Research Topics
| S P GunasekeraSummaryAffiliation: Harbor Branch Oceanographic Institution Country: USA Publications
| Collaborators
|
Detail Information
Publications
Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzaminesAlejandro M S Mayer
Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
BMC Pharmacol 5:6. 2005..The purpose of this investigation was to conduct a structure-activity relationship study with manzamines (MZ) A, B, C, D, E and F on agonist-stimulated release of TXB2 and O2- from E. coli LPS-activated rat neonatal microglia in vitro...
Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activitySarath P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
J Nat Prod 65:1830-7. 2002..The preparation, structure elucidation, and biological activity of these new analogues are described...- Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus BatzellaS P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 62:1208-11. 1999..Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described... - Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activityS P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 64:171-4. 2001..The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described... - Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activitySarath P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 67:749-56. 2004..The preparation, purification, structure elucidation, and biological activity of these new analogues are described... - Five new discodermolide analogues from the marine sponge Discodermia speciesSarath P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 65:1643-8. 2002.... - Plakolide A, a new gamma-lactone from the marine sponge Plakortis spSarath P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
J Nat Prod 67:110-1. 2004..was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described... - Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus BatzellaSarath P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 66:1615-7. 2003..These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described... - Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus BatzellaS P Gunasekera
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 62:173-5. 1999..It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described... - Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicityR A Isbrucker
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, FL 34946, USA
Cancer Chemother Pharmacol 48:29-36. 2001..The study reported here is the first to provide information on the structure-activity relationships of discodermolide using human tumor cells and analogs produced by semisynthetic modification of natural discodermolide... - Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia speciesGopal K Paul
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, Florida 34946, USA
J Nat Prod 65:59-61. 2002..collected from Honduras. 1 and 2 showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation, biological activities, and structure elucidation of theopederins K (1) and L (2) are described... - Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of MexicoYoung Chul Park
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U.S. 1 North, Fort Pierce, FL 34946, USA
J Nat Prod 69:580-4. 2006..The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies... 
Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroaSarath P Gunasekera
Smithsonian Marine Station, Fort Pierce, FL 34949, USA
J Nat Prod 71:887-90. 2008..The new compounds were assigned the trivial names dragonamide C (1) and dragonamide D (2), as their peptide moiety is related to previously reported dragonamides A and B...