S P Gunasekera

Summary

Affiliation: Harbor Branch Oceanographic Institution
Country: USA

Publications

  1. pmc Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 5:6. 2005
  2. ncbi Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 65:1830-7. 2002
  3. ncbi Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 62:1208-11. 1999
  4. ncbi Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 64:171-4. 2001
  5. ncbi Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 67:749-56. 2004
  6. ncbi Five new discodermolide analogues from the marine sponge Discodermia species
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 65:1643-8. 2002
  7. ncbi Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 67:110-1. 2004
  8. ncbi Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 66:1615-7. 2003
  9. ncbi Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 62:173-5. 1999
  10. ncbi Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity
    R A Isbrucker
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, FL 34946, USA
    Cancer Chemother Pharmacol 48:29-36. 2001

Collaborators

Detail Information

Publications13

  1. pmc Differential modulation of microglia superoxide anion and thromboxane B2 generation by the marine manzamines
    Alejandro M S Mayer
    Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
    BMC Pharmacol 5:6. 2005
    ..The purpose of this investigation was to conduct a structure-activity relationship study with manzamines (MZ) A, B, C, D, E and F on agonist-stimulated release of TXB2 and O2- from E. coli LPS-activated rat neonatal microglia in vitro...
  2. ncbi Semisynthetic analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 65:1830-7. 2002
    ..The preparation, structure elucidation, and biological activity of these new analogues are described...
  3. ncbi Secobatzellines A and B, two new enzyme inhibitors from a deep-water Caribbean sponge of the genus Batzella
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 62:1208-11. 1999
    ..Both compounds showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of secobatzellines A (1) and B (2) are described...
  4. ncbi Acetylated analogues of the microtubule-stabilizing agent discodermolide: preparation and biological activity
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 64:171-4. 2001
    ..The acetylated analogues showed a significant variation of cytotoxicity and suggested the importance of C-11 and C-17 hydroxyl groups for potency. The preparation and structure elucidation of the new analogues are described...
  5. ncbi Synthetic analogues of the microtubule-stabilizing agent (+)-discodermolide: preparation and biological activity
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 67:749-56. 2004
    ..The preparation, purification, structure elucidation, and biological activity of these new analogues are described...
  6. ncbi Five new discodermolide analogues from the marine sponge Discodermia species
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 65:1643-8. 2002
    ....
  7. ncbi Plakolide A, a new gamma-lactone from the marine sponge Plakortis sp
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 67:110-1. 2004
    ..was found to inhibit inducible nitric oxide synthase (iNOS) activity. The isolation, structure elucidation, and biological activity of plakolide A is described...
  8. ncbi Discorhabdins S, T, and U, new cytotoxic pyrroloiminoquinones from a deep-water Caribbean sponge of the genus Batzella
    Sarath P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 US 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 66:1615-7. 2003
    ..These discorhabdin analogues showed in vitro cytotoxicity against PANC-1, P-388, and A-549 cell lines. The isolation and structure elucidation of discorhabdins S, T, and U are described...
  9. ncbi Discorhabdin P, a new enzyme inhibitor from a deep-water Caribbean sponge of the genus Batzella
    S P Gunasekera
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 62:173-5. 1999
    ..It also showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation and structure elucidation of discorhabdin P (1) are described...
  10. ncbi Structure-activity relationship studies of discodermolide and its semisynthetic acetylated analogs on microtubule function and cytotoxicity
    R A Isbrucker
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Fort Pierce, FL 34946, USA
    Cancer Chemother Pharmacol 48:29-36. 2001
    ..The study reported here is the first to provide information on the structure-activity relationships of discodermolide using human tumor cells and analogs produced by semisynthetic modification of natural discodermolide...
  11. ncbi Theopederins K and L. Highly potent cytotoxic metabolites from a marine sponge Discodermia species
    Gopal K Paul
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, Florida 34946, USA
    J Nat Prod 65:59-61. 2002
    ..collected from Honduras. 1 and 2 showed in vitro cytotoxicity against P-388 and A-549 cell lines. The isolation, biological activities, and structure elucidation of theopederins K (1) and L (2) are described...
  12. ncbi Metabolites from the marine-derived fungus Chromocleista sp. isolated from a deep-water sediment sample collected in the Gulf of Mexico
    Young Chul Park
    Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, 5600 U S 1 North, Fort Pierce, FL 34946, USA
    J Nat Prod 69:580-4. 2006
    ..The structures of the new metabolites were determined on the basis of mass spectroscopy, NMR experiments, and derivatization methods. The absolute configuration of 1 was determined by X-ray crystallography studies...
  13. doi Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa
    Sarath P Gunasekera
    Smithsonian Marine Station, Fort Pierce, FL 34949, USA
    J Nat Prod 71:887-90. 2008
    ..The new compounds were assigned the trivial names dragonamide C (1) and dragonamide D (2), as their peptide moiety is related to previously reported dragonamides A and B...