Sanjeev Gupta

Summary

Country: USA

Publications

  1. ncbi Hepatic polyploidy and liver growth control
    S Gupta
    Marion Bessin Liver Research Center, and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Semin Cancer Biol 10:161-71. 2000
  2. ncbi Therapeutic potential of hepatocyte transplantation
    Sanjeev Gupta
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Cell Dev Biol 13:439-46. 2002
  3. ncbi Hepatocyte transplantation
    Sanjeev Gupta
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Gastroenterol Hepatol 17:S287-93. 2002
  4. ncbi Emerging insights into liver-directed cell therapy for genetic and acquired disorders
    Sanjeev Gupta
    Department of Medicine, Marion Bessin Liver Research Center, Cancer Research Center and General Clinical Research Center, Albert Einstein College of Medicine Ullmann Building, Rm 625, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Transpl Immunol 12:289-302. 2004
  5. ncbi Re-Engineering the liver with natural biomaterials
    S Gupta
    General Clinical Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Yonsei Med J 41:814-24. 2000
  6. ncbi Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Gastrointest Liver Physiol 279:G815-26. 2000
  7. ncbi Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy
    S Gupta
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gene Med 1:386-92. 1999
  8. ncbi Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats
    S Gupta
    Marion Bessin Liver Research Center and Gastroenterology Division, Department of Medicine, Jack and Pearl Resnick Campus, Bronx, New York, USA
    J Pathol 190:203-10. 2000
  9. ncbi Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Hepatology 29:509-19. 1999
  10. ncbi Lessons From Genetically Engineered Animal Models VI. Liver repopulation systems and study of pathophysiological mechanisms in animals
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:G1097-102. 1999

Research Grants

  1. Transplantation of Endothelial Cells
    Sanjeev Gupta; Fiscal Year: 2007
  2. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2007
  3. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2002
  4. Transplantation of Endothelial Cells
    Sanjeev Gupta; Fiscal Year: 2010

Collaborators

Detail Information

Publications75

  1. ncbi Hepatic polyploidy and liver growth control
    S Gupta
    Marion Bessin Liver Research Center, and Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Semin Cancer Biol 10:161-71. 2000
    ..Working models indicate that extensive polyploidy could lead to organ failure, as well as to oncogenesis with activation of precancerous cell clones...
  2. ncbi Therapeutic potential of hepatocyte transplantation
    Sanjeev Gupta
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Semin Cell Dev Biol 13:439-46. 2002
    ....
  3. ncbi Hepatocyte transplantation
    Sanjeev Gupta
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Gastroenterol Hepatol 17:S287-93. 2002
    ..The general conclusion is that cell therapy has become more practical in recent years and insights into how the normal liver and the diseased liver can be repopulated will offer effective ways to treat many disorders in the near future...
  4. ncbi Emerging insights into liver-directed cell therapy for genetic and acquired disorders
    Sanjeev Gupta
    Department of Medicine, Marion Bessin Liver Research Center, Cancer Research Center and General Clinical Research Center, Albert Einstein College of Medicine Ullmann Building, Rm 625, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Transpl Immunol 12:289-302. 2004
    ..Taken together, these advances indicate that liver-directed cell therapy will be well positioned in the near future to play significant roles in transplantation medicine...
  5. ncbi Re-Engineering the liver with natural biomaterials
    S Gupta
    General Clinical Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Yonsei Med J 41:814-24. 2000
    ..In other situations, gradual liver repopulation alone might well be effective without additional manipulations...
  6. ncbi Cell transplantation causes loss of gap junctions and activates GGT expression permanently in host liver
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol Gastrointest Liver Physiol 279:G815-26. 2000
    ..The findings indicated the onset of ischemic liver injury after cell transplantation. These hepatic perturbations must be considered when transplanted cells are utilized as reporters for biological studies...
  7. ncbi Liver repopulation with hepatocyte transplantation: new avenues for gene and cell therapy
    S Gupta
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Gene Med 1:386-92. 1999
    ..Moreover, hepatocyte transplantation systems offer creative tools for defining critical mechanisms in gene regulation and survival of transduced cells...
  8. ncbi Integration and proliferation of transplanted cells in hepatic parenchyma following D-galactosamine-induced acute injury in F344 rats
    S Gupta
    Marion Bessin Liver Research Center and Gastroenterology Division, Department of Medicine, Jack and Pearl Resnick Campus, Bronx, New York, USA
    J Pathol 190:203-10. 2000
    ....
  9. ncbi Entry and integration of transplanted hepatocytes in rat liver plates occur by disruption of hepatic sinusoidal endothelium
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Hepatology 29:509-19. 1999
    ....
  10. ncbi Lessons From Genetically Engineered Animal Models VI. Liver repopulation systems and study of pathophysiological mechanisms in animals
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 277:G1097-102. 1999
    ..Transplanted hepatocytes are susceptible to hepatitis viruses. These aspects of transplanted hepatocyte biology indicate that liver repopulation systems can help address questions concerning pathophysiological mechanisms...
  11. ncbi Mechanisms of cell engraftment during liver repopulation with hepatocyte transplantation
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Semin Liver Dis 19:15-26. 1999
    ..Finally, analysis of the safety of cell transplantation is necessary for clinical applications of liver repopulation with cell transplantation. This review highlights selected advances in related areas concerning liver repopulation...
  12. ncbi Transplanted hepatocytes proliferate differently after CCl4 treatment and hepatocyte growth factor infusion
    S Gupta
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Am J Physiol 276:G629-38. 1999
    ..Repopulation of the liver with genetically marked hepatocytes can provide effective reporters for studying liver growth control in the intact animal...
  13. ncbi Analysis of the functional integrity of cryopreserved human liver cells including xenografting in immunodeficient mice to address suitability for clinical applications
    Jae-Jin Cho
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Liver Int 24:361-70. 2004
    ..These studies offer suitable paradigms aimed at characterizing liver cells prior to transplantation in people...
  14. ncbi Cyclophosphamide disrupts hepatic sinusoidal endothelium and improves transplanted cell engraftment in rat liver
    Harmeet Malhi
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann 625, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Hepatology 36:112-21. 2002
    ..These results provide insights into hepatocyte engraftment in the liver and will help in optimizing liver-directed cell therapy...
  15. ncbi Hepatic targeting and biodistribution of human fetal liver stem/progenitor cells and adult hepatocytes in mice
    Kang Cheng
    Marion Bessin Liver Research Center, Diabetes Research Center, and Cancer Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 50:1194-203. 2009
    ..This should facilitate continued development of cell therapies through further animal and clinical studies...
  16. ncbi Perturbations in ataxia telangiectasia mutant signaling pathways after drug-induced acute liver failure and their reversal during rescue of animals by cell therapy
    Sriram Bandi
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York, USA
    Am J Pathol 178:161-74. 2011
    ..We concluded that Atm signaling played critical roles in the pathological features of liver failure. These studies should help redirect examination of pathophysiologic and therapeutic mechanisms in liver failure...
  17. ncbi Hepatocyte transplantation and drug-induced perturbations in liver cell compartments
    Yao Ming Wu
    Marion Bessin Liver Research Center, Diabetes Center, Cancer Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Hepatology 47:279-87. 2008
    ....
  18. ncbi Phenotype reversion in fetal human liver epithelial cells identifies the role of an intermediate meso-endodermal stage before hepatic maturation
    Mari Inada
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Cell Sci 121:1002-13. 2008
    ....
  19. ncbi Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning
    Brigid Joseph
    Department of Medicine and Pathology, Marion Bessin Liver Research Center, Jack and Pearl Resnick Campus, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 44:1411-20. 2006
    ..In conclusion, development of drugs with monocrotaline-like effects will help advance liver cell therapy...
  20. ncbi Hepatocyte transplantation-induced liver inflammation is driven by cytokines-chemokines associated with neutrophils and Kupffer cells
    Natan Krohn
    Department of Medicine, Marion Bessin Liver Research Center, Diabetes Research Center and Cancer Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Gastroenterology 136:1806-17. 2009
    ..Hepatocyte transplantation-induced liver inflammation impairs cell engraftment. We defined whether proinflammatory cytokines and chemokines played roles in regulation of hepatocyte engraftment in the liver...
  21. ncbi Adenosine triphosphate-binding cassette subfamily C member 2 is the major transporter of the hepatobiliary imaging agent (99m)Tc-mebrofenin
    Kuldeep K Bhargava
    Division of Nuclear Medicine and Molecular Imaging, North Shore Long Island Health System, New Hyde Park, New York, USA
    J Nucl Med 50:1140-6. 2009
    ..Hepatic excretion of (99m)Tc-mebrofenin was largely dependent on Abcc2. This molecular basis of (99m)Tc-mebrofenin excretion will advance studies of pathophysiologic mechanisms in hepatic Abcc2 pathways...
  22. ncbi Isolation of human progenitor liver epithelial cells with extensive replication capacity and differentiation into mature hepatocytes
    Harmeet Malhi
    Department of Medicine, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    J Cell Sci 115:2679-88. 2002
    ..The studies indicate that isolation of progenitor cells from fetal organs will be appropriate for establishing novel systems to investigate basic mechanisms and for cell and gene therapy...
  23. ncbi Integrin and extracellular matrix interactions regulate engraftment of transplanted hepatocytes in the rat liver
    Vinay Kumaran
    Department of Medicine, Marion Bessin Liver Research Center, Cancer Research Center, Diabetes Research Center, and General Clinical Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Gastroenterology 129:1643-53. 2005
    ..Such mechanisms will be relevant for engraftment of other cell types and for strategies concerning liver-directed cell therapy...
  24. ncbi Regulation of hepatobiliary transport activity and noninvasive identification of cytokine-dependent liver inflammation
    Brigid Joseph
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY, USA
    J Nucl Med 46:146-52. 2005
    ..This cytokine-mediated process establishes a paradigm for identifying and monitoring organ inflammation, including in viral or alcoholic hepatitis, fatty liver disease, allograft rejection, and responses to gene therapy vectors...
  25. ncbi Systemic and local release of inflammatory cytokines regulates hepatobiliary excretion of 99mTc-mebrofenin
    Brigid Joseph
    Department of Medicine and Pathology, Marion Bessin Liver Research Center, Jack and Pearl Resnick Campus, North Shore Long Island Jewish Health System Campus, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nucl Med Commun 29:336-44. 2008
    ..To demonstrate the effects of liver injury on the disposal of the organic anion mebrofenin, we performed animal studies...
  26. ncbi Kupffer cells participate in early clearance of syngeneic hepatocytes transplanted in the rat liver
    Brigid Joseph
    Marion Bessin Liver Research Center, Long Island Jewish Hospital, New York, USA
    Gastroenterology 123:1677-85. 2002
    ..CONCLUSIONS: Perturbation of Kupffer cell activity will benefit liver repopulation with cells and further analysis of clinically suitable approaches to exploit this mechanism will be appropriate...
  27. ncbi Molecular perturbations restrict potential for liver repopulation of hepatocytes isolated from non-heart-beating donor rats
    Yuta Enami
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 55:1182-92. 2012
    ..Insights into molecular changes in hepatocytes from non-heart-beating donors offer opportunities for improving donor cell viability, which will advance the utility of non-heart-beating donor organs for cell therapy or other applications...
  28. ncbi Molecular pathway-specific 99mTc-N-(3-bromo-2,4,6-trimethyacetanilide) iminodiacetic acid liver imaging to assess innate immune responses induced by cell transplantation
    Brigid Joseph
    Departments of Medicine and Pathology, Marion Bessin Liver Research Center, Cancer Research Center, Diabetes Center, Jack and Pearl Resnick Campus, New York, USA
    Nucl Med Commun 30:126-33. 2009
    ..We studied whether perturbations in specific molecular pathways after inflammation in a syngeneic cell transplantation model could be identified by noninvasive imaging...
  29. ncbi Bile salt-induced pro-oxidant liver damage promotes transplanted cell proliferation for correcting Wilson disease in the Long-Evans Cinnamon rat model
    Brigid Joseph
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 49:1616-24. 2009
    ..We concluded that pro-oxidant perturbations were uniquely effective for cell therapy in Wilson disease because of the nature of preexisting hepatic damage...
  30. ncbi TGF-β and iron differently alter HBV replication in human hepatocytes through TGF-β/BMP signaling and cellular microRNA expression
    Sun O Park
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, New York, USA
    PLoS ONE 7:e39276. 2012
    ..This knowledge should advance studies of mechanisms in viral-host interactions, hepatic injury, and therapeutic developments for hepatitis B...
  31. ncbi PET with 64Cu-histidine for noninvasive diagnosis of biliary copper excretion in Long-Evans cinnamon rat model of Wilson disease
    Ralf Bahde
    Marion Bessin Liver Research Center, Department of Medicine and Pathology, Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Nucl Med 53:961-8. 2012
    ..We hypothesized that a radiocopper-histidine complex would be effective for diagnosing Wilson disease by molecular imaging and tested this hypothesis in the Long-Evans cinnamon (LEC) rat model with Atp7b deficiency...
  32. ncbi Development of cell therapy strategies to overcome copper toxicity in the LEC rat model of Wilson disease
    Harmeet Malhi
    Albert Einstein College of Medicine, Department of Medicine, Bronx, NY 10461, USA
    Regen Med 3:165-73. 2008
    ..As copper toxicosis due to ATP7B deficiency in Wilson disease produces significant liver injury, disease-specific study of transplanted cell proliferation will offer insights into cell and gene therapy mechanisms...
  33. ncbi Control of HBV replication by antiviral microRNAs transferred by lentiviral vectors for potential cell and gene therapy approaches
    Mukesh Kumar
    Department of Medicine, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Antivir Ther 17:519-28. 2012
    ..Because molecular mechanisms regulating host cell and virus interactions are not fully understood, we further defined roles of antiviral microRNAs (miRNAs) in HBV replication...
  34. ncbi Transplanted endothelial cells repopulate the liver endothelium and correct the phenotype of hemophilia A mice
    Antonia Follenzi
    Department of Pathology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, New York, New York 10461, USA
    J Clin Invest 118:935-45. 2008
    ....
  35. ncbi Isolated small intestinal segments support auxiliary livers with maintenance of hepatic functions
    Brigid Joseph
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Med 10:749-53. 2004
    ..This ability to produce functionally competent auxiliary livers in vascularized intestinal segments offers therapeutic potential for liver disease and genetic deficiency...
  36. ncbi Cell transplantation after oxidative hepatic preconditioning with radiation and ischemia-reperfusion leads to extensive liver repopulation
    Harmeet Malhi
    Marion Bessin Liver Research Center, Departments of Medicine, Radiation Oncology, and Pathology, Comprehensive Cancer Research Center, and General Clinical Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 99:13114-9. 2002
    ..Progressive loss of cells experiencing oxidative DNA damage after radiation and ischemia-reperfusion injury could be of significance for epithelial renewal in additional organs...
  37. ncbi Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat
    Daniel Benten
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 42:1072-81. 2005
    ..Manipulation of hepatic stellate cells might provide new strategies to improve liver repopulation after enhanced transplanted cell engraftment...
  38. ncbi Quantitative tools for assessing the fate of xenotransplanted human stem/progenitor cells in chimeric mice
    Kang Cheng
    Department of Medicine, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, 10461 NY, USA
    Xenotransplantation 16:145-51. 2009
    ..Probes for single copy genes, as well as repetitive genetic elements are available for detecting transplanted cells, although their value relative to one another had not been defined...
  39. ncbi Spontaneous origin from human embryonic stem cells of liver cells displaying conjoint meso-endodermal phenotype with hepatic functions
    Sriram Bandi
    Ruth L and David S Gottesman Institute for Stem Cell and Regenerative Medicine Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Sci 125:1274-83. 2012
    ..This offers opportunities to prospectively identify whether suitable cells have been generated through manipulation of stem cells for cell therapy and other applications...
  40. ncbi Sestamibi is a substrate for MDR1 and MDR2 P-glycoprotein genes
    Brigid Joseph
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann 625, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Eur J Nucl Med Mol Imaging 30:1024-31. 2003
    ..Assessment of P-glycoprotein activity with sestamibi should consider how regulation of ABCB1 and related family members might modulate sestamibi incorporation...
  41. ncbi 99mTc-mebrofenin scintigraphy for evaluating liver disease in a rat model of Wilson's disease
    Harmeet Malhi
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 11040, USA
    J Nucl Med 43:246-52. 2002
    ....
  42. ncbi Hepatic targeting of transplanted liver sinusoidal endothelial cells in intact mice
    Daniel Benten
    Department of Medicine and Pathology, Marion Bessin Liver Research Center, Cancer Research Center, Diabetes Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 42:140-8. 2005
    ..These findings may facilitate analysis of LSEC for cell and gene therapy applications...
  43. ncbi Polyploidy associated with oxidative injury attenuates proliferative potential of cells
    G R Gorla
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Cell Sci 114:2943-51. 2001
    ..The findings provide novel frameworks in the context of polyploidy for understanding tissue development, regeneration and oncogenesis...
  44. ncbi Role of bone marrow transplantation for correcting hemophilia A in mice
    Antonia Follenzi
    Department of Pathology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Blood 119:5532-42. 2012
    ..These insights into FVIII synthesis and production in alternative cell types will advance studies of pathophysiological mechanisms and therapeutic development in hemophilia A...
  45. ncbi Identification of transplanted human cells in animal tissues
    Daniel Benten
    Department of Medicine, Albert Einstein College, Bronx, NY, USA
    Methods Mol Biol 326:189-201. 2006
    ..Incorporation of these strategies will facilitate translational studies aimed at understanding mechanisms concerning the trafficking, engraftment, proliferation, differentiation and function of human stem cells in animals...
  46. ncbi Novel hepatic progenitor cell surface markers in the adult rat liver
    Mladen I Yovchev
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 45:139-49. 2007
    ..Our studies also reveal the mesenchymal/epithelial phenotype of these cells and the existence of species diversity in the hepatic progenitor cell identity...
  47. ncbi Hepatic sinusoidal vasodilators improve transplanted cell engraftment and ameliorate microcirculatory perturbations in the liver
    Sanjeev Slehria
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Hepatology 35:1320-8. 2002
    ..This shall facilitate optimization of clinical cell transplantation and offers novel ways to investigate vascular mechanisms regulating hepatic sinusoidal reactivity...
  48. ncbi Immunosuppression using the mTOR inhibition mechanism affects replacement of rat liver with transplanted cells
    Yao-Ming Wu
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Hepatology 44:410-9. 2006
    ..In conclusion, insights into the biological effects of specific drugs on transplanted cells are critical in identifying suitable immunosuppressive strategies for cell therapy...
  49. ncbi Hepatocyte transplantation: new horizons and challenges
    H Malhi
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Hepatobiliary Pancreat Surg 8:40-50. 2001
    ..Recruitment of an increasing number of investigators to the field and the success of recent pilot studies indicate that hepatocyte transplantation will become routine clinical practice in the near future...
  50. ncbi Directly acting drugs prostacyclin or nitroglycerine and endothelin receptor blocker bosentan improve cell engraftment in rodent liver
    Ralf Bahde
    Department of Medicine, Albert Einstein College of Medicine, Bronx, NY Department of Visceral and General Surgery, University Hospital of Muenster, Muenster, Germany
    Hepatology 57:320-30. 2013
    ..Ongoing clinical use of these drugs will permit rapid translation of the findings in people. (HEPATOLOGY 2013)...
  51. ncbi Enzymatically labeled chromosomal probes for in situ identification of human cells in xenogeneic transplant models
    Jae-Jin Cho
    Marion Bessin Liver Research Center, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Nat Med 8:1033-6. 2002
    ..The ability to localize all types of nucleated human cells with such probes will facilitate studies of stem cell biology and cell and gene therapy, as well as the development of new animal models...
  52. ncbi Metal-catalyzed oxidation of extracellular matrix components perturbs hepatocyte survival with activation of intracellular signaling pathways
    Ranjit K Giri
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Exp Cell Res 291:451-62. 2003
    ..Such cell-extracellular matrix interactions may play roles in organ homeostasis and oncogenetic progression...
  53. ncbi Stage-specific regulation of adhesion molecule expression segregates epithelial stem/progenitor cells in fetal and adult human livers
    Mari Inada
    Departments of Medicine and Pathology, Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Ullmann 625, 1300 Morris Park Avenue, Bronx, NY, 10461, USA
    Hepatol Int 2:50-62. 2008
    ..Therefore, we determined fetal and adult stage-specific roles of cell adhesion in liver cell compartments...
  54. ncbi ADAMTS13 is expressed in hepatic stellate cells
    Wenhua Zhou
    Division of Hematology, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, NY 10467, USA
    Lab Invest 85:780-8. 2005
    ....
  55. ncbi Differentiation of human embryonic stem cells into hematopoietic cells by coculture with human fetal liver cells recapitulates the globin switch that occurs early in development
    Caihong Qiu
    Einstein Center for Human Embryonic Stem Cell Research, Department of Medicine, Division of Hematology and Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA
    Exp Hematol 33:1450-8. 2005
    ..This experimental system will be useful for studying the regulation of globin gene expression during early human hematopoiesis...
  56. ncbi Early cell transplantation in LEC rats modeling Wilson's disease eliminates hepatic copper with reversal of liver disease
    Harmeet Malhi
    Marion Bessin Liver Research Center, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Gastroenterology 122:438-47. 2002
    ..Cell transplantation eventually restored copper homeostasis and reversed liver disease without hepatic preconditioning in LEC rats...
  57. ncbi Correction of liver disease following transplantation of normal rat hepatocytes into Long-Evans Cinnamon rats modeling Wilson's disease
    A N Irani
    Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Mol Ther 3:302-9. 2001
    ..These data indicate that liver repopulation with functionally intact cells can reverse pathophysiological perturbations and cure Wilson's disease...
  58. ncbi Amelioration of radiation-induced liver damage in partially hepatectomized rats by hepatocyte transplantation
    C Guha
    Department of Radiation Oncology, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Cancer Res 59:5871-4. 1999
    ..We further demonstrated that transplanted hepatocytes extensively repopulate and function in a heavily irradiated rat liver...
  59. ncbi Transplantation of human cells in the peritoneal cavity of immunodeficient mice for rapid assays of hepatitis B virus replication
    Mukesh Kumar
    Marion Bessin Liver Research Center, Cancer Research Center, Diabetes Research Center, Albert Einstein College of Medicine of Yeshiva University, Bronx, NY, USA
    Xenotransplantation 18:380-9. 2011
    ..Availability of small animal models that are easily produced and permit rapid assays will be quite helpful...
  60. ncbi Switching of mesodermal and endodermal properties in hTERT-modified and expanded fetal human pancreatic progenitor cells
    Kang Cheng
    Hepatology Division, Department of Medicine, Albert Einstein College of Medicine, Ullmann Bldg, Rm 625, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    Stem Cell Res Ther 1:6. 2010
    ..Therefore, superior insights into lineage maintenance mechanisms will be helpful for cell/gene therapy...
  61. ncbi The effect of CD28/B7 blockade on alloreactive T and B cells after liver cell transplantation
    B Reddy
    Department of Medicine, Marion Bessin Research Liver Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Transplantation 71:801-11. 2001
    ..Strategies to specifically antagonize CD8+ T cells or to modulate MHC class I expression in association with costimulatory blockade by CTLA4Ig may enhance the clinical feasibility of transplanting allogeneic hepatocytes...
  62. ncbi Transplantation of endothelial cells corrects the phenotype in hemophilia A mice
    V Kumaran
    Marion Bessin Liver Research Center, Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Thromb Haemost 3:2022-31. 2005
    ..Therefore, endothelial cells should be suitable additional targets for cell and gene therapy in hemophilia A...
  63. ncbi Simvastatin reverses impaired regulation of renal oxygen consumption in congestive heart failure
    S Adler
    Division of Nephrology, Department of Medicine, New York Medical College, Valhalla, New York 10532, USA
    Am J Physiol Renal Physiol 281:F802-9. 2001
    ..Responses to SNAP were unaffected. These data demonstrate that treatment with simvastatin improves renal production of NO in CHF, restoring the normal regulation of renal O(2) consumption by NO...
  64. ncbi Pressure modulates monocyte migration
    P C Singhal
    Department of Medicine, Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park 11040, USA
    Am J Hypertens 10:1297-301. 1997
    ....
  65. ncbi The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals
    S Gupta
    Department of Medicine, Columbia University, NY 10032, USA
    EMBO J 15:1075-84. 1996
    ..In addition, these studies implicate the SH2 domain in another step in the signaling cascade, namely mediation of the interaction between STATs and their activating kinases (i.e. the JAKs)...
  66. ncbi Green tea constituent (--)-epigallocatechin-3-gallate inhibits topoisomerase I activity in human colon carcinoma cells
    S J Berger
    Department of Medicine, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
    Biochem Biophys Res Commun 288:101-5. 2001
    ..The possible role of EGCG as a chemotherapeutic agent needs to be investigated...
  67. ncbi Stage-specific modulation of IFN-regulatory factor 4 function by Krüppel-type zinc finger proteins
    S Gupta
    Department of Medicine, Columbia University, New York, NY 10032, USA
    J Immunol 166:6104-11. 2001
    ..These findings thus support a model whereby IRF-4 function is modulated in a stage-specific manner by its interaction with developmentally restricted sets of Krüppel-type zinc finger proteins...
  68. ncbi Regulation of hepatocyte engraftment and proliferation after cytotoxic drug-induced perturbation of the rat liver
    Kyung Sik Kim
    Department of Surgery, Yonsei University College of Medicine, Seoul, Korea
    Transplantation 80:653-9. 2005
    ..CONCLUSIONS: Doxorubicin-induced hepatic endothelial damage enhanced cell engraftment, which should be useful in cell therapy strategies...
  69. ncbi Differentiation and enrichment of hepatocyte-like cells from human embryonic stem cells in vitro and in vivo
    Yuyou Duan
    Transplant Research Institute, University of California Davis Medical Center, 4635 2nd Avenue, Suite 1001, Sacramento, California 95817, USA
    Stem Cells 25:3058-68. 2007
    ..This study is an initial step in establishing a viable hepatocyte-like cell line from hESC. Disclosure of potential conflicts of interest is found at the end of this article...
  70. ncbi Strategies for liver support: from stem cells to xenotransplantation
    Patrizia Burra
    Department of Surgical and Gastroenterological Sciences, University Hospital, Padova, Italy
    J Hepatol 41:1050-9. 2004
  71. ncbi Heterotopic auxiliary liver in an isolated and vascularized segment of the small intestine in rats
    Ekaterine Berishvili
    Department of Clinical Anatomy and Operative Surgery, Georgian State Medical Academy, Tbilisi, Georgia
    Transplantation 75:1827-32. 2003
    ..Further development of this auxiliary liver system will provide insights into mechanisms concerning neo-organogenesis and into potential therapeutic applications of heterotopic liver in specific diseases...
  72. ncbi Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells
    Michal Zalzman
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Ramat Aviv, Tel Aviv 69978, Israel
    Proc Natl Acad Sci U S A 100:7253-8. 2003
    ..This approach offers the potential of a novel source of cells for transplantation into patients with type 1 diabetes...
  73. ncbi Embryonic mouse STO cell-derived xenografts express hepatocytic functions in the livers of nonimmunosuppressed adult rats
    Mingjun Zhang
    Department of Pharmacology, University of California, San Diego, La Jolla, California, 92093 0636, USA
    Stem Cells 23:186-99. 2005
    ....
  74. ncbi Hog heaven on the road to liver cell therapy
    Sanjeev Gupta
    Gastroenterology 132:450-3. 2007
  75. ncbi Telomerase reconstitution immortalizes human fetal hepatocytes without disrupting their differentiation potential
    Henning Wege
    Transplant Research Institute, University of California, Davis Medical Center, Sacramento 95817, USA
    Gastroenterology 124:432-44. 2003
    ....

Research Grants22

  1. Transplantation of Endothelial Cells
    Sanjeev Gupta; Fiscal Year: 2007
    ..We expect that these studies will generate insights into endothelial cell biology, offer novel biological models and help define the therapeutic potential of liver endothelial cells. ..
  2. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2007
    ..Our studies will provide valuable preclinical information for eventual applications of cell therapy in people. ..
  3. LIVER REPOPULATION FOR LIVER INJURY AND GENE THERAPY
    Sanjeev Gupta; Fiscal Year: 2002
    ..Completion of our proposed studies will greatly advance fundamental knowledge of the ontogeny and differentiation of the liver, therapeutic potential of hepatocyte transplantation, and development of novel biological systems. ..
  4. Transplantation of Endothelial Cells
    Sanjeev Gupta; Fiscal Year: 2010
    ..We expect that these studies will generate insights into endothelial cell biology, offer novel biological models and help define the therapeutic potential of liver endothelial cells. ..