James Niemann

Summary

Affiliation: Harbor-UCLA Medical Center
Country: USA

Publications

  1. pmc TNF-α blockade improves early post-resuscitation survival and hemodynamics in a swine model of ischemic ventricular fibrillation
    James T Niemann
    David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Resuscitation 84:103-7. 2013
  2. ncbi request reprint Intracardiac voltage gradients during transthoracic defibrillation: implications for postshock myocardial injury
    James T Niemann
    Harbor UCLA Medical Center, Department of Emergency Medicine, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
    Acad Emerg Med 12:99-105. 2005
  3. ncbi request reprint Post-resuscitation plasma catecholamines after prolonged arrest in a swine model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
    Resuscitation 65:97-101. 2005
  4. ncbi request reprint A new device producing manual sternal compression with thoracic constraint for cardiopulmonary resuscitation
    James T Niemann
    Department of Emergency Medicine, Division of Cardiology, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
    Resuscitation 69:295-301. 2006
  5. ncbi request reprint Monophasic versus biphasic transthoracic countershock after prolonged ventricular fibrillation in a swine model
    J T Niemann
    UCLA School of Medicine, Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Am Coll Cardiol 36:932-8. 2000
  6. pmc The proinflammatory cytokine response following resuscitation in the swine model depends on the method of ventricular fibrillation induction
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Acad Emerg Med 15:939-44. 2008
  7. pmc Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine
    James T Niemann
    The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
    J Interferon Cytokine Res 29:749-58. 2009
  8. pmc Transthoracic defibrillation potential gradients in a closed chest porcine model of prolonged spontaneous and electrically induced ventricular fibrillation
    James T Niemann
    The David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Resuscitation 81:477-80. 2010
  9. pmc Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Crit Care Med 38:1162-7. 2010
  10. pmc Does early postresuscitation stress hyperglycemia affect 72-hour neurologic outcome? Preliminary observations in the Swine model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Prehosp Emerg Care 15:405-9. 2011

Research Grants

Detail Information

Publications32

  1. pmc TNF-α blockade improves early post-resuscitation survival and hemodynamics in a swine model of ischemic ventricular fibrillation
    James T Niemann
    David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Resuscitation 84:103-7. 2013
    ..We hypothesized that administration of infliximab after return of spontaneous circulation (ROSC) would ameliorate hypotension and myocardial dysfunction and prolong survival...
  2. ncbi request reprint Intracardiac voltage gradients during transthoracic defibrillation: implications for postshock myocardial injury
    James T Niemann
    Harbor UCLA Medical Center, Department of Emergency Medicine, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
    Acad Emerg Med 12:99-105. 2005
    ..It is not clear how common descriptors of shock dose, e.g., joules (J), relate to VGs...
  3. ncbi request reprint Post-resuscitation plasma catecholamines after prolonged arrest in a swine model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
    Resuscitation 65:97-101. 2005
    ..The purpose of this study was to measure plasma catecholamines after successful resuscitation and to determine their relationship to post-resuscitation hemodynamics...
  4. ncbi request reprint A new device producing manual sternal compression with thoracic constraint for cardiopulmonary resuscitation
    James T Niemann
    Department of Emergency Medicine, Division of Cardiology, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
    Resuscitation 69:295-301. 2006
    ..The purpose of this study was to evaluate the mechanism of blood flow with the device, determine the optimal compression force and compare the device to standard manual CPR in a swine arrest model...
  5. ncbi request reprint Monophasic versus biphasic transthoracic countershock after prolonged ventricular fibrillation in a swine model
    J T Niemann
    UCLA School of Medicine, Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    J Am Coll Cardiol 36:932-8. 2000
    ..We sought to compare the defibrillation efficacy of a low-energy biphasic truncated exponential (BTE) waveform and a conventional higher-energy monophasic truncated exponential (MTE) waveform after prolonged ventricular fibrillation (VF)...
  6. pmc The proinflammatory cytokine response following resuscitation in the swine model depends on the method of ventricular fibrillation induction
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Acad Emerg Med 15:939-44. 2008
    ..The purpose of this study was to compare the magnitude of the tumor necrosis factor-alpha (TNF-alpha) response in two different swine models of ventricular fibrillation (VF) arrest...
  7. pmc Cardiac function and the proinflammatory cytokine response after recovery from cardiac arrest in swine
    James T Niemann
    The David Geffen School of Medicine at UCLA, University of California Los Angeles, CA, USA
    J Interferon Cytokine Res 29:749-58. 2009
    ..TNF-alpha increases during recovery from cardiac arrest are associated with depression of left ventricle (LV) function. The effect of TNF-alpha can be attenuated by anti-TNF-alpha antibodies...
  8. pmc Transthoracic defibrillation potential gradients in a closed chest porcine model of prolonged spontaneous and electrically induced ventricular fibrillation
    James T Niemann
    The David Geffen School of Medicine at UCLA, Los Angeles, CA, United States
    Resuscitation 81:477-80. 2010
    ..We hypothesized that prolonged ischaemic VF would be more difficult to terminate when compared to electrically induced VF of similar duration...
  9. pmc Infliximab attenuates early myocardial dysfunction after resuscitation in a swine cardiac arrest model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Crit Care Med 38:1162-7. 2010
    ..We hypothesized that blocking the effects of tumor necrosis factor-alpha with infliximab would prevent or minimize postresuscitation cardiac dysfunction...
  10. pmc Does early postresuscitation stress hyperglycemia affect 72-hour neurologic outcome? Preliminary observations in the Swine model
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Prehosp Emerg Care 15:405-9. 2011
    ..Hyperglycemia is common in the early period following resuscitation from cardiac arrest and has been shown to be a predictor of neurologic outcome in retrospective studies...
  11. ncbi request reprint Tumor necrosis factor-alpha is associated with early postresuscitation myocardial dysfunction
    James T Niemann
    Department of Emergency Medicine, Research and Education Institute at Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, CA 90509, USA
    Crit Care Med 32:1753-8. 2004
    ....
  12. ncbi request reprint A model of ischemically induced ventricular fibrillation for comparison of fixed-dose and escalating-dose defibrillation strategies
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Acad Emerg Med 11:619-24. 2004
    ..The authors hypothesized that a model of ischemically induced VF would exhibit heterogeneous defibrillation shock strength requirements and that an escalating-dose strategy would more effectively achieve prompt defibrillation...
  13. ncbi request reprint Transthoracic monophasic and biphasic defibrillation in a swine model: a comparison of efficacy, ST segment changes, and postshock hemodynamics
    J T Niemann
    The Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 West Carson Street, Box 21, Torrance, CA 90509, USA
    Resuscitation 47:51-8. 2000
    ..The purpose of this study was to compare the effects mono- and biphasic waveforms for DF on postdefibrillation ST segments and left ventricular pressure, markers of myocardial injury, after more extended periods of VF (30 and 90 s)...
  14. ncbi request reprint Milrinone facilitates resuscitation from cardiac arrest and attenuates postresuscitation myocardial dysfunction
    James T Niemann
    Harbor UCLA Medical Center, Department of Emergency Medicine and the David Geffen UCLA School of Medicine, Los Angeles, Calif, USA
    Circulation 108:3031-5. 2003
    ..The purpose of this study was to investigate the use of milrinone, a selective phosphodiesterase III inhibitor, as treatment for LV dysfunction after resuscitation...
  15. ncbi request reprint The Utstein template and the effect of in-hospital decisions: the impact of do-not-attempt resuscitation status on survival to discharge statistics
    J T Niemann
    Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
    Resuscitation 51:233-7. 2001
    ..Post-resuscitation care has not been standardized and in-hospital events that affect SHD are not considered in the template...
  16. ncbi request reprint Left ventricular function after monophasic and biphasic waveform defibrillation: the impact of cardiopulmonary resuscitation time on contractile indices
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, CA 90509, USA
    Acad Emerg Med 10:9-15. 2003
    ..To the best of the authors' knowledge, the effect of cardiopulmonary resuscitation (CPR) duration and total ischemia time on LV function after countershock, controlling for waveform type, has not been evaluated...
  17. ncbi request reprint Endotracheal drug administration during out-of-hospital resuscitation: where are the survivors?
    James T Niemann
    Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
    Resuscitation 53:153-7. 2002
    ..The purpose of this study was to compare the effect of intravenous (IV) and ET drug therapy on outcome from out-of-hospital cardiac arrest secondary to all cardiac arrest rhythms...
  18. pmc Endothelin-1 is not predictive of ventricular ectopy or ventricular fibrillation during acute myocardial ischemia
    Atman P Shah
    Department of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Interferon Cytokine Res 28:639-41. 2008
    ..There is a significant increase in ET-1 level within 20 min of acute myocardial ischemia. Despite known effects of ET-1 on the AP, this increase did not correlate with the occurrence of VF...
  19. pmc Plasma endothelin-1 level at the onset of ischemic ventricular fibrillation predicts resuscitation outcome
    Atman P Shah
    Department of Medicine, Division of Cardiology, Harbor UCLA Medical Center, Torrance, CA, United States
    Resuscitation 80:580-3. 2009
    ..Prior work has demonstrated that ET-1 increases significantly after coronary occlusion. The purpose of this study was to assess changes in ET-1 following induction of ischaemia and VF...
  20. pmc Is the tumour necrosis factor-alpha response following resuscitation gender dependent in the swine model?
    James T Niemann
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, United States
    Resuscitation 77:258-63. 2008
    ..The purpose of this study was to determine whether the tumour necrosis factor-alpha response following resuscitation was gender dependent...
  21. ncbi request reprint Transthoracic impedance does not decrease with rapidly repeated countershocks in a swine cardiac arrest model
    James T Niemann
    Department of Emergency Medicine, UCLA School of Medicine, Harbor UCLA Medical Center, Box 21, 1000 West Carson Street, Torrance, CA 90509, USA
    Resuscitation 56:91-5. 2003
    ..The purpose of this study was to evaluate changes in transthoracic impedance with repeated defibrillation shocks in an animal model of cardiac arrest due to ventricular fibrillation (VF)...
  22. doi request reprint Derivation of clinical predictors of failed rescue shock during out-of-hospital ventricular fibrillation
    James J Menegazzi
    Department of Emergency Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Prehosp Emerg Care 12:347-51. 2008
    ..Failed rescue shocks have been shown to decrease the likelihood of survival in the treatment of out-of-hospital ventricular fibrillation (VF). Avoidance of failed shocks may improve survival...
  23. ncbi request reprint Reconsideration of proximate Utstein-style end points
    Samuel J Stratton
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509 2910, USA
    Crit Care Med 30:S137-9. 2002
    ..Furthermore, because in-hospital care is not standardized and uncontrolled variables exist, the primary Utstein end point of SHD should be reconsidered when evaluating cardiac arrest interventions...
  24. ncbi request reprint A Bayesian sensitivity analysis of out-of-hospital 12-lead electrocardiograms: implications for regionalization of cardiac care
    Scott T Youngquist
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Acad Emerg Med 14:1165-71. 2007
    ..Although estimates of sensitivity and specificity of PHTL for STEMI have been reported, the impact of out-of-hospital STEMI prevalence on positive predictive value (PPV) has not been evaluated...
  25. pmc Beta-blocker use and the changing epidemiology of out-of-hospital cardiac arrest rhythms
    Scott T Youngquist
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90590, United States
    Resuscitation 76:376-80. 2008
    ..This changing epidemiology has occurred concomitant with an increase in beta-blocker use...
  26. ncbi request reprint Is the ACLS score a valid prediction rule for survival after cardiac arrest?
    Jason S Haukoos
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    Acad Emerg Med 10:621-6. 2003
    ..However, the ACLS Score has not been validated in other emergency medical services systems...
  27. ncbi request reprint Prediction rules for estimating neurologic outcome following out-of-hospital cardiac arrest
    Jason S Haukoos
    Department of Emergency Medicine, Denver Health Medical Center, 777 Bannock Street, Mail Code 0108, Denver, CO 80204, USA
    Resuscitation 63:145-55. 2004
    ..The purpose of this study was to develop a prediction model for meaningful survival following out-of-hospital cardiac arrest using variables available during resuscitation...
  28. ncbi request reprint A percutaneous catheter-based system for the measurement of potential gradients applicable to the study of transthoracic defibrillation
    John P Rosborough
    Department of Emergency Medicine, Harbor UCLA Medical Center, Torrance, California 90509, USA
    Pacing Clin Electrophysiol 30:166-74. 2007
    ..In this study we evaluated a multiple electrode, catheter-based device for closed-chest 3D measurements of E field from transthoracic defibrillation shocks...
  29. pmc The effect of ischemia on ventricular fibrillation as measured by fractal dimension and frequency measures
    Lawrence D Sherman
    St Francis Hospital, Federal Way, WA, USA
    Resuscitation 75:499-505. 2007
    ..The scaling exponent (ScE), the logarithm of the absolute correlations (LAC) and the Hurst exponent (HE) are three measures of the fractal dimension of VF...
  30. ncbi request reprint Is all ventricular fibrillation the same? A comparison of ischemically induced with electrically induced ventricular fibrillation in a porcine cardiac arrest and resuscitation model
    James T Niemann
    David Geffen School of Medicine at UCLA, USA
    Crit Care Med 35:1356-61. 2007
    ....
  31. ncbi request reprint Vasopressin in piglet "pediatric models" of cardiac arrest
    James T Niemann
    Crit Care Med 30:1158-9. 2002
  32. ncbi request reprint Manual vs device-assisted CPR: reconciling apparently contradictory results
    Roger J Lewis
    JAMA 295:2661-4. 2006

Research Grants4

  1. Ischemic Arrest, Cytokines, and Organ Dysfunction
    James Niemann; Fiscal Year: 2007
    ..In aim 3, the effect of anti-TNF therapy on long-term survival and neurologic outcome will be evaluated. ..