Nan Shan Chang

Summary

Affiliation: Guthrie Research Institute
Country: USA

Publications

  1. ncbi 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Oncogene 24:714-23. 2005
  2. ncbi Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Pharmacol 66:1347-54. 2003
  3. ncbi The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania, 18840, USA
    J Biol Chem 277:10323-31. 2002
  4. ncbi JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:9195-202. 2003
  5. ncbi WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:43100-8. 2005
  6. ncbi TIAF1 participates in the transforming growth factor beta1--mediated growth regulation
    Smaira Khera
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann N Y Acad Sci 995:11-21. 2003
  7. ncbi TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53
    Lori Schultz
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania, USA
    DNA Cell Biol 23:67-74. 2004
  8. ncbi Conformationally altered hyaluronan restricts complement classical pathway activation by binding to C1q, C1r, C1s, C2, C5 and C9, and suppresses WOX1 expression in prostate DU145 cells
    Qunying Hong
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Int J Mol Med 19:173-9. 2007
  9. pmc Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania, 18840, USA
    BMC Cell Biol 3:8. 2002
  10. ncbi Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1
    Li Jin Hsu
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Biophys Res Commun 327:415-23. 2005

Collaborators

  • Li Jin Hsu
  • Qunying Hong
  • Robert J Boackle
  • Udo Oppermann
  • Ester W J A Albrecht
  • Subbiah Pugazhenthi
  • Lori Schultz
  • Smaira Khera
  • Chen Peng Lo
  • Shur Tzu Chen
  • Feng Jie Lai
  • Chun I Sze
  • John Heath
  • Judith van der Leij
  • Se Yei Hsu
  • Sing Ru Lin
  • Jih Ing Chuang
  • Ming Shu Tsai
  • Meng Yen Li
  • Ching Liang Shen
  • Sheau Chiou Chao
  • Maw Chang Sheen
  • Chin Han Wu
  • Hamm Ming Sheu
  • J Yu Yun Lee
  • Ching Li Cheng
  • Meng Su
  • Purevsuren Jambal
  • Daniel Sleve
  • Coen A Stegeman
  • Ramon Roozendaal
  • Anke van den Berg
  • Harry van Goor
  • Sibrand Poppema
  • Koert P de Jong
  • Annette S H Gouw
  • Tjasso Blokzijl

Detail Information

Publications19

  1. ncbi 17beta-Estradiol upregulates and activates WOX1/WWOXv1 and WOX2/WWOXv2 in vitro: potential role in cancerous progression of breast and prostate to a premetastatic state in vivo
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Oncogene 24:714-23. 2005
    ..Together, sex steroid hormone-induced activation of WOX1 and WOX2 is independent of ER and AR, and this activation positively correlates with cancerous progression of prostate and breast to a premetastatic state...
  2. ncbi Molecular mechanisms underlying WOX1 activation during apoptotic and stress responses
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Pharmacol 66:1347-54. 2003
    ..Taken together, WOX1 is involved in stress and apoptotic responses, and is likely to regulate the activation of both p53 and JNK1...
  3. ncbi The non-ankyrin C terminus of Ikappa Balpha physically interacts with p53 in vivo and dissociates in response to apoptotic stress, hypoxia, DNA damage, and transforming growth factor-beta 1-mediated growth suppression
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania, 18840, USA
    J Biol Chem 277:10323-31. 2002
    ..Together, the IkappaBalpha x p53 complex plays an important role in responses involving growth regulation, apoptosis, and hypoxic stress...
  4. ncbi JNK1 physically interacts with WW domain-containing oxidoreductase (WOX1) and inhibits WOX1-mediated apoptosis
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, Sayre, Pennsylvania 18840, USA
    J Biol Chem 278:9195-202. 2003
    ..This mutant protein bound p53 but could not interact with JNK1, as determined in yeast two-hybrid analysis. Taken together, phosphorylation of JNK1 and WOX1 is necessary for their physical interaction and functional antagonism...
  5. ncbi WOX1 is essential for tumor necrosis factor-, UV light-, staurosporine-, and p53-mediated cell death, and its tyrosine 33-phosphorylated form binds and stabilizes serine 46-phosphorylated p53
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania 18840, USA
    J Biol Chem 280:43100-8. 2005
    ..Together, our data show that WOX1 plays a critical role in conferring cellular sensitivity to apoptotic stress and that Tyr33 phosphorylation in WOX1 is essential for binding and stabilizing Ser46-phosphorylated p53...
  6. ncbi TIAF1 participates in the transforming growth factor beta1--mediated growth regulation
    Smaira Khera
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, Pennsylvania 18840, USA
    Ann N Y Acad Sci 995:11-21. 2003
    ..Antisense TIAF1 mRNA significantly enhanced the proliferation of mink lung Mv1Lu epithelial cells. Together, these observations indicate that TIAF1 participates in the TGF-beta-mediated growth regulation...
  7. ncbi TIAF1 and p53 functionally interact in mediating apoptosis and silencing of TIAF1 abolishes nuclear translocation of serine 15-phosphorylated p53
    Lori Schultz
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, Pennsylvania, USA
    DNA Cell Biol 23:67-74. 2004
    ..Taken together, TIAF1 and p53 functionally interact in regulating apoptosis, and TIAF1 is likely to participate in the nuclear translocation of activated p53...
  8. ncbi Conformationally altered hyaluronan restricts complement classical pathway activation by binding to C1q, C1r, C1s, C2, C5 and C9, and suppresses WOX1 expression in prostate DU145 cells
    Qunying Hong
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Int J Mol Med 19:173-9. 2007
    ..It may recognize cell surface receptors differently from native HA, thereby differentially regulating the expression of cellular proteins...
  9. pmc Transforming growth factor-beta1 blocks the enhancement of tumor necrosis factor cytotoxicity by hyaluronidase Hyal-2 in L929 fibroblasts
    Nan Shan Chang
    Guthrie Research Institute, Laboratory of Molecular Immunology, Guthrie Medical Center, 1 Guthrie Square, Sayre, Pennsylvania, 18840, USA
    BMC Cell Biol 3:8. 2002
    ..TGF-beta1 blocks PH-20-increased TNF cytotoxicity. In the present study, the functional antagonism between TGF-beta1 and lysosomal hyaluronidases Hyal-1 and Hyal-2 was examined...
  10. ncbi Cloning and characterization of a small-size peptide Zfra that regulates the cytotoxic function of tumor necrosis factor by interacting with JNK1
    Li Jin Hsu
    Guthrie Research Institute, Laboratory of Molecular Immunology, 1 Guthrie Square, Sayre, PA 18840, USA
    Biochem Biophys Res Commun 327:415-23. 2005
    ..While JNK1 is a downstream effector of the TNF signaling, Zfra regulation of the TNF cytotoxic function is likely due to its interaction, in part, with JNK1...
  11. pmc Complement C1q activates tumor suppressor WWOX to induce apoptosis in prostate cancer cells
    Qunying Hong
    Guthrie Research Institute, Laboratory of Molecular Immunology, Sayre, PA, USA
    PLoS ONE 4:e5755. 2009
    ..We examined specific serum complement components in coordinating the activation of tumor suppressors p53 and WWOX (also named FOR or WOX1) and kinases ERK, JNK1 and STAT3 in human prostate DU145 cells...
  12. ncbi A potential role of p53 and WOX1 in mitochondrial apoptosis (review)
    Nan Shan Chang
    Laboratory of Molecular Immunology, Guthrie Research Institute, Sayre, PA 18840, USA
    Int J Mol Med 9:19-24. 2002
    ..In this review article, the potential role of WOX1/p53 as a signaling complex in the mitochondrial apoptosis is discussed...
  13. ncbi WOX1 is essential for UVB irradiation-induced apoptosis and down-regulated via translational blockade in UVB-induced cutaneous squamous cell carcinoma in vivo
    Feng Jie Lai
    Department of Dermatology, National Cheng Kung University, Tainan, Taiwan
    Clin Cancer Res 11:5769-77. 2005
    ..We investigated the role of candidate tumor suppressor and proapoptotic WOX1 (also named WWOX, FOR, or WWOXv1) in UVB-induced apoptosis and formation of cutaneous squamous cell carcinomas (SCC)...
  14. ncbi Down-regulation of WW domain-containing oxidoreductase induces Tau phosphorylation in vitro. A potential role in Alzheimer's disease
    Chun I Sze
    Department of Pathology, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 279:30498-506. 2004
    ..Together WOX1 binds Tau via its short-chain alcohol dehydrogenase/reductase domain and is likely to play a critical role in regulating Tau hyperphosphorylation and NFT formation in vivo...
  15. ncbi WW domain-containing oxidoreductase: a candidate tumor suppressor
    Nan Shan Chang
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan 70101, Republic of China
    Trends Mol Med 13:12-22. 2007
    ..We propose that suppression of WWOX expression by overexpressed hyaluronidases might contribute in part to the development of hormone independence in invasive cancer...
  16. pmc Zfra affects TNF-mediated cell death by interacting with death domain protein TRADD and negatively regulates the activation of NF-kappaB, JNK1, p53 and WOX1 during stress response
    Qunying Hong
    Institute of Molecular Medicine, National Cheng Kung University Medical College, Tainan, Taiwan, ROC
    BMC Mol Biol 8:50. 2007
    ..To further delineate the functional properties of Zfra, here we investigated Zfra regulation of the activation of p53, WOX1 (WWOX or FOR), NF-kappaB, and JNK1 under apoptotic stress...
  17. doi MPP+-induced neuronal death in rats involves tyrosine 33 phosphorylation of WW domain-containing oxidoreductase WOX1
    Chen Peng Lo
    Institute of Basic Medical Sciences, National Cheng Kung University, Tainan, Taiwan 70101, ROC
    Eur J Neurosci 27:1634-46. 2008
    ..Together, activated WOX1 plays an essential role in the MPP+-induced neuronal death. Our synthetic phospho-WOX1 peptide prevents neuronal death, suggestive of its therapeutic potential in mitigating the symptoms of PD...
  18. doi Zfra is an inhibitor of Bcl-2 expression and cytochrome c release from the mitochondria
    Li Jin Hsu
    Department of Immunology and Microbiology, National Cheng Kung University Medical College, 1 University Road, Tainan, 701 Taiwan, ROC
    Cell Signal 20:1303-12. 2008
    ..Zfra downregulates Bcl-2 and induces MMP dissipation but causes no cytochrome c release, indicating a novel death pathway from the mitochondria...
  19. ncbi High expression of TIAF-1 in chronic kidney and liver allograft rejection and in activated T-helper cells
    Judith van der Leij
    Department of Pathology and Laboratory Medicine, University Hospital Groningen, Groningen, The Netherlands
    Transplantation 75:2076-82. 2003
    ..We hypothesized that TIAF-1 plays a protective role against apoptosis during allograft rejection...