Timothy Yeatman

Summary

Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Country: USA

Publications

  1. ncbi request reprint A renaissance for SRC
    Timothy J Yeatman
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Rev Cancer 4:470-80. 2004
  2. pmc On the eve of personalized medicine in oncology
    Timothy J Yeatman
    Total Cancer Care, H Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 68:7250-2. 2008
  3. pmc EMT is the dominant program in human colon cancer
    Andre Loboda
    Merck, Sharp and Dohme, West Point, PA 19486, USA
    BMC Med Genomics 4:9. 2011
  4. pmc Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study
    Xinglai Ji
    Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens 30602, GA, USA
    BMC Cancer 10:426. 2010
  5. pmc Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
    Dung Tsa Chen
    Biostatistics Department, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA
    Breast Cancer Res Treat 119:335-46. 2010
  6. pmc Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    Domenico Coppola
    Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Am J Pathol 179:37-45. 2011
  7. pmc Correlation between Mcl-1 and pAKT protein expression in colorectal cancer
    Evita B Henderson-Jackson
    Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
    Int J Clin Exp Pathol 3:768-74. 2010
  8. pmc SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    Neha Kabra
    Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 284:18210-7. 2009
  9. pmc Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
    Cancer 113:2665-70. 2008
  10. pmc Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry
    Yi Chen
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
    J Proteome Res 9:4215-27. 2010

Research Grants

  1. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy J Yeatman; Fiscal Year: 2010
  2. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2009
  3. Chip Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2007
  4. Screening for Breast Cancer Using Molecular Signatures
    Timothy Yeatman; Fiscal Year: 2007
  5. Molecular Profiling to Predict Response to Chemotherapy
    Timothy Yeatman; Fiscal Year: 2004
  6. SRC AS A NOVEL TARGET FOR HUMAN COLON CANCER THERAPY
    Timothy Yeatman; Fiscal Year: 2004
  7. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2009

Detail Information

Publications62

  1. ncbi request reprint A renaissance for SRC
    Timothy J Yeatman
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Nat Rev Cancer 4:470-80. 2004
  2. pmc On the eve of personalized medicine in oncology
    Timothy J Yeatman
    Total Cancer Care, H Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Cancer Res 68:7250-2. 2008
  3. pmc EMT is the dominant program in human colon cancer
    Andre Loboda
    Merck, Sharp and Dohme, West Point, PA 19486, USA
    BMC Med Genomics 4:9. 2011
    ..Colon cancer has been classically described by clinicopathologic features that permit the prediction of outcome only after surgical resection and staging...
  4. pmc Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot study
    Xinglai Ji
    Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens 30602, GA, USA
    BMC Cancer 10:426. 2010
    ..As an initial test of this strategy, we conducted a pilot study with human colorectal cancer (CRC) and its mouse model C57BL/6J ApcMin/+, focusing on human 5q22.2 and 18q21.1-q21.2...
  5. pmc Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissue
    Dung Tsa Chen
    Biostatistics Department, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA
    Breast Cancer Res Treat 119:335-46. 2010
    ..95 with P < 0.0001) with microarray data. These results suggest a predictive role for the malignancy-risk signature in normal breast tissue. Proliferative biology dominates the earliest stages of tumor development...
  6. pmc Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    Domenico Coppola
    Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Am J Pathol 179:37-45. 2011
    ....
  7. pmc Correlation between Mcl-1 and pAKT protein expression in colorectal cancer
    Evita B Henderson-Jackson
    Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
    Int J Clin Exp Pathol 3:768-74. 2010
    ..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC...
  8. pmc SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    Neha Kabra
    Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 284:18210-7. 2009
    ..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer...
  9. pmc Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
    Cancer 113:2665-70. 2008
    ..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated...
  10. pmc Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometry
    Yi Chen
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
    J Proteome Res 9:4215-27. 2010
    ..This LC-MRM platform has been translated from in vitro models to clinical specimens, forming the basis for future experiments in patient assessment...
  11. pmc A predictive risk probability approach for microarray data with survival as an endpoint
    Dung Tsa Chen
    Biostatistics Division, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    J Biopharm Stat 18:841-52. 2008
    ..Third, analysis of resampling the risk probability suggested the variation pattern of the log-rank chi(2) in the colon cancer data set was unlikely caused by chance...
  12. ncbi request reprint Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution
    James F Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:288-94. 2008
    ....
  13. doi request reprint The 2010 Health Care Reform Act: a potential opportunity to advance cancer research by taking cancer personally
    William S Dalton
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 16:5987-96. 2010
    ....
  14. ncbi request reprint Differential expression of the Tie-2 receptor and its ligands in human pancreatic tumors
    Alan J Durkin
    Department of Surgery, University of South Florida College of Medicine and Tampa General Hospital, Digestive Disorders Center, Tampa, FL, USA
    J Am Coll Surg 199:724-31. 2004
    ....
  15. pmc Proteomic contributions to personalized cancer care
    John M Koomen
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Mol Cell Proteomics 7:1780-94. 2008
    ....
  16. doi request reprint Toward a measure of classification complexity in gene expression signatures
    Vidya Kamath
    Biomedical Engineering program at the University of South Florida, Tampa, Florida, USA
    Conf Proc IEEE Eng Med Biol Soc 2008:5704-7. 2008
    ..Therefore, classification complexity can be used to estimate maximum attainable accuracy for a problem reducing the need to evaluate many different classifiers...
  17. pmc A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancer
    Elizabeth R Remily-Wood
    Molecular Oncology and Proteomics, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
    Proteomics Clin Appl 5:383-96. 2011
    ..moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification...
  18. pmc Multi-platform, multi-site, microarray-based human tumor classification
    Greg Bloom
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 9497, USA
    Am J Pathol 164:9-16. 2004
    ..These cDNA- and oligonucleotide-based classifiers provide a first proof of principle that data derived from multiple platforms and performance sites can be exploited to build multi-tissue tumor classifiers...
  19. pmc Evaluation of malignancy-risk gene signature in breast cancer patients
    Dung Tsa Chen
    Biostatistics Division, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA
    Breast Cancer Res Treat 120:25-34. 2010
    ..Proliferative biology dominates not only the earliest stages of tumor development but also later stages of tumor progression and metastasis...
  20. ncbi request reprint Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia
    Ozlen Saglam
    Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 6:652-6. 2007
    ..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression...
  21. ncbi request reprint Down-regulation of pro-apoptotic genes is an early event in the progression of malignant melanoma
    Eric H Jensen
    Department of Interdisciplinary Oncology, Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Stabile Research Building, Room 22043, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Ann Surg Oncol 14:1416-23. 2007
    ..We used cDNA microarray to evaluate pro-apoptotic gene expression comparing normal skin to melanoma (thin and thick), nodal disease and distant metastases...
  22. ncbi request reprint Elucidation of a protein signature discriminating six common types of adenocarcinoma
    Gregory C Bloom
    Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 120:769-75. 2007
    ....
  23. ncbi request reprint EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinoma
    Alan J Durkin
    University of South Florida College of Medicine, Department of Surgery, Tampa General Hospital, Digestive Disorders Center, Tampa, Florida 33612, USA
    J Surg Res 135:195-201. 2006
    ..The purpose of this study was to determine whether inhibition of the epidermal growth factor receptor (EGFR) is a plausible therapeutic strategy in pancreatic cancer...
  24. ncbi request reprint HPP1-mediated tumor suppression requires activation of STAT1 pathways
    Abul Elahi
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 122:1567-72. 2008
    ..Moreover, activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties...
  25. ncbi request reprint Identification of molecular markers specific for pancreatic neuroendocrine tumors by genetic profiling of core biopsies
    Mark Bloomston
    Surgery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Ann Surg Oncol 11:413-9. 2004
    ..We hypothesized that novel markers for pancreatic neuroendocrine tumors could be identified with molecular fingerprinting of pooled RNA samples from core biopsies...
  26. ncbi request reprint DNA microarrays and data analysis: an overview
    Steven Eschrich
    Department of Surgery, Biostatistics and Bioinformatics Core, H Lee Moffitt Cancer Center and Research Institute, Tampa, Fla, USA
    Surgery 136:500-3. 2004
  27. ncbi request reprint Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotype
    Rosalyn B Irby
    Department of Surgery, H Lee Moffit Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    Cancer Res 65:1814-21. 2005
    ..In this manner, numerous members of a "transcriptional cascade" pathway for metastatic activity have been identified and functionally validated...
  28. ncbi request reprint The future of clinical cancer management: one tumor, one chip
    Timothy J Yeatman
    Department of Surgery, H Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Am Surg 69:41-4. 2003
    ..These developments signal a significant paradigm shift in the clinical management of human cancer...
  29. ncbi request reprint Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma
    James Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Clin Cancer Res 11:2478-85. 2005
    ....
  30. pmc Regulation of MDMX expression by mitogenic signaling
    Daniele M Gilkes
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 28:1999-2010. 2008
    ..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development...
  31. ncbi request reprint Prediction of radiation sensitivity using a gene expression classifier
    Javier F Torres-Roca
    Department of Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 65:7169-76. 2005
    ..We establish that radiation sensitivity can be predicted based on gene expression profiles and we introduce a genomic approach to the identification of novel molecular markers of radiation sensitivity...
  32. ncbi request reprint Flat and polypoid adenocarcinomas of the colorectum: A comparative histomorphologic analysis of 47 cases
    Aejaz Nasir
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
    Hum Pathol 35:604-11. 2004
    ..Based on these data, FCRC appears to be a worse subtype of colon cancer than PCRC. Further appraisal of FCRCs and additional studies to further elucidate the molecular mechanisms underlying their morphogenesis are warranted...
  33. pmc SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikis
    Hirohito Yamaguchi
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:19112-8. 2008
    ..Together, these results suggest that phosphorylation of Bif-1 impairs its binding to Bax and represses apoptosis, providing another mechanism by which Src oncogenic signaling can prevent cell death...
  34. ncbi request reprint Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma
    Jennifer Reed
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
    Clin Colorectal Cancer 2:119-22. 2002
    ..However, further study of c-Kit expression in poorly differentiated colon cancers may be useful since these generally chemoresistant tumors may respond to therapy with inhibitor compounds directed against c-Kit...
  35. ncbi request reprint Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies
    Domenico Coppola
    Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA
    Clin Cancer Res 10:184-90. 2004
    ..Although various studies have assessed OPN protein levels in several tumor types, a broad survey of OPN expression in human neoplasia under the same experimental conditions has not been carried out...
  36. ncbi request reprint Regulation of caspase expression and apoptosis by adenomatous polyposis coli
    Tingan Chen
    Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA
    Cancer Res 63:4368-74. 2003
    ..These data provide support for the hypothesis that one of the functions of APC is the regulation of caspase activity and other apoptotic proteins by controlling their expression levels in the cell...
  37. ncbi request reprint Osteopontin and colon cancer progression
    Timothy J Yeatman
    H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Clin Exp Metastasis 20:85-90. 2003
    ....
  38. ncbi request reprint The future of cancer management: translating the genome, transcriptome, and proteome
    Timothy J Yeatman
    Department of Surgery, H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
    Ann Surg Oncol 10:7-14. 2003
    ..In particular, we will focus on the potential for clinical application of microarray-based gene-expression profiling to the diagnosis, prognosis, and therapy of malignancies...
  39. ncbi request reprint Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples
    Barbara A Centeno
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33609, USA
    Cancer 105:101-9. 2005
    ..For this technology to be relevant, however, it must be applicable to tumor biopsy samples, which most often are fine-needle aspiration biopsy (FNAB) samples...
  40. pmc Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancer
    Susan McCarthy
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA
    Mol Oncol 1:196-204. 2007
    ..Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role...
  41. ncbi request reprint The promise of microarray technology in melanoma care
    Christina J Kim
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, USA
    Cancer Control 9:49-53. 2002
    ..These DNA alterations result in significant changes in gene expression that may now be measured and catalogued. The microarray technique screens and identifies expressed genes that may be responsible for tumorigenesis...
  42. pmc A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiation
    Steven A Eschrich
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Int J Radiat Oncol Biol Phys 75:489-96. 2009
    ..Development of a radiosensitivity predictive assay is a central goal of radiation oncology. We reasoned a gene expression model could be developed to predict intrinsic radiosensitivity and treatment response in patients...
  43. ncbi request reprint The potential role of gene expression in the management of primary and metastatic colorectal cancer
    Michael D Alvarado
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Cancer Control 13:27-31. 2006
    ..Although there have been recent advances in treatment of colorectal cancer, microarray technology has the potential to improve the application of these therapies by interrogating tumor-specific molecular "fingerprints."..
  44. ncbi request reprint Microarrays in gastrointestinal cancer: is personalized prediction of response to chemotherapy at hand?
    Eric H Jensen
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Curr Opin Oncol 18:374-80. 2006
    ..This review outlines some of the more recent advances in the use of microarrays as a novel means to advance the standard of care for patients with gastrointestinal cancers...
  45. ncbi request reprint Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways
    Scott T Kelley
    H Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
    Clin Colorectal Cancer 5:114-8. 2005
    ..We tested the hypothesis that rectal tumors are most responsive to neoadjuvant therapy if they possess p53 and/or caspase 8 activity...
  46. ncbi request reprint Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy
    Aejaz Nasir
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, USA
    Clin Colorectal Cancer 3:243-7. 2004
    ..Our data also suggest that stratification of patients with CRC into right- and left-sided subsets may be important in optimal patient selection for COX-2 inhibitor therapy and for subsequent assessment of objective therapeutic response...
  47. pmc Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosis
    Chang Gong Li
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Int J Cancer 123:273-82. 2008
    ..Our findings show that Insig2 is a novel colon cancer biomarker, and suggest, for the first time, a reasonable connection between Insig2 and Bax-mediated apoptosis through the mitochondrial pathway...
  48. ncbi request reprint Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utility
    Aejaz Nasir
    Gastrointestinal Tumor Program, Neuroendocrine Cancer Research, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Cancer Control 13:52-60. 2006
    ..In patients with SSTR-negative ETs, the clinical response is generally absent or suboptimal, while nonfunctioning ETs with SSTR positivity show a variable response to such therapy...
  49. ncbi request reprint Defining the role of the epidermal growth factor receptor in pancreatic cancer grown in vitro
    Alan J Durkin
    Department of Surgery, GI Tumor Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, P O Box 1289, Room F 145, Tampa, FL 33601, USA
    Am J Surg 186:431-6. 2003
    ..The purpose of this study was to determine the effect of a novel epidermal growth factor (EGF) receptor tyrosine kinase inhibitor, Erlotinib, on pancreatic cancer cell lines of varying differentiation in vitro...
  50. ncbi request reprint Molecular staging for survival prediction of colorectal cancer patients
    Steven Eschrich
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 23:3526-35. 2005
    ..We hypothesized that molecular fingerprints could provide more accurate staging and potentially assist in directing adjuvant therapy...
  51. ncbi request reprint Osteopontin identified as colon cancer tumor progression marker
    Deepak Agrawal
    Department of Cell Biology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    C R Biol 326:1041-3. 2003
    ..Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression...
  52. ncbi request reprint Clinical relevance of targeted interference with Src-mediated signal transduction events
    Quan P Ly
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Recent Results Cancer Res 172:169-88. 2007
  53. doi request reprint Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum
    Rajesh M Nair
    Division of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9497, USA
    J Gastrointest Surg 12:1797-805; discussion 1805-6. 2008
    ..We report our experience of TAE for T2 and T3 rectal cancers following NCR...
  54. ncbi request reprint TNM staging is obsolete
    Pamela J Hodul
    J Surg Oncol 95:8-9. 2007
  55. ncbi request reprint Colon cancer clinical practice guidelines in oncology
    Paul F Engstrom
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 3:468-91. 2005
  56. pmc Within the fold: assessing differential expression measures and reproducibility in microarray assays
    Ivana V Yang
    The Institute for Genomic Research, Rockville, MD 20850, USA
    Genome Biol 3:research0062. 2002
    ..Further, the analysis of a large number of expression profiles is facilitated by a common reference sample, the construction of which must be carefully addressed...
  57. ncbi request reprint Anal canal cancer clinical practice guidelines in oncology
    Paul F Engstrom
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 3:510-5. 2005
  58. pmc Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation study
    Kerby Shedden
    Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
    Nat Med 14:822-7. 2008
    ..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas...
  59. ncbi request reprint Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarrays
    Kevin K Dobbin
    Cancer Diagnosis Program, National Cancer Institute NIH, Bethesda, MD 20894, USA
    Clin Cancer Res 11:565-72. 2005
    ..The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study...
  60. ncbi request reprint Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samples
    Mark Bloomston
    Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
    Cancer Res 66:2592-9. 2006
    ..Of these, fibrinogen gamma, a protein associated with the hypercoagulable state of pancreatic cancer, discriminated cancer from normal sera. Fibrinogen is a potential tumor marker in pancreatic cancer...
  61. ncbi request reprint Carcinoembryonic antigen, biomarker discovery, and trial design
    Timothy J Yeatman
    Ann Surg Oncol 13:600-1. 2006
  62. ncbi request reprint Rectal cancer clinical practice guidelines in oncology
    Paul F Engstrom
    Fox Chase Cancer Center, Philadelphia, PA, USA
    J Natl Compr Canc Netw 3:492-508. 2005

Research Grants15

  1. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy J Yeatman; Fiscal Year: 2010
    ..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
  2. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2009
    ..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
  3. Chip Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2007
    ..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
  4. Screening for Breast Cancer Using Molecular Signatures
    Timothy Yeatman; Fiscal Year: 2007
    ....
  5. Molecular Profiling to Predict Response to Chemotherapy
    Timothy Yeatman; Fiscal Year: 2004
    ..Finally, we will validate the expression and characterize the function of informative genes useful in tumor classification. ..
  6. SRC AS A NOVEL TARGET FOR HUMAN COLON CANCER THERAPY
    Timothy Yeatman; Fiscal Year: 2004
    ..The surgical residency and the Society of Surgical Oncology approved surgical oncology fellowship will provide a continuous stream of candidates for this comprehensive laboratory and clinical research experience. ..
  7. Chip-Based Diagnosis of Problematic Liver Tumors
    Timothy Yeatman; Fiscal Year: 2009
    ..Finally, the molecular classifiers will be tested using prospectively acquired Diopsy samples on tissues of known and unknown sites of origin. ..