JOHN NOTI

Summary

Affiliation: Guthrie Research Institute
Country: USA

Publications

  1. ncbi request reprint Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C
    J D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 272:24038-45. 1997
  2. ncbi request reprint Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3
    J D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 275:8959-69. 2000
  3. ncbi request reprint Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Int J Oncol 17:1237-43. 2000
  4. ncbi request reprint Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 18:195-201. 2001
  5. ncbi request reprint The leukocyte integrins are regulated by transcriptional and post-transcriptional mechanisms in a leukemic cell that overexpresses protein kinase C-zeta
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 19:1311-8. 2001
  6. ncbi request reprint Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins
    John D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Mol Med 10:721-7. 2002
  7. ncbi request reprint Expression and function of the leukocyte integrins in organ transplant rejection
    John D Noti
    Guthrie Foundation for Medical Research, Sayre, PA 18840, USA
    Curr Med Chem 11:477-90. 2004
  8. ncbi request reprint The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter
    John D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 279:26948-58. 2004
  9. ncbi request reprint The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells
    John D Noti
    Guthrie Foundation for Education and Research, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:3449-57. 2005

Research Grants

Detail Information

Publications9

  1. ncbi request reprint Sp3 mediates transcriptional activation of the leukocyte integrin genes CD11C and CD11B and cooperates with c-Jun to activate CD11C
    J D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 272:24038-45. 1997
    ..Antisense experiments that knocked out endogenous Sp3 expression in the myelomocytic cell line, HL60, revealed that Sp3 participates in activation of the CD11c and CD11b promoters in vivo...
  2. ncbi request reprint Structural and functional characterization of the leukocyte integrin gene CD11d. Essential role of Sp1 and Sp3
    J D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 275:8959-69. 2000
    ..In contrast, this site is bound in both unstimulated and phorbol ester-stimulated IM9 and Jurkat cells. Together, these results show that myelomonocyte-specific phorbol ester down-regulation of CD11d is mediated through both Sp1 and Sp3...
  3. ncbi request reprint Adherence to osteopontin via alphavbeta3 suppresses phorbol ester-mediated apoptosis in MCF-7 breast cancer cells that overexpress protein kinase C-alpha
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, One Guthrie Square, Sayre, PA 18840, USA
    Int J Oncol 17:1237-43. 2000
    ..This study suggests that breast cancer cells that have metastasized to bone may have a survival advantage resulting from interaction of alphavbeta3 on these cells with the bone protein osteopontin...
  4. ncbi request reprint Integrin alpha 5 beta 1 suppresses apoptosis triggered by serum starvation but not phorbol ester in MCF-7 breast cancer cells that overexpress protein kinase C-alpha
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 18:195-201. 2001
    ....
  5. ncbi request reprint The leukocyte integrins are regulated by transcriptional and post-transcriptional mechanisms in a leukemic cell that overexpresses protein kinase C-zeta
    J D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Oncol 19:1311-8. 2001
    ..Thus, overexpression of PKC-zeta in U937 cells leads not only to leukemic cell differentiation, but also to differential regulation of the leukocyte integrins...
  6. ncbi request reprint Expression of the myeloid-specific leukocyte integrin gene CD11d during macrophage foam cell differentiation and exposure to lipoproteins
    John D Noti
    Laboratory of Molecular Biology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Mol Med 10:721-7. 2002
    ....
  7. ncbi request reprint Expression and function of the leukocyte integrins in organ transplant rejection
    John D Noti
    Guthrie Foundation for Medical Research, Sayre, PA 18840, USA
    Curr Med Chem 11:477-90. 2004
    ..The potential of anti-adhesion therapy to prolong organ transplant survival will be discussed in both animal and patient studies...
  8. ncbi request reprint The zinc finger transcription factor transforming growth factor beta-inducible early gene-1 confers myeloid-specific activation of the leukocyte integrin CD11d promoter
    John D Noti
    Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 279:26948-58. 2004
    ..We propose that up-regulation of CD11d expression following differentiation of myeloid cells is mediated through increased binding of TIEG1 binding to the CD11d promoter...
  9. ncbi request reprint The leukocyte integrin gene CD11d is repressed by gut-enriched Kruppel-like factor 4 in myeloid cells
    John D Noti
    Guthrie Foundation for Education and Research, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:3449-57. 2005
    ....

Research Grants1

  1. Molecular Mechanisms That Regulate CD11d Expression
    JOHN NOTI; Fiscal Year: 2004
    ..Transgenic analysis of the CD11d cis elements will be done to complement these studies. These studies will expand our understanding of normal myeloid development and leukemogenesis. ..