Carol L Williams

Summary

Affiliation: Guthrie Research Institute
Country: USA

Publications

  1. ncbi request reprint The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
    Carol L Williams
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Cell Signal 15:1071-80. 2003
  2. ncbi request reprint Muscarinic signaling in carcinoma cells
    Carol L Williams
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Life Sci 72:2173-82. 2003
  3. ncbi request reprint Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death
    Shulamith H Shafer
    Molecular Pharmacology Laboratory, One Guthrie Square, Sayre, PA 18840, USA
    Mol Pharmacol 65:1080-91. 2004
  4. ncbi request reprint The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin
    Rebecca Ruiz-Velasco
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, Pennsylvania 18840, USA
    J Biol Chem 277:33081-91. 2002
  5. ncbi request reprint The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1
    Cathy Cole Lanning
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 279:44197-210. 2004
  6. ncbi request reprint Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1
    Cathy Cole Lanning
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:12495-506. 2003
  7. ncbi request reprint The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies
    Kimberly A Varker
    Department of Surgery, Guthrie Healthcare System, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 22:671-81. 2003
  8. ncbi request reprint Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment
    Shulamith H Shafer
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 23:389-400. 2003
  9. ncbi request reprint Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration
    Kimberly A Varker
    Department of Surgery, Guthrie Clinic, One Guthrie Square, Sayre, PA 18840, USA
    Biochem Pharmacol 63:597-605. 2002
  10. ncbi request reprint Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS
    Yue Zhang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Cell Microbiol 9:2192-201. 2007

Collaborators

  • Joseph Barbieri
  • Shulamith H Shafer
  • Cathy Cole Lanning
  • Rebecca Ruiz-Velasco
  • Kimberly A Varker
  • Gaik Wei Tew
  • Rebecca Thill
  • Yue Zhang
  • Ellen L Lorimer
  • Huiying Zhi
  • Tracy J Berg
  • William B Campbell
  • Rongshan Li
  • Qing Deng
  • Jaclyn A Porath
  • Kristin J Pederson-Gulrud
  • Janelle L Daddona
  • Marina M King
  • Scott H Phelps

Detail Information

Publications12

  1. ncbi request reprint The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences
    Carol L Williams
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Cell Signal 15:1071-80. 2003
    ..These diverse functions of the PBR indicate its critical role in signaling by Ras and Rho family GTPases...
  2. ncbi request reprint Muscarinic signaling in carcinoma cells
    Carol L Williams
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Life Sci 72:2173-82. 2003
    ..The demonstration by other investigators that acetylcholine is expressed by a variety of cells in the airways supports the possibility that acetylcholine may activate mAChR expressed by SCLC cells in primary tumors...
  3. ncbi request reprint Elevated Rac1 activity changes the M3 muscarinic acetylcholine receptor-mediated inhibition of proliferation to induction of cell death
    Shulamith H Shafer
    Molecular Pharmacology Laboratory, One Guthrie Square, Sayre, PA 18840, USA
    Mol Pharmacol 65:1080-91. 2004
    ..These findings indicate that in the context of high Rac1 activity, but not RhoA activity, M(3) mAChR-mediated activation of these participants triggers cell death...
  4. ncbi request reprint The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin
    Rebecca Ruiz-Velasco
    Molecular Pharmacology Laboratory, Guthrie Research Institute, One Guthrie Square, Sayre, Pennsylvania 18840, USA
    J Biol Chem 277:33081-91. 2002
    ..These results indicate that M(3) mAChR activation converts Rac1 to the GTP-bound form, alters interactions between Rac1, IQGAP1, and actin, and causes the junctional accumulation of Rac1 and IQGAP1...
  5. ncbi request reprint The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1
    Cathy Cole Lanning
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 279:44197-210. 2004
    ..These findings support the model that nuclear localization signal sequences in the PBR direct Rac1 to the nucleus, where Rac1 participates in signaling pathways that ultimately target it for degradation...
  6. ncbi request reprint Novel mechanism of the co-regulation of nuclear transport of SmgGDS and Rac1
    Cathy Cole Lanning
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:12495-506. 2003
    ..These results indicate that small GTPases with a PBR can regulate the nuclear transport of armadillo proteins...
  7. ncbi request reprint The small GTPase RhoA has greater expression in small cell lung carcinoma than in non-small cell lung carcinoma and contributes to their unique morphologies
    Kimberly A Varker
    Department of Surgery, Guthrie Healthcare System, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 22:671-81. 2003
    ..These results indicate that Rho-mediated signaling may regulate different events in SCLC and NSCLC cells, including adhesion of SCLC cells and proliferation of NSCLC cells...
  8. ncbi request reprint Non-small and small cell lung carcinoma cell lines exhibit cell type-specific sensitivity to edelfosine-induced cell death and different cell line-specific responses to edelfosine treatment
    Shulamith H Shafer
    Molecular Pharmacology Laboratory, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 23:389-400. 2003
    ..These findings also identify edelfosine as one of the few potential chemotherapeutic agents that has a greater cytotoxic effect against NSCLC cells than SCLC cells...
  9. ncbi request reprint Involvement of the muscarinic acetylcholine receptor in inhibition of cell migration
    Kimberly A Varker
    Department of Surgery, Guthrie Clinic, One Guthrie Square, Sayre, PA 18840, USA
    Biochem Pharmacol 63:597-605. 2002
    ..These findings suggest that mAChR activation diminishes the ability of cells to detach from the substratum, resulting in diminished migration. This is in contrast to the direct activation of PKC with PMA, which stimulates migration...
  10. ncbi request reprint Plasma membrane localization affects the RhoGAP specificity of Pseudomonas ExoS
    Yue Zhang
    Department of Microbiology and Molecular Genetics, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA
    Cell Microbiol 9:2192-201. 2007
    ..This study shows the importance of membrane localization in the targeting of Rho GTPases by ExoS RhoGAP...
  11. ncbi request reprint SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma
    Gaik Wei Tew
    Department of Pharmacology and Toxicology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, 53226, USA
    J Biol Chem 283:963-76. 2008
    ..These results demonstrate that SmgGDS promotes the malignant NSCLC phenotype and is an intriguing therapeutic target in NSCLC...
  12. doi request reprint Identification and characterization of the unique guanine nucleotide exchange factor, SmgGDS, in vascular smooth muscle cells
    Rebecca Thill
    Department of Pharmacology and Toxicology, Cardiovascular Center, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA
    J Cell Biochem 104:1760-70. 2008
    ..Taken together these results identify SmgGDS as a novel regulator of myosin organization and contraction in VSMC...