OMID A KHORRAM

Summary

Affiliation: Harbor-UCLA Medical Center
Country: USA

Publications

  1. ncbi Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes
    Naseem M Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and David Geffen School of Medicine at University of California, Los Angeles, CA 90502, USA
    Reprod Sci 18:931-40. 2011
  2. ncbi Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor University of California at Los Angeles Medical Center, 1000 W Carson St, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 293:R745-53. 2007
  3. ncbi Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Reprod Sci 14:73-80. 2007
  4. ncbi Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome
    Omid Khorram
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Fertil Steril 85:1448-51. 2006
  5. ncbi Influence of progesterone on endometrial nitric oxide synthase expression
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, California 90502, USA
    Fertil Steril 91:2157-62. 2009
  6. ncbi Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide-mediated pathway
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, USA
    Fertil Steril 93:257-63. 2010
  7. ncbi Identification and characterization of a novel luciferase-like protein in the human female reproductive tract
    O Khorram
    Department of Obstetrics and Gynecology, Box 489, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, California 90502, USA
    J Clin Endocrinol Metab 89:5837-46. 2004
  8. ncbi Expression of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in human spermatozoa
    Omid Khorram
    Department of Obstetrics and Gynecology, University of Wisconsin, and Wisconsin Regional Primate Research Center, Madison, WI, USA
    Med Sci Monit 10:BR135-8. 2004
  9. ncbi Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring
    O Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1366-74. 2010
  10. ncbi Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v)beta(3) integrin in women with endometriosis
    Omid Khorram
    Department of Obstetrics and Gynecology, University of Wisconsin, Wisconsin, Madison, USA
    Fertil Steril 78:860-4. 2002

Research Grants

  1. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
  2. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2007

Detail Information

Publications19

  1. ncbi Maternal undernutrition programs offspring adrenal expression of steroidogenic enzymes
    Naseem M Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and David Geffen School of Medicine at University of California, Los Angeles, CA 90502, USA
    Reprod Sci 18:931-40. 2011
    ..The common finding of increased ACTH receptor expression in MUN adults of both genders suggests an increased sensitivity of these offspring to stress...
  2. ncbi Maternal undernutrition inhibits angiogenesis in the offspring: a potential mechanism of programmed hypertension
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor University of California at Los Angeles Medical Center, 1000 W Carson St, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 293:R745-53. 2007
    ....
  3. ncbi Nutrient restriction in utero induces remodeling of the vascular extracellular matrix in rat offspring
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Reprod Sci 14:73-80. 2007
    ..By 2 months of life, the compositions of both vessel types are consistent with stiff vessels, a contributing factor to hypertension...
  4. ncbi Two weeks of metformin improves clomiphene citrate-induced ovulation and metabolic profiles in women with polycystic ovary syndrome
    Omid Khorram
    Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Fertil Steril 85:1448-51. 2006
    ..To determine if short courses of metformin (MET) administration in patients with polycystic ovary syndrome (PCOS) would reduce fasting insulin and improve the efficacy of clomiphene citrate (CC) to induce ovulation...
  5. ncbi Influence of progesterone on endometrial nitric oxide synthase expression
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center and Los Angeles Biomedical Institute, Torrance, California 90502, USA
    Fertil Steril 91:2157-62. 2009
    ..To determine the effect of P on nitric oxide synthase (NOS) expression in human endometrial epithelial cells...
  6. ncbi Cigarette smoke inhibits endometrial epithelial cell proliferation through a nitric oxide-mediated pathway
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California, USA
    Fertil Steril 93:257-63. 2010
    ..To determine the direct effects of cigarette smoke (CS) on human endometrial surface epithelial cell line proliferation...
  7. ncbi Identification and characterization of a novel luciferase-like protein in the human female reproductive tract
    O Khorram
    Department of Obstetrics and Gynecology, Box 489, Harbor UCLA Medical Center, 1000 West Carson Street, Torrance, California 90502, USA
    J Clin Endocrinol Metab 89:5837-46. 2004
    ....
  8. ncbi Expression of aryl hydrocarbon receptor (AHR) and aryl hydrocarbon receptor nuclear translocator (ARNT) mRNA expression in human spermatozoa
    Omid Khorram
    Department of Obstetrics and Gynecology, University of Wisconsin, and Wisconsin Regional Primate Research Center, Madison, WI, USA
    Med Sci Monit 10:BR135-8. 2004
    ..The objective of this study was to determine if human spermatozoa express AHR (dioxin receptor) and ARNT and if mRNA levels for these transcription factors correlate with sperm concentration, motility or morphology...
  9. ncbi Effect of maternal undernutrition on vascular expression of micro and messenger RNA in newborn and aging offspring
    O Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, 1000 W Carson Street, Torrance, CA 90502, USA
    Am J Physiol Regul Integr Comp Physiol 298:R1366-74. 2010
    ..These results are consistent with the hypothesis that MUN modulation of offspring gene expression may be mediated in part by a miRNA mechanism...
  10. ncbi Alterations in expression of endometrial endothelial nitric oxide synthase and alpha(v)beta(3) integrin in women with endometriosis
    Omid Khorram
    Department of Obstetrics and Gynecology, University of Wisconsin, Wisconsin, Madison, USA
    Fertil Steril 78:860-4. 2002
    ..To determine the expression of endometrial endothelial nitric oxide synthase (eNOS) protein and alpha(v)beta(3) integrin in patients with and without endometriosis...
  11. ncbi In utero undernutrition in rats induces increased vascular smooth muscle content in the offspring
    Omid Khorram
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Am J Obstet Gynecol 196:486.e1-8. 2007
    ..We hypothesized that undernutrition in utero alters the structure of conduit and resistance vessels early in development...
  12. ncbi Physiologic role of nitric oxide and nitric oxide synthase in female lower urinary tract
    Mat H Ho
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, David Geffen School of Medicine, University of California, Los Angeles, California, USA
    Curr Opin Obstet Gynecol 16:423-9. 2004
    ..This review discusses recently published data related to the physiologic and pathophysiologic roles of NO and nitric oxide synthase (NOS) in the female lower urinary tract...
  13. ncbi Expression of endometrial glycogen synthase kinase-3beta protein throughout the menstrual cycle and its regulation by progesterone
    Wael Salameh
    Department of Internal Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Mol Hum Reprod 12:543-9. 2006
    ..In vitro experiments demonstrate that progesterone through receptor-mediated mechanisms induces phosphorylation of endometrial GSK-3beta...
  14. ncbi Human seminal plasma nitric oxide: correlation with sperm morphology and testosterone
    Ivan Huang
    Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, Torrance, CA, USA
    Med Sci Monit 12:CR103-6. 2006
    ..CONCLUSIONS: NO and testosterone are detectable in seminal plasma and are potentially involved in spermatogenesis. Low levels of seminal plasma NO and T are associated with defects in sperm morphology...
  15. ncbi Gestational programming of offspring obesity: a potential contributor to Alzheimer's disease
    Michael G Ross
    Department of Obstetrics and Gynecology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    Curr Alzheimer Res 4:213-7. 2007
    ..These findings suggest that potential risk factors for the development of Alzheimer's disease may be present as early as newborn life...
  16. ncbi Regulation of nitric oxide synthase isoforms by estrogen in the human endometrium
    Guang Han
    Department of Obstetrics and Gynecology, Harbor-UCLA Medical Center, LA Biomedical Institute, Torrance, California, USA
    Fertil Steril 84:1220-7. 2005
    ..CONCLUSION(S): Estradiol through a genomic mechanism stimulates the expression of NOS isoforms in endometrial derived primary and HES cells. This effect is potentiated by progesterone...
  17. ncbi Down-regulation of transcription factor peroxisome proliferator-activated receptor in programmed hepatic lipid dysregulation and inflammation in intrauterine growth-restricted offspring
    Thomas R Magee
    Department of Obstetrics and Gynecology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA
    Am J Obstet Gynecol 199:271.e1-5. 2008
    ..We hypothesized that IUGR-induced inhibition of hepatic peroxisome proliferator-activated receptors (PPARs) is associated with an increased inflammatory response...
  18. ncbi The influence of sex hormones on circulating nitric oxide (NOx) levels in rhesus monkeys (Macaca Mulatta)
    Omid Khorram
    Department of Obstetrics and Gynecology, University of Wisconsin, Madison, WI, USA
    Med Sci Monit 8:BR489-95. 2002
    ..Circulating NOx was higher during the luteal phase. In both ERT treated and cycling monkeys estradiol correlated negatively with NOx suggesting the existence of a negative feedback of NO on either NOS activity or expression...
  19. ncbi Nitric oxide and its role in blastocyst implantation
    Omid Khorram
    Department of Obstetrics and Gynecology, Box 489, Harbor-UCLA Medical Center, 1000 W. Carson Street, Torrance, CA 90502, USA
    Rev Endocr Metab Disord 3:145-9. 2002

Research Grants3

  1. Human Endometrial Nitric Oxide: Regulation and Function
    Omid Khorram; Fiscal Year: 2003
    ..This pilot study should shed light on regulation and function of human endometrial NO pathway, an uninvestigated area of research with profound clinical significance. ..
  2. Glucocorticoids and Programming of the Hypertensive Vascular Phenotype
    Omid Khorram; Fiscal Year: 2007
    ..We plan to prevent development of high blood pressure and changes in the structure of blood vessels in the offspring by preventing the excessive production of stress hormone during a critical time point in pregnancy. ..