Research Topics
| C WangSummaryAffiliation: Harbor-UCLA Medical Center Country: USA Publications
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Detail Information
Publications
Sublingual testosterone replacement improves muscle mass and strength, decreases bone resorption, and increases bone formation markers in hypogonadal men--a clinical research center studyC Wang
Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance 90509 2910, USA
J Clin Endocrinol Metab 81:3654-62. 1996....- Oligozoospermia induced by exogenous testosterone is associated with normal functioning residual spermatozoaC Wang
Department of Medicine, Harbor University of California Los Angeles Medical Center, Torrance 90509, USA
Fertil Steril 68:149-53. 1997..To determine the functional capacity of residual spermatozoa in semen samples from normal men with T enanthate-induced oligozoospermia... - Effect of increased scrotal temperature on sperm production in normal menC Wang
Department of Medicine, Harbor University of California, Los Angeles Medical Center, Torrance 90509 2910, USA
Fertil Steril 68:334-9. 1997..To determine whether application of polyester-lined athletic supports to bring the testes closer to the abdomen increases scrotal temperature and decreases sperm production... - Androgen replacement therapyC Wang
Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
Ann Med 29:365-70. 1997..In the future, designer androgens with specific beneficial effect on sexual function, mood, bone and muscle mass but with attenuated effects on serum lipid profiles and the prostate gland may be developed... - Graded testosterone infusions distinguish gonadotropin negative-feedback responsiveness in Asian and white men--a Clinical Research Center studyC Wang
Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
J Clin Endocrinol Metab 83:870-6. 1998..Whether these differences contribute to the observed differences in suppression of spermatogenesis in Asians vs. non-Asians in male contraceptive studies is not yet known... - Comparative pharmacokinetics of three doses of percutaneous dihydrotestosterone gel in healthy elderly men--a clinical research center studyC Wang
Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
J Clin Endocrinol Metab 83:2749-57. 1998..0001) on both days 1 and 14. We conclude that the three doses of DHT gel tested might provide adequate androgen replacement in hypogonadal men at the low, middle, and high physiological androgen (T + DHT) range... - Pharmacokinetics of transdermal testosterone gel in hypogonadal men: application of gel at one site versus four sites: a General Clinical Research Center StudyC Wang
Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
J Clin Endocrinol Metab 85:964-9. 2000..Dose-ranging studies are required to determine dosage regimens for T gel application as a replacement therapy in hypogonadal men... - Effects of transdermal testosterone gel on bone turnover markers and bone mineral density in hypogonadal menC Wang
Divisions of Endocrinology, Department of Medicine, Harbor UCLA Medical Center and Research and Education Institute, Torrance, CA, USA
Clin Endocrinol (Oxf) 54:739-50. 2001..Androgen replacement has been reported to increase bone mineral density (BMD) in hypogonadal men. We studied the effects of 6 months of treatment with a new transdermal testosterone (T) gel preparation on bone turnover markers and BMD... - Myocardial creatine kinase kinetics and isoform expression in hearts with severe LV hypertrophyY Ye
Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, Minnesota 55455, USA
Am J Physiol Heart Circ Physiol 281:H376-86. 2001..However, myocardial free ADP was increased in LVH hearts. This finding suggests that the CK alterations result in a need for higher ADP levels to maintain ATP synthesis in the hypertrophied heart... - Levonorgestrel implants (Norplant II) for male contraception clinical trials: combination with transdermal and injectable testosteroneI T Gaw Gonzalo
Division of Endocrinology, Department of Medicine, Harbor-University of California at Los Angeles Medical Center and Research and Education Institute, Torrance, California 90509, USA
J Clin Endocrinol Metab 87:3562-72. 2002..This study demonstrates that the dose or route of administration of androgens is critical for sperm suppression in combined androgen-progestagen regimens for hormonal male contraception... 
Transplanted XY germ cells produce spermatozoa in testes of XXY miceY Lue
Division of Endocrinology, Department of Medicine, David Geffen School of Medicine at UCLA, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Int J Androl 33:581-7. 2010..The results demonstrated that the donor XY germ cells were able to qualitatively complete spermatogenesis in some of the seminiferous tubules of XXY mice...- Transdermal androgens: pharmacology and applicability to hypogonadal elderly menR S Swerdloff
Division of Endocrinology, Department of Medicine Harbor UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance 90509, USA
J Endocrinol Invest 28:112-6. 2005.... - Suppression of spermatogenesis in man induced by Nal-Glu gonadotropin releasing hormone antagonist and testosterone enanthate (TE) is maintained by TE aloneR S Swerdloff
Department of Medicine, Harbor University of California, Los Angeles Medical Center, Torrance 90509, USA
J Clin Endocrinol Metab 83:3527-33. 1998..This concept should be explored further in the development of effective, safe, and affordable hormonal male contraceptives... - Reproductive aging in the Brown Norway rat is characterized by accelerated germ cell apoptosis and is not altered by luteinizing hormone replacementC Wang
Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90509 2910, USA
J Androl 20:509-18. 1999..Replacement therapy with LH for 6 months does not decrease or delay the testicular dysfunction associated with aging. It is unlikely that hypothalamic-pituitary dysregulation is the major cause of testicular aging... - Impairment of spermatogenesis in transgenic mice with selective overexpression of Bcl-2 in the somatic cells of the testisC M Yamamoto
Department of Medicine, Harbor-UCLA Medical Center and Research and Education Institute, Torrance, California 90509, USA
J Androl 22:981-91. 2001..Collectively, these results support the critical role of Bcl-2 in male germ cell development and are consistent with the gender-specific role of the Bcl-2 family members in reproduction... - Steady-state pharmacokinetics of oral testosterone undecanoate with concomitant inhibition of 5α-reductase by finasterideM Y Roth
Population Center for Research in Human Reproduction and Department of Medicine, University of Washington, Seattle, WA 98195, USA
Int J Androl 34:541-7. 2011..Oral TU differs from other formulations of oral testosterone in its response to concomitant inhibition of 5α-reductase, perhaps because of its unique lymphatic route of absorption... - Three-year follow-up of androgen treatment in hypogonadal men: preliminary report with testosterone gelR S Swerdloff
Swerdloff, Harbor-UCLA Medical Center, Division of Endocrinology, Box 446, 1000 W. Carson Street, Torrance, CA 90509-2910, USA
Aging Male 6:207-11. 2003..Monitoring for prostate disease through PSA measurements and digital rectal examination is recommended for hypogonadal men in the older age groups when treated with testosterone... - XXY male mice: an experimental model for Klinefelter syndromeY Lue
Division of Endocrinology, Department of Medicine, Harbor-University of California-Los Angeles Medical Center and Research and Education Institute, Torrance, California 90509, USA
Endocrinology 142:1461-70. 2001..The XXY mouse provides an experimental model for its human XXY counterpart, Klinefelter syndrome... - Pratical aspects of testosterone substitutionC Wang
Division of Endocrinology, Department of Medicine Harbor UCLA Medical Center and Los Angeles Biomedical Research Center, Torrance, USA
J Endocrinol Invest 28:109-11. 2005..Monitoring for manifestations of prostate disease, erythrocytosis and other adverse events of androgen treatment is critical in the management of older men with androgen replacement therapy... - Influence of pituitary disease on sexual development and functioningR S Swerdloff
Division of Endocrinology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, USA
Psychother Psychosom 67:173-80. 1998..The effects of pituitary insufficiency and pituitary adenomas on sexual development, reproductive function and sexuality in men and women are discussed... - Obesity, low testosterone levels and erectile dysfunctionM Diaz-Arjonilla
Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90803, USA
Int J Impot Res 21:89-98. 2009..This review describes the relationships between low serum testosterone concentrations and ED in obese patients and those with metabolic syndrome and type 2 diabetes mellitus... - Mitochondrial ATPase and high-energy phosphates in failing heartsJ Liu
Department of Medicine, University of Minnesota Health Sciences, Minneapolis, Minnesota 55455, USA
Am J Physiol Heart Circ Physiol 281:H1319-26. 2001..Thus in failing hearts, reductions in mitochondrial F(0)F(1)-ATPase protein expression are associated with increased myocardial free ADP... - ISA, ISSAM, EAU, EAA and ASA recommendations: investigation, treatment and monitoring of late-onset hypogonadism in malesC Wang
Division of Endocrinology, Department of Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Int J Impot Res 21:1-8. 2009.... - Cold storage induces time-dependent F2-isoprostane formation in renal tubular cells and rat kidneysA Salahudeen
Department of Medicine, University of Mississippi Medical Center, Jackson, USA
Kidney Int 55:1759-62. 1999..Because free radical-induced lipid peroxidation catalyzes the cyclooxygenase-independent formation of vasoconstrictive F2-isoprostanes, the hypothesis that isoprostanes are produced during cold storage was tested in this study...