V Rehan

Summary

Affiliation: Harbor-UCLA Medical Center
Country: USA

Publications

  1. ncbi request reprint 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Mol Genet Metab 76:46-56. 2002
  2. ncbi request reprint A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L182-90. 2007
  3. ncbi request reprint Diaphragm dimensions of the healthy term infant
    V K Rehan
    Department of Pediatrics, Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    Acta Paediatr 92:1062-7. 2003
  4. ncbi request reprint Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation
    V Rehan
    Department of Pediatrics, Harbor UCLA Medical Center Research and Education Institute, UCLA School of Medicine, Torrance, CA, USA
    Cell Biochem Biophys 38:239-50. 2003
  5. ncbi request reprint Biologic role of fetal lung fibroblast triglycerides as antioxidants
    J S Torday
    Division of Neonatology, Department of Pediatrics, Harbor UCLA Medical Center, Research and Education Institute, RB 1, Torrance, California, USA
    Pediatr Res 49:843-9. 2001
  6. ncbi request reprint Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 62:2-7. 2007
  7. ncbi request reprint Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signaling
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson St, RB1, California, Torrance 90502, USA
    Lung 185:151-9. 2007
  8. ncbi request reprint In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L323-33. 2007
  9. ncbi request reprint Evidence for the presence of lipofibroblasts in human lung
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine, University of California, Los Angeles, California 90502, USA
    Exp Lung Res 32:379-93. 2006
  10. ncbi request reprint Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
    Pediatr Res 60:382-8. 2006

Detail Information

Publications20

  1. ncbi request reprint 1Alpha,25-dihydroxy-3-epi-vitamin D3, a natural metabolite of 1alpha,25-dihydroxy vitamin D3: production and biological activity studies in pulmonary alveolar type II cells
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, USA
    Mol Genet Metab 76:46-56. 2002
    ....
  2. ncbi request reprint A paradoxical temporal response of the PTHrP/PPARgamma signaling pathway to lipopolysaccharide in an in vitro model of the developing rat lung
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor University of California at Los Angeles, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Am J Physiol Lung Cell Mol Physiol 293:L182-90. 2007
    ....
  3. ncbi request reprint Diaphragm dimensions of the healthy term infant
    V K Rehan
    Department of Pediatrics, Memorial Hospital of Rhode Island, Pawtucket, RI, USA
    Acta Paediatr 92:1062-7. 2003
    ..Such assessments have not been made in healthy term infants. This study was designed to evaluate the relationships among t(di), body dimensions and P(dimax) in healthy term infants...
  4. ncbi request reprint Hyperoxia augments pulmonary lipofibroblast-to-myofibroblast transdifferentiation
    V Rehan
    Department of Pediatrics, Harbor UCLA Medical Center Research and Education Institute, UCLA School of Medicine, Torrance, CA, USA
    Cell Biochem Biophys 38:239-50. 2003
    ..These results suggest that exposure to hyperoxia (95% O2) augments the transdifferentiation of pulmonary lipofibroblasts to myofibroblasts...
  5. ncbi request reprint Biologic role of fetal lung fibroblast triglycerides as antioxidants
    J S Torday
    Division of Neonatology, Department of Pediatrics, Harbor UCLA Medical Center, Research and Education Institute, RB 1, Torrance, California, USA
    Pediatr Res 49:843-9. 2001
    ..These data are consistent with the hypothesized role of FRLF triglycerides as antioxidants...
  6. ncbi request reprint Developmental cell/molecular biologic approach to the etiology and treatment of bronchopulmonary dysplasia
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Pediatr Res 62:2-7. 2007
    ..It is critically important to judiciously select physiologically and developmentally relevant interventions when treating the preterm neonate...
  7. ncbi request reprint Reversal of nicotine-induced alveolar lipofibroblast-to-myofibroblast transdifferentiation by stimulants of parathyroid hormone-related protein signaling
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, 1124 West Carson St, RB1, California, Torrance 90502, USA
    Lung 185:151-9. 2007
    ....
  8. ncbi request reprint In utero nicotine exposure alters fetal rat lung alveolar type II cell proliferation, differentiation, and metabolism
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, 1124 West Carson St, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 292:L323-33. 2007
    ..More importantly, concomitant administration of PPAR-gamma agonists can effectively attenuate many of the effects of in utero exposure to nicotine on ATII cells...
  9. ncbi request reprint Evidence for the presence of lipofibroblasts in human lung
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine, University of California, Los Angeles, California 90502, USA
    Exp Lung Res 32:379-93. 2006
    ....
  10. ncbi request reprint Up-regulation of fetal rat lung parathyroid hormone-related protein gene regulatory network down-regulates the Sonic Hedgehog/Wnt/betacatenin gene regulatory network
    John S Torday
    Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor UCLA, Torrance, California 90502, USA
    Pediatr Res 60:382-8. 2006
    ..This is the first evidence that alveolar fluid distension is an organizing principle for PTHrP signaling down-regulation of the Shh/Wnt/betacatenin pathway...
  11. ncbi request reprint Oxygen-induced metabolic changes and transdifferentiation in immature fetal rat lung lipofibroblasts
    Laszlo G Boros
    Division of Pediatric Endocrinology, Department of Pediatrics, Stable Isotope Research Laboratory, UCLA School of Medicine, Harbor UCLA Research and Education Institute, 1124 West Carson St, RB1, Torrance, CA 90502, USA
    Mol Genet Metab 77:230-6. 2002
    ..Hyperoxia-induced metabolic changes thus play a key role in the transdifferentiation of lung fibroblasts to myofibroblasts and the pathogenesis of BPD...
  12. ncbi request reprint Rosiglitazone, a peroxisome proliferator-activated receptor-gamma agonist, prevents hyperoxia-induced neonatal rat lung injury in vivo
    Virender K Rehan
    Department of Pediatrics, Los Angeles Biomedical Research Center at Harbor UCLA, David Geffen UCLA School of Medicine, University of California at Los Angeles, Torrance, California 90502, USA
    Pediatr Pulmonol 41:558-69. 2006
    ....
  13. ncbi request reprint Mechanism of nicotine-induced pulmonary fibroblast transdifferentiation
    Virender K Rehan
    Dept of Pediatrics, Harbor University of California Los Angeles Medical Center, Torrance, CA 90502, USA
    Am J Physiol Lung Cell Mol Physiol 289:L667-76. 2005
    ..Potential therapeutic implications of these observations against in utero nicotine-induced lung injury remain to be tested...
  14. ncbi request reprint Deconvoluting lung evolution using functional/comparative genomics
    John S Torday
    Department of Pediatrics, Harbor UCLA Research and Education Institute, Torrance, CA, 90502
    Am J Respir Cell Mol Biol 31:8-12. 2004
    ..This mechanism is discussed as a function of increased evolutionary respiratory demand to keep up with the increased metabolic demand for oxygen, and the role of the PTHrP signaling mechanism in leveraging this process...
  15. ncbi request reprint Comment on "Evo-Devo and the lungfish: the last gasp of intelligent design"
    J S Torday
    FASEB J 21:2640-1; author reply 2641. 2007
  16. ncbi request reprint Exploiting the PTHrP signaling pathway to treat chronic lung disease
    Virender K Rehan
    Department of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Research Institute at Harbor UCLA, David Geffen School of Medicine at UCLA, Torrance, California 90502, USA
    Drugs Today (Barc) 43:317-31. 2007
    ..However, to avoid any subsequent unexpected adverse consequences, it is important to emphasize that before translating the suggested approach into human trials, further testing and refinement in animal models is needed...
  17. ncbi request reprint Outcome of very-low-birth-weight (< 1,500 grams) infants born to mothers with diabetes
    Virender K Rehan
    Harbor UCLA Medical Center, Research and Education Institute, RB1, 1124 West Carson Street, Torrance, CA 90502, USA
    Clin Pediatr (Phila) 41:481-91. 2002
    ..It seems that with reasonable diabetic control, prematurity rather than the diabetic state determines the neonatal outcome, and this knowledge can be useful in parental counselling...
  18. ncbi request reprint Lower parathyroid hormone-related protein content of tracheal aspirates in very low birth weight infants who develop bronchopulmonary dysplasia
    Virender K Rehan
    Departmet of Pediatrics, Harbor UCLA Medical Center, Los Angeles Biomedical Reserach Institute at Harbor UCLA, CA 90502, USA
    Pediatr Res 60:216-20. 2006
    ..In contrast, MMP-8 levels did not correlate with BPD. We conclude that lower TA PTHrP content during the first week of life in ventilated VLBWI inversely correlates with prolonged ventilation and the later development of BPD...
  19. ncbi request reprint Prevention of bronchopulmonary dysplasia: finally, something that works
    Virender K Rehan
    David Geffen School of Medicine at UCLA, Torrance, USA
    Indian J Pediatr 73:1027-32. 2006
    ..However, to avoid any later surprises, it is important to emphasize that before translating it into human trials, this approach needs further testing and refinement in animal models...
  20. doi request reprint Prevention and treatment of bronchopulmonary dysplasia: contemporary status and future outlook
    Laura Cerny
    Harbor UCLA CHOC Neonatal Perinatal Fellowship Program, Los Angeles Biomedical Research Institute at Harbor UCLA Medical Center, Torrance, California 90502, USA
    Lung 186:75-89. 2008
    ....