Mokenge Malafa

Summary

Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Country: USA

Publications

  1. pmc Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
    Pamela J Hodul
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 8:e52526. 2013
  2. ncbi request reprint Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer
    Kazim Husain
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612
    Cancer Prev Res (Phila) 6:1074-83. 2013
  3. ncbi request reprint The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care
    Mokenge P Malafa
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Control 16:318-27. 2009
  4. pmc Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer
    Kazim Husain
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Ther 10:2363-72. 2011
  5. doi request reprint Florida Initiative for Quality Cancer Care: improvements on colorectal cancer quality of care indicators during a 3-year interval
    Erin M Siegel
    Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL Electronic address
    J Am Coll Surg 218:16-25.e1-4. 2014
  6. ncbi request reprint Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia
    Ozlen Saglam
    Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 6:652-6. 2007
  7. pmc Evaluating the quality of colorectal cancer care in the state of Florida: results from the Florida Initiative for Quality Cancer Care
    Erin M Siegel
    Moffitt Cancer Center, Tampa, FL 33612, USA
    J Oncol Pract 8:239-45. 2012
  8. doi request reprint Evaluating the quality of psychosocial care in outpatient medical oncology settings using performance indicators
    Paul B Jacobsen
    Moffitt Cancer Center, Tampa, FL 33612, USA
    Psychooncology 20:1221-7. 2011
  9. pmc Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer
    Manish Patel
    Division of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Surg Oncol 104:155-61. 2011
  10. ncbi request reprint Initial evaluation of quality indicators for psychosocial care of adults with cancer
    Paul B Jacobsen
    Department of Health Outcomes and Behavior, the H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Control 16:328-34. 2009

Collaborators

Detail Information

Publications28

  1. pmc Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
    Pamela J Hodul
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 8:e52526. 2013
    ....
  2. ncbi request reprint Vitamin E δ-tocotrienol prolongs survival in the LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre (KPC) transgenic mouse model of pancreatic cancer
    Kazim Husain
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612
    Cancer Prev Res (Phila) 6:1074-83. 2013
    ..These results strongly support further investigation of VEDT alone and in combination with gemcitabine for pancreatic cancer prevention and treatment...
  3. ncbi request reprint The Florida Initiative for Quality Cancer Care: a regional project to measure and improve cancer care
    Mokenge P Malafa
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Control 16:318-27. 2009
    ..The ultimate goal of the FIQCC is to improve cancer care throughout the state. This report provides an overview of the development and implementation of the FIQCC...
  4. pmc Vitamin E δ-tocotrienol augments the antitumor activity of gemcitabine and suppresses constitutive NF-κB activation in pancreatic cancer
    Kazim Husain
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Ther 10:2363-72. 2011
    ..Our data also support future clinical investigation of δ-tocotrienol to augment gemcitabine activity in pancreatic cancer...
  5. doi request reprint Florida Initiative for Quality Cancer Care: improvements on colorectal cancer quality of care indicators during a 3-year interval
    Erin M Siegel
    Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL Electronic address
    J Am Coll Surg 218:16-25.e1-4. 2014
    ..The current report focuses on evaluating the direction and magnitude of change in adherence to QCIs for colorectal cancer patients between the 2 assessments...
  6. ncbi request reprint Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia
    Ozlen Saglam
    Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 6:652-6. 2007
    ..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression...
  7. pmc Evaluating the quality of colorectal cancer care in the state of Florida: results from the Florida Initiative for Quality Cancer Care
    Erin M Siegel
    Moffitt Cancer Center, Tampa, FL 33612, USA
    J Oncol Pract 8:239-45. 2012
    ..This study assessed adherence to validated quality indicators in colorectal cancer (CRC) and the variability in adherence by practice site, volume, and patient age...
  8. doi request reprint Evaluating the quality of psychosocial care in outpatient medical oncology settings using performance indicators
    Paul B Jacobsen
    Moffitt Cancer Center, Tampa, FL 33612, USA
    Psychooncology 20:1221-7. 2011
    ..The present report describes the first large-scale use of these indicators to evaluate psychosocial care in outpatient medical oncology settings...
  9. pmc Neoadjuvant GTX chemotherapy and IMRT-based chemoradiation for borderline resectable pancreatic cancer
    Manish Patel
    Division of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Surg Oncol 104:155-61. 2011
    ..The utility of computed tomography (CT), endoscopic ultrasound (EUS), positron emission tomography (PET), and CA 19-9 during diagnostic workup and assessment of response was also examined...
  10. ncbi request reprint Initial evaluation of quality indicators for psychosocial care of adults with cancer
    Paul B Jacobsen
    Department of Health Outcomes and Behavior, the H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Cancer Control 16:328-34. 2009
    ..The American Psychosocial Oncology Society has developed the first indicators of the quality of psychosocial care for cancer patients. This report describes the initial evaluation of these indicators...
  11. doi request reprint Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA
    Cancer 115:4080-9. 2009
    ....
  12. ncbi request reprint Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution
    James F Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:288-94. 2008
    ....
  13. doi request reprint Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels
    Aejaz Nasir
    Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Pancreas 36:309-13. 2008
    ..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy...
  14. ncbi request reprint Silencing of the candidate tumor suppressor gene solute carrier family 5 member 8 (SLC5A8) in human pancreatic cancer
    Jong Y Park
    Division of Cancer Prevention and Control, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Pancreas 36:e32-9. 2008
    ....
  15. ncbi request reprint Early detection of pancreatic cancer: why, who, and how to screen
    Jason Klapman
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:280-7. 2008
    ..Because of the relatively low incidence, current efforts are focused on early detection and screening only in patients at high risk for the development of the disease...
  16. ncbi request reprint PET/CT fusion scan enhances CT staging in patients with pancreatic neoplasms
    Jeffrey M Farma
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Ann Surg Oncol 15:2465-71. 2008
    ..PET/CT may serve as an adjunct to standard imaging by increasing occult metastases detection. The purpose of this study was to assess the additional value, in relation to computed tomography (CT), of PET/CT imaging for patients with PN...
  17. pmc Measuring quality of care in the treatment of colorectal cancer: the moffitt quality practice initiative
    Paul B Jacobsen
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL Space Coast Medical Associates, Titusville, FL Center for Cancer Care and Research, Lakeland, FL and Sarasota Memorial Hospital, Sarasota, FL
    J Oncol Pract 3:60-5. 2007
    ..The initial phase of this project focused on developing procedures, determining feasibility, and evaluating utility for assessing quality of care for colorectal cancer within an existing affiliate network...
  18. doi request reprint IκB Kinase ε expression in pancreatic ductal adenocarcinoma
    Anna Cheng
    Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Am J Clin Pathol 136:60-6. 2011
    ..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention...
  19. ncbi request reprint Biomarkers predict outcomes following cytoreductive surgery for hepatic metastases from functional carcinoid tumors
    Eric H Jensen
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Ann Surg Oncol 14:780-5. 2007
    ..We evaluated whether CgA and 5HIAA could predict symptomatic relief and control of disease progression after cytoreductive surgery...
  20. ncbi request reprint Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia
    Elizabeth Sagatys
    Division of Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Hum Pathol 38:1526-31. 2007
    ....
  21. pmc MicroRNAs in pancreatic ductal adenocarcinoma
    Jong Y Park
    Jong Y Park, Division of Cancer Prevention and Control, Moffitt Cancer Center, FL 33612, United States
    World J Gastroenterol 17:817-27. 2011
    ..The purpose of this review is to summarize our knowledge of deregulated miRNA expression in pancreatic cancer and discuss the implication for potential translation of this knowledge into clinical practice...
  22. doi request reprint Long-term results of transanal excision after neoadjuvant chemoradiation for T2 and T3 adenocarcinomas of the rectum
    Rajesh M Nair
    Division of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9497, USA
    J Gastrointest Surg 12:1797-805; discussion 1805-6. 2008
    ..We report our experience of TAE for T2 and T3 rectal cancers following NCR...
  23. pmc Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration
    Kazim Husain
    Department of Gastrointestinal Oncology and Drug Discovery, Moffitt Cancer Center, Department of Oncological Sciences University of South Florida, Tampa, FL 33612, USA
    Pharmacology 83:157-63. 2009
    ..Our data suggest that bioactive levels of delta-tocotrienol can be achieved in the pancreas following oral administration and supports its clinical investigation in pancreatic cancer...
  24. ncbi request reprint Green tea polyphenols in the prevention of colon cancer
    Nagi Kumar
    Division of Health Outcomes and Behavior, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Front Biosci 12:2309-15. 2007
    ....
  25. ncbi request reprint Targeting AKT protein kinase in gastric cancer
    Khaldoun Almhanna
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Anticancer Res 31:4387-92. 2011
    ..In this article, we will review the current knowledge on AKT signaling in the pathogenesis of gastric cancer and the evolving therapeutic implications of targeting this pathway...
  26. ncbi request reprint Interdisciplinary management of an intraductal papillary mucinous neoplasm of the pancreas
    Rajesh M Nair
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:322-33. 2008
    ..Often multifocal in its existence along the pancreatic duct, IPMN is associated with a significant risk for recurrence and warrants vigilant surveillance, even after a margin-negative resection...
  27. ncbi request reprint RRR-alpha-tocopherol succinate down-regulates oncogenic Ras signaling
    Sreenivasa Donapaty
    Gastrointestinal Tumor Program, Division of Gastrointestinal Tumors, Department of Interdisciplinary Oncology, University of South Florida, Tampa, Florida 33612, USA
    Mol Cancer Ther 5:309-16. 2006
    ..This data supports further investigation of the chemopreventive and therapeutic potential of TS in tumors that are dependent on activated Ras signaling and identifies phosphor-Erk and phosphor-Akt as potential biomarkers of TS activity...
  28. ncbi request reprint Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis
    Mokenge P Malafa
    Division of GI Tumors, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 118:2441-7. 2006
    ..These results suggest a potential therapeutic utility of VES for patients with prostate cancer...

Research Grants3

  1. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge Malafa; Fiscal Year: 2009
    ..The results from these studies will advance our understanding of how a bioactive food component such as delta-tocotrienol can be exploited for the prevention and treatment of pancreatic cancer. ..
  2. Intervention of Pancreatic Oncogenic Pathways with Dietary Tocotrienol
    Mokenge P Malafa; Fiscal Year: 2010
    ..The results from these studies will advance our understanding of how a bioactive food component such as delta-tocotrienol can be exploited for the prevention and treatment of pancreatic cancer. ..