C Hart

Summary

Country: USA

Publications

  1. pmc The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation
    David E Green
    Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 47:718-26. 2012
  2. pmc Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells
    Clintoria R Williams
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Georgia, USA
    Am J Physiol Cell Physiol 303:C213-23. 2012
  3. pmc The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
    Bum Yong Kang
    Department of Medicine, Atlanta Veterans Affairs Medical Centers, GA 30033, USA
    Am J Physiol Lung Cell Mol Physiol 301:L881-91. 2011
  4. doi request reprint PPARgamma: a novel molecular target in lung disease
    C Michael Hart
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University Medical Centers, Atlanta, GA, USA
    J Investig Med 56:515-7. 2008
  5. doi request reprint The Role of PPARgamma in pulmonary vascular disease
    C Michael Hart
    Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA
    J Investig Med 56:518-21. 2008
  6. doi request reprint PPARgamma as a potential therapeutic target in pulmonary hypertension
    Roy L Sutliff
    Division of Pulmonary, Allergy and Critical Care Medicine, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Ther Adv Respir Dis 4:143-60. 2010
  7. pmc Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia 30033, USA
    Am J Respir Cell Mol Biol 42:482-90. 2010
  8. pmc The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Center, Atlanta, Georgia, USA
    Am J Respir Cell Mol Biol 40:601-9. 2009
  9. ncbi request reprint The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice
    Fernando Holguin
    Emory University and the Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30308, USA
    Lung 185:367-72. 2007
  10. pmc Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production
    Jennifer M Kleinhenz
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 297:H1647-54. 2009

Collaborators

  • Roy Sutliff
  • Raju Reddy
  • PATRICIA JANET SIME
  • Jesse Roman
  • Dean J Kleinhenz
  • Bum Yong Kang
  • Jennifer M Kleinhenz
  • Rachel E Nisbet
  • Jinah Hwang
  • Tamara C Murphy
  • Xianghuai Lu
  • Heidi L Rupnow
  • David E Green
  • Clintoria R Williams
  • Carmelo Blanquicett
  • Jeffrey D Ritzenthaler
  • Patrick O Mitchell
  • Fernando Holguin
  • Rabih I Bechara
  • John A Polikandriotis
  • Patrick Page
  • Cedric Szyndralewiez
  • Erik R Walp
  • Mark S Nanes
  • Dean P Jones
  • Jennifer M Bland
  • Shaojin You
  • Anitra S Graves
  • David R Archer
  • Jason M Hansen
  • Alana L Reed
  • Tai Hwang M Fan
  • Adam G Campbell
  • Mauricio Rojas
  • Peter M Thule
  • Robert Raynor
  • Kathy K Griendling
  • Sergey Dikalov
  • Lou Ann S Brown
  • Louis J Mazzella
  • Andres Pelaez
  • David M Guidot
  • BERNARD LASSEGUE
  • Pratibha C Joshi
  • Andres Palacio

Detail Information

Publications16

  1. pmc The Nox4 inhibitor GKT137831 attenuates hypoxia-induced pulmonary vascular cell proliferation
    David E Green
    Department of Medicine, Emory University, Atlanta Veterans Affairs Medical Center, Decatur, GA 30033, USA
    Am J Respir Cell Mol Biol 47:718-26. 2012
    ..Targeting Nox4 with GKT137831 provides a novel strategy to attenuate hypoxia-induced alterations in pulmonary vascular wall cells that contribute to vascular remodeling and RVH, key features involved in PH pathogenesis...
  2. pmc Rosiglitazone attenuates NF-κB-mediated Nox4 upregulation in hyperglycemia-activated endothelial cells
    Clintoria R Williams
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Georgia, USA
    Am J Physiol Cell Physiol 303:C213-23. 2012
    ..This study provides novel insights into mechanisms by which the thiazolidinedione peroxisome proliferator-activated receptor-γ ligand RSG favorably modulates endothelial responses in the diabetic vasculature...
  3. pmc The PPARγ ligand rosiglitazone attenuates hypoxia-induced endothelin signaling in vitro and in vivo
    Bum Yong Kang
    Department of Medicine, Atlanta Veterans Affairs Medical Centers, GA 30033, USA
    Am J Physiol Lung Cell Mol Physiol 301:L881-91. 2011
    ..Targeting PPARγ represents a novel therapeutic strategy to inhibit enhanced ET-1 signaling in PH pathogenesis...
  4. doi request reprint PPARgamma: a novel molecular target in lung disease
    C Michael Hart
    Division of Pulmonary, Allergy and Critical Care Medicine, Emory University Medical Centers, Atlanta, GA, USA
    J Investig Med 56:515-7. 2008
    ..This brief introduction to the symposium will provide background information about PPARs to facilitate the general reader's appreciation of the more in-depth and disease-specific discussions that follow...
  5. doi request reprint The Role of PPARgamma in pulmonary vascular disease
    C Michael Hart
    Atlanta Veterans Affairs Medical Center, Atlanta, GA, USA
    J Investig Med 56:518-21. 2008
    ..This report reviews current evidence that PPARgamma may represent a novel therapeutic target in pulmonary hypertension and examines studies that have begun to elucidate mechanisms that underlie these potential therapeutic effects...
  6. doi request reprint PPARgamma as a potential therapeutic target in pulmonary hypertension
    Roy L Sutliff
    Division of Pulmonary, Allergy and Critical Care Medicine, Atlanta VA Medical Center, Decatur, GA 30033, USA
    Ther Adv Respir Dis 4:143-60. 2010
    ..Mediators of PH that are regulated by PPARgamma are reviewed to provide insights into potential mechanisms underlying therapeutic effects of PPARgamma ligands in PH...
  7. pmc Rosiglitazone attenuates chronic hypoxia-induced pulmonary hypertension in a mouse model
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia 30033, USA
    Am J Respir Cell Mol Biol 42:482-90. 2010
    ....
  8. pmc The role of NADPH oxidase in chronic intermittent hypoxia-induced pulmonary hypertension in mice
    Rachel E Nisbet
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Center, Atlanta, Georgia, USA
    Am J Respir Cell Mol Biol 40:601-9. 2009
    ..These findings demonstrate that NADPH oxidase-derived ROS contribute to the development of pulmonary vascular remodeling and hypertension caused by CIH...
  9. ncbi request reprint The peroxisome proliferator activated receptor gamma (PPARgamma) ligand rosiglitazone modulates bronchoalveolar lavage levels of leptin, adiponectin, and inflammatory cytokines in lean and obese mice
    Fernando Holguin
    Emory University and the Atlanta Veterans Affairs Medical Center, Atlanta, Georgia 30308, USA
    Lung 185:367-72. 2007
    ..These results demonstrate that obesity is associated with alterations in adipokine and cytokine levels in the airways that can be modulated by treatment with roziglitazone...
  10. pmc Disruption of endothelial peroxisome proliferator-activated receptor-gamma reduces vascular nitric oxide production
    Jennifer M Kleinhenz
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, Georgia, USA
    Am J Physiol Heart Circ Physiol 297:H1647-54. 2009
    ..These findings demonstrate that endothelial PPARgamma regulates vascular nitric oxide production and that the disruption of endothelial PPARgamma contributes to endothelial dysfunction in vivo...
  11. pmc Oxidative stress modulates PPAR gamma in vascular endothelial cells
    Carmelo Blanquicett
    Department of Medicine, Emory University, and Atlanta VA Medical Centers, Atlanta, GA 30033, USA
    Free Radic Biol Med 48:1618-25. 2010
    ....
  12. pmc PPAR{gamma} regulates hypoxia-induced Nox4 expression in human pulmonary artery smooth muscle cells through NF-{kappa}B
    Xianghuai Lu
    Department of Medicine, Atlanta Veterans Affairs, Emory University Medical Centers, Georgia, USA
    Am J Physiol Lung Cell Mol Physiol 299:L559-66. 2010
    ....
  13. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands stimulate endothelial nitric oxide production through distinct peroxisome proliferator-activated receptor gamma-dependent mechanisms
    John A Polikandriotis
    Department of Medicine, Atlanta Veterans Affairs and Emory University Medical Centers, Atlanta, GA, USA
    Arterioscler Thromb Vasc Biol 25:1810-6. 2005
    ..The current study was designed to characterize further the molecular mechanisms underlying PPARgamma-ligand-stimulated increases in endothelial cell NO production...
  14. ncbi request reprint The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice
    Jinah Hwang
    Division of Pulmonary and Critical Care Medicine, Veterans Affairs and Emory University Medical Centers, Decatur, GA 30033, USA
    Vascul Pharmacol 46:456-62. 2007
    ..production through mechanisms that do not appear to depend on correction of diabetic metabolic derangements...
  15. ncbi request reprint Angiotensin II mediates glutathione depletion, transforming growth factor-beta1 expression, and epithelial barrier dysfunction in the alcoholic rat lung
    Rabih I Bechara
    Atlanta Veterans Affairs Medical Center Pulmonary Section, Decatur, GA 30033, USA
    Am J Physiol Lung Cell Mol Physiol 289:L363-70. 2005
    ..Together, these results suggest that angiotensin II mediates oxidative stress and the consequent TGF-beta1 expression and alveolar epithelial barrier dysfunction that characterize the alcoholic lung...
  16. ncbi request reprint Peroxisome proliferator-activated receptor-gamma ligands regulate endothelial membrane superoxide production
    Jinah Hwang
    Division of Pulmonary and Critical Care Medicine, Pulmonary Section, Atlanta Veterans Affairs and Emory University Medical Centers 151 P 1670 Clairmont Road, Decatur, GA 30033, USA
    Am J Physiol Cell Physiol 288:C899-905. 2005
    ..metabolism through suppression of NADPH oxidase and induction of Cu/Zn-SOD. These findings further elucidate the molecular mechanisms by which PPAR-gamma ligands directly alter vascular endothelial function...

Research Grants10

  1. PPAR gamma and alveolar macrophage function during chronic alcohol ingestion
    C Hart; Fiscal Year: 2007
    ....
  2. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2010
    ....
  3. Fatty Acids Alter Endothelial Nitric Oxide Production
    C Hart; Fiscal Year: 2004
    ..These novel studies will clarify cellular and molecular mechanisms of endothelial dysfunction that contribute to diabetic macrovascular disease. ..
  4. PPAR gamma regulates vascular endothelial reactive species production in diabetes
    C Michael Hart; Fiscal Year: 2011
    ....