Shashwath A Meda

Summary

Affiliation: Hartford Hospital
Country: USA

Publications

  1. pmc A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
    Schizophr Res 101:95-105. 2008
  2. pmc Alcohol dose effects on brain circuits during simulated driving: an fMRI study
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Hum Brain Mapp 30:1257-70. 2009
  3. pmc An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Res 104:85-95. 2008
  4. pmc Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut 06106, USA
    Behav Pharmacol 20:390-9. 2009
  5. pmc Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America
    PLoS ONE 4:e7911. 2009
  6. doi request reprint A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Neuroimage 53:1007-15. 2010
  7. pmc Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study
    Sabin Khadka
    Olin Neuropsychiatry Research Center, Hartford Hospital Institute of Living, Hartford, CT 06106, USA
    Biol Psychiatry 74:458-66. 2013
  8. pmc Functional imaging of cognitive control during acute alcohol intoxication
    Beth M Anderson
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Alcohol Clin Exp Res 35:156-65. 2011
  9. pmc Robust changes in reward circuitry during reward loss in current and former cocaine users during performance of a monetary incentive delay task
    Krishna T Patel
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut Electronic address
    Biol Psychiatry 74:529-37. 2013
  10. doi request reprint Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study
    Sharna Jamadar
    Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Ave, Hartford, CT 06106, USA
    Brain Imaging Behav 7:15-27. 2013

Collaborators

Detail Information

Publications20

  1. pmc A large scale (N=400) investigation of gray matter differences in schizophrenia using optimized voxel-based morphometry
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, CT 06106, USA
    Schizophr Res 101:95-105. 2008
    ..However, results from these studies vary widely, likely due to different methodological or statistical approaches...
  2. pmc Alcohol dose effects on brain circuits during simulated driving: an fMRI study
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Hum Brain Mapp 30:1257-70. 2009
    ..Overall, results suggest that alcohol (especially at high doses) causes significant impairment of both driving behavior and brain functionality related to motor planning and control, goal directedness, error monitoring, and memory...
  3. pmc An fMRI study of working memory in first-degree unaffected relatives of schizophrenia patients
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, CT 06106, USA
    Schizophr Res 104:85-95. 2008
    ..Additionally, fMRI differences in both conditions were modulated by load, with a parametric increase in between-group differences with load in several key regions during encoding and an opposite effect during response selection...
  4. pmc Investigating the behavioral and self-report constructs of impulsivity domains using principal component analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut 06106, USA
    Behav Pharmacol 20:390-9. 2009
    ..In addition, our supplemental analysis also suggested that the impulsivity constructs were largely, but not entirely the same within the healthy and ARA groups...
  5. pmc Evidence for anomalous network connectivity during working memory encoding in schizophrenia: an ICA based analysis
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America
    PLoS ONE 4:e7911. 2009
    ..Numerous neuroimaging studies report abnormal regional brain activity during working memory performance in schizophrenia, but few have examined brain network integration as determined by "functional connectivity" analyses...
  6. doi request reprint A pilot multivariate parallel ICA study to investigate differential linkage between neural networks and genetic profiles in schizophrenia
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Avenue, Hartford, CT 06106, USA
    Neuroimage 53:1007-15. 2010
    ....
  7. pmc Is aberrant functional connectivity a psychosis endophenotype? A resting state functional magnetic resonance imaging study
    Sabin Khadka
    Olin Neuropsychiatry Research Center, Hartford Hospital Institute of Living, Hartford, CT 06106, USA
    Biol Psychiatry 74:458-66. 2013
    ..Schizophrenia and bipolar disorder share overlapping symptoms and risk genes. Shared aberrant functional connectivity is hypothesized in both disorders and in relatives...
  8. pmc Functional imaging of cognitive control during acute alcohol intoxication
    Beth M Anderson
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Connecticut, USA
    Alcohol Clin Exp Res 35:156-65. 2011
    ..The effects of different doses of alcohol on activity within these brain regions during a functional magnetic resonance imaging (fMRI) task where errors are frequently committed have not been fully explored...
  9. pmc Robust changes in reward circuitry during reward loss in current and former cocaine users during performance of a monetary incentive delay task
    Krishna T Patel
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut Electronic address
    Biol Psychiatry 74:529-37. 2013
    ..Abnormal function in reward circuitry in cocaine addiction could predate drug use as a risk factor, follow drug use as a consequence of substance-induced alterations, or both...
  10. doi request reprint Genetic influences of resting state fMRI activity in language-related brain regions in healthy controls and schizophrenia patients: a pilot study
    Sharna Jamadar
    Olin Neuropsychiatry Research Center, Institute of Living, 200 Retreat Ave, Hartford, CT 06106, USA
    Brain Imaging Behav 7:15-27. 2013
    ..Thus these RD-genes may exert a more important influence on structure rather than function of language-related networks in schizophrenia...
  11. pmc Effects of alcohol on performance on a distraction task during simulated driving
    Allyssa J Allen
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, 200 Retreat Avenue, Hartford, Connecticut 06106, USA
    Alcohol Clin Exp Res 33:617-25. 2009
    ..Previous functional MRI (fMRI) studies of the VO task have shown activation in the anterior cingulate, hippocampus, and prefrontal cortex. Thus, we predicted dose-dependent decreases in activation of these areas during VO performance...
  12. pmc Individuals family history positive for alcoholism show functional magnetic resonance imaging differences in reward sensitivity that are related to impulsivity factors
    Melissa M Andrews
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, USA
    Biol Psychiatry 69:675-83. 2011
    ..However, there is limited information on whether this uncharacteristic behavior represents a biological predisposition toward alcohol abuse, a consequence of chronic alcohol use, or both...
  13. pmc Diffusion tensor imaging in schizophrenia: relationship to symptoms
    Laurie R Skelly
    Olin Neuropsychiatry Research Center, Institute of Living, Hartford, CT 06106, USA
    Schizophr Res 98:157-62. 2008
    ....
  14. pmc Disruptions in functional network connectivity during alcohol intoxicated driving
    Catherine I Rzepecki-Smith
    Olin Neuropsychiatry Research Center, Institute of Living Hartford Hospital, Hartford, Connecticut, USA
    Alcohol Clin Exp Res 34:479-87. 2010
    ..However, the functional connectivity between these circuits has not yet been explored in order to determine how these networks communicate with each other during sober and alcohol-intoxicated states...
  15. pmc A large scale multivariate parallel ICA method reveals novel imaging-genetic relationships for Alzheimer's disease in the ADNI cohort
    Shashwath A Meda
    Olin Neuropsychiatric Research Center, Hartford Hospital IOL, Hartford, CT 06106, USA
    Neuroimage 60:1608-21. 2012
    ..Further, the study exemplifies the value of this novel approach to explore large-scale data sets involving high-dimensional gene and endophenotype data...
  16. doi request reprint Differences in resting-state functional magnetic resonance imaging functional network connectivity between schizophrenia and psychotic bipolar probands and their unaffected first-degree relatives
    Shashwath A Meda
    Olin Neuropsychiatry Research Center, Hartford Hospital Institute of Living, Hartford, Connecticut 06106, USA
    Biol Psychiatry 71:881-9. 2012
    ..Schizophrenia and bipolar disorder share overlapping symptoms and genetic etiology. Functional brain dysconnectivity is seen in both disorders...
  17. doi request reprint Error processing in current and former cocaine users
    Brian C Castelluccio
    Olin Neuropsychiatric Research Center, Institute of Living, Hartford Hospital, 200 Retreat Avenue, Whitehall Building, Hartford, CT, 06106, USA
    Brain Imaging Behav 8:87-96. 2014
    ..Overall, our results support a hypothesis that neural activity in former users differs more from healthy controls than that of current users due to cognitive compensation that facilitates abstinence. ..
  18. pmc Influence of alcohol use on neural response to Go/No-Go task in college drinkers
    Aral Ahmadi
    Olin Neuropsychiatry Research Center, Hartford Hospital Institute of Living, Hartford, CT, USA
    Neuropsychopharmacology 38:2197-208. 2013
    ..The extent to which these tendencies relate to impulsive decision-making and behaviors in real-life settings and may guide intervention development warrants additional investigation. ..
  19. doi request reprint Relationships between reward sensitivity, risk-taking and family history of alcoholism during an interactive competitive fMRI task
    Haley L Yarosh
    Olin Neuropsychiatry Research Center, Institute of Living at Hartford Hospital, Hartford, Connecticut, United States of America Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, United States of America
    PLoS ONE 9:e88188. 2014
    ..Here we describe impulsivity measures in FHN and FHP individuals as they relate to a socially interactive functional magnetic resonance imaging (fMRI) task...
  20. ncbi request reprint Global white matter analysis of diffusion tensor images is predictive of injury severity in traumatic brain injury
    Randall R Benson
    Department of Neurology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA
    J Neurotrauma 24:446-59. 2007
    ..FA is globally deceased in WM, including mild TBI, possibly reflecting widespread involvement. FA changes appear to be correlated with injury severity suggesting a role in early diagnosis and prognosis of TBI...