Affiliation: H. Lee Moffitt Cancer Center and Research Institute
Challa S, Guo J, Ding X, Xu C, Li Y, Kim D, et al. IKBKE Is a Substrate of EGFR and a Therapeutic Target in Non-Small Cell Lung Cancer with Activating Mutations of EGFR. Cancer Res. 2016;76:4418-29 pubmed publisher
Richards E, Zhang G, Li Z, Permuth Wey J, Challa S, Li Y, et al. Long non-coding RNAs (LncRNA) regulated by transforming growth factor (TGF) Î²: LncRNA-hit-mediated TGFÎ²-induced epithelial to mesenchymal transition in mammary epithelia. J Biol Chem. 2015;290:6857-67 pubmed publisher
..Collectively, these data suggest that a subset of lncRNAs such as lncRNA-HIT play a significant role in regulation of EMT and breast cancer invasion and metastasis, and could be potential therapeutic targets in breast cancers. ..