L Chang

Summary

Affiliation: Harbor-UCLA Medical Center
Country: USA

Publications

  1. ncbi Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    Am J Psychiatry 156:716-22. 1999
  2. ncbi Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats
    L Chang
    Department of Neurology, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
    Arch Neurol 55:305-11. 1998
  3. ncbi Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders
    R E Poland
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    J Psychiatr Res 33:41-51. 1999
  4. ncbi Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 10:521-6. 1999
  5. ncbi Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
    L Chang
    Department of Neurology, University of California at Los Angeles School of Medicine, USA
    Neurology 53:782-9. 1999
  6. ncbi Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000
  7. ncbi Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered (1)H MRS and SPECT study
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 12:859-65. 2000
  8. ncbi Correlation of regional cerebral blood flow from perfusion MRI and spect in normal subjects
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Magn Reson Imaging 17:349-54. 1999
  9. ncbi Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
    Psychiatry Res 98:15-28. 2000
  10. ncbi Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study
    T Ernst
    Department of Neurology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 54:1344-9. 2000

Collaborators

Detail Information

Publications22

  1. ncbi Gender effects on persistent cerebral metabolite changes in the frontal lobes of abstinent cocaine users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance 90509, USA
    Am J Psychiatry 156:716-22. 1999
    ..The aim of this study was to investigate persistent neurochemical changes in the frontal lobes of subjects with a history of crack cocaine dependence and to determine whether these changes are different in male and female users...
  2. ncbi Proton spectroscopy in myotonic dystrophy: correlations with CTG repeats
    L Chang
    Department of Neurology, Harbor UCLA Medical Center, Torrance, Calif 90509, USA
    Arch Neurol 55:305-11. 1998
    ....
  3. ncbi Brain N-acetyl aspartate concentrations measured by H MRS are reduced in adult male rats subjected to perinatal stress: preliminary observations and hypothetical implications for neurodevelopmental disorders
    R E Poland
    Department of Psychiatry, Harbor UCLA Medical Center, Torrance, CA 90509, USA
    J Psychiatr Res 33:41-51. 1999
    ..particularly in relation to NAA. For hypothesis-generating purposes, the possible relevance of stress and NAA to the neurodevelopmental hypothesis of schizophrenia is discussed in greater detail...
  4. ncbi Cerebral (1)H MRS alterations in recreational 3, 4-methylenedioxymethamphetamine (MDMA, "ecstasy") users
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 10:521-6. 1999
    ..However, the usage-related increase in MI suggests that exposure to MDMA, even at recreational doses, may cause increased glial content. J. Magn. Reson. Imaging 1999;10:521-526...
  5. ncbi Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild HIV dementia
    L Chang
    Department of Neurology, University of California at Los Angeles School of Medicine, USA
    Neurology 53:782-9. 1999
    ..To determine whether cerebral metabolite abnormalities normalize with highly active antiretroviral therapy (HAART)...
  6. ncbi Differences in somatic perception in female patients with irritable bowel syndrome with and without fibromyalgia
    L Chang
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine and Physiology, UCLA School of Medicine, Los Angeles, CA 90024, USA
    Pain 84:297-307. 2000
    ..Because there is a significant overlap of IBS and FM, shared pathophysiological mechanisms have been suggested. Although visceral perception has been well studied in IBS, somatic perception has not...
  7. ncbi Changes in cerebral metabolism are detected prior to perfusion changes in early HIV-CMC: A coregistered (1)H MRS and SPECT study
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, California 90502, USA
    J Magn Reson Imaging 12:859-65. 2000
    ..This finding suggests that metabolite concentrations on (1)H MRS are better surrogate markers than rCBF measurements with SPECT for the evaluation of brain injury in early HIV-CMC. J. Magn. Reson. Imaging 2000;12:859-865...
  8. ncbi Correlation of regional cerebral blood flow from perfusion MRI and spect in normal subjects
    T Ernst
    Department of Radiology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Magn Reson Imaging 17:349-54. 1999
    ..pMRI is a reliable noninvasive method for rCBF measurements...
  9. ncbi Effect of ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] on cerebral blood flow: a co-registered SPECT and MRI study
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 1000 W Carson Street, B 4, Torrance, CA 90509, USA
    Psychiatry Res 98:15-28. 2000
    ....
  10. ncbi Evidence for long-term neurotoxicity associated with methamphetamine abuse: A 1H MRS study
    T Ernst
    Department of Neurology, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 54:1344-9. 2000
    ..To determine whether proton MRS (1H MRS) can detect long-term metabolite abnormalities in abstinent methamphetamine users...
  11. ncbi Neuroimaging findings in patients with AIDS
    I Walot
    Department of Radiology, Harbor UCLA Medical Center, Torrance 90509, USA
    Clin Infect Dis 22:906-19. 1996
    ..As therapeutic modes improve, imaging may assume a growing role in monitoring the responses to therapy among these patients...
  12. ncbi Neural correlates of attention and working memory deficits in HIV patients
    L Chang
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, Torrance, CA, USA
    Neurology 57:1001-7. 2001
    ..To evaluate the neural correlates of attention and working memory deficits in patients with HIV-1...
  13. ncbi Perceptual responses in patients with inflammatory and functional bowel disease
    L Chang
    UCLA CURE Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California 90073, USA
    Gut 47:497-505. 2000
    ....
  14. ncbi Approaches to the modulation of abdominal pain
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Brain Research Institute, UCLA School of Medicine, Los Angeles, California 90073, USA
    Can J Gastroenterol 13:65A-70A. 1999
    ....
  15. ncbi V. Stress and irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Departments of Medicine, Physiology, and Biobehavioral Sciences, UCLA School of Medicine, Los Angeles, California 90024, USA
    Am J Physiol Gastrointest Liver Physiol 280:G519-24. 2001
    ..Functional brain imaging techniques are beginning to identify brain circuits involved in the perceptual alterations. Animal models have recently been proposed that mimic key features of the human syndrome...
  16. ncbi Biexponential modeling of multigradient-echo MRI data of the brain
    O Speck
    Department of Neurology, Harbor UCLA Medical Center, UCLA School of Medicine, Torrance, California, USA
    Magn Reson Med 45:1116-21. 2001
    ..The activation-induced parameter changes are detected with a sensitivity equal to that of a monoexponential method. The resulting T2* and DeltaT2* values describe the experimental data more accurately...
  17. ncbi Brain proton magnetic resonance spectroscopy in children exposed to methamphetamine in utero
    L M Smith
    Department of Pediatrics, Harbor UCLA Medical Center, University of California, Los Angeles School of Medicine, Torrance 90502, USA
    Neurology 57:255-60. 2001
    ..To examine the possible neurotoxic effects of prenatal methamphetamine exposure on the developing brain using 1H-MRS...
  18. ncbi HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis
    M Issakhanian
    Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA
    J Neuroimaging 11:212-6. 2001
    ..The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis...
  19. ncbi Cerebral perfusion abnormalities in abstinent cocaine abusers: a perfusion MRI and SPECT study
    T Ernst
    Department of Neurology, UCLA School of Medicine, Harbor UCLA Medical Center, 100 West Carson Street, B 4, 90509, Torrance, CA, USA
    Psychiatry Res 99:63-74. 2000
    ..The hypoperfusion in the cortex and deep gray matter of the cocaine users is consistent with previous results. The increased rCBF in the white matter of cocaine users may be due to the presence of reactive glia...
  20. ncbi Basic pathophysiologic mechanisms in irritable bowel syndrome
    E A Mayer
    UCLA CURE Neuroenteric Disease Program, Department of Medicine, Physiology and Biobehavioral Sciences, UCLA School of Medicine, 11301 Wilshire Boulevard, Los Angeles, CA 90073, USA
    Dig Dis 19:212-8. 2001
    ..IBS patients show an enhanced responsiveness of this system manifesting in altered modulation of gastrointestinal motility, secretion, immune function and in alterations in the perceptual and emotional response to visceral events...
  21. ncbi Gender-related differences in IBS symptoms
    O Y Lee
    CURE Digestive Diseases Research Center/Neuroenteric Disease Program, Department of Medicine and Physiology, UCLA School of Medicine, Los Angeles, California, USA
    Am J Gastroenterol 96:2184-93. 2001
    ..The apparent differences in sensitivity to nonpainful visceral sensations, medications, and food may represent altered sensory processes, autonomic responses, and/or cognitive hypervigilance...
  22. ncbi Cerebral metabolites in HIV-infected children followed for 10 months with 1H-MRS
    M A Keller
    Los Angeles Biomedical Research Institute, Harbor UCLA Medical Center, Torrance, CA 90502, USA
    Neurology 66:874-9. 2006
    ..0 years +/- 3.7 years) and repeated the MR spectroscopy at 24.1 +/- 3.7 weeks and 42.2 +/- 3.5 weeks following the entry time with repeated neuropsychological testing...