G C Hard

Summary

Country: USA

Publications

  1. doi request reprint Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: a pathology working group review and re-evaluation
    Gordon C Hard
    Regul Toxicol Pharmacol 59:430-6. 2011
  2. pmc Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity
    Gordon C Hard
    Private Consultant, 203 Paku Drive, Tairua 3508, New Zealand
    Toxicol Sci 132:268-75. 2013
  3. doi request reprint Association of advanced chronic progressive nephropathy (CPN) with renal tubule tumors and precursor hyperplasia in control F344 rats from two-year carcinogenicity studies
    Gordon C Hard
    Toxicol Pathol 40:473-81. 2012
  4. ncbi request reprint Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN)
    Gordon C Hard
    National Toxicology Program Archives, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:641-9. 2005
  5. doi request reprint A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment
    Gordon C Hard
    203 Paku Drive, Tairua 3508, New Zealand
    Crit Rev Toxicol 39:332-46. 2009
  6. doi request reprint Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy
    G C Hard
    Vet Pathol 46:1248-57. 2009
  7. ncbi request reprint A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment
    Gordon C Hard
    Pfizer R and D, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 32:171-80. 2004
  8. ncbi request reprint Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk
    Gordon C Hard
    American Health Foundation, One Dana Road, Valhalla, New York 10595, USA
    Toxicol Sci 69:30-41. 2002
  9. ncbi request reprint A search for an animal model of the Spanish toxic oil syndrome
    G C Hard
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Food Chem Toxicol 40:1551-67. 2002
  10. ncbi request reprint Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor
    G C Hard
    American Health Foundation, Valhalla, New York 10595, USA
    Toxicol Pathol 29:379-86. 2001

Collaborators

Detail Information

Publications24

  1. doi request reprint Renal histopathology in toxicity and carcinogenicity studies with tert-butyl alcohol administered in drinking water to F344 rats: a pathology working group review and re-evaluation
    Gordon C Hard
    Regul Toxicol Pharmacol 59:430-6. 2011
    ..The PWG concluded that both α(2u)-g nephropathy and exacerbated CPN modes of action were operative in TBA renal tumorigenicity in male rats, neither of which has relevance for human cancer risk...
  2. pmc Consideration of rat chronic progressive nephropathy in regulatory evaluations for carcinogenicity
    Gordon C Hard
    Private Consultant, 203 Paku Drive, Tairua 3508, New Zealand
    Toxicol Sci 132:268-75. 2013
    ..Guidelines are proposed for evaluation of exacerbation of CPN and RTT as a valid MOA for a given chemical...
  3. doi request reprint Association of advanced chronic progressive nephropathy (CPN) with renal tubule tumors and precursor hyperplasia in control F344 rats from two-year carcinogenicity studies
    Gordon C Hard
    Toxicol Pathol 40:473-81. 2012
    ..The regulatory significance of this finding is that chemicals exacerbating CPN as their only renal effect are likely to show a numerical increase in RTT with dose, which does not represent a direct tumorigenic effect of the chemical...
  4. ncbi request reprint Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN)
    Gordon C Hard
    National Toxicology Program Archives, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 33:641-9. 2005
    ..Criteria were developed to distinguish these CPN-associated lesions from atypical tubule hyperplasia, a precursor of adenoma, both of which were also represented in this survey of advanced CPN...
  5. doi request reprint A comparison of rat chronic progressive nephropathy with human renal disease-implications for human risk assessment
    Gordon C Hard
    203 Paku Drive, Tairua 3508, New Zealand
    Crit Rev Toxicol 39:332-46. 2009
    ..We recommend that chemically induced exacerbation of CPN not be acknowledged as an indicator of human toxic hazard. Increases in the incidence of CPN-related renal tumor is not considered relevant to humans...
  6. doi request reprint Re-evaluation of kidney histopathology from 13-week toxicity and two-year carcinogenicity studies of melamine in the F344 rat: morphologic evidence of retrograde nephropathy
    G C Hard
    Vet Pathol 46:1248-57. 2009
    ..However, the rat findings may be relevant to melamine-associated kidney disease recently reported in infants in China...
  7. ncbi request reprint A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment
    Gordon C Hard
    Pfizer R and D, Ann Arbor, Michigan 48105, USA
    Toxicol Pathol 32:171-80. 2004
    ....
  8. ncbi request reprint Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk
    Gordon C Hard
    American Health Foundation, One Dana Road, Valhalla, New York 10595, USA
    Toxicol Sci 69:30-41. 2002
    ....
  9. ncbi request reprint A search for an animal model of the Spanish toxic oil syndrome
    G C Hard
    American Health Foundation, 1 Dana Road, Valhalla, NY 10595, USA
    Food Chem Toxicol 40:1551-67. 2002
    ..Of the more exotic species, the mink and ferret have characteristics that might make them suitable candidates for testing oil samples...
  10. ncbi request reprint Rat kidney pathology induced by chronic exposure to fumonisin B1 includes rare variants of renal tubule tumor
    G C Hard
    American Health Foundation, Valhalla, New York 10595, USA
    Toxicol Pathol 29:379-86. 2001
    ....
  11. ncbi request reprint Re-evaluation of the 2-year chloroform drinking water carcinogenicity bioassay in Osborne-Mendel rats supports chronic renal tubule injury as the mode of action underlying the renal tumor response
    G C Hard
    American Health Foundation, Valhalla, New York 10595, USA
    Toxicol Sci 53:237-44. 2000
    ..This new information adds substantially to the weight of evidence that the key events in chloroform-induced carcinogenicity in rat kidney include sustained cellular toxicity and chronic regenerative hyperplasia...
  12. pmc Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the national toxicology program
    Gordon C Hard
    Private Consultant, Tairua, New Zealand
    Toxicol Pathol 36:388-96. 2008
    ..Accordingly, it is suggested that this distinctive renal tumor phenotype be recorded as a separate category from conventional RTT when assessing the carcinogenic potential of a test compound...
  13. ncbi request reprint Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy
    G C Hard
    American Health Foundation, Valhalla, New York 10595, USA
    Toxicol Pathol 25:132-43. 1997
    ..In summary, this histopathological review suggest a mechanism for hydroquinone-related adenoma formation that includes enhancement of the severity of CPN coupled with stimulation of tubule proliferation...
  14. ncbi request reprint Atypical tubule hyperplasia and renal tubule tumors in conventional rats on 90-day toxicity studies
    G C Hard
    American Health Foundation, Valhalla, New York 10595
    Toxicol Pathol 22:489-96. 1994
    ..The multiplicity of renal tubule tumors, early age of onset, and tumor morphology described in the cases from the 90-day studies were very similar to those characterizing the hereditary renal tumor model.(ABSTRACT TRUNCATED AT 250 WORDS)..
  15. ncbi request reprint Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year rat carcinogenicity bioassay of quercetin
    Gordon C Hard
    Private Consultant, 203 Paku Drive, Tairua 3508, New Zealand
    Food Chem Toxicol 45:600-8. 2007
    ....
  16. ncbi request reprint Histological investigation of diagnostically challenging tubule profiles in advanced chronic progressive nephropathy (CPN) in the fischer 344 RaT
    Gordon C Hard
    National Toxicology Program Archives, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 34:941-8. 2006
    ....
  17. ncbi request reprint Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent
    G C Hard
    American Health Foundation, Valhalla, New York 10595, USA
    Toxicol Pathol 26:104-12. 1998
    ..These various mechanistic pathways have implications for the nature of the induced cancer process with respect to tumor incidence, latency, malignancy, and sex predisposition...
  18. doi request reprint Methyl isobutyl ketone (MIBK) induction of alpha2u-globulin nephropathy in male, but not female rats
    S J Borghoff
    Integrated Laboratory Systems Inc, Division of Investigative Toxicology, Research Triangle Park, NC 27709, USA
    Toxicology 258:131-8. 2009
    ....
  19. ncbi request reprint Ochratoxin A: 13-week oral toxicity and cell proliferation in male F344/n rats
    Eva Rached
    Department of Toxicology, University of Wurzburg, Wurzburg, Germany
    Toxicol Sci 97:288-98. 2007
    ....
  20. ncbi request reprint Chemically induced renal tubule tumors in the laboratory rat and mouse: review of the NCI/NTP database and categorization of renal carcinogens based on mechanistic information
    Edward A Lock
    Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom
    Crit Rev Toxicol 34:211-99. 2004
    ....
  21. ncbi request reprint Subchronic toxicity of ethylene glycol in Wistar and F-344 rats related to metabolism and clearance of metabolites
    George Cruzan
    ToxWorks, 1153 Roadstown Road, Bridgeton, New Jersey 08302, USA
    Toxicol Sci 81:502-11. 2004
    ..This study confirms that the Wistar rat is more sensitive to ethylene glycol-induced renal toxicity than the F-344 rat and indicates that metabolism or clearance plays a role in the strain differences...
  22. ncbi request reprint Methyl tertiary-butyl ether mode of action for cancer endpoints in rodents
    George Cruzan
    ToxWorks, Bridgeton, NJ, USA
    Regul Toxicol Pharmacol 47:156-65. 2007
    ..These MOAs either do not occur in humans or humans are much less susceptible to these effects. It is, therefore, unlikely that humans would be exposed to sufficient levels of MTBE to cause these tumorigenic responses...
  23. ncbi request reprint Biotransformation and nephrotoxicity of ochratoxin B in rats
    Angela Mally
    Institut fur Toxikologie, Universitat Wurzburg, 97078 Wurzburg, Germany
    Toxicol Appl Pharmacol 206:43-53. 2005
    ..OTB is more extensively metabolized and more rapidly eliminated than OTA. The lack of specific retention of OTB in the kidneys and the differences in toxicokinetics may therefore provide an explanation for the lower toxicity of OTB...
  24. ncbi request reprint Are 4-hydroxy-2(E)-nonenal derived mercapturic acids and (1)H NMR metabonomics potential biomarkers of chemically induced oxidative stress in the kidney?
    Angela Mally
    Department of Toxicology, University of Wurzburg, Versbacher Str 9, 97078 Wurzburg, Germany
    Toxicology 230:244-55. 2007
    ....