Domenico Coppola

Summary

Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Country: USA

Publications

  1. pmc EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
    Sandeep Singh
    Department of Tumor Biology, H, Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA
    Mol Cancer 11:73. 2012
  2. ncbi request reprint Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas
    Rodney Shackelford
    12902 Magnolia Drive, Tampa, FL, USA
    Anticancer Res 33:3047-52. 2013
  3. ncbi request reprint Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Anticancer Res 32:4963-9. 2012
  4. pmc Natriuretic peptide receptor a as a novel target for prostate cancer
    Xiaoqin Wang
    Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Cancer 10:56. 2011
  5. pmc Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines
    Rossella Solmi
    Dipartimento di Istologia, Embriologia e Biologia Applicata, Universita di Bologna, Via Belmeloro 8, 40126 Bologna, Italy
    BMC Cancer 8:227. 2008
  6. doi request reprint Substantially reduced expression of PIAS1 is associated with colon cancer development
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
    J Cancer Res Clin Oncol 135:1287-91. 2009
  7. doi request reprint Expression of the insulin-like growth factor receptor 1 during human embryogenesis
    Domenico Coppola
    Department of Interdisciplinary Oncology, Anatomic Pathology Division, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 9497, USA
    Fetal Pediatr Pathol 28:47-54. 2009
  8. pmc Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
    Cancer 113:2665-70. 2008
  9. pmc Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, University of South Florida, Tampa, FL, USA
    Pancreas 40:433-7. 2011
  10. ncbi request reprint Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway
    Madhavi Sekharam
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Res 63:7708-16. 2003

Detail Information

Publications100

  1. pmc EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer
    Sandeep Singh
    Department of Tumor Biology, H, Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL, 33612, USA
    Mol Cancer 11:73. 2012
    ..Further, we investigated if the self-renewal of SP cells is dependent on EGFR mediated signaling...
  2. ncbi request reprint Nicotinamide phosphoribosyltransferase and SIRT3 expression are increased in well-differentiated thyroid carcinomas
    Rodney Shackelford
    12902 Magnolia Drive, Tampa, FL, USA
    Anticancer Res 33:3047-52. 2013
    ....
  3. ncbi request reprint Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Anticancer Res 32:4963-9. 2012
    ..We evaluated MMR protein expression in three population-based samples of epithelial ovarian cancers...
  4. pmc Natriuretic peptide receptor a as a novel target for prostate cancer
    Xiaoqin Wang
    Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
    Mol Cancer 10:56. 2011
    ..However, the direct role of NPRA signaling in prostate cancer remains unclear...
  5. pmc Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell lines
    Rossella Solmi
    Dipartimento di Istologia, Embriologia e Biologia Applicata, Universita di Bologna, Via Belmeloro 8, 40126 Bologna, Italy
    BMC Cancer 8:227. 2008
    ..EGFR is frequently overexpressed in colon cancer. We characterized HT-29 and Caco-2, human colon cancer cell lines, untreated and treated with cetuximab or gefitinib alone and in combination with EGF...
  6. doi request reprint Substantially reduced expression of PIAS1 is associated with colon cancer development
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
    J Cancer Res Clin Oncol 135:1287-91. 2009
    ..PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer...
  7. doi request reprint Expression of the insulin-like growth factor receptor 1 during human embryogenesis
    Domenico Coppola
    Department of Interdisciplinary Oncology, Anatomic Pathology Division, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 9497, USA
    Fetal Pediatr Pathol 28:47-54. 2009
    ..On study shows the preferential IGF-1R immunolocalizatrion in specific areas of the developing embryo, suggesting a role of IGF1-R for the optimal maturation of those areas, during developing human embryos...
  8. pmc Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
    Cancer 113:2665-70. 2008
    ..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated...
  9. pmc Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma
    Domenico Coppola
    Department of Anatomic Pathology, University of South Florida, Tampa, FL, USA
    Pancreas 40:433-7. 2011
    ..Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied...
  10. ncbi request reprint Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway
    Madhavi Sekharam
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Cancer Res 63:7708-16. 2003
    ..Our data demonstrate, for the first time, that IGF1-R/Akt/Bcl-x(L) pathway may contribute to a more aggressive malignant phenotype, in a subset of colorectal cancers...
  11. pmc IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancer
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:3676-84. 2010
    ..These data suggest that ERalpha is a bona fide substrate of IKKepsilon and IKKepsilon plays an important role in tamoxifen resistance. Thus, IKKepsilon represents a critical therapeutic target in breast cancer...
  12. ncbi request reprint Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activity
    Jiazhi Sun
    Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
    Oncogene 24:3236-45. 2005
    ..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition...
  13. doi request reprint Expression of the antiapoptotic protein survivin in colon cancer
    Jonathan M Hernandez
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
    Clin Colorectal Cancer 10:188-93. 2011
    ..We sought to evaluate survivin expression in colonic neoplasia and identify relationships with additional regulators of apoptosis...
  14. pmc Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancer
    Kiran Mahajan
    Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 287:22112-22. 2012
    ....
  15. pmc MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA
    William Kong
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
    Mol Cell Biol 28:6773-84. 2008
    ..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention...
  16. doi request reprint SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinoma
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Pancreas 41:904-9. 2012
    ..This study aimed to assess the role of SLC5A8 expression in the survival of pancreatic cancer...
  17. pmc ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signaling
    Smitha Pillai
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
    Mol Cell Biol 31:3052-67. 2011
    ....
  18. pmc Correlation between Mcl-1 and pAKT protein expression in colorectal cancer
    Evita B Henderson-Jackson
    Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
    Int J Clin Exp Pathol 3:768-74. 2010
    ..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC...
  19. pmc Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancer
    Jian Ping Guo
    Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 175:324-33. 2009
    ..IKKepsilon could also serve as a prognostic marker and potential therapeutic target for this malignancy...
  20. ncbi request reprint AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistance
    Zeng Qiang Yuan
    Department of Pathology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 278:23432-40. 2003
    ..Further, regulation of the ASK1/JNK/p38/Bax pathway by AKT2 provides a new mechanism contributing to its antiapoptotic effects...
  21. pmc Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profiling
    Domenico Coppola
    Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Am J Pathol 179:37-45. 2011
    ....
  22. pmc ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumors
    Piyali Dasgupta
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Natl Cancer Inst 103:317-33. 2011
    ..However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known...
  23. doi request reprint Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancer
    James Helm
    Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA
    Cancer 115:4080-9. 2009
    ....
  24. ncbi request reprint Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinoma
    James Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
    Clin Cancer Res 11:2478-85. 2005
    ....
  25. ncbi request reprint Molecular staging for survival prediction of colorectal cancer patients
    Steven Eschrich
    Department of Surgery, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 23:3526-35. 2005
    ..We hypothesized that molecular fingerprints could provide more accurate staging and potentially assist in directing adjuvant therapy...
  26. pmc Nicotine promotes tumor growth and metastasis in mouse models of lung cancer
    Rebecca Davis
    Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 4:e7524. 2009
    ..This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches...
  27. ncbi request reprint Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasia
    Ozlen Saglam
    Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 6:652-6. 2007
    ..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression...
  28. ncbi request reprint Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptors
    Jiazhi Sun
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612, USA
    Oncogene 24:4701-9. 2005
    ..Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis...
  29. ncbi request reprint P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cells
    K Akhilender Naidu
    Division of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Anticancer Res 27:3927-34. 2007
    ..We have previously demonstrated that Asc-S inhibits ovarian carcinoma cell proliferation through modulation of the cell cycle. This study was designed to further elucidate the mechanisms underlying such regulation...
  30. pmc IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformation
    Jian Ping Guo
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 286:37389-98. 2011
    ..Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive Akt resulted from elevated IKBKE...
  31. doi request reprint Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinoma
    Dung Tsa Chen
    Department of Biomedical Informatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    J Gastrointest Surg 16:905-12; discussion 912-3. 2012
    ..However, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers...
  32. pmc MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancer
    Jian Jun Zhao
    H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 283:31079-86. 2008
    ....
  33. doi request reprint RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasms
    Aejaz Nasir
    Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Pancreas 40:627-33. 2011
    ....
  34. pmc SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    Neha Kabra
    Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    J Biol Chem 284:18210-7. 2009
    ..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer...
  35. pmc Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous mice
    Robert W Engelman
    Department of Pathology and Cell Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Exp Mol Pathol 82:234-44. 2007
    ..Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype...
  36. ncbi request reprint Osteopontin identified as colon cancer tumor progression marker
    Deepak Agrawal
    Department of Cell Biology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
    C R Biol 326:1041-3. 2003
    ..Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression...
  37. pmc Ack1 tyrosine kinase activation correlates with pancreatic cancer progression
    Kiran Mahajan
    Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Am J Pathol 180:1386-93. 2012
    ..Collectively, our data indicate that activated Ack1 could be a prognostic marker for ascertaining early or advanced pancreatic cancer. Thus, Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth...
  38. pmc Regulation of MDMX expression by mitogenic signaling
    Daniele M Gilkes
    H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 28:1999-2010. 2008
    ..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development...
  39. pmc Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancer
    Dung Tsa Chen
    Department of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Natl Cancer Inst 103:1859-70. 2011
    ..We hypothesized that the malignancy-risk gene signature has prognostic and predictive value for early-stage non-small cell lung cancer (NSCLC) patients...
  40. pmc MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancer
    William Kong
    Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
    J Biol Chem 285:17869-79. 2010
    ..In conclusion, our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer...
  41. ncbi request reprint Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologies
    Domenico Coppola
    Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA
    Clin Cancer Res 10:184-90. 2004
    ..Although various studies have assessed OPN protein levels in several tumor types, a broad survey of OPN expression in human neoplasia under the same experimental conditions has not been carried out...
  42. ncbi request reprint Role of p53, CD44V6 and CD57 in differentiating between benign and malignant follicular neoplasms of the thyroid
    Aejaz Nasir
    Department of Pathology, University of South Florida, College of Medicine Moffitt Cancer Center, Tampa, USA
    In Vivo 18:189-95. 2004
    ..The results of this study indicate that immunohistochemical detection of p53, CD44V6 and CD57 may have practical utility in the differential diagnosis of FCAs from FADs in routine surgical pathology...
  43. doi request reprint MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTEN
    Hua Yang
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    Cancer Res 68:425-33. 2008
    ..These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway...
  44. ncbi request reprint Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathway
    Quan Fang
    Department of Pathology Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Anticancer Res 26:203-9. 2006
    ..These studies indicate that the antiproliferative effect of ascorbyl stearate on ovarian epithelial cancer cells is associated with decreased PI3K/AKT activity, and point toward the PI3K/AKT signaling pathway as a target for this drug...
  45. pmc Vitamin E δ-tocotrienol induces p27(Kip1)-dependent cell-cycle arrest in pancreatic cancer cells via an E2F-1-dependent mechanism
    Pamela J Hodul
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
    PLoS ONE 8:e52526. 2013
    ....
  46. ncbi request reprint Evaluation of toxicity following electrically mediated interleukin-12 gene delivery in a B16 mouse melanoma model
    Loree Heller
    Department of Medical Microbiology and Immunology, University of South Florida, Tampa 33612, USA
    Clin Cancer Res 12:3177-83. 2006
    ..To translate this observation to the clinic, an evaluation of toxicity was done in the mouse model...
  47. ncbi request reprint Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitro
    Madhavi Sekharam
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612 9497, USA
    Anticancer Res 23:1517-24. 2003
    ..Based on the above observations, we conclude that an overexpressed and activated IGF1-R may increase the degree of transformation and motility of colon cancer cells by activating c-Src...
  48. doi request reprint First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomas
    Jonathan R Strosberg
    Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer 117:268-75. 2011
    ..The authors retrospectively evaluated the efficacy of capecitabine and temozolomide in 30 patients with metastatic pancreatic endocrine carcinomas to assess response rate, progression free survival (PFS), and overall survival (OS)...
  49. ncbi request reprint Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomas
    Evita B Henderson-Jackson
    Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Anticancer Res 31:2957-62. 2011
    ..Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known...
  50. doi request reprint Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumors
    Nicole Draper
    Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Hum Pathol 39:1784-91. 2008
    ..We report a direct correlation between cyclin D3 and p27 expression in gastrointestinal stromal tumors. Additional alterations in cyclin D1, Ki-67, and retinoblastoma protein expression indicate a disregulated cell cycle in these tumors...
  51. ncbi request reprint Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasia
    Elizabeth Sagatys
    Division of Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
    Hum Pathol 38:1526-31. 2007
    ....
  52. doi request reprint Cytoplasmic Clusterin expression correlates with pancreatic neuroendocrine tumor size and pathological stage
    Evita B Henderson-Jackson
    Department of Anatomic Pathology, Moffitt Cancer Center and University of South Florida, College of Medicine, Tampa, FL 33612, USA
    Pancreas 42:967-70. 2013
    ..In this study, Clusterin expression was evaluated in a subset of PNETs, and the results were correlated with the clinical-pathological features of the tumors...
  53. ncbi request reprint Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptor
    Jiazhi Sun
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer Res 64:3586-92. 2004
    ..Taken together, these results demonstrate that a synthetic molecule capable of disrupting the binding of VEGF to its receptor selectively inhibits VEGF-dependent signaling and suppresses angiogenesis and tumorigenesis...
  54. pmc Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis
    Yoshinori Takahashi
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, FL 33612, USA
    Nat Cell Biol 9:1142-51. 2007
    ..Moreover, knockout of Bif-1 significantly enhances the development of spontaneous tumours in mice. These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor...
  55. ncbi request reprint New and old regulators of uterine leiomyoma growth from screening with DNA arrays
    John C M Tsibris
    Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
    Fertil Steril 80:279-81. 2003
  56. ncbi request reprint Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis
    Han C Dan
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL 33612, USA
    Oncogene 23:706-15. 2004
    ..Owing to the fact that upregulation of Akt and survivin as well as inactivation of p53 are frequently associated with chemoresistance, GGTIs could be valuable agents to overcome antitumor drug resistance...
  57. doi request reprint Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activity
    Kiran Mahajan
    Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
    Prostate 70:1274-85. 2010
    ..However, whether a small molecule inhibitor that can mitigate Ack1 activation is sufficient to abrogate AR activity on AR regulated promoters in androgen-depleted environment is not known...
  58. ncbi request reprint Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancer
    Tatiana M Gritsko
    Department of Pathology and Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
    Clin Cancer Res 9:1420-6. 2003
    ..To our knowledge, this is the first demonstration of recurrent activation and overexpression of BTAK/Aurora-A in human ovarian cancer, which may play a critical role in development of this malignancy...
  59. pmc Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressiveness
    Hui Yi Lin
    Department of Biostatistics, H Lee Moffitt Cancer Center, Tampa, FL, USA
    Urology 78:971.e1-9. 2011
    ..Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis...
  60. ncbi request reprint Elucidation of a protein signature discriminating six common types of adenocarcinoma
    Gregory C Bloom
    Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 120:769-75. 2007
    ....
  61. ncbi request reprint Regulation of caspase expression and apoptosis by adenomatous polyposis coli
    Tingan Chen
    Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA
    Cancer Res 63:4368-74. 2003
    ..These data provide support for the hypothesis that one of the functions of APC is the regulation of caspase activity and other apoptotic proteins by controlling their expression levels in the cell...
  62. pmc Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 protein
    Hansoo Lee
    Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
    Mol Cell Biol 27:2103-19. 2007
    ..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation...
  63. ncbi request reprint Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasia
    Shohreh Iravani
    Department of Surgery, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA
    Hum Pathol 34:975-82. 2003
    ..These findings indicate important roles of these growth regulatory proteins in the malignant progression of Barrett's-associated neoplasia...
  64. ncbi request reprint Neoadjuvant chemoradiotherapy is not associated with a higher complication rate vs. surgery alone in patients undergoing esophagectomy
    Scott T Kelley
    H Lee Moffitt Cancer and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
    J Gastrointest Surg 8:227-31; discussion 231-2. 2004
    ..4%). Neoadjuvant chemoradiotherapy in patients with esophageal cancer was not associated with increased perioperative morbidity or mortality. Complete response to chemoradiotherapy also did not affect the complication rate (26% vs. 22%)...
  65. pmc Bax-interacting factor-1 expression in prostate cancer
    Domenico Coppola
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Clin Genitourin Cancer 6:117-21. 2008
    ..Loss of Bif-1 suppresses the intrinsic pathway of apoptosis and promotes tumorigenesis. We examined the expression levels of Bif-1 protein in human prostate cancer...
  66. pmc Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administration
    Kazim Husain
    Department of Gastrointestinal Oncology and Drug Discovery, Moffitt Cancer Center, Department of Oncological Sciences University of South Florida, Tampa, FL 33612, USA
    Pharmacology 83:157-63. 2009
    ..Our data suggest that bioactive levels of delta-tocotrienol can be achieved in the pancreas following oral administration and supports its clinical investigation in pancreatic cancer...
  67. doi request reprint Combined IL-8 and TGF-beta blockade efficiently prevents neutrophil infiltrates into an A549-cell tumor
    Kristy Kazemfar
    Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, United States
    Immunol Lett 122:26-9. 2009
    ..Surprisingly, blockade of both cytokines rescued both tumor volume and metastasis, underscoring the difficulty of understanding the effects of complete tumor cytokine elaboration profiles by isolating the effects of only one cytokine...
  68. doi request reprint Prognostic validity of the American Joint Committee on Cancer staging classification for midgut neuroendocrine tumors
    Jonathan R Strosberg
    Department of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    J Clin Oncol 31:420-5. 2013
    ..This classification has not been validated in a population consisting solely of midgut NETs. The purpose of this study was to test the prognostic validity of the classification in such a population...
  69. doi request reprint Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKT
    Christopher R Garrett
    Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612 9497, USA
    Invest New Drugs 29:1381-9. 2011
    ..AKT is an intracellular protein that, when activated, leads to cellular division; it is dysregulated in a large number of malignancies, and constitutively activating AKT mutations are present in a minority of cancers...
  70. doi request reprint IκB Kinase ε expression in pancreatic ductal adenocarcinoma
    Anna Cheng
    Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
    Am J Clin Pathol 136:60-6. 2011
    ..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention...
  71. ncbi request reprint Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathways
    Scott T Kelley
    H Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
    Clin Colorectal Cancer 5:114-8. 2005
    ..We tested the hypothesis that rectal tumors are most responsive to neoadjuvant therapy if they possess p53 and/or caspase 8 activity...
  72. ncbi request reprint Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanoma
    Subhra Mohapatra
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cancer Res 5:145-51. 2007
    ..The results of this study show that roscovitine has the potential to inhibit the differentiation and invasion of metastatic melanoma and may be useful as a therapy for the treatment of patients with metastatic melanoma...
  73. doi request reprint Purified human chorionic gonadotropin induces apoptosis in breast cancer
    Dayami Lopez
    Don and Erika Wallace Comprehensive Breast Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9416, USA
    Mol Cancer Ther 7:2837-44. 2008
    ..Preoperative apoptotic induction by factors such as purified hCG may improve local control or work synergistically with neoadjuvant chemotherapy to improve complete pathologic response of locally advanced breast cancer...
  74. pmc The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functions
    Zhigang Yuan
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
    Mol Cell Biol 30:3004-15. 2010
    ..Together, these results provide novel mechanistic insights into the function of ATDC and offer an explanation for how ATDC promotes cancer cell proliferation...
  75. doi request reprint Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumors
    Jonathan Strosberg
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Hum Pathol 40:1262-8. 2009
    ..Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade...
  76. ncbi request reprint Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells
    Lanxi Song
    Thoracic Oncology Experimental Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
    Cancer Biol Ther 4:267-76. 2005
    ..Mcl-1 protein is overexpressed in a subset of human NSCLC and enhanced levels of Mcl-1 may protect lung cancer cells from death induced by a variety of pro-apoptotic stimuli...
  77. ncbi request reprint Flat and polypoid adenocarcinomas of the colorectum: A comparative histomorphologic analysis of 47 cases
    Aejaz Nasir
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
    Hum Pathol 35:604-11. 2004
    ..Based on these data, FCRC appears to be a worse subtype of colon cancer than PCRC. Further appraisal of FCRCs and additional studies to further elucidate the molecular mechanisms underlying their morphogenesis are warranted...
  78. ncbi request reprint Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapy
    Aejaz Nasir
    H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, USA
    Clin Colorectal Cancer 3:243-7. 2004
    ..Our data also suggest that stratification of patients with CRC into right- and left-sided subsets may be important in optimal patient selection for COX-2 inhibitor therapy and for subsequent assessment of objective therapeutic response...
  79. ncbi request reprint Cytology of human ovarian surface epithelial brushings
    Santo V Nicosia
    Department of Pathology, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
    Cancer 102:1-10. 2004
    ..The current study was designed to provide a database of normal HOSE cell features for diagnostic and research applications...
  80. pmc Multi-platform, multi-site, microarray-based human tumor classification
    Greg Bloom
    H Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612 9497, USA
    Am J Pathol 164:9-16. 2004
    ..These cDNA- and oligonucleotide-based classifiers provide a first proof of principle that data derived from multiple platforms and performance sites can be exploited to build multi-tissue tumor classifiers...
  81. ncbi request reprint Electrochemotherapy for the treatment of human sarcoma in athymic rats
    Mark J Jaroszeski
    Department of Chemical Engineering, College of Engineering, University of South Florida, Tampa, FL 33612, USA
    Technol Cancer Res Treat 1:393-9. 2002
    ..9% durable complete responses; ECT that employed bleomycin resulted in the highest antitumor effects. This indicates the feasibility of electrochemotherapy as a modality for limb preserving treatments for sarcoma of the extremities...
  82. doi request reprint Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literature
    Marilyn M Bui
    Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
    Clin Colorectal Cancer 9:179-82. 2010
    ..However, it is important to recognize this entity as a cause of colonic mass to avoid a misdiagnosis of malignancy...
  83. pmc Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarray
    David L Morse
    H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States
    Biochem Pharmacol 80:748-54. 2010
    ..These validated targets have potential for the development of diagnostic imaging and therapeutic agents for pancreatic cancer...
  84. doi request reprint Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levels
    Aejaz Nasir
    Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Pancreas 36:309-13. 2008
    ..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy...
  85. pmc Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancers
    Rodney E Shackelford
    Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL, USA
    Int J Clin Exp Pathol 3:522-7. 2010
    ..Last, since an effective pharmacologic Nampt inhibitor is currently in clinical use, further studies of Nampt overexpression in OSA may be used in selecting patients for Nampt inhibitor therapy...
  86. pmc Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell lines
    Piyali Dasgupta
    Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Int J Cancer 124:36-45. 2009
    ..Therefore, it is probable that the ability of nicotine to induce invasion and EMT may contribute to the progression of breast and lung cancers...
  87. ncbi request reprint Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinoma
    Ardeshir Hakam
    Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33612 9497, USA
    Dig Dis Sci 48:1972-8. 2003
    ..In conclusion, our data support the role of IGF-1R and c-Src in human pancreatic carcinogenesis; the coexpression of both these molecules may play an important role in transformation of pancreatic ductal cells...
  88. ncbi request reprint Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumors
    Masoumeh Ghayouri
    Department of Pathology, University of South Florida, College of Medicine, Tampa, FL, USA
    Anticancer Res 30:5063-7. 2010
    ..Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters...
  89. doi request reprint Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumors
    Jonathan R Strosberg
    Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL, USA
    J Clin Oncol 29:3044-9. 2011
    ..This classification has not yet been validated...
  90. ncbi request reprint Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profiling
    Deepak Agrawal
    Department of Cell Biology, Interdisciplinary Oncology, H Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
    J Natl Cancer Inst 94:513-21. 2002
    ..Gene expression profiling techniques offer the opportunity to discover such markers. We investigated the feasibility of sample pooling strategy in combination with a novel analysis algorithm to identify markers...
  91. ncbi request reprint Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institution
    James F Helm
    Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
    Cancer Control 15:288-94. 2008
    ....
  92. ncbi request reprint Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 cases
    Abderrahman Ouban
    Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
    Clin Colorectal Cancer 1:243-8. 2002
    ..This type of tumor should be considered in the differential diagnosis of a bowel biopsy with multiple histopathologic variants...
  93. ncbi request reprint Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinoma
    Jennifer Reed
    Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
    Clin Colorectal Cancer 2:119-22. 2002
    ..However, further study of c-Kit expression in poorly differentiated colon cancers may be useful since these generally chemoresistant tumors may respond to therapy with inhibitor compounds directed against c-Kit...
  94. ncbi request reprint Effect of electrochemotherapy on muscle and skin
    Richard Heller
    Center for Molecular Delivery, University of South Florida, Tampa, FL 33612, USA
    Technol Cancer Res Treat 1:385-92. 2002
    ..The treated sites were examined histologically 3, 14 and 56 days later. Limb function was not affected by the treatment and skin and muscle necrosis was only seen at the higher doses...
  95. ncbi request reprint Retroperitoneal fibrosis (Ormond's disease): clinical pathologic study of eight cases
    Jamie Wu
    Department of Interdisciplinary Oncology and Pathology, H Lee Moffitt Cancer Center Research Institute, University of South Florida College of Medicine, Tampa, 33612, USA
    Cancer Control 9:432-7. 2002
  96. ncbi request reprint Insights from gene arrays on the development and growth regulation of uterine leiomyomata
    John C M Tsibris
    Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
    Fertil Steril 78:114-21. 2002
    ..To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata...
  97. ncbi request reprint Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasms
    Marilyn M Bui
    Department of Interdisciplinary Oncology, University of South Florida, College of Medicine, Tampa, FL 33612 9497, USA
    In Vivo 21:729-37. 2007
    ..Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas...
  98. ncbi request reprint Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samples
    Barbara A Centeno
    Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33609, USA
    Cancer 105:101-9. 2005
    ..For this technology to be relevant, however, it must be applicable to tumor biopsy samples, which most often are fine-needle aspiration biopsy (FNAB) samples...
  99. ncbi request reprint Significance of Fas receptor protein expression in epithelial ovarian cancer
    Jennifer Reed
    Department of Pathology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
    Hum Pathol 36:971-6. 2005
    ....
  100. ncbi request reprint Oncogenic pathways implicated in ovarian epithelial cancer
    Santo V Nicosia
    Department of Pathology and Laboratory Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, MDC Box 11, Tampa, FL 33612, USA
    Hematol Oncol Clin North Am 17:927-43. 2003
    ....