J C Harris

Summary

Country: USA

Publications

  1. doi request reprint Advances in understanding behavioral phenotypes in neurogenetic syndromes
    James C Harris
    Developmental Neuropsychiatry program at the Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Med Genet C Semin Med Genet 154:389-99. 2010
  2. ncbi request reprint Craniocerebral magnetic resonance imaging measurement and findings in Lesch-Nyhan syndrome
    J C Harris
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 55:547-53. 1998
  3. ncbi request reprint Social neuroscience, empathy, brain integration, and neurodevelopmental disorders
    James C Harris
    Psychiatry and Behavioral Sciences and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Physiol Behav 79:525-31. 2003
  4. ncbi request reprint The spectrum of inherited mutations causing HPRT deficiency: 75 new cases and a review of 196 previously reported cases
    H A Jinnah
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Mutat Res 463:309-26. 2000
  5. ncbi request reprint The spectrum of mutations causing HPRT deficiency: an update
    H A Jinnah
    Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Nucleosides Nucleotides Nucleic Acids 23:1153-60. 2004
  6. ncbi request reprint Neurocognitive functioning in Lesch-Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiency
    D J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 7:805-12. 2001
  7. pmc Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo
    D F Wong
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:5539-43. 1996
  8. ncbi request reprint Ocular motor dysfunction in Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Pediatr Neurol 24:200-4. 2001
  9. ncbi request reprint Behavioral aspects of Lesch-Nyhan disease and its variants
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Dev Med Child Neurol 47:673-7. 2005
  10. pmc Delineation of the motor disorder of Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    Brain 129:1201-17. 2006

Collaborators

Detail Information

Publications12

  1. doi request reprint Advances in understanding behavioral phenotypes in neurogenetic syndromes
    James C Harris
    Developmental Neuropsychiatry program at the Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Am J Med Genet C Semin Med Genet 154:389-99. 2010
    ..New treatments based on knowledge of underlying neurobiology call for more fine-grained definition of behavior...
  2. ncbi request reprint Craniocerebral magnetic resonance imaging measurement and findings in Lesch-Nyhan syndrome
    J C Harris
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Arch Neurol 55:547-53. 1998
    ..To provide the first comprehensive magnetic resonance imaging (MRI) assessment of brain in a series of patients with Lesch-Nyhan syndrome (LNS), with emphasis on basal ganglia measurements...
  3. ncbi request reprint Social neuroscience, empathy, brain integration, and neurodevelopmental disorders
    James C Harris
    Psychiatry and Behavioral Sciences and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA
    Physiol Behav 79:525-31. 2003
    ..MacLean's models laid the groundwork for studies focused on understanding brain functioning in these conditions...
  4. ncbi request reprint The spectrum of inherited mutations causing HPRT deficiency: 75 new cases and a review of 196 previously reported cases
    H A Jinnah
    Department of Neurology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA
    Mutat Res 463:309-26. 2000
    ....
  5. ncbi request reprint The spectrum of mutations causing HPRT deficiency: an update
    H A Jinnah
    Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland 21287, USA
    Nucleosides Nucleotides Nucleic Acids 23:1153-60. 2004
    ..The reasons for some apparent exceptions to this proposal are addressed...
  6. ncbi request reprint Neurocognitive functioning in Lesch-Nyhan disease and partial hypoxanthine-guanine phosphoribosyltransferase deficiency
    D J Schretlen
    Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    J Int Neuropsychol Soc 7:805-12. 2001
    ..The variants produced scores that were intermediate between those of patients with LND and normal participants on nearly every cognitive measure. We discuss these findings in terms of what is known about the neuropathology of LND...
  7. pmc Dopamine transporters are markedly reduced in Lesch-Nyhan disease in vivo
    D F Wong
    Department of Radiology, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA
    Proc Natl Acad Sci U S A 93:5539-43. 1996
    ..To our knowledge, these findings provide the first in vivo documentation of a dopaminergic reduction in LND and illustrate the role of positron emission tomography imaging in investigating neurodevelopmental disorders...
  8. ncbi request reprint Ocular motor dysfunction in Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, Johns Hopkins Hospital, Baltimore, MD 21287, USA
    Pediatr Neurol 24:200-4. 2001
    ..These disturbances of ocular motility are consistent with dysfunction of the basal ganglia or its connections with ocular motor centers in the prefrontal cortex or midbrain...
  9. ncbi request reprint Behavioral aspects of Lesch-Nyhan disease and its variants
    David J Schretlen
    Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21287 7218, USA
    Dev Med Child Neurol 47:673-7. 2005
    ..Although patients with LNV typically do not self-injure or display severe aggression, attention problems are common and a few patients demonstrate other behavioral anomalies...
  10. pmc Delineation of the motor disorder of Lesch-Nyhan disease
    H A Jinnah
    Department of Neurology, University of Maryland School of Medicine, Baltimore, MD, USA
    Brain 129:1201-17. 2006
    ..Explanations for the differing observations available in the literature are provided, along with a summary of how the motor disorder of LND relates to current understanding of its pathophysiology involving the basal ganglia...
  11. ncbi request reprint The motor disorder of classic Lesch-Nyhan disease
    Jasper E Visser
    Department Neurology, University Hospital St Radboud, Nijmegen, The Netherlands
    Nucleosides Nucleotides Nucleic Acids 23:1161-4. 2004
    ..Dystonia was the most frequent and severe movement disorder. At rest, hypotonia was more frequent than hypertonia. These findings are compatible with basal ganglia dysfunction in LND...
  12. ncbi request reprint Lesch-Nyhan disease in a female with a clinically normal monozygotic twin
    Laura De Gregorio
    University of California San Diego, La Jolla, CA 92093, USA
    Mol Genet Metab 85:70-7. 2005
    ..As in many other reported cases of X-linked diseases, the discordant phenotype of the two monozygous twin sisters suggests that the process responsible for monozygotic twinning can trigger skewed X inactivation...