide synthesis, we tested its effects on vascular function in humans...
  4. pmc PPARalpha L162V underlies variation in serum triglycerides and subcutaneous fat volume in young males
    Julieta Uthurralt
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 8:55. 2007
    ..We hypothesized that the study of younger populations would mitigate many confounding variables, and allow us to better define genetic predisposition loci for metabolic syndrome...
  5. pmc INSIG2 gene polymorphism is associated with increased subcutaneous fat in women and poor response to resistance training in men
    Funda E Orkunoglu-Suer
    Research Center for Genetic Medicine, Children s National Medical Center, Washington, DC 20010, USA
    BMC Med Genet 9:117. 2008
    ....
  6. pmc Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fat
    Richard L Seip
    Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
    Nutr Metab (Lond) 5:4. 2008
    ..We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets...
  7. pmc Interactive effects of APOE haplotype, sex, and exercise on postheparin plasma lipase activities
    Richard L Seip
    Preventive Cardiology JB704, Hartford Hospital, Hartford, CT 06102 5037, USA
    J Appl Physiol 110:1021-8. 2011
    ....
  8. pmc Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Pharmacogenomics 11:959-71. 2010
    ..We hypothesized novel genetic underpinnings for variation in LDLC levels in the context of statin therapy...
  9. ncbi request reprint Angiotensin-converting enzyme genotype and adherence to aerobic exercise training
    Paul D Thompson
    Hartford Hospital, Hartford, CT 06102, USA
    Prev Cardiol 9:21-4. 2006
    ..These preliminary results suggest that ACE genotype affects exercise adherence and raises the possibility that superior endurance capacity in subjects with the I allele is related to a genetic propensity to adhere to an exercise regimen...
  10. pmc Mechanisms of statin-induced myalgia assessed by physiogenomic associations
    GUALBERTO RUANO
    Genetics Research Center, Hartford Hospital, Hartford, CT, USA
    Atherosclerosis 218:451-6. 2011
    ..We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia...
  11. ncbi request reprint Physiogenomic association of statin-related myalgia to serotonin receptors
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
    Muscle Nerve 36:329-35. 2007
    ..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...
  12. ncbi request reprint Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise training
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Atherosclerosis 185:65-9. 2006
    ..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training...
  13. ncbi request reprint CYP2C19 genotype-guided antiplatelet therapy in a patient with clopidogrel resistance
    Mridula Rai
    Hartford Hospital, Hartford, USA
    Conn Med 76:267-72. 2012
    ..A medication switch to prasugrel,which does not rely on activation by the 2C19 enzyme, reduced platelet reactivity by 86%. The patient has suffered no cardiovascular events in the 18 months since initiation of prasugrel therapy...
  14. doi request reprint Validation of candidate genes associated with cardiovascular risk factors in psychiatric patients
    Andreas Windemuth
    Genomas, Inc and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA
    Prog Neuropsychopharmacol Biol Psychiatry 36:213-9. 2012
    ..We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population...
  15. pmc CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studies
    David Villagra
    Laboratory of Personalized Health, Genomas, Inc, Hartford, CT 06106, USA
    Clin Chim Acta 411:1306-11. 2010
    ..Accordingly, this study is aimed at investigating whether a correlation between overall genetic similarity and CYP2C9 and/or VKORC1 genotypes could be established...
  16. doi request reprint Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazone
    GUALBERTO RUANO
    Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
    Clin Chim Acta 400:48-55. 2009
    ..The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema...
  17. doi request reprint Length of psychiatric hospitalization is correlated with CYP2D6 functional status in inpatients with major depressive disorder
    GUALBERTO RUANO
    Genetics Research Center, Hartford Hospital, 67 Jefferson Street, Hartford, CT 06106, USA
    Biomark Med 7:429-39. 2013
    ..This study aimed to determine the effect of the CYP2D6 genotype on the length of hospitalization stay for patients treated for major depressive disorder...
  18. ncbi request reprint Allometric scaling of biceps strength before and after resistance training in men
    Robert F Zoeller
    Department of Exercise Science and Health Promotion, Florida Atlantic University, Davie, FL 33314, and Division of Cardiology, Hartford Hospital, Hartford, CT, USA
    Med Sci Sports Exerc 39:1013-9. 2007
    ....
  19. doi request reprint Correlates of endothelial function and the peak systolic blood pressure response to a graded maximal exercise test
    Kayla M Olson
    Mount Sinai Rehabilitation Hospital, Hartford, CT 06112, USA
    Atherosclerosis 222:202-7. 2012
    ..We examined relationships among the GEST peak SBP response and indicators of endothelial function...
  20. pmc Implementing genotype-guided antithrombotic therapy
    Richard L Seip
    Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
    Future Cardiol 6:409-24. 2010
    ..The US FDA-mandated drug labeling recognizes the relevance of genotyping in the selection and dosing of both warfarin and clopidogrel...
  21. doi request reprint Effectiveness of thrice weekly ezetimibe
    Carmelo V Venero
    Hartford Hospital, Hartford, Connecticut, USA
    Am J Cardiol 102:1205-6. 2008
    ..In conclusion, thrice-weekly ezetimibe decreases total and low-density lipoprotein cholesterol and is well tolerated. It is a viable treatment for patients intolerant of other lipid-lowering medications...
  22. ncbi request reprint Decreasing LDL cholesterol and medication cost with every-other-day statin therapy
    Monika A Juszczyk
    Preventive Cardiology, Henry Low Heart Center, Division of Cardiology, Hartford Hospital, 86 Seymour Street, Hartford, CT 06102, USA
    Prev Cardiol 8:197-9. 2005
    ..o.d. (n=16; p<0.05 for all). We conclude that q.o.d. treatment with long-acting statins significantly improves serum lipid levels...
  23. ncbi request reprint Value of peripheral vascular endothelial function in the detection of relative myocardial ischemia in asymptomatic type 2 diabetic patients who underwent myocardial perfusion imaging
    Georgios I Papaioannou
    Henry Low Heart Center, Cardiology Division, Hartford Hospital, CT 06102, USA
    J Nucl Cardiol 13:362-8. 2006
    ..Myocardial perfusion imaging (MPI) is an effective method of detection of coronary artery disease (CAD); however, the relationship between endothelial function and MPI in asymptomatic patients with T2DM has not been examined...
  24. pmc Apolipoprotein E genotype and sex influence C-reactive protein levels regardless of exercise training status
    Theodore J Angelopoulos
    Center for Lifestyle Medicine and Department of Health Professions, University of Central Florida, Orlando, FL 32826, USA
    Metabolism 57:1204-10. 2008
    ..How apo E genotype affects CRP is not known...
  25. ncbi request reprint ACTN3 genotype is associated with increases in muscle strength in response to resistance training in women
    Priscilla M Clarkson
    Dept of Exercise Science, Univ of Massachusetts, Amherst, MA 01003, USA
    J Appl Physiol 99:154-63. 2005
    ..01), suggesting that ACTN3 is one of many genes contributing to genetic variation in muscle performance and adaptation to exercise...
  26. ncbi request reprint ACE ID genotype and the muscle strength and size response to unilateral resistance training
    Linda S Pescatello
    School of Allied Health, University of Connecticut, Storrs, CT 06269 2101, USA
    Med Sci Sports Exerc 38:1074-81. 2006
    ..wk) unilateral, upper-arm resistance training (RT) program in the trained (T, nondominant) and untrained (UT, dominant) arms...
  27. doi request reprint Effects of exercise at different times on postprandial lipemia and endothelial function
    Ricardo Silvestre
    Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT 06269, USA
    Med Sci Sports Exerc 40:264-74. 2008
    ..The purpose of this study was to examine the effects of previous exercise on metabolic, hormonal, and endothelial responses to an oral fat-tolerance test (OFTT)...
  28. ncbi request reprint The influence of short and long duration on the blood pressure response to an acute bout of dynamic exercise
    Margaux A Guidry
    University of CT, Storrs, CT 06269 2101, USA
    Am Heart J 151:1322.e5-12. 2006
    ..The minimum duration of exercise needed to acutely lower blood pressure (BP) has not been established. The purpose of this study is to compare the effects of short and long duration on the BP response to a session of aerobic exercise...
  29. ncbi request reprint Do age and baseline LDL cholesterol levels determine the effect of regular exercise on plasma lipoprotein cholesterol and apolipoprotein B levels?
    Theodore J Angelopoulos
    Center for Lifestyle Medicine, Department of Health Professions, College of Health and Public Affairs, University of Central Florida, Orlando, FL 32816 2205, USA
    Eur J Appl Physiol 101:621-8. 2007
    ..Age does not affect apoB or lipoproteins in response to exercise. Individuals with high baseline LDLc experienced acute reduction in TC and LDLc produced by each exercise session...
  30. ncbi request reprint Resistin polymorphisms are associated with muscle, bone, and fat phenotypes in white men and women
    Emidio E Pistilli
    Division of Exercise Physiology, School of Medicine, West Virginia University, Morgantown, WV 26506 9227, USA
    Obesity (Silver Spring) 15:392-402. 2007
    ..The objective of this study was to examine the effects of single nucleotide polymorphisms (SNPs) in the human RST gene on muscle, bone, and adipose tissue phenotypes and in response to resistance training (RT)...