Research Topics
Genomes and GenesSpecies | James NiemannSummaryAffiliation: Harbor-UCLA Medical Center Country: USA Publications
Research Grants
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Detail Information
Publications
TNF-α blockade improves early post-resuscitation survival and hemodynamics in a swine model of ischemic ventricular fibrillationJames T Niemann
David Geffen School of Medicine at UCLA, Los Angeles, CA, United States Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, United States Electronic address
Resuscitation 84:103-7. 2013..We hypothesized that administration of infliximab after return of spontaneous circulation (ROSC) would ameliorate hypotension and myocardial dysfunction and prolong survival...
Intracardiac voltage gradients during transthoracic defibrillation: implications for postshock myocardial injuryJames T Niemann
Harbor UCLA Medical Center, Department of Emergency Medicine, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
Acad Emerg Med 12:99-105. 2005..It is not clear how common descriptors of shock dose, e.g., joules (J), relate to VGs...- Post-resuscitation plasma catecholamines after prolonged arrest in a swine modelJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
Resuscitation 65:97-101. 2005..The purpose of this study was to measure plasma catecholamines after successful resuscitation and to determine their relationship to post-resuscitation hemodynamics... - A new device producing manual sternal compression with thoracic constraint for cardiopulmonary resuscitationJames T Niemann
Department of Emergency Medicine, Division of Cardiology, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
Resuscitation 69:295-301. 2006..The purpose of this study was to evaluate the mechanism of blood flow with the device, determine the optimal compression force and compare the device to standard manual CPR in a swine arrest model... - Monophasic versus biphasic transthoracic countershock after prolonged ventricular fibrillation in a swine modelJ T Niemann
UCLA School of Medicine, Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
J Am Coll Cardiol 36:932-8. 2000..We sought to compare the defibrillation efficacy of a low-energy biphasic truncated exponential (BTE) waveform and a conventional higher-energy monophasic truncated exponential (MTE) waveform after prolonged ventricular fibrillation (VF)... - The proinflammatory cytokine response following resuscitation in the swine model depends on the method of ventricular fibrillation inductionJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Acad Emerg Med 15:939-44. 2008..The purpose of this study was to compare the magnitude of the tumor necrosis factor-alpha (TNF-alpha) response in two different swine models of ventricular fibrillation (VF) arrest... - Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swineJames T Niemann
The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
J Interferon Cytokine Res 29:749-58. 2009..TNF-alpha increases during recovery from cardiac arrest are associated with depression of left ventricle (LV) function. The effect of TNF-alpha can be attenuated by anti-TNF-alpha antibodies... - Transthoracic defibrillation potential gradients in a closed chest porcine model of prolonged spontaneous and electrically induced ventricular fibrillationJames T Niemann
The David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
Resuscitation 81:477-80. 2010..We hypothesized that prolonged ischaemic VF would be more difficult to terminate when compared to electrically induced VF of similar duration... - Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest modelJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Crit Care Med 38:1162-7. 2010..We hypothesized that blocking the effects of tumor necrosis factor-alpha with infliximab would prevent or minimize postresuscitation cardiac dysfunction... - Does early postresuscitation stress hyperglycemia affect 72-hour neurologic outcome? Preliminary observations in the Swine modelJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Prehosp Emerg Care 15:405-9. 2011..Hyperglycemia is common in the early period following resuscitation from cardiac arrest and has been shown to be a predictor of neurologic outcome in retrospective studies... - Tumor necrosis factor-alpha is associated with early postresuscitation myocardial dysfunctionJames T Niemann
Department of Emergency Medicine, Research and Education Institute at Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
Crit Care Med 32:1753-8. 2004.... - A model of ischemically induced ventricular fibrillation for comparison of fixed-dose and escalating-dose defibrillation strategiesJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Acad Emerg Med 11:619-24. 2004..The authors hypothesized that a model of ischemically induced VF would exhibit heterogeneous defibrillation shock strength requirements and that an escalating-dose strategy would more effectively achieve prompt defibrillation... - Transthoracic monophasic and biphasic defibrillation in a swine model: a comparison of efficacy, ST segment changes, and postshock hemodynamicsJ T Niemann
The Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
Resuscitation 47:51-8. 2000..The purpose of this study was to compare the effects mono- and biphasic waveforms for DF on postdefibrillation ST segments and left ventricular pressure, markers of myocardial injury, after more extended periods of VF (30 and 90 s)... - Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunctionJames T Niemann
Harbor UCLA Medical Center, Department of Emergency Medicine and the David Geffen UCLA School of Medicine, Los Angeles, Calif, USA
Circulation 108:3031-5. 2003..The purpose of this study was to investigate the use of milrinone, a selective phosphodiesterase III inhibitor, as treatment for LV dysfunction after resuscitation... - The Utstein template and the effect of in-hospital decisions: the impact of do-not-attempt resuscitation status on survival to discharge statisticsJ T Niemann
Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
Resuscitation 51:233-7. 2001..Post-resuscitation care has not been standardized and in-hospital events that affect SHD are not considered in the template... - Left ventricular function after monophasic and biphasic waveform defibrillation: the impact of cardiopulmonary resuscitation time on contractile indicesJames T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, CA 90509, USA
Acad Emerg Med 10:9-15. 2003..To the best of the authors' knowledge, the effect of cardiopulmonary resuscitation (CPR) duration and total ischemia time on LV function after countershock, controlling for waveform type, has not been evaluated... - Endotracheal drug administration during out-of-hospital resuscitation: where are the survivors?James T Niemann
Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
Resuscitation 53:153-7. 2002..The purpose of this study was to compare the effect of intravenous (IV) and ET drug therapy on outcome from out-of-hospital cardiac arrest secondary to all cardiac arrest rhythms... - Endothelin-1 is not predictive of ventricular ectopy or ventricular fibrillation during acute myocardial ischemiaAtman P Shah
Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
J Interferon Cytokine Res 28:639-41. 2008..There is a significant increase in ET-1 level within 20 min of acute myocardial ischemia. Despite known effects of ET-1 on the AP, this increase did not correlate with the occurrence of VF... - Plasma endothelin-1 level at the onset of ischemic ventricular fibrillation predicts resuscitation outcomeAtman P Shah
Department of Medicine, Division of Cardiology, Harbor UCLA Medical Center, Torrance, CA, United States
Resuscitation 80:580-3. 2009..Prior work has demonstrated that ET-1 increases significantly after coronary occlusion. The purpose of this study was to assess changes in ET-1 following induction of ischaemia and VF... - Is the tumour necrosis factor-alpha response following resuscitation gender dependent in the swine model?James T Niemann
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, United States
Resuscitation 77:258-63. 2008..The purpose of this study was to determine whether the tumour necrosis factor-alpha response following resuscitation was gender dependent... - Transthoracic impedance does not decrease with rapidly repeated countershocks in a swine cardiac arrest modelJames T Niemann
Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
Resuscitation 56:91-5. 2003..The purpose of this study was to evaluate changes in transthoracic impedance with repeated defibrillation shocks in an animal model of cardiac arrest due to ventricular fibrillation (VF)... 
Derivation of clinical predictors of failed rescue shock during out-of-hospital ventricular fibrillationJames J Menegazzi
Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Prehosp Emerg Care 12:347-51. 2008..Failed rescue shocks have been shown to decrease the likelihood of survival in the treatment of out-of-hospital ventricular fibrillation (VF). Avoidance of failed shocks may improve survival...- Reconsideration of proximate Utstein-style end pointsSamuel J Stratton
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
Crit Care Med 30:S137-9. 2002..Furthermore, because in-hospital care is not standardized and uncontrolled variables exist, the primary Utstein end point of SHD should be reconsidered when evaluating cardiac arrest interventions... - A Bayesian sensitivity analysis of out-of-hospital 12-lead electrocardiograms: implications for regionalization of cardiac careScott T Youngquist
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
Acad Emerg Med 14:1165-71. 2007..Although estimates of sensitivity and specificity of PHTL for STEMI have been reported, the impact of out-of-hospital STEMI prevalence on positive predictive value (PPV) has not been evaluated... - Beta-blocker use and the changing epidemiology of out-of-hospital cardiac arrest rhythmsScott T Youngquist
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90590, United States
Resuscitation 76:376-80. 2008..This changing epidemiology has occurred concomitant with an increase in beta-blocker use... - Is the ACLS score a valid prediction rule for survival after cardiac arrest?Jason S Haukoos
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
Acad Emerg Med 10:621-6. 2003..However, the ACLS Score has not been validated in other emergency medical services systems... - Prediction rules for estimating neurologic outcome following out-of-hospital cardiac arrestJason S Haukoos
Department of Emergency Medicine, Denver Health Medical Center, 777 Bannock Street, Mail Code 0108, Denver, CO 80204, USA
Resuscitation 63:145-55. 2004..The purpose of this study was to develop a prediction model for meaningful survival following out-of-hospital cardiac arrest using variables available during resuscitation... - A percutaneous catheter-based system for the measurement of potential gradients applicable to the study of transthoracic defibrillationJohn P Rosborough
Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
Pacing Clin Electrophysiol 30:166-74. 2007..In this study we evaluated a multiple electrode, catheter-based device for closed-chest 3D measurements of E field from transthoracic defibrillation shocks... - The effect of ischemia on ventricular fibrillation as measured by fractal dimension and frequency measuresLawrence D Sherman
St Francis Hospital, Federal Way, WA, USA
Resuscitation 75:499-505. 2007..The scaling exponent (ScE), the logarithm of the absolute correlations (LAC) and the Hurst exponent (HE) are three measures of the fractal dimension of VF... - Is all ventricular fibrillation the same? A comparison of ischemically induced with electrically induced ventricular fibrillation in a porcine cardiac arrest and resuscitation modelJames T Niemann
David Geffen School of Medicine at UCLA, USA
Crit Care Med 35:1356-61. 2007.... - Vasopressin in piglet "pediatric models" of cardiac arrestJames T Niemann
Crit Care Med 30:1158-9. 2002 - Manual vs device-assisted CPR: reconciling apparently contradictory resultsRoger J Lewis
JAMA 295:2661-4. 2006
Research Grants
- Ischemic Arrest, Cytokines, and Organ DysfunctionJames Niemann; Fiscal Year: 2007..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. ..