Research Topics
Genomes and Genes | Timothy YeatmanSummaryAffiliation: H. Lee Moffitt Cancer Center and Research Institute Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
A renaissance for SRCTimothy J Yeatman
H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Nat Rev Cancer 4:470-80. 2004
On the eve of personalized medicine in oncologyTimothy J Yeatman
Total Cancer Care, H. Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Cancer Res 68:7250-2. 2008- EMT is the dominant program in human colon cancerAndre Loboda
Merck, Sharp and Dohme, West Point, PA 19486, USA
BMC Med Genomics 4:9. 2011..Colon cancer has been classically described by clinicopathologic features that permit the prediction of outcome only after surgical resection and staging... - Distinguishing between cancer driver and passenger gene alteration candidates via cross-species comparison: a pilot studyXinglai Ji
Department of Biochemistry and Molecular Biology, Institute of Bioinformatics, University of Georgia, Athens 30602, GA, USA
BMC Cancer 10:426. 2010..As an initial test of this strategy, we conducted a pilot study with human colorectal cancer (CRC) and its mouse model C57BL/6J ApcMin/+, focusing on human 5q22.2 and 18q21.1-q21.2... - Proliferative genes dominate malignancy-risk gene signature in histologically-normal breast tissueDung Tsa Chen
Biostatistics Department, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA
Breast Cancer Res Treat 119:335-46. 2010..95 with P < 0.0001) with microarray data. These results suggest a predictive role for the malignancy-risk signature in normal breast tissue. Proliferative biology dominates the earliest stages of tumor development... - Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profilingDomenico Coppola
Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Am J Pathol 179:37-45. 2011.... - Correlation between Mcl-1 and pAKT protein expression in colorectal cancerEvita B Henderson-Jackson
Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
Int J Clin Exp Pathol 3:768-74. 2010..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC... - SirT1 is an inhibitor of proliferation and tumor formation in colon cancerNeha Kabra
Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 284:18210-7. 2009..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer... - Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinomaDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
Cancer 113:2665-70. 2008..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated... - Quantification of beta-catenin signaling components in colon cancer cell lines, tissue sections, and microdissected tumor cells using reaction monitoring mass spectrometryYi Chen
H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
J Proteome Res 9:4215-27. 2010..This LC-MRM platform has been translated from in vitro models to clinical specimens, forming the basis for future experiments in patient assessment... - A predictive risk probability approach for microarray data with survival as an endpointDung Tsa Chen
Biostatistics Division, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
J Biopharm Stat 18:841-52. 2008..Third, analysis of resampling the risk probability suggested the variation pattern of the log-rank chi(2) in the colon cancer data set was unlikely caused by chance... - Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institutionJames F Helm
Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 15:288-94. 2008.... 
The 2010 Health Care Reform Act: a potential opportunity to advance cancer research by taking cancer personallyWilliam S Dalton
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Clin Cancer Res 16:5987-96. 2010....- Differential expression of the Tie-2 receptor and its ligands in human pancreatic tumorsAlan J Durkin
Department of Surgery, University of South Florida College of Medicine and Tampa General Hospital, Digestive Disorders Center, Tampa, FL, USA
J Am Coll Surg 199:724-31. 2004..Differential expression of Ang-2 in human tumors may be useful as a diagnostic and therapeutic target... - Proteomic contributions to personalized cancer careJohn M Koomen
H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Mol Cell Proteomics 7:1780-94. 2008.... - Toward a measure of classification complexity in gene expression signaturesVidya Kamath
Biomedical Engineering program at the University of South Florida, Tampa, Florida, USA
Conf Proc IEEE Eng Med Biol Soc 2008:5704-7. 2008..Therefore, classification complexity can be used to estimate maximum attainable accuracy for a problem reducing the need to evaluate many different classifiers... - A database of reaction monitoring mass spectrometry assays for elucidating therapeutic response in cancerElizabeth R Remily-Wood
Molecular Oncology and Proteomics, H Lee Moffitt Cancer Center, Tampa, FL 33612, USA
Proteomics Clin Appl 5:383-96. 2011..moffitt.org/QUAD/, facilitates widespread implementation of quantitative mass spectrometry in cancer biology and clinical research through sharing of methods and reagents for monitoring protein expression and modification... - Multi-platform, multi-site, microarray-based human tumor classificationGreg Bloom
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612-9497, USA
Am J Pathol 164:9-16. 2004..These cDNA- and oligonucleotide-based classifiers provide a first proof of principle that data derived from multiple platforms and performance sites can be exploited to build multi-tissue tumor classifiers... - Evaluation of malignancy-risk gene signature in breast cancer patientsDung Tsa Chen
Biostatistics Division, Moffitt Cancer Center and Research Institute, Tampa, FL, 33612, USA
Breast Cancer Res Treat 120:25-34. 2010..Proliferative biology dominates not only the earliest stages of tumor development but also later stages of tumor progression and metastasis... - Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasiaOzlen Saglam
Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Clin Colorectal Cancer 6:652-6. 2007..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression... - Down-regulation of pro-apoptotic genes is an early event in the progression of malignant melanomaEric H Jensen
Department of Interdisciplinary Oncology, Cutaneous Oncology Program, H Lee Moffitt Cancer Center and Research Institute, Stabile Research Building, Room 22043, 12902 Magnolia Drive, Tampa, FL 33612, USA
Ann Surg Oncol 14:1416-23. 2007..We used cDNA microarray to evaluate pro-apoptotic gene expression comparing normal skin to melanoma (thin and thick), nodal disease and distant metastases... - Elucidation of a protein signature discriminating six common types of adenocarcinomaGregory C Bloom
Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 120:769-75. 2007.... - EGF receptor antagonism improves survival in a murine model of pancreatic adenocarcinomaAlan J Durkin
University of South Florida College of Medicine, Department of Surgery, Tampa General Hospital, Digestive Disorders Center, Tampa, Florida 33612, USA
J Surg Res 135:195-201. 2006..05, Fisher's exact test). CONCLUSION: EGF receptor antagonism is not only a plausible therapy for treatment of ductal adenocarcinoma of the pancreas, but is also superior to matrix metalloproteinase inhibition alone or in combination... - HPP1-mediated tumor suppression requires activation of STAT1 pathwaysAbul Elahi
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 122:1567-72. 2008..Moreover, activation of the STAT1 pathway likely represents the principal mediator of HPP1's tumor suppressive properties... - Identification of molecular markers specific for pancreatic neuroendocrine tumors by genetic profiling of core biopsiesMark Bloomston
Surgery, Moffitt Cancer Center, Tampa, Florida 33612, USA
Ann Surg Oncol 11:413-9. 2004..These novel markers may prove useful as molecular markers or therapeutic targets unique to pancreatic neuroendocrine tumors... - DNA microarrays and data analysis: an overviewSteven Eschrich
Department of Surgery, Biostatistics and Bioinformatics Core, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla, USA
Surgery 136:500-3. 2004 - Iterative microarray and RNA interference-based interrogation of the SRC-induced invasive phenotypeRosalyn B Irby
Department of Surgery, H. Lee Moffit Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
Cancer Res 65:1814-21. 2005..In this manner, numerous members of a "transcriptional cascade" pathway for metastatic activity have been identified and functionally validated... - The future of clinical cancer management: one tumor, one chipTimothy J Yeatman
Department of Surgery, H. Lee Moffitt Cancer Center, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Am Surg 69:41-4. 2003..These developments signal a significant paradigm shift in the clinical management of human cancer... - Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinomaJames Helm
Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Clin Cancer Res 11:2478-85. 2005.... - Regulation of MDMX expression by mitogenic signalingDaniele M Gilkes
H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 28:1999-2010. 2008..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development... - Prediction of radiation sensitivity using a gene expression classifierJavier F Torres-Roca
Department of Interdisciplinary Oncology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Res 65:7169-76. 2005..We establish that radiation sensitivity can be predicted based on gene expression profiles and we introduce a genomic approach to the identification of novel molecular markers of radiation sensitivity... - Flat and polypoid adenocarcinomas of the colorectum: A comparative histomorphologic analysis of 47 casesAejaz Nasir
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Hum Pathol 35:604-11. 2004..Based on these data, FCRC appears to be a worse subtype of colon cancer than PCRC. Further appraisal of FCRCs and additional studies to further elucidate the molecular mechanisms underlying their morphogenesis are warranted... - SRC directly phosphorylates Bif-1 and prevents its interaction with Bax and the initiation of anoikisHirohito Yamaguchi
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 283:19112-8. 2008..Together, these results suggest that phosphorylation of Bif-1 impairs its binding to Bax and represses apoptosis, providing another mechanism by which Src oncogenic signaling can prevent cell death... - Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinomaJennifer Reed
Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
Clin Colorectal Cancer 2:119-22. 2002..However, further study of c-Kit expression in poorly differentiated colon cancers may be useful since these generally chemoresistant tumors may respond to therapy with inhibitor compounds directed against c-Kit... - Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologiesDomenico Coppola
Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA
Clin Cancer Res 10:184-90. 2004..The strong correlation between pathological stage and OPN across multiple tumor types suggests a role for OPN in tumor progression... - Regulation of caspase expression and apoptosis by adenomatous polyposis coliTingan Chen
Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA
Cancer Res 63:4368-74. 2003..These data provide support for the hypothesis that one of the functions of APC is the regulation of caspase activity and other apoptotic proteins by controlling their expression levels in the cell... - Osteopontin and colon cancer progressionTimothy J Yeatman
H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
Clin Exp Metastasis 20:85-90. 2003.... - The future of cancer management: translating the genome, transcriptome, and proteomeTimothy J Yeatman
Department of Surgery, H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612, USA
Ann Surg Oncol 10:7-14. 2003..In particular, we will focus on the potential for clinical application of microarray-based gene-expression profiling to the diagnosis, prognosis, and therapy of malignancies... - Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samplesBarbara A Centeno
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33609, USA
Cancer 105:101-9. 2005..For this technology to be relevant, however, it must be applicable to tumor biopsy samples, which most often are fine-needle aspiration biopsy (FNAB) samples... - Green tea catechins suppress the DNA synthesis marker MCM7 in the TRAMP model of prostate cancerSusan McCarthy
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida, USA
Mol Oncol 1:196-204. 2007..Together, these results suggest a possible role of GTCs in CaP chemoprevention in which MCM7 plays a critical role... - The promise of microarray technology in melanoma careChristina J Kim
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, USA
Cancer Control 9:49-53. 2002..It may be possible to efficiently screen the entire human genome to identify the particular aberrations in gene expression responsible for tumorigenesis in melanoma... - A gene expression model of intrinsic tumor radiosensitivity: prediction of response and prognosis after chemoradiationSteven A Eschrich
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Int J Radiat Oncol Biol Phys 75:489-96. 2009..Development of a radiosensitivity predictive assay is a central goal of radiation oncology. We reasoned a gene expression model could be developed to predict intrinsic radiosensitivity and treatment response in patients... - The potential role of gene expression in the management of primary and metastatic colorectal cancerMichael D Alvarado
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612-9497, USA
Cancer Control 13:27-31. 2006..Future care may soon incorporate the data derived from a single microarray chip or similar technology that will describe a patient's tumor, predict prognosis, and direct specific therapy... - Microarrays in gastrointestinal cancer: is personalized prediction of response to chemotherapy at hand?Eric H Jensen
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Curr Opin Oncol 18:374-80. 2006..This review outlines some of the more recent advances in the use of microarrays as a novel means to advance the standard of care for patients with gastrointestinal cancers... - Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathwaysScott T Kelley
H. Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
Clin Colorectal Cancer 5:114-8. 2005.... - Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapyAejaz Nasir
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, USA
Clin Colorectal Cancer 3:243-7. 2004..Our data also suggest that stratification of patients with CRC into right- and left-sided subsets may be important in optimal patient selection for COX-2 inhibitor therapy and for subsequent assessment of objective therapeutic response... - Insig2 is associated with colon tumorigenesis and inhibits Bax-mediated apoptosisChang Gong Li
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Int J Cancer 123:273-82. 2008..Our findings show that Insig2 is a novel colon cancer biomarker, and suggest, for the first time, a reasonable connection between Insig2 and Bax-mediated apoptosis through the mitochondrial pathway... - Somatostatin receptor profiling in hepatic metastases from small intestinal and pancreatic neuroendocrine neoplasms: immunohistochemical approach with potential clinical utilityAejaz Nasir
Gastrointestinal Tumor Program, Neuroendocrine Cancer Research, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Cancer Control 13:52-60. 2006..In patients with SSTR-negative ETs, the clinical response is generally absent or suboptimal, while nonfunctioning ETs with SSTR positivity show a variable response to such therapy... - Defining the role of the epidermal growth factor receptor in pancreatic cancer grown in vitroAlan J Durkin
Department of Surgery, GI Tumor Program, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, P.O. Box 1289, Room F-145, Tampa, FL 33601, USA
Am J Surg 186:431-6. 2003..05). The EGF augmentation increased proliferation of each cell line but this increase was only significant in AsPc-1. CONCLUSIONS: Inhibition of EGF receptor is a valid therapeutic strategy in pancreatic cancer... - Molecular staging for survival prediction of colorectal cancer patientsSteven Eschrich
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Clin Oncol 23:3526-35. 2005..CONCLUSION: These data support further evaluation of molecular staging to discriminate good from poor prognosis patients, with the potential to direct adjuvant therapy... - Osteopontin identified as colon cancer tumor progression markerDeepak Agrawal
Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
C R Biol 326:1041-3. 2003..Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression... - Clinical relevance of targeted interference with Src-mediated signal transduction eventsQuan P Ly
H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Recent Results Cancer Res 172:169-88. 2007 - Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectumRajesh M Nair
Division of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9497, USA
J Gastrointest Surg 12:1797-805; discussion 1805-6. 2008..We report our experience of TAE for T2 and T3 rectal cancers following NCR... - TNM staging is obsoletePamela J Hodul
J Surg Oncol 95:8-9. 2007 - Colon cancer clinical practice guidelines in oncologyPaul F Engstrom
Fox Chase Cancer Center, Philadelphia, PA, USA
J Natl Compr Canc Netw 3:468-91. 2005 - Within the fold: assessing differential expression measures and reproducibility in microarray assaysIvana V Yang
The Institute for Genomic Research, Rockville, MD 20850, USA
Genome Biol 3:research0062. 2002..We show that pooled reference samples should be based not only on the expression of individual genes in each cell line but also on the expression levels of genes within cell lines... - Anal canal cancer clinical practice guidelines in oncologyPaul F Engstrom
Fox Chase Cancer Center, Philadelphia, PA, USA
J Natl Compr Canc Netw 3:510-5. 2005 - Gene expression-based survival prediction in lung adenocarcinoma: a multi-site, blinded validation studyKerby Shedden
Department of Statistics, 1085 South University, University of Michigan, Ann Arbor, Michigan 48109, USA
Nat Med 14:822-7. 2008..This study also provides the largest available set of microarray data with extensive pathological and clinical annotation for lung adenocarcinomas... - Interlaboratory comparability study of cancer gene expression analysis using oligonucleotide microarraysKevin K Dobbin
Cancer Diagnosis Program, National Cancer Institute NIH, Bethesda, MD 20894, USA
Clin Cancer Res 11:565-72. 2005..The findings indicate that under properly controlled conditions it is feasible to perform complete tumor microarray analysis, from tissue processing to hybridization and scanning, at multiple independent laboratories for a single study... - Fibrinogen gamma overexpression in pancreatic cancer identified by large-scale proteomic analysis of serum samplesMark Bloomston
Division of Surgical Oncology, James Cancer Hospital and Solove Research Institute, Columbus, Ohio, USA
Cancer Res 66:2592-9. 2006..Of these, fibrinogen gamma, a protein associated with the hypercoagulable state of pancreatic cancer, discriminated cancer from normal sera. Fibrinogen is a potential tumor marker in pancreatic cancer... - Carcinoembryonic antigen, biomarker discovery, and trial designTimothy J Yeatman
Ann Surg Oncol 13:600-1. 2006 - Rectal cancer clinical practice guidelines in oncologyPaul F Engstrom
Fox Chase Cancer Center, Philadelphia, PA, USA
J Natl Compr Canc Netw 3:492-508. 2005
Research Grants
- Chip-Based Diagnosis of Problematic Liver TumorsTimothy J Yeatman; Fiscal Year: 2010..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
- Chip-Based Diagnosis of Problematic Liver TumorsTimothy Yeatman; Fiscal Year: 2009..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
- Chip Based Diagnosis of Problematic Liver TumorsTimothy Yeatman; Fiscal Year: 2007..Finally, the molecular classifiers will be tested using prospectively acquired biopsy samples on tissues of known and unknown sites of origin. ..
- Screening for Breast Cancer Using Molecular SignaturesTimothy Yeatman; Fiscal Year: 2007....
- Molecular Profiling to Predict Response to ChemotherapyTimothy Yeatman; Fiscal Year: 2004..Finally, we will validate the expression and characterize the function of informative genes useful in tumor classification. ..
- SRC AS A NOVEL TARGET FOR HUMAN COLON CANCER THERAPYTimothy Yeatman; Fiscal Year: 2004..The surgical residency and the Society of Surgical Oncology approved surgical oncology fellowship will provide a continuous stream of candidates for this comprehensive laboratory and clinical research experience. ..
- Chip-Based Diagnosis of Problematic Liver TumorsTimothy Yeatman; Fiscal Year: 2009..Finally, the molecular classifiers will be tested using prospectively acquired Diopsy samples on tissues of known and unknown sites of origin. ..