Ambuj Kumar

Summary

Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Country: USA

Publications

  1. doi request reprint Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis
    Ambuj Kumar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA
    J Natl Cancer Inst 101:100-6. 2009
  2. doi request reprint Bisphosphonates in multiple myeloma: a network meta-analysis
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 5:CD003188. 2012
  3. ncbi request reprint Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: what is the published evidence?
    Mohamed A Kharfan-Dabaja
    Division of Blood and Marrow Transplantation, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Rsearch Institute, University of South Florida, Tampa, FL 33612, USA
    Br J Haematol 139:234-42. 2007
  4. doi request reprint Optimal information size in trial sequential analysis of time-to-event outcomes reveals potentially inconclusive results because of the risk of random error
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, 3515 East Fletcher Avenue, MDC 27, Tampa, FL 33612, USA
    J Clin Epidemiol 66:654-9. 2013
  5. pmc Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    BMJ 331:1295. 2005
  6. pmc Treatment success in cancer: industry compared to publicly sponsored randomized controlled trials
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, Florida, USA
    PLoS ONE 8:e58711. 2013
  7. doi request reprint Gemtuzumab ozogamicin for treatment of newly diagnosed acute myeloid leukaemia: a systematic review and meta-analysis
    Mohamed A Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Tampa, FL, USA Department of Oncologic Sciences, H Lee Moffitt Cancer Center University of South Florida College of Medicine, Tampa, FL, USA
    Br J Haematol 163:315-25. 2013
  8. pmc Instrumental variable meta-analysis of individual patient data: application to adjust for treatment non-compliance
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Res Methodol 11:55. 2011
  9. doi request reprint Role of high-dose chemotherapy and autologous hematopoietic cell transplantation in primary systemic amyloidosis: a systematic review
    Rahul Mhaskar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Biol Blood Marrow Transplant 15:893-902. 2009
  10. pmc Published methodological quality of randomized controlled trials does not reflect the actual quality assessed in protocols
    Rahul Mhaskar
    Division and Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Clin Epidemiol 65:602-9. 2012

Detail Information

Publications35

  1. doi request reprint Tandem versus single autologous hematopoietic cell transplantation for the treatment of multiple myeloma: a systematic review and meta-analysis
    Ambuj Kumar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, FL, USA
    J Natl Cancer Inst 101:100-6. 2009
    ..We performed a systematic review and meta-analysis to synthesize the existing evidence related to the effectiveness of tandem vs single AHCT in patients with MM...
  2. doi request reprint Bisphosphonates in multiple myeloma: a network meta-analysis
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 5:CD003188. 2012
    ..This is an update of a Cochrane review first published in 2002 and previously updated in 2010...
  3. ncbi request reprint Systematic review of high dose chemotherapy and autologous haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: what is the published evidence?
    Mohamed A Kharfan-Dabaja
    Division of Blood and Marrow Transplantation, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Rsearch Institute, University of South Florida, Tampa, FL 33612, USA
    Br J Haematol 139:234-42. 2007
    ..It is uncertain whether autograft is superior to conventional therapy. The high incidence of myelodysplastic syndrome (9-12%) is particularly concerning in CLL, where median survival is 9 years...
  4. doi request reprint Optimal information size in trial sequential analysis of time-to-event outcomes reveals potentially inconclusive results because of the risk of random error
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, 3515 East Fletcher Avenue, MDC 27, Tampa, FL 33612, USA
    J Clin Epidemiol 66:654-9. 2013
    ..We conducted a TSA for time-to-event outcomes and applied the method to determine the risk of random error in MAs for treatments of multiple myeloma...
  5. pmc Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    BMJ 331:1295. 2005
    ....
  6. pmc Treatment success in cancer: industry compared to publicly sponsored randomized controlled trials
    Benjamin Djulbegovic
    Center for Evidence based medicine and Health Outcomes Research, Tampa, Florida, USA
    PLoS ONE 8:e58711. 2013
    ..To assess if commercially sponsored trials are associated with higher success rates than publicly-sponsored trials...
  7. doi request reprint Gemtuzumab ozogamicin for treatment of newly diagnosed acute myeloid leukaemia: a systematic review and meta-analysis
    Mohamed A Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Tampa, FL, USA Department of Oncologic Sciences, H Lee Moffitt Cancer Center University of South Florida College of Medicine, Tampa, FL, USA
    Br J Haematol 163:315-25. 2013
    ..Addition of GO to conventional chemotherapy as induction therapy may improve relapse-free and event-free survival, but does not impact overall survival and significantly increases early mortality in AML. ..
  8. pmc Instrumental variable meta-analysis of individual patient data: application to adjust for treatment non-compliance
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    BMC Med Res Methodol 11:55. 2011
    ..Our objective is to correct for bias in non-experimental data from previously published individual patient data meta-analysis by applying IV methods..
  9. doi request reprint Role of high-dose chemotherapy and autologous hematopoietic cell transplantation in primary systemic amyloidosis: a systematic review
    Rahul Mhaskar
    Department of Health Outcomes and Behavior, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Biol Blood Marrow Transplant 15:893-902. 2009
    ..But the quality of our evidence is low, indicating a need for well-designed and adequately powered RCTs to better address the role of AHCT in AL amyloidosis...
  10. pmc Published methodological quality of randomized controlled trials does not reflect the actual quality assessed in protocols
    Rahul Mhaskar
    Division and Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Clinical and Translational Science Institute, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA
    J Clin Epidemiol 65:602-9. 2012
    ..To assess whether the reported methodological quality of randomized controlled trials (RCTs) reflects the actual methodological quality and to evaluate the association of effect size (ES) and sample size with methodological quality...
  11. ncbi request reprint Management of multiple myeloma: a systematic review and critical appraisal of published studies
    Ambuj Kumar
    Interdisciplinary Oncology Program of the H Lee Moffitt Cancer and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Lancet Oncol 4:293-304. 2003
    ..We conclude that the quality of total evidence supporting treatment recommendations in myeloma is modest at best and has an ample scope for improvement...
  12. ncbi request reprint Bisphosphonates in multiple myeloma
    Rahul Mhaskar
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 3:CD003188. 2010
    ..Also, with the baseline risk of 35% to 86% for SREs without treatment, we estimate that between six and 15 MM patients should be treated to prevent SRE(s) in one patient. No bisphoshphonate appears to be superior to others...
  13. ncbi request reprint External validation of a web-based prognostic tool for predicting survival for patients in hospice care
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, Morsani College of Medicine, University of South Florida, 3515 E Fletcher Avenue, MDT1200, Mail Code MDC27, Tampa, Florida 33612, USA
    J Palliat Care 29:140-6. 2013
    ..If it is to be useful to patients and clinicians, Prognostat needs to explicitly report patient risk scores and estimates of baseline survival...
  14. pmc Comparative efficacy of tandem autologous versus autologous followed by allogeneic hematopoietic cell transplantation in patients with newly diagnosed multiple myeloma: a systematic review and meta-analysis of randomized controlled trials
    Mohamed A Kharfan-Dabaja
    Blood and Marrow Transplantation Program, H Lee Moffitt Cancer Center University of South Florida College of Medicine, Tampa, FL, USA
    J Hematol Oncol 6:2. 2013
    ..A previously published meta-analysis has been reported; however, it suffers from serious methodological flaws...
  15. doi request reprint Trial sequential analysis may be insufficient to draw firm conclusions regarding statistically significant treatment differences using observed intervention effects: a case study of meta-analyses of multiple myeloma trials
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL, USA
    Contemp Clin Trials 34:257-61. 2013
    ..We recommend that the conclusion of significant treatment differences in cumulative MA should be weighed against acceptable thresholds regarding the type I error, power and apriori specified clinically meaningful treatment difference...
  16. pmc Treatment success in cancer: new cancer treatment successes identified in phase 3 randomized controlled trials conducted by the National Cancer Institute-sponsored cooperative oncology groups, 1955 to 2006
    Benjamin Djulbegovic
    H Lee Moffitt Cancer Center, 12902 Magnolia Dr, MRC, Room 2067H, Tampa, FL 33612, USA
    Arch Intern Med 168:632-42. 2008
    ..We assessed how often experimental cancer treatments that undergo testing in randomized clinical trials (RCTs) result in discovery of successful new interventions...
  17. ncbi request reprint Treatment tolerance and efficacy in geriatric oncology: a systematic review of phase III randomized trials conducted by five National Cancer Institute-sponsored cooperative groups
    Ambuj Kumar
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Tampa, FL 33612, USA
    J Clin Oncol 25:1272-6. 2007
    ..A systematic review to assess the accurate participation of elderly patients in RCTs has not been performed...
  18. pmc Survival of patients with non-small cell lung cancer without treatment: a systematic review and meta-analysis
    Hesborn Wao
    Center for Evidence Based Medicine and Outcomes Research, Department of Internal Medicine, Morsani College of Medicine, University of South Florida Clinical and Translational Science Institute, 3515 East Fletcher Avenue, MDT 1202, Tampa, FL, 33612, USA
    Syst Rev 2:10. 2013
    ..Specifically, we estimated overall survival when no anticancer therapy is provided...
  19. pmc A flexible alternative to the Cox proportional hazards model for assessing the prognostic accuracy of hospice patient survival
    Branko Miladinovic
    Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, Florida, USA
    PLoS ONE 7:e47804. 2012
    ..Researchers involved in prognosticating patient survival are encouraged to consider the Royston-Parmar model as an alternative to Cox...
  20. ncbi request reprint What kind of evidence do patients and practitioners need: evidence profiles based on 5 key evidence-based principles to summarize data on benefits and harms
    Benjamin Djulbegovic
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Treat Rev 32:572-6. 2006
  21. ncbi request reprint Evidence profiles for colo-rectal cancer: benefit/harms data based on the totality of randomized evidence
    Ambuj Kumar
    H Lee Moffitt Cancer Center and Research Institute at the University of South Florida, Department of Interdisciplinary Oncology and Cancer Prevention and Control, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Treat Rev 32:577-80. 2006
  22. ncbi request reprint Evidence-based medicine for rare diseases: implications for data interpretation and clinical trial design
    Madhusmita Behera
    Malignant Hematology Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Control 14:160-6. 2007
    ..The randomized, controlled trial (RCT) is the "gold standard" for establishing the effect of any intervention. This approach, however, is often not feasible with rare diseases such as cutaneous T-cell lymphoma...
  23. doi request reprint Multiple myeloma: detecting the effects of new treatments
    Benjamin Djulbegovic
    Division of Hematologic Malignancies, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Lancet 371:1642-4. 2008
  24. pmc Optimism bias leads to inconclusive results-an empirical study
    Benjamin Djulbegovic
    Department of Medicine, Center for Evidence based medicine and Health Outcomes Research, University of South Florida, Tampa, FL 33612, USA
    J Clin Epidemiol 64:583-93. 2011
    ..We assessed the impact of optimism bias on a proportion of trials that did not answer their research question successfully and explored whether poor accrual or optimism bias is responsible for inconclusive results...
  25. pmc Systematic review and meta-analysis of ovarian cancers: estimation of microsatellite-high frequency and characterization of mismatch repair deficient tumor histology
    Tuya Pal
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Clin Cancer Res 14:6847-54. 2008
    ....
  26. pmc Efficacy and safety of prophylactic vaccines against cervical HPV infection and diseases among women: a systematic review & meta-analysis
    Beibei Lu
    Risk Assessment, Detection and Intervention Program, H, Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    BMC Infect Dis 11:13. 2011
    ..We conducted a systematic review and meta-analysis to assess efficacy and safety of prophylactic HPV vaccines against cervical cancer precursor events in women...
  27. ncbi request reprint Salvage radiotherapy increases survival in people with residual disease after chemotherapy for advance diffuse large cell lymphoma
    Ambuj Kumar
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Cancer Treat Rev 32:487-90. 2006
  28. pmc New treatments compared to established treatments in randomized trials
    Benjamin Djulbegovic
    USF Clinical Translational Science Institute, Dpts of Medicine, Hematology and Health Outcome Research, USF and H LeeMoffitt Cancer Center, USF Health Clinical Research, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 10:MR000024. 2012
    ..We investigated how often new, experimental treatments evaluated in randomized controlled trials (RCTs) are superior to established treatments...
  29. doi request reprint Efficacy of rituximab in the setting of steroid-refractory chronic graft-versus-host disease: a systematic review and meta-analysis
    Mohamed A Kharfan-Dabaja
    Department of Blood and Marrow Transplantation, Moffitt Cancer Center, Tampa, Florida, USA
    Biol Blood Marrow Transplant 15:1005-13. 2009
    ....
  30. pmc Bad reporting does not mean bad methods for randomised trials: observational study of randomised controlled trials performed by the Radiation Therapy Oncology Group
    Heloisa P Soares
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    BMJ 328:22-4. 2004
    ..To determine whether poor reporting of methods in randomised controlled trials reflects on poor methods...
  31. ncbi request reprint Allogeneic hematopoietic cell transplantation for adult acute lymphoblastic leukemia (ALL) in first complete remission
    Joseph Pidala
    Department of Blood and Marrow Transplantation, H Lee Moffitt Cancer Center, Division of Oncologic Sciences, University of South Florida, Tampa, Florida, USA
    Cochrane Database Syst Rev 10:CD008818. 2011
    ....
  32. pmc Do community health worker interventions improve rates of screening mammography in the United States? A systematic review
    Kristen J Wells
    University of South Florida, Tampa, FL 33612, USA
    Cancer Epidemiol Biomarkers Prev 20:1580-98. 2011
    ..Community health workers (CHW) are lay individuals who are trained to serve as liaisons between members of their communities and health care providers and services...
  33. ncbi request reprint Totality of evidence: one of the keys to better oncology management
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Dr, Tampa, FL 33612, USA
    J Oncol Manag 14:12-4. 2005
    ..Systematic review is the most promising technique to critically appraise and synthesize the findings and also argues for the totality of evidence, which is important for effective oncology management...
  34. ncbi request reprint Nonmyeloablative allogeneic stem-cell transplantation for hematologic malignancies: a systematic review
    Benjamin Djulbegovic
    Malignant Hematology Program, H Lee Moffitt Cancer Center Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Control 10:17-41. 2003
    ..They hypothesize that NM-allo-SCT is equally efficacious to standard allo-SCT but produces less regimen-related toxicity...
  35. ncbi request reprint Why evidence based oncology management
    Ambuj Kumar
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    J Oncol Manag 11:13-6. 2002