Research Topics
Genomes and GenesSpecies | GUALBERTO RUANOSummaryAffiliation: Hartford Hospital Country: USA Publications
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Detail Information
Publications
Mechanisms of statin-induced myalgia assessed by physiogenomic associationsGUALBERTO RUANO
Genetics Research Center, Hartford Hospital, Hartford, CT, USA
Atherosclerosis 218:451-6. 2011..We investigated genetic variants predictive of muscular side effects in patients treated with statins. We utilized a physiogenomic approach to prototype a multi-gene panel correlated with statin-induced myalgia...- Physiogenomic analysis of CYP450 drug metabolism correlates dyslipidemia with pharmacogenetic functional status in psychiatric patientsGUALBERTO RUANO
Genomas Inc, Hartford, CT 06106, USA
Biomark Med 5:439-49. 2011.... - Physiogenomic analysis of statin-treated patients: domain-specific counter effects within the ACACB gene on low-density lipoprotein cholesterol?GUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Pharmacogenomics 11:959-71. 2010..We hypothesized novel genetic underpinnings for variation in LDLC levels in the context of statin therapy... 
Validation of candidate genes associated with cardiovascular risk factors in psychiatric patientsAndreas Windemuth
Genomas, Inc and Genetics Research Center, Hartford Hospital, Hartford, CT 06106, USA
Prog Neuropsychopharmacol Biol Psychiatry 36:213-9. 2012..We confirmed 8 of the 13 candidate genes at the 95% confidence level. An increased genetic effect size was observed for triglycerides in the psychiatric population compared to that in the cardiovascular population...- CYP2C9 and VKORC1 genotypes in Puerto Ricans: A case for admixture-matching in clinical pharmacogenetic studiesDavid Villagra
Laboratory of Personalized Health, Genomas, Inc, Hartford, CT 06106, USA
Clin Chim Acta 411:1306-11. 2010..Accordingly, this study is aimed at investigating whether a correlation between overall genetic similarity and CYP2C9 and/or VKORC1 genotypes could be established... - Physiogenomic comparison of edema and BMI in patients receiving rosiglitazone or pioglitazoneGUALBERTO RUANO
Genomas, Inc, 67 Jefferson St, Hartford, CT, United States
Clin Chim Acta 400:48-55. 2009..The balance of efficacy and safety of TZD varies widely from patient to patient. Genetic variability may reveal pathophysiological pathways underlying weight gain associated with TZD therapy and due to adiposity and/or edema... - Novel drug metabolism indices for pharmacogenetic functional status based on combinatory genotyping of CYP2C9, CYP2C19 and CYP2D6 genesDavid Villagra
Genomas Inc, Hartford, CT, USA
Biomark Med 5:427-38. 2011..Each index considers all three genes as complementary components of a liver enzyme drug metabolism system and uniquely benchmarks innate hepatic drug metabolism reserve or alteration through CYP450 combinatory genotype scores... 
Physiogenomic association of statin-related myalgia to serotonin receptorsGUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, Connecticut 06102, USA
Muscle Nerve 36:329-35. 2007..Individual differences in pain perception and nociception related to specific serotonergic gene variants may affect the development of myalgia in statin-treated patients...- Implementing genotype-guided antithrombotic therapyRichard L Seip
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Future Cardiol 6:409-24. 2010..The US FDA-mandated drug labeling recognizes the relevance of genotyping in the selection and dosing of both warfarin and clopidogrel... - CYP2C19 genotype-guided antiplatelet therapy in a patient with clopidogrel resistanceMridula Rai
Hartford Hospital, Hartford, USA
Conn Med 76:267-72. 2012..A medication switch to prasugrel,which does not rely on activation by the 2C19 enzyme, reduced platelet reactivity by 86%. The patient has suffered no cardiovascular events in the 18 months since initiation of prasugrel therapy... - Physiogenomic analysis of the Puerto Rican populationGUALBERTO RUANO
Genomas Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Pharmacogenomics 10:565-77. 2009..This research was aimed at determining the frequencies of SNPs in key physiological, pharmacological and biochemical genes to infer population structure and ancestry in the Puerto Rican population... - Genetic associations of brain structural networks in schizophrenia: a preliminary studyKanchana Jagannathan
Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut 06106, USA
Biol Psychiatry 68:657-66. 2010..We used structural parameters as potential intermediate illness markers to investigate genomic factors derived from single nucleotide polymorphism (SNP) arrays... - Integrating genomic based information into clinical warfarin (Coumadin) management: an illustrative case reportAnthony LaSala
Hartford Hospital, USA
Conn Med 72:399-403. 2008..This illustrative case report demonstrates the clinical importance of this new information. Clinicians need to incorporate these new genomic findings into appropriate management of warfarin dose anticoagulation... - Physiogenomic analysis of localized FMRI brain activity in schizophreniaAndreas Windemuth
Genomas, Inc, Hartford, CT, 06106, USA
Ann Biomed Eng 36:877-88. 2008..The results of this study support the physiogenomic analysis of neuroimaging data to discover associations between genotype and disease-related phenotypes... - Physiogenomic analysis links serum creatine kinase activities during statin therapy to vascular smooth muscle homeostasisGUALBERTO RUANO
Genomas, Inc, 67 Jefferson St, Hartford, CT 06106, USA
Pharmacogenomics 6:865-72. 2005.... - Somatic complications of psychotropic medications in a patient with multiple CYP2 drug metabolism deficienciesGUALBERTO RUANO
Genomas Inc, Hartford, USA
Conn Med 71:197-200. 2007..DNA typing for multigene CYP2 deficiencies is diagnostically useful in individuals with histories of multiple ADRs, which could be avoided by DNA-guided individualized prescription... - Physiogenomic comparison of human fat loss in response to diets restrictive of carbohydrate or fatRichard L Seip
Genomas, Inc, 67 Jefferson St, Hartford, Connecticut, USA
Nutr Metab (Lond) 5:4. 2008..We used physiogenomics to explore associations among polymorphisms in candidate genes and changes in relative body fat (Delta%BF) to low fat and low carbohydrate diets... - Apolipoprotein A1 genotype affects the change in high density lipoprotein cholesterol subfractions with exercise trainingGUALBERTO RUANO
Genomas, Inc, 67 Jefferson Street, Hartford, CT 06106, USA
Atherosclerosis 185:65-9. 2006..3+/-6.6 mg/dL versus 4.7+/-1.2 mg/dL, p<0.005). These results show that genetic variation at the APOA1 gene promoter is associated with HDL subfraction redistribution resulting from exercise training... - Pharmacogenomic data submissions to the FDA: clinical pharmacology case studiesGUALBERTO RUANO
Genomas LLC, New Haven, CT, USA
Pharmacogenomics 5:513-7. 2004