Research Topics
Genomes and Genes
| Domenico CoppolaSummaryAffiliation: H. Lee Moffitt Cancer Center and Research Institute Country: USA Publications
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Detail Information
Publications
Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancerDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, FL, USA
Anticancer Res 32:4963-9. 2012..We evaluated MMR protein expression in three population-based samples of epithelial ovarian cancers...
Natriuretic peptide receptor a as a novel target for prostate cancerXiaoqin Wang
Department of Molecular Medicine, University of South Florida, Tampa, FL 33612, USA
Mol Cancer 10:56. 2011..However, the direct role of NPRA signaling in prostate cancer remains unclear...- Displayed correlation between gene expression profiles and submicroscopic alterations in response to cetuximab, gefitinib and EGF in human colon cancer cell linesRossella Solmi
Dipartimento di Istologia, Embriologia e Biologia Applicata, Universita di Bologna, Via Belmeloro 8, 40126 Bologna, Italy
BMC Cancer 8:227. 2008..EGFR is frequently overexpressed in colon cancer. We characterized HT-29 and Caco-2, human colon cancer cell lines, untreated and treated with cetuximab or gefitinib alone and in combination with EGF... - Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinomaDomenico Coppola
Department of Anatomic Pathology, University of South Florida, Tampa, FL, USA
Pancreas 40:433-7. 2011..Bax-interacting factor 1 (Bif-1) protein plays a critical role in apoptosis, mitochondrial morphogenesis, and autophagy, and its loss promotes tumorigenesis. The role of Bif-1 in pancreatic cancer has not been studied... - Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinomaDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center, Tampa, Florida 33612 9497, USA
Cancer 113:2665-70. 2008..Loss of Bif-1 suppresses programmed cell death and promotes tumorigenesis. The connection of Bif-1 to colorectal cancer remains to be evaluated... 
Expression of the insulin-like growth factor receptor 1 during human embryogenesisDomenico Coppola
Department of Interdisciplinary Oncology, Anatomic Pathology Division, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612 9497, USA
Fetal Pediatr Pathol 28:47-54. 2009..On study shows the preferential IGF-1R immunolocalizatrion in specific areas of the developing embryo, suggesting a role of IGF1-R for the optimal maturation of those areas, during developing human embryos...- Substantially reduced expression of PIAS1 is associated with colon cancer developmentDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, USA
J Cancer Res Clin Oncol 135:1287-91. 2009..PIAS's also regulate STAT family members not directly involved in IFN-gamma signaling. This project was designed to assess PIAS1 expression in colon cancer... - Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathwayMadhavi Sekharam
Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, 12902 Magnolia Drive, Tampa, FL 33612, USA
Cancer Res 63:7708-16. 2003..Our data demonstrate, for the first time, that IGF1-R/Akt/Bcl-x(L) pathway may contribute to a more aggressive malignant phenotype, in a subset of colorectal cancers... - Expression of the antiapoptotic protein survivin in colon cancerJonathan M Hernandez
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL, USA
Clin Colorectal Cancer 10:188-93. 2011..We sought to evaluate survivin expression in colonic neoplasia and identify relationships with additional regulators of apoptosis... - IKKepsilon phosphorylation of estrogen receptor alpha Ser-167 and contribution to tamoxifen resistance in breast cancerJian Ping Guo
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 285:3676-84. 2010..These data suggest that ERalpha is a bona fide substrate of IKKepsilon and IKKepsilon plays an important role in tamoxifen resistance. Thus, IKKepsilon represents a critical therapeutic target in breast cancer... - Cucurbitacin Q: a selective STAT3 activation inhibitor with potent antitumor activityJiazhi Sun
Department of Interdisciplinary Oncology, Drug Discovery and Molecular Oncology Programs, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612 9497, USA
Oncogene 24:3236-45. 2005..These studies further validate STAT3 as a drug discovery target and provide evidence that pharmacological agents that can selectively reduce the P-STAT3 levels in human cancer cells result in tumor apoptosis and growth inhibition... - Ack1-mediated androgen receptor phosphorylation modulates radiation resistance in castration-resistant prostate cancerKiran Mahajan
Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 287:22112-22. 2012.... - MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoAWilliam Kong
Departments of Molecular Oncology, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Dr, SRB3, Tampa, FL 33612, USA
Mol Cell Biol 28:6773-84. 2008..These data suggest that miR-155 may play an important role in TGF-beta-induced EMT and cell migration and invasion by targeting RhoA and indicate that it is a potential therapeutic target for breast cancer intervention... - SLC5A8 nuclear translocation and loss of expression are associated with poor outcome in pancreatic ductal adenocarcinomaJames Helm
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, FL 33612, USA
Pancreas 41:904-9. 2012..This study aimed to assess the role of SLC5A8 expression in the survival of pancreatic cancer... - ID1 facilitates the growth and metastasis of non-small cell lung cancer in response to nicotinic acetylcholine receptor and epidermal growth factor receptor signalingSmitha Pillai
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, Florida 33612, USA
Mol Cell Biol 31:3052-67. 2011.... - AKT2 inhibition of cisplatin-induced JNK/p38 and Bax activation by phosphorylation of ASK1: implication of AKT2 in chemoresistanceZeng Qiang Yuan
Department of Pathology, University of South Florida College of Medicine and H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 278:23432-40. 2003..Further, regulation of the ASK1/JNK/p38/Bax pathway by AKT2 provides a new mechanism contributing to its antiapoptotic effects... - Deregulation of IKBKE is associated with tumor progression, poor prognosis, and cisplatin resistance in ovarian cancerJian Ping Guo
Departments of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
Am J Pathol 175:324-33. 2009..IKKepsilon could also serve as a prognostic marker and potential therapeutic target for this malignancy... - Correlation between Mcl-1 and pAKT protein expression in colorectal cancerEvita B Henderson-Jackson
Departments of Oncologic Sciences Moffitt Cancer Center and Research Institute, at the University of South Florida, School of Medicine, Tampa, Florida 33612 3275, USA
Int J Clin Exp Pathol 3:768-74. 2010..008). We report the correlation of Mcl-1 protein expression with higher grade and stage in colorectal cancer. Mcl-1 correlated also with pAKT expression. We also report the up regulation of pAKT during the transition from NR to CRC... - Dedifferentiation precedes invasion in the progression from Barrett's metaplasia to esophageal adenocarcinomaJames Helm
Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, Florida 33612, USA
Clin Cancer Res 11:2478-85. 2005.... - Molecular staging for survival prediction of colorectal cancer patientsSteven Eschrich
Department of Surgery, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Clin Oncol 23:3526-35. 2005..CONCLUSION: These data support further evaluation of molecular staging to discriminate good from poor prognosis patients, with the potential to direct adjuvant therapy... - Histologic characteristics enhance predictive value of American Joint Committee on Cancer staging in resectable pancreas cancerJames Helm
Department of Gastrointestinal Oncology, Moffitt Cancer Center, Tampa, Florida, USA
Cancer 115:4080-9. 2009.... - ARRB1-mediated regulation of E2F target genes in nicotine-induced growth of lung tumorsPiyali Dasgupta
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Natl Cancer Inst 103:317-33. 2011..However, whether ARRB1 translocates to the nucleus upon nicotinic acetylcholine receptor activation and how it regulates growth of human NSCLCs are not known... - Unique ectopic lymph node-like structures present in human primary colorectal carcinoma are identified by immune gene array profilingDomenico Coppola
Anatomic Pathology Division, Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Am J Pathol 179:37-45. 2011.... - Activation of the serine/threonine protein kinase AKT during the progression of colorectal neoplasiaOzlen Saglam
Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Clin Colorectal Cancer 6:652-6. 2007..AKT has been identified as a major regulator of cell proliferation, tumorigenesis, and apoptosis. In this study, we evaluated changes in the activity of AKT during colorectal cancer (CRC) progression... - Nicotine promotes tumor growth and metastasis in mouse models of lung cancerRebecca Davis
Department of Oncologic Sciences, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
PLoS ONE 4:e7524. 2009..This effect was observed when nicotine was administered through intraperitoneal injections, or through over-the-counter transdermal patches... - IKBKE protein activates Akt independent of phosphatidylinositol 3-kinase/PDK1/mTORC2 and the pleckstrin homology domain to sustain malignant transformationJian Ping Guo
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 286:37389-98. 2011..Our data also suggest that Akt inhibitors targeting the PH domain have no effect on the tumors in which hyperactive Akt resulted from elevated IKBKE... - Complementary strand microRNAs mediate acquisition of metastatic potential in colonic adenocarcinomaDung Tsa Chen
Department of Biomedical Informatics, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
J Gastrointest Surg 16:905-12; discussion 912-3. 2012..However, little is known about the genome-wide alterations in miRNA expression during the neoplastic progression of primary colorectal cancers... - Loss of nuclear p21(Cip1/WAF1) during neoplastic progression to metastasis in gamma-irradiated p21 hemizygous miceRobert W Engelman
Department of Pathology and Cell Biology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Exp Mol Pathol 82:234-44. 2007..Cellular subclones of malignant tumors, especially those of mesenchymal cell origin, which lack nuclear p21 may more readily acquire the genetic alterations of the metastatic phenotype... - MicroRNA-221/222 negatively regulates estrogen receptor alpha and is associated with tamoxifen resistance in breast cancerJian Jun Zhao
H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 283:31079-86. 2008.... - SirT1 is an inhibitor of proliferation and tumor formation in colon cancerNeha Kabra
Molecular Oncology Program, Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
J Biol Chem 284:18210-7. 2009..These results suggest a rationale for the use of SirT1 activators and inhibitors in the prevention and treatment of colon cancer... - RUNX1T1: a novel predictor of liver metastasis in primary pancreatic endocrine neoplasmsAejaz Nasir
Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Pancreas 40:627-33. 2011.... - Osteopontin identified as colon cancer tumor progression markerDeepak Agrawal
Department of Cell Biology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa, FL, USA
C R Biol 326:1041-3. 2003..Osteopontin is a secreted glycoprotein known to bind integrins and CD44. Its actual molecular function remains elusive but its increased expression correlates strongly with tumor progression... - Regulation of MDMX expression by mitogenic signalingDaniele M Gilkes
H Lee Moffitt Cancer Center, MRC3057A, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 28:1999-2010. 2008..Therefore, MDMX expression is regulated by mitogenic signaling pathways. This mechanism may protect normal proliferating cells from p53 but also hamper p53 response during tumor development... - Ack1 tyrosine kinase activation correlates with pancreatic cancer progressionKiran Mahajan
Department of Drug Discovery, Moffitt Cancer Center, Tampa, Florida 33612, USA
Am J Pathol 180:1386-93. 2012..Collectively, our data indicate that activated Ack1 could be a prognostic marker for ascertaining early or advanced pancreatic cancer. Thus, Ack1 inhibitors hold promise for therapeutic intervention to inhibit pancreatic tumor growth... - Prognostic and predictive value of a malignancy-risk gene signature in early-stage non-small cell lung cancerDung Tsa Chen
Department of Biostatistics, Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Natl Cancer Inst 103:1859-70. 2011..We hypothesized that the malignancy-risk gene signature has prognostic and predictive value for early-stage non-small cell lung cancer (NSCLC) patients... - Inhibiting angiogenesis and tumorigenesis by a synthetic molecule that blocks binding of both VEGF and PDGF to their receptorsJiazhi Sun
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, MRC DRDIS, Tampa, FL 33612, USA
Oncogene 24:4701-9. 2005..Finally, treatment of mice with GFB-204 suppresses human tumor growth and angiogenesis. Thus, inhibition of VEGF and PDGF receptor binding with a synthetic molecule results in potent inhibition of angiogenesis and tumorigenesis... - P53 enhances ascorbyl stearate-induced G2/M arrest of human ovarian cancer cellsK Akhilender Naidu
Division of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Anticancer Res 27:3927-34. 2007..We have previously demonstrated that Asc-S inhibits ovarian carcinoma cell proliferation through modulation of the cell cycle. This study was designed to further elucidate the mechanisms underlying such regulation... - Correlation of osteopontin protein expression and pathological stage across a wide variety of tumor histologiesDomenico Coppola
Department of Pathology, University of South Florida College of Medicine, Tampa, Florida, USA
Clin Cancer Res 10:184-90. 2004..The strong correlation between pathological stage and OPN across multiple tumor types suggests a role for OPN in tumor progression... - Ascorbyl stearate inhibits cell proliferation and tumor growth in human ovarian carcinoma cells by targeting the PI3K/AKT pathwayQuan Fang
Department of Pathology Oncology, H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, College of Medicine, Tampa, FL 33612, USA
Anticancer Res 26:203-9. 2006..These studies indicate that the antiproliferative effect of ascorbyl stearate on ovarian epithelial cancer cells is associated with decreased PI3K/AKT activity, and point toward the PI3K/AKT signaling pathway as a target for this drug... - MicroRNA-155 regulates cell survival, growth, and chemosensitivity by targeting FOXO3a in breast cancerWilliam Kong
Department of Molecular Oncology, H Lee Moffitt Cancer Center, Tampa, Florida 33612, USA
J Biol Chem 285:17869-79. 2010..In conclusion, our study reveals a molecular link between miR-155 and FOXO3a and presents evidence that miR-155 is a critical therapeutic target in breast cancer... - Increased cyclin D3 expression significantly correlates with p27 nuclear positivity in gastrointestinal stromal tumorsNicole Draper
Department of Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Hum Pathol 39:1784-91. 2008..We report a direct correlation between cyclin D3 and p27 expression in gastrointestinal stromal tumors. Additional alterations in cyclin D1, Ki-67, and retinoblastoma protein expression indicate a disregulated cell cycle in these tumors... - Evaluation of toxicity following electrically mediated interleukin-12 gene delivery in a B16 mouse melanoma modelLoree Heller
Department of Medical Microbiology and Immunology, University of South Florida, Tampa 33612, USA
Clin Cancer Res 12:3177-83. 2006..No significant toxic effects due to the IL-12 gene therapy were observed... - Activation of the serine/threonine protein kinase Akt during the progression of Barrett neoplasiaElizabeth Sagatys
Division of Anatomic Pathology, Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center, Tampa, FL 33612 9497, USA
Hum Pathol 38:1526-31. 2007.... - Palladin is a marker of liver metastasis in primary pancreatic endocrine carcinomasEvita B Henderson-Jackson
Department of Pathology, Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Anticancer Res 31:2957-62. 2011..Palladin is a metastasis-associated gene regulating cell motility. The expression of palladin protein in pancreatic neuroendocrine tumors (PET) and carcinomas (PECA) is not known... - Insulin-like growth factor 1 receptor activates c-SRC and modifies transformation and motility of colon cancer in vitroMadhavi Sekharam
Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612 9497, USA
Anticancer Res 23:1517-24. 2003..Based on the above observations, we conclude that an overexpressed and activated IGF1-R may increase the degree of transformation and motility of colon cancer cells by activating c-Src... - Blocking angiogenesis and tumorigenesis with GFA-116, a synthetic molecule that inhibits binding of vascular endothelial growth factor to its receptorJiazhi Sun
Drug Discovery Program, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer Res 64:3586-92. 2004..Taken together, these results demonstrate that a synthetic molecule capable of disrupting the binding of VEGF to its receptor selectively inhibits VEGF-dependent signaling and suppresses angiogenesis and tumorigenesis... - First-line chemotherapy with capecitabine and temozolomide in patients with metastatic pancreatic endocrine carcinomasJonathan R Strosberg
Department of Gastrointestinal Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer 117:268-75. 2011..The authors retrospectively evaluated the efficacy of capecitabine and temozolomide in 30 patients with metastatic pancreatic endocrine carcinomas to assess response rate, progression free survival (PFS), and overall survival (OS)... - Effect of Ack1 tyrosine kinase inhibitor on ligand-independent androgen receptor activityKiran Mahajan
Drug Discovery Department, Moffitt Cancer Center, Tampa, Florida 33612, USA
Prostate 70:1274-85. 2010..However, whether a small molecule inhibitor that can mitigate Ack1 activation is sufficient to abrogate AR activity on AR regulated promoters in androgen-depleted environment is not known... - Activation and overexpression of centrosome kinase BTAK/Aurora-A in human ovarian cancerTatiana M Gritsko
Department of Pathology and Molecular Oncology Program, H Lee Moffitt Cancer Center and Research Institute, College of Medicine, University of South Florida, Tampa, Florida 33612, USA
Clin Cancer Res 9:1420-6. 2003..To our knowledge, this is the first demonstration of recurrent activation and overexpression of BTAK/Aurora-A in human ovarian cancer, which may play a critical role in development of this malignancy... - Protein expressions and genetic variations of SLC5A8 in prostate cancer risk and aggressivenessHui Yi Lin
Department of Biostatistics, H Lee Moffitt Cancer Center, Tampa, FL, USA
Urology 78:971.e1-9. 2011..Previous studies have suggested that SLC5A8 might function as a tumor suppressor gene, whose silencing by epigenetic changes might contribute to carcinogenesis... - Neoadjuvant chemoradiotherapy is not associated with a higher complication rate vs. surgery alone in patients undergoing esophagectomyScott T Kelley
H Lee Moffitt Cancer and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, FL 33612, USA
J Gastrointest Surg 8:227-31; discussion 231-2. 2004..4%). Neoadjuvant chemoradiotherapy in patients with esophageal cancer was not associated with increased perioperative morbidity or mortality. Complete response to chemoradiotherapy also did not affect the complication rate (26% vs. 22%)... - Modification of insulin-like growth factor 1 receptor, c-Src, and Bcl-XL protein expression during the progression of Barrett's neoplasiaShohreh Iravani
Department of Surgery, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa 33612, USA
Hum Pathol 34:975-82. 2003..These findings indicate important roles of these growth regulatory proteins in the malignant progression of Barrett's-associated neoplasia... - Role of p53, CD44V6 and CD57 in differentiating between benign and malignant follicular neoplasms of the thyroidAejaz Nasir
Department of Pathology, University of South Florida, College of Medicine-Moffitt Cancer Center, Tampa, USA
In Vivo 18:189-95. 2004..The results of this study indicate that immunohistochemical detection of p53, CD44V6 and CD57 may have practical utility in the differential diagnosis of FCAs from FADs in routine surgical pathology... - Elucidation of a protein signature discriminating six common types of adenocarcinomaGregory C Bloom
Biostatistics Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 120:769-75. 2007.... - Regulation of caspase expression and apoptosis by adenomatous polyposis coliTingan Chen
Department of Interdisciplinary Oncology and Surgery, University of South Florida, Tampa, FL 33612, USA
Cancer Res 63:4368-74. 2003..These data provide support for the hypothesis that one of the functions of APC is the regulation of caspase activity and other apoptotic proteins by controlling their expression levels in the cell... - Identification and characterization of putative tumor suppressor NGB, a GTP-binding protein that interacts with the neurofibromatosis 2 proteinHansoo Lee
Department of Pathology, H Lee Moffitt Cancer Center, University of South Florida, Tampa, FL 33612, USA
Mol Cell Biol 27:2103-19. 2007..Collectively, these findings indicate that NGB is a tumor suppressor that regulates and requires merlin to suppress cell proliferation... - Vitamin E delta-tocotrienol levels in tumor and pancreatic tissue of mice after oral administrationKazim Husain
Department of Gastrointestinal Oncology and Drug Discovery, Moffitt Cancer Center, Department of Oncological Sciences University of South Florida, Tampa, FL 33612, USA
Pharmacology 83:157-63. 2009..Our data suggest that bioactive levels of delta-tocotrienol can be achieved in the pancreas following oral administration and supports its clinical investigation in pancreatic cancer... - Combined IL-8 and TGF-beta blockade efficiently prevents neutrophil infiltrates into an A549-cell tumorKristy Kazemfar
Department of Molecular Medicine, College of Medicine, University of South Florida, Tampa, FL 33612, United States
Immunol Lett 122:26-9. 2009..Surprisingly, blockade of both cytokines rescued both tumor volume and metastasis, underscoring the difficulty of understanding the effects of complete tumor cytokine elaboration profiles by isolating the effects of only one cytokine... - Bax-interacting factor-1 expression in prostate cancerDomenico Coppola
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Clin Genitourin Cancer 6:117-21. 2008..Loss of Bif-1 suppresses the intrinsic pathway of apoptosis and promotes tumorigenesis. We examined the expression levels of Bif-1 protein in human prostate cancer... - MicroRNA expression profiling in human ovarian cancer: miR-214 induces cell survival and cisplatin resistance by targeting PTENHua Yang
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, University of South Florida College of Medicine, Tampa, Florida 33612, USA
Cancer Res 68:425-33. 2008..These findings indicate that deregulation of miRNAs is a recurrent event in human ovarian cancer and that miR-214 induces cell survival and cisplatin resistance primarily through targeting the PTEN/Akt pathway... - Prognostic validity of the American Joint Committee on Cancer staging classification for midgut neuroendocrine tumorsJonathan R Strosberg
Department of GI Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
J Clin Oncol 31:420-5. 2013..This classification has not been validated in a population consisting solely of midgut NETs. The purpose of this study was to test the prognostic validity of the classification in such a population... - Phase I pharmacokinetic and pharmacodynamic study of triciribine phosphate monohydrate, a small-molecule inhibitor of AKT phosphorylation, in adult subjects with solid tumors containing activated AKTChristopher R Garrett
Department of Experimental Therapeutics, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612 9497, USA
Invest New Drugs 29:1381-9. 2011..AKT is an intracellular protein that, when activated, leads to cellular division; it is dysregulated in a large number of malignancies, and constitutively activating AKT mutations are present in a minority of cancers... - Roscovitine inhibits differentiation and invasion in a three-dimensional skin reconstruction model of metastatic melanomaSubhra Mohapatra
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute and the University of South Florida Medical Center, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cancer Res 5:145-51. 2007..The results of this study show that roscovitine has the potential to inhibit the differentiation and invasion of metastatic melanoma and may be useful as a therapy for the treatment of patients with metastatic melanoma... - Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosisHan C Dan
Department of Pathology, University of South Florida College of Medicine, Tampa, FL 33612, USA
Oncogene 23:706-15. 2004..Owing to the fact that upregulation of Akt and survivin as well as inactivation of p53 are frequently associated with chemoresistance, GGTIs could be valuable agents to overcome antitumor drug resistance... - New and old regulators of uterine leiomyoma growth from screening with DNA arraysJohn C M Tsibris
Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
Fertil Steril 80:279-81. 2003 - Purified human chorionic gonadotropin induces apoptosis in breast cancerDayami Lopez
Don and Erika Wallace Comprehensive Breast Program, H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, WCB 2, Tampa, FL 33612 9416, USA
Mol Cancer Ther 7:2837-44. 2008..Preoperative apoptotic induction by factors such as purified hCG may improve local control or work synergistically with neoadjuvant chemotherapy to improve complete pathologic response of locally advanced breast cancer... - The ATDC (TRIM29) protein binds p53 and antagonizes p53-mediated functionsZhigang Yuan
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA
Mol Cell Biol 30:3004-15. 2010..Together, these results provide novel mechanistic insights into the function of ATDC and offer an explanation for how ATDC promotes cancer cell proliferation... - IκB Kinase ε expression in pancreatic ductal adenocarcinomaAnna Cheng
Anatomic Pathology, Moffitt Cancer Center, Tampa, FL 33612, USA
Am J Clin Pathol 136:60-6. 2011..In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention... - Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cellsLanxi Song
Thoracic Oncology Experimental Therapeutics, University of South Florida College of Medicine, Tampa, Florida, USA
Cancer Biol Ther 4:267-76. 2005..Mcl-1 protein is overexpressed in a subset of human NSCLC and enhanced levels of Mcl-1 may protect lung cancer cells from death induced by a variety of pro-apoptotic stimuli... - Tumor response to neoadjuvant chemoradiation therapy for rectal adenocarcinoma is mediated by p53-dependent and caspase 8-dependent apoptotic pathwaysScott T Kelley
H. Lee Moffitt Cancer Center and Department of Surgery, Tampa, FL, USA
Clin Colorectal Cancer 5:114-8. 2005.... - Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesisYoshinori Takahashi
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive Tampa, FL 33612, USA
Nat Cell Biol 9:1142-51. 2007..Moreover, knockout of Bif-1 significantly enhances the development of spontaneous tumours in mice. These findings suggest that Bif-1 joins the UVRAG-Beclin 1 complex as a potential activator of autophagy and tumour suppressor... - Correlation between grade and prognosis in metastatic gastroenteropancreatic neuroendocrine tumorsJonathan Strosberg
H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Hum Pathol 40:1262-8. 2009..Both mitotic rates and Ki-67 indexes are inversely associated with survival and can be analyzed independently for assignment of grade... - Flat and polypoid adenocarcinomas of the colorectum: A comparative histomorphologic analysis of 47 casesAejaz Nasir
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL, USA
Hum Pathol 35:604-11. 2004..Based on these data, FCRC appears to be a worse subtype of colon cancer than PCRC. Further appraisal of FCRCs and additional studies to further elucidate the molecular mechanisms underlying their morphogenesis are warranted... - Cyclooxygenase-2 expression in right- and left-sided colon cancer: a rationale for optimization of cyclooxygenase-2 inhibitor therapyAejaz Nasir
H. Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, USA
Clin Colorectal Cancer 3:243-7. 2004..Our data also suggest that stratification of patients with CRC into right- and left-sided subsets may be important in optimal patient selection for COX-2 inhibitor therapy and for subsequent assessment of objective therapeutic response... - Cytology of human ovarian surface epithelial brushingsSanto V Nicosia
Department of Pathology, University of South Florida College of Medicine, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33612, USA
Cancer 102:1-10. 2004..The current study was designed to provide a database of normal HOSE cell features for diagnostic and research applications... - Electrochemotherapy for the treatment of human sarcoma in athymic ratsMark J Jaroszeski
Department of Chemical Engineering, College of Engineering, University of South Florida, Tampa, FL 33612, USA
Technol Cancer Res Treat 1:393-9. 2002..9% durable complete responses; ECT that employed bleomycin resulted in the highest antitumor effects. This indicates the feasibility of electrochemotherapy as a modality for limb preserving treatments for sarcoma of the extremities... - Multimodality management of a polyfunctional pancreatic endocrine carcinoma with markedly elevated serum vasoactive intestinal polypeptide and calcitonin levelsAejaz Nasir
Department of Interdisciplinary Oncology, Neuroendocrine Cancer Research Group, H Lee Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Pancreas 36:309-13. 2008..In summary, this is a unique case of metastatic VIP- and calcitonin-secreting pancreatic ECA with dramatic sustained clinical, biochemical, and objective tumor response to peptide receptor radionuclide therapy... - Colonic angiolymphoid hyperplasia with eosinophilia masquerading as malignancy: a case report and review of the literatureMarilyn M Bui
Department of Anatomic Pathology, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612 9497, USA
Clin Colorectal Cancer 9:179-82. 2010..However, it is important to recognize this entity as a cause of colonic mass to avoid a misdiagnosis of malignancy... - Identification of novel pancreatic adenocarcinoma cell-surface targets by gene expression profiling and tissue microarrayDavid L Morse
H Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, United States
Biochem Pharmacol 80:748-54. 2010..These validated targets have potential for the development of diagnostic imaging and therapeutic agents for pancreatic cancer... - Multi-platform, multi-site, microarray-based human tumor classificationGreg Bloom
H. Lee Moffitt Cancer Center, University of South Florida, Tampa, Florida 33612-9497, USA
Am J Pathol 164:9-16. 2004..These cDNA- and oligonucleotide-based classifiers provide a first proof of principle that data derived from multiple platforms and performance sites can be exploited to build multi-tissue tumor classifiers... - Nicotine induces cell proliferation, invasion and epithelial-mesenchymal transition in a variety of human cancer cell linesPiyali Dasgupta
Drug Discovery Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Int J Cancer 124:36-45. 2009..Therefore, it is probable that the ability of nicotine to induce invasion and EMT may contribute to the progression of breast and lung cancers... - Over-expression of nicotinamide phosphoribosyltransferase in ovarian cancersRodney E Shackelford
Department of Pathology and Cell Biology, University of South Florida, 12901 Bruce B Downs Blvd, Tampa, FL, USA
Int J Clin Exp Pathol 3:522-7. 2010..Last, since an effective pharmacologic Nampt inhibitor is currently in clinical use, further studies of Nampt overexpression in OSA may be used in selecting patients for Nampt inhibitor therapy... - Activation of the serine/theronine protein kinase Akt in enteropancreatic neuroendocrine tumorsMasoumeh Ghayouri
Department of Pathology, University of South Florida, College of Medicine, Tampa, FL, USA
Anticancer Res 30:5063-7. 2010..Akt is a regulator of cell proliferation, tumorigenesis and apoptosis. This study evaluated the incidence of Akt activation in a subset of neuroendocrine tumors (NETs) and its correlation to clinical pathological parameters... - Coexpression of IGF-1R and c-Src proteins in human pancreatic ductal adenocarcinomaArdeshir Hakam
Department of Interdisciplinary Oncology, Moffitt Cancer Center and Research Institute, University of South Florida, 12902 Magnolia Drive, Tampa, Florida 33612 9497, USA
Dig Dis Sci 48:1972-8. 2003..In conclusion, our data support the role of IGF-1R and c-Src in human pancreatic carcinogenesis; the coexpression of both these molecules may play an important role in transformation of pancreatic ductal cells... - Osteopontin identified as lead marker of colon cancer progression, using pooled sample expression profilingDeepak Agrawal
Department of Cell Biology, Interdisciplinary Oncology, H. Lee Moffitt Cancer Center, University of South Florida, Tampa 33612, USA
J Natl Cancer Inst 94:513-21. 2002..We identified osteopontin as a clinically useful marker of tumor progression by use of gene expression profiling on pooled samples... - Prognostic validity of a novel American Joint Committee on Cancer Staging Classification for pancreatic neuroendocrine tumorsJonathan R Strosberg
Moffitt Cancer Center, 12902 Magnolia Dr, Tampa, FL, USA
J Clin Oncol 29:3044-9. 2011..This classification has not yet been validated... - Outcomes following resection of pancreatic adenocarcinoma: 20-year experience at a single institutionJames F Helm
Gastrointestinal Tumor Program, H Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA
Cancer Control 15:288-94. 2008.... - Immunohistochemical staining for c-Kit (CD117) is a rare event in human colorectal carcinomaJennifer Reed
Department of Pathology, University of South Florida College of Medicine, Tampa, FL, USA
Clin Colorectal Cancer 2:119-22. 2002..However, further study of c-Kit expression in poorly differentiated colon cancers may be useful since these generally chemoresistant tumors may respond to therapy with inhibitor compounds directed against c-Kit... - Diagnostic and pathogenetic implications of colorectal carcinomas with multidirectional differentiation: a report of 4 casesAbderrahman Ouban
Department of Pathology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA
Clin Colorectal Cancer 1:243-8. 2002..This type of tumor should be considered in the differential diagnosis of a bowel biopsy with multiple histopathologic variants... - Altered expression of cell cycle regulatory proteins in benign and malignant bone and soft tissue neoplasmsMarilyn M Bui
Department of Interdisciplinary Oncology, University of South Florida, College of Medicine, Tampa, FL 33612 9497, USA
In Vivo 21:729-37. 2007..Here the expression of G1 cyclins D1 and D3, and of Ki-67 in a variety of bone and soft tissue sarcomas was assessed as compared to adjacent normal tissue and to a subset of leiomyomas... - Insights from gene arrays on the development and growth regulation of uterine leiomyomataJohn C M Tsibris
Department of Obstetrics and Gynecology, University of South Florida, Tampa, Florida 33606, USA
Fertil Steril 78:114-21. 2002..To use microarray analysis as an unbiased approach to identify genes involved in the induction and growth of uterine leiomyomata... - Retroperitoneal fibrosis (Ormond's disease): clinical pathologic study of eight casesJamie Wu
Department of Interdisciplinary Oncology and Pathology, H. Lee Moffitt Cancer Center Research Institute, University of South Florida College of Medicine, Tampa, 33612, USA
Cancer Control 9:432-7. 2002 - Effect of electrochemotherapy on muscle and skinRichard Heller
Center for Molecular Delivery, University of South Florida, Tampa, FL 33612, USA
Technol Cancer Res Treat 1:385-92. 2002..The treated sites were examined histologically 3, 14 and 56 days later. Limb function was not affected by the treatment and skin and muscle necrosis was only seen at the higher doses... - Classification of human tumors using gene expression profiles obtained after microarray analysis of fine-needle aspiration biopsy samplesBarbara A Centeno
Department of Interdisciplinary Oncology, H Lee Moffitt Cancer Center and Research Institute, Tampa, Florida 33609, USA
Cancer 105:101-9. 2005..For this technology to be relevant, however, it must be applicable to tumor biopsy samples, which most often are fine-needle aspiration biopsy (FNAB) samples... - Significance of Fas receptor protein expression in epithelial ovarian cancerJennifer Reed
Department of Pathology, Moffitt Cancer Center and Research Institute, University of South Florida, Tampa, FL 33612, USA
Hum Pathol 36:971-6. 2005.... - Oncogenic pathways implicated in ovarian epithelial cancerSanto V Nicosia
Department of Pathology and Laboratory Medicine, University of South Florida College of Medicine, 12901 Bruce B Downs Boulevard, MDC Box 11, Tampa, FL 33612, USA
Hematol Oncol Clin North Am 17:927-43. 2003....