Nan Shan Chang

Summary

Affiliation: Guthrie Research Institute
Country: USA

Publications

  1. ncbi Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity
    N S Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    Biochem Biophys Res Commun 253:743-9. 1998
  2. ncbi WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:43100-8. 2005
  3. ncbi WW domain-containing oxidoreductase: a candidate tumor suppressor
    Nan Shan Chang
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan 70101, Republic of China
    Trends Mol Med 13:12-22. 2007
  4. pmc Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response
    Qunying Hong
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    BMC Mol Biol 8:50. 2007
  5. doi MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1
    Chen Peng Lo
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan 70101, ROC
    Eur J Neurosci 27:1634-46. 2008
  6. ncbi p53 overexpression and downregulation of inter-alpha-inhibitor are associated with hyaluronidase enhancement of TNF cytotoxicity in L929 fibroblasts
    N S Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, PA 18840, USA
    Cancer Lett 131:45-54. 1998
  7. ncbi JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:9195-202. 2003
  8. pmc Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania, 18840, USA
    BMC Cell Biol 3:8. 2002
  9. ncbi The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania, 18840, USA
    J Biol Chem 277:10323-31. 2002
  10. ncbi A potential role of p53 and WOX1 in mitochondrial apoptosis (review)
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Mol Med 9:19-24. 2002

Collaborators

Detail Information

Publications26

  1. ncbi Cloning and characterization of a novel transforming growth factor-beta1-induced TIAF1 protein that inhibits tumor necrosis factor cytotoxicity
    N S Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    Biochem Biophys Res Commun 253:743-9. 1998
    ..Despite the fact that the mechanism for blocking TNF cytotoxicity is unknown, TIAF1 is apparently involved in TGF-beta1 inhibition of IkappaB-alpha expression and suppression of TNF-mediated IkappaB-alpha degradation...
  2. ncbi WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:43100-8. 2005
    ..Together, our data show that WOX1 plays a critical role in conferring cellular sensitivity to apoptotic stress and that Tyr33 phosphorylation in WOX1 is essential for binding and stabilizing Ser46-phosphorylated p53...
  3. ncbi WW domain-containing oxidoreductase: a candidate tumor suppressor
    Nan Shan Chang
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan 70101, Republic of China
    Trends Mol Med 13:12-22. 2007
    ..We propose that suppression of WWOX expression by overexpressed hyaluronidases might contribute in part to the development of hormone independence in invasive cancer...
  4. pmc Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response
    Qunying Hong
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    BMC Mol Biol 8:50. 2007
    ..To further delineate the functional properties of Zfra, here we investigated Zfra regulation of the activation of p53, WOX1 (WWOX or FOR), NF-kappaB, and JNK1 under apoptotic stress...
  5. doi MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1
    Chen Peng Lo
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan 70101, ROC
    Eur J Neurosci 27:1634-46. 2008
    ..Together, activated WOX1 plays an essential role in the MPP+-induced neuronal death. Our synthetic phospho-WOX1 peptide prevents neuronal death, suggestive of its therapeutic potential in mitigating the symptoms of PD...
  6. ncbi p53 overexpression and downregulation of inter-alpha-inhibitor are associated with hyaluronidase enhancement of TNF cytotoxicity in L929 fibroblasts
    N S Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, PA 18840, USA
    Cancer Lett 131:45-54. 1998
    ..Conceivably, hyaluronidase enhancement of TNF sensitivity in L929 cells is p53-dependent and the matrix inter-alpha-inhibitor contributes a protective role against TNF cytotoxicity...
  7. ncbi JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:9195-202. 2003
    ..This mutant protein bound p53 but could not interact with JNK1, as determined in yeast two-hybrid analysis. Taken together, phosphorylation of JNK1 and WOX1 is necessary for their physical interaction and functional antagonism...
  8. pmc Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania, 18840, USA
    BMC Cell Biol 3:8. 2002
    ..TGF-beta1 blocks PH-20-increased TNF cytotoxicity. In the present study, the functional antagonism between TGF-beta1 and lysosomal hyaluronidases Hyal-1 and Hyal-2 was examined...
  9. ncbi The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania, 18840, USA
    J Biol Chem 277:10323-31. 2002
    ..Together, the IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress...
  10. ncbi A potential role of p53 and WOX1 in mitochondrial apoptosis (review)
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Mol Med 9:19-24. 2002
    ..In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed...
  11. ncbi Hyaluronidase activation of c-Jun N-terminal kinase is necessary for protection of L929 fibrosarcoma cells from staurosporine-mediated cell death
    N S Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    Biochem Biophys Res Commun 283:278-86. 2001
    ..Together, hyaluronidase-mediated JNK activation is necessary to generate resistance to various anticancer drugs in L929 cells...
  12. ncbi Hyaluronidase induction of a WW domain-containing oxidoreductase that enhances tumor necrosis factor cytotoxicity
    N S Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    J Biol Chem 276:3361-70. 2001
    ..Blocking of WOX1 expression by antisense mRNA abolished p53 apoptosis. Thus, WOX1 is a mitochondrial apoptogenic protein and an essential partner of p53 in cell death...
  13. ncbi Suppression of IkappaBalpha expression is necessary for c-Jun N-terminal kinase-mediated enhancement of Fas cytotoxicity
    N S Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania 18840, USA
    Biochem Biophys Res Commun 274:4-10. 2000
    ..Together, these results indicate that suppression of IkappaBalpha expression is essential for JNK-mediated enhancement of Fas cytotoxicity...
  14. ncbi TGF-beta-induced matrix proteins inhibit p42/44 MAPK and JNK activation and suppress TNF-mediated IkappaBalpha degradation and NF-kappaB nuclear translocation in L929 fibroblasts
    N S Chang
    Guthrie Research Institute, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania, 18840, USA
    Biochem Biophys Res Commun 267:194-200. 2000
    ..Immunostaining of L929 cells revealed that the antibodies were bound to a membrane protein of 100 kDa (p100). Thus, the matrix p46 is likely derived from the released membrane p100...
  15. ncbi IkappaBalpha is essential for maintaining basal c-Jun N-terminal kinase (JNK) activation and regulating JNK-mediated resistance to tumor necrosis factor cytotoxicity in L929 cells
    N S Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, 1 Guthrie Square, Sayre, Pennsylvania 18840, USA
    Biochem Biophys Res Commun 263:107-12. 1999
    ..Thus, these observations indicate that IkappaBalpha is essential for maintaining the basal level of JNK activation and regulating the JNK-induced TNF resistance...
  16. ncbi 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Oncogene 24:714-23. 2005
    ..Together, sex steroid hormone-induced activation of WOX1 and WOX2 is independent of ER and AR, and this activation positively correlates with cancerous progression of prostate and breast to a premetastatic state...
  17. ncbi Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1
    Li Jin Hsu
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Biophys Res Commun 327:415-23. 2005
    ..While JNK1 is a downstream effector of the TNF signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1...
  18. ncbi TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53
    Lori Schultz
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania, USA
    DNA Cell Biol 23:67-74. 2004
    ..Taken together, TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53...
  19. ncbi Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Pharmacol 66:1347-54. 2003
    ..Taken together, WOX1 is involved in stress and apoptotic responses, and is likely to regulate the activation of both p53 and JNK1...
  20. ncbi TIAF1 participates in the transforming growth factor beta1--mediated growth regulation
    Smaira Khera
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann N Y Acad Sci 995:11-21. 2003
    ..Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-beta-mediated growth regulation...
  21. ncbi Conformationally altered hyaluronan restricts complement classical pathway activation by binding to C1q, C1r, C1s, C2, C5 and C9, and suppresses WOX1 expression in prostate DU145 cells
    Qunying Hong
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Int J Mol Med 19:173-9. 2007
    ..It may recognize cell surface receptors differently from native HA, thereby differentially regulating the expression of cellular proteins...
  22. pmc Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells
    Qunying Hong
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, PA, USA
    PLoS ONE 4:e5755. 2009
    ..We examined specific serum complement components in coordinating the activation of tumor suppressors p53 and WWOX (also named FOR or WOX1) and kinases ERK, JNK1 and STAT3 in human prostate DU145 cells...
  23. doi Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria
    Li Jin Hsu
    Department of Immunology and Microbiology, National Cheng Kung University Medical College, 1 University Road, Tainan, 701 Taiwan, ROC
    Cell Signal 20:1303-12. 2008
    ..Zfra downregulates Bcl-2 and induces MMP dissipation but causes no cytochrome c release, indicating a novel death pathway from the mitochondria...
  24. ncbi WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo
    Feng Jie Lai
    Department of Dermatology, National Cheng Kung University, Tainan, Taiwan
    Clin Cancer Res 11:5769-77. 2005
    ..We investigated the role of candidate tumor suppressor and proapoptotic WOX1 (also named WWOX, FOR, or WWOXv1) in UVB-induced apoptosis and formation of cutaneous squamous cell carcinomas (SCC)...
  25. ncbi High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells
    Judith van der Leij
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Transplantation 75:2076-82. 2003
    ..We hypothesized that TIAF-1 plays a protective role against apoptosis during allograft rejection...
  26. ncbi Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease
    Chun I Sze
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:30498-506. 2004
    ..Together WOX1 binds Tau via its short-chain alcohol dehydrogenase/reductase domain and is likely to play a critical role in regulating Tau hyperphosphorylation and NFT formation in vivo...