Eric B Larson

Summary

Affiliation: Group Health Cooperative
Country: USA

Publications

  1. ncbi Survival after initial diagnosis of Alzheimer disease
    Eric B Larson
    University of Washington and the Group Health Cooperative, Seattle, Washington, USA
    Ann Intern Med 140:501-9. 2004
  2. ncbi Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
  3. ncbi Health care system chaos should spur innovation: summary of a report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine
    Eric B Larson
    Group Health Cooperative, Center for Health Studies, Seattle, Washington 98101 1448, USA
    Ann Intern Med 140:639-43. 2004
  4. ncbi Physicians should be civic professionals, not just knowledge workers
    Eric B Larson
    Group Health Center for Health Studies, Seattle, Wash 98101-1448, USA
    Am J Med 120:1005-9. 2007
  5. ncbi Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older
    Eric B Larson
    Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101 1448, USA
    Ann Intern Med 144:73-81. 2006
  6. ncbi Prospects for delaying the rising tide of worldwide, late-life dementias
    Eric B Larson
    Group Health Research Institute, Seattle, Washington 98101 1448, USA
    Int Psychogeriatr 22:1196-202. 2010
  7. ncbi The rising tide of dementia worldwide
    Eric B Larson
    Group Health Center for Health Studies, Seattle, WA 98101, USA
    Lancet 372:430-2. 2008
  8. ncbi The future of general internal medicine. Report and recommendations from the Society of General Internal Medicine (SGIM) Task Force on the Domain of General Internal Medicine
    Eric B Larson
    Group Health Center for Health Studies, Seattle, Washington 98101 1448, USA
    J Gen Intern Med 19:69-77. 2004
  9. ncbi The future of generalism in medicine
    Eric B Larson
    Group Health Cooperative, Center for Health Studies, Seattle, Washington 98101-1448, USA
    Ann Intern Med 142:689-90. 2005
  10. ncbi Blood pressure and brain injury in older adults: findings from a community-based autopsy study
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
    J Am Geriatr Soc 57:1975-81. 2009

Research Grants

  1. Re-Engineering the Clinical Research Enterprise
    Eric Larson; Fiscal Year: 2004
  2. Alzheimer's Disease Patient Registry (ADPR)
    Eric Larson; Fiscal Year: 2007
  3. Development and Use of Network Infrastructure for High-Throughput GWA Studies
    Eric Larson; Fiscal Year: 2007

Detail Information

Publications114 found, 100 shown here

  1. ncbi Survival after initial diagnosis of Alzheimer disease
    Eric B Larson
    University of Washington and the Group Health Cooperative, Seattle, Washington, USA
    Ann Intern Med 140:501-9. 2004
    ..Alzheimer disease is an increasingly common condition in older people. Knowledge of life expectancy after the diagnosis of Alzheimer disease and of associations of patient characteristics with survival may help planning for future care...
  2. ncbi Using built environment characteristics to predict walking for exercise
    Gina S Lovasi
    Institute for Social and Economic Research and Policy, Columbia University, New York, NY, USA
    Int J Health Geogr 7:10. 2008
    ..In order to limit confounding by prior health conditions, the sample was restricted to participants in good self-reported health and without a documented history of cardiovascular disease...
  3. ncbi Health care system chaos should spur innovation: summary of a report of the Society of General Internal Medicine Task Force on the Domain of General Internal Medicine
    Eric B Larson
    Group Health Cooperative, Center for Health Studies, Seattle, Washington 98101 1448, USA
    Ann Intern Med 140:639-43. 2004
    ..The task force believes that these changes will benefit patients and the public and reenergize general internal medicine...
  4. ncbi Physicians should be civic professionals, not just knowledge workers
    Eric B Larson
    Group Health Center for Health Studies, Seattle, Wash 98101-1448, USA
    Am J Med 120:1005-9. 2007
  5. ncbi Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older
    Eric B Larson
    Center for Health Studies, Group Health Cooperative, Seattle, Washington 98101 1448, USA
    Ann Intern Med 144:73-81. 2006
    ..Alzheimer disease and other dementing disorders are major sources of morbidity and mortality in aging societies. Proven strategies to delay onset or reduce risk for dementing disorders would be greatly beneficial...
  6. ncbi Prospects for delaying the rising tide of worldwide, late-life dementias
    Eric B Larson
    Group Health Research Institute, Seattle, Washington 98101 1448, USA
    Int Psychogeriatr 22:1196-202. 2010
    ..Rather than the personal difficulties and public health burdens of many years of functional impairment, dependency, and suffering with dementia, some interventions may delay the onset of Alzheimer's disease and other dementias...
  7. ncbi The rising tide of dementia worldwide
    Eric B Larson
    Group Health Center for Health Studies, Seattle, WA 98101, USA
    Lancet 372:430-2. 2008
  8. ncbi The future of general internal medicine. Report and recommendations from the Society of General Internal Medicine (SGIM) Task Force on the Domain of General Internal Medicine
    Eric B Larson
    Group Health Center for Health Studies, Seattle, Washington 98101 1448, USA
    J Gen Intern Med 19:69-77. 2004
    ..We believe these changes constitute a paradigm shift that can benefit patients and the public and reenergize general internal medicine...
  9. ncbi The future of generalism in medicine
    Eric B Larson
    Group Health Cooperative, Center for Health Studies, Seattle, Washington 98101-1448, USA
    Ann Intern Med 142:689-90. 2005
  10. ncbi Blood pressure and brain injury in older adults: findings from a community-based autopsy study
    Lucy Y Wang
    Mental Illness Research and Education Clinical Center, Veterans Affairs Puget Sound Healthcare System, Seattle, Washington 98108, USA
    J Am Geriatr Soc 57:1975-81. 2009
    ..To examine correlations between blood pressure (BP) and dementia-related pathological brain changes in a community-based autopsy sample...
  11. ncbi Alcohol and cognitive performance: a longitudinal study of older Japanese Americans. The Kame Project
    Gail E Bond
    Department of Psychosocial and Community Health, University of Washington, Seattle, WA 98195 7263, USA
    Int Psychogeriatr 17:653-68. 2005
    ..Recent data demonstrate that moderate consumption of alcohol (13-52 grams of ethanol per day) may be beneficial to cognitive functioning among older adults...
  12. ncbi Age-varying association between statin use and incident Alzheimer's disease
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA
    J Am Geriatr Soc 58:1311-7. 2010
    ..To determine whether risk reduction of statins for Alzheimer's disease (AD) varies by age or presence of apolipoprotein E (APOE) epsilon4 allele...
  13. ncbi Effect of vascular lesions on cognition in Alzheimer's disease: a community-based study
    Robert G Riekse
    Department of Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 52:1442-8. 2004
    ....
  14. ncbi Association between lifetime cigarette smoking and lewy body accumulation
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:412-8. 2010
    ..Although cigarette smoking is too toxic to suggest as a treatment, if confirmed, these findings may guide future therapeutic strategies that attempt to suppress LRP in human brain by other means...
  15. ncbi Education modifies the effect of apolipoprotein epsilon 4 on cognitive decline
    Marie Florence Shadlen
    Department of Medicine, Division of Gerontology and Geriatric Medicine, Harborview Medical Center, University of Washington School of Medicine, 325 9th Avenue, Box 359755, Seattle, WA 98104 2499, USA
    Neurobiol Aging 26:17-24. 2005
    ..To assess the influence of education on the association between apolipoprotein E and cognitive change...
  16. ncbi Cognitive impairment in older adults without dementia: clinical and pathologic outcomes in a community-based sample
    Lucy Y Wang
    Mental Illness Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, Washington, USA
    J Geriatr Psychiatry Neurol 22:256-65. 2009
    ..4 +/- 2.1 vs 3.1 +/- 2.7, P = .02). These observations are consistent with the view that nondemented patients with underlying AD may be more likely to present with memory than nonmemory cognitive impairment...
  17. ncbi Neuropathology in the adult changes in thought study: a review
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104 2420, USA
    J Alzheimers Dis 18:703-11. 2009
    ..This study examines correlations between clinical characteristics including extensive, longitudinal medication histories, and longitudinal cognitive testing against structural and biochemical features of disease...
  18. ncbi Group health cooperative's transformation toward patient-centered access
    James D Ralston
    Center for Health Studies, Seattle, Washington, USA
    Med Care Res Rev 66:703-24. 2009
    ....
  19. ncbi How trainees would disclose medical errors: educational implications for training programmes
    Andrew A White
    Department of Internal Medicine, University of Washington, Seattle, WA, USA
    Med Educ 45:372-80. 2011
    ..Understanding how trainees disclose errors and how their practices evolve during training could help educators design programmes to address this gap. This study was conducted to determine how trainees would disclose medical errors...
  20. ncbi Japanese-English language equivalence of the Cognitive Abilities Screening Instrument among Japanese-Americans
    Laura E Gibbons
    Department of Medicine, University of Washington, Seattle, USA
    Int Psychogeriatr 21:129-37. 2009
    ..S.A. The measurement equivalence in Japanese and English had not been confirmed in prior studies...
  21. ncbi Temporal relationship between depression and dementia: findings from a large community-based 15-year follow-up study
    Ge Li
    Departments of Psychiatry andBehavioral Sciences, University of Washington, Seattle, USA
    Arch Gen Psychiatry 68:970-7. 2011
    ..Late-life depression is associated with increased risk of dementia, but the temporal relationship between depression and development of dementia remains unclear...
  22. ncbi Adult Changes in Thought study: dementia is an individually varying convergent syndrome with prevalent clinically silent diseases that may be modified by some commonly used therapeutics
    Thomas J Montine
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Curr Alzheimer Res 9:718-23. 2012
    ....
  23. ncbi Dementia and Alzheimer disease incidence: a prospective cohort study
    Walter A Kukull
    National Alzheimer Coordinating Center, Department of Epidemiology, Box 357236, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98195 7236, USA
    Arch Neurol 59:1737-46. 2002
    ..Incidence estimates for the United States are few and vary with the population sampled and study design; we present data that will contribute to a consensus of these rates...
  24. ncbi Different patterns of cerebral injury in dementia with or without diabetes
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Arch Neurol 66:315-22. 2009
    ..Diabetes mellitus (DM) increases the risk of dementia in the elderly. However, its underlying mechanisms, its connection with Alzheimer disease and vascular cognitive impairment, and effects of therapy remain unclear...
  25. ncbi Motivating factors for physician ordering of factor V Leiden genetic tests
    Lucia A Hindorff
    Department of Epidemiology, University of Washington, Seattle, USA
    Arch Intern Med 169:68-74. 2009
    ..The factor V Leiden (FVL) genetic test is used by many physicians despite its uncertain clinical utility...
  26. ncbi Subjective memory deterioration and future dementia in people aged 65 and older
    Li Wang
    Department of Medicine, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 52:2045-51. 2004
    ..These findings suggest that a high level of subjective memory deterioration in persons with normal objective cognitive function may identify a subset of individuals at greater risk for developing dementia...
  27. ncbi Atrial fibrillation and risk of dementia: a prospective cohort study
    Sascha Dublin
    Group Health Research Institute, Seattle, Washington, USA
    J Am Geriatr Soc 59:1369-75. 2011
    ..To determine whether atrial fibrillation (AF) is associated with risk of incident dementia or Alzheimer's disease (AD), beyond its effect on stroke...
  28. ncbi Executive dysfunction and presbycusis in older persons with and without memory loss and dementia
    George A Gates
    Department of Otolaryngology Head Neck Surgery, University of Washington, Seattle, WA 98195 7923, USA
    Cogn Behav Neurol 23:218-23. 2010
    ..To determine the relation of age-related auditory processing dysfunction and executive functioning...
  29. ncbi The attitudes and experiences of trainees regarding disclosing medical errors to patients
    Andrew A White
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98105 4608, USA
    Acad Med 83:250-6. 2008
    ..To measure trainees' attitudes and experiences regarding medical error and error disclosure...
  30. ncbi Protective association between neighborhood walkability and depression in older men
    Ethan M Berke
    Department of Family Medicine, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 55:526-33. 2007
    ..To evaluate the association between neighborhood walkability and depression in older adults...
  31. ncbi Effects of varying diagnostic criteria on prevalence of mild cognitive impairment in a community based sample
    Emily H Trittschuh
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA
    J Alzheimers Dis 25:163-73. 2011
    ..Longitudinal follow-up will determine whether varying diagnostic criteria improves sensitivity and specificity of the MCI diagnosis as a predictor for dementia...
  32. ncbi Interrater reliability and accuracy in identifying ischemic strokes using computed tomography scans in people with dementia
    James D Bowen
    Department of Neurology, University of Washington, Seattle, Washington 98195, USA
    J Am Geriatr Soc 53:1743-7. 2005
    ..To assess the reliability and interobserver agreement of stroke identification on neuroimaging in patients presenting with dementia...
  33. ncbi Increasing walking and bright light exposure to improve sleep in community-dwelling persons with Alzheimer's disease: results of a randomized, controlled trial
    Susan M McCurry
    Department of Psychosocial and Community Health, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 59:1393-402. 2011
    ..To test the effects of walking, light exposure, and a combination intervention (walking, light, and sleep education) on the sleep of persons with Alzheimer's disease (AD)...
  34. ncbi Alcohol, gender, and cognitive performance: a longitudinal study comparing older Japanese and non-Hispanic white Americans
    Gail E Bond
    University of Washington, Psychosocial and Community Health, Box 357263, Seattle, WA 98195 7263, USA
    J Aging Health 16:615-40. 2004
    ..Background: Recent data demonstrate that moderate consumption of alcohol may be beneficial to cognition...
  35. ncbi The UCHL1 S18Y polymorphism and Parkinson's disease in a Japanese population
    Katherine W Snapinn
    Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington, USA
    Parkinsonism Relat Disord 17:473-5. 2011
    ..47-1.20; YY vs. SS, OR, 0.64; 95% CI, 0.36-1.14; trend test, P=0.12). These results indicate that, if involved in PD, the S18Y variant is not a major determinant of risk and its effect might be restricted to early-onset disease...
  36. ncbi Item response theory facilitated cocalibrating cognitive tests and reduced bias in estimated rates of decline
    Paul K Crane
    Department of Medicine, University of Washington, Seattle, WA, USA
    J Clin Epidemiol 61:1018-27.e9. 2008
    ....
  37. ncbi Accuracy of blood pressure measurements reported in an electronic medical record during routine primary care visits
    Paul A Fishman
    Group Health Research Institute, Seattle, WA 98101, USA
    J Clin Hypertens (Greenwich) 13:821-8. 2011
    ..However, BP control for individuals, as defined by an SBP <140 mm Hg and DBP 90 mm Hg, differed by almost 25%. Known variability of BP and clinic procedures for measuring and recording BP may account for these differences...
  38. ncbi Clinical and neuropathological characteristics of hippocampal sclerosis: a community-based study
    James B Leverenz
    Veterans Affairs Northwest Network Mental Illness Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, 1660 S Columbian Way, 116 MIRECC, Seattle, WA 98108, USA
    Arch Neurol 59:1099-106. 2002
    ..However, these studies were from selected samples and therefore are not necessarily representative of patients seen in the general medical community...
  39. ncbi Evaluation of selection bias in an incident-based dementia autopsy case series
    Debby Tsuang
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    Alzheimer Dis Assoc Disord 19:67-73. 2005
    ....
  40. ncbi Ecology of the aging human brain
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, 98104, USA
    Arch Neurol 68:1049-56. 2011
    ..Alzheimer disease, cerebral vascular brain injury, and isocortical Lewy body disease (LBD) are the major contributors to dementia in community- and population-based studies...
  41. ncbi Histamine-2 receptor antagonist use and incident dementia in an older cohort
    Shelly L Gray
    School of Pharmacy, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 59:251-7. 2011
    ..To examine whether histamine-2 receptor antagonist medications (H2RAs) are associated with a lower incidence of all-cause dementia or Alzheimer's disease (AD), as some studies have suggested...
  42. ncbi Association of the built environment with physical activity and obesity in older persons
    Ethan M Berke
    Department of Family Medicine, University of Washington, Seattle, USA
    Am J Public Health 97:486-92. 2007
    ..We examined whether older persons who live in areas that are conducive to walking are more active or less obese than those living in areas where walking is more difficult...
  43. ncbi Free radical damage to cerebral cortex in Alzheimer's disease, microvascular brain injury, and smoking
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, USA
    Ann Neurol 65:226-9. 2009
    ....
  44. ncbi Predicting lewy body pathology in a community-based sample with clinical diagnosis of Alzheimer's disease
    Debby Tsuang
    University of Washington Departments of Psychiatry and Behavioral Sciences, Seattle, WA, USA
    J Geriatr Psychiatry Neurol 19:195-201. 2006
    ..The model also identified other demographic and clinical characteristics that might enhance the prediction of Lewy body pathology...
  45. ncbi A randomized controlled clinical trial of the Seattle Protocol for Activity in older adults
    Linda Teri
    Departments of Psychosocial and Community Health, University of Washington, Seattle, WA 98115, USA
    J Am Geriatr Soc 59:1188-96. 2011
    ....
  46. ncbi Age-varying association between blood pressure and risk of dementia in those aged 65 and older: a community-based prospective cohort study
    Ge Li
    Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 55:1161-7. 2007
    ..To assess variation in the association between blood pressure (BP) and risk for dementia across a spectrum of older ages and to examine BP changes before dementia onset...
  47. ncbi Pathological correlates of dementia in a longitudinal, population-based sample of aging
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA, USA
    Ann Neurol 62:406-13. 2007
    ..Our goal was to determine the independent pathological correlates associated with dementia in a typical US population...
  48. ncbi Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults
    Nadia Postupna
    Department of Pathology, University of Washington, Seattle, USA
    Brain Pathol 22:472-84. 2012
    ....
  49. ncbi Spreading a patient-centered medical home redesign: a case study
    Clarissa Hsu
    Center for Community Health and Evaluation, Group Health Research Institute, 1730 Minor Avenue, Seattle, WA 98101, USA
    J Ambul Care Manage 35:99-108. 2012
    ..Group Health's experience provides valuable insights that can be used to improve the design and implementation of future PCMH models...
  50. ncbi Trajectories of kidney function decline in the 2 years before initiation of long-term dialysis
    ANN M O'HARE
    Department of Medicine, VA Puget Sound Healthcare System and University of Washington, Seattle, WA 98108, USA
    Am J Kidney Dis 59:513-22. 2012
    ..Little is known about patterns of kidney function decline leading up to the initiation of long-term dialysis...
  51. ncbi Insulin and sex interactions in older adults with mild cognitive impairment
    Brenna Cholerton
    Geriatric Research, Education, and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA 98493, USA
    J Alzheimers Dis 31:401-10. 2012
    ..Future research will help determine whether insulin dysregulation results in differential effects on vascular function and AD pathology as a function of sex and/or APOE genotype...
  52. ncbi Longitudinal change in positive affect in community-dwelling older persons
    Brenda F Kurland
    Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    J Am Geriatr Soc 54:1846-53. 2006
    ..To determine whether positive affect, defined as emotional contentment and happiness, remains stable in late life and to identify predictors of longitudinal change in positive affect...
  53. ncbi Central auditory dysfunction in older persons with memory impairment or Alzheimer dementia
    George A Gates
    Department of Otolaryngology Head and Neck Surgery, University of Washington, Seattle, WA, USA
    Arch Otolaryngol Head Neck Surg 134:771-7. 2008
    ..To assess the effect of memory impairment on central auditory function...
  54. ncbi Predictors of short- and long-term adherence to a daily walking program in persons with Alzheimer's disease
    Susan M McCurry
    Department of Psychosocial and Community Health, University of Washington, Seattle, 98115, USA
    Am J Alzheimers Dis Other Demen 25:505-12. 2010
    ..To examine factors associated with adherence to a walking program in community-dwelling individuals with Alzheimer's disease (AD)...
  55. ncbi Glad you asked: participants' opinions of re-consent for dbGap data submission
    Evette J Ludman
    Group Health Research Institute, USA
    J Empir Res Hum Res Ethics 5:9-16. 2010
    ..These results suggest that re-consent for dbGaP deposition may be advisable in certain cases to anticipate and honor participant preferences...
  56. ncbi Functional status is a confounder of the association of influenza vaccine and risk of all cause mortality in seniors
    Lisa A Jackson
    Center for Health Studies, Group Health Cooperative, Seattle, WA 98101, USA
    Int J Epidemiol 35:345-52. 2006
    ....
  57. ncbi Esterified estrogen and conjugated equine estrogen and the risk of incident myocardial infarction and stroke
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, and Center for Health Studies, Group Health Cooperative, Seattle 98101 1448, USA
    Arch Intern Med 166:399-404. 2006
    ..The association of these end points with the use of esterified estrogen (EE) is unknown...
  58. ncbi Performance-based physical function and future dementia in older people
    Li Wang
    Health Services Research and Development Center of Excellence, VA Puget Sound Health Care System, Seattle, USA
    Arch Intern Med 166:1115-20. 2006
    ..The study suggests that poor physical function may precede the onset of dementia and AD and higher levels of physical function may be associated with a delayed onset...
  59. ncbi Central auditory dysfunction as a harbinger of Alzheimer dementia
    George A Gates
    Virginia Merrill Bloedel Hearing Research Center, Department of Otolaryngology Head and Neck Surgery, University of Washington, P O Box 357923, Seattle, WA 98195 7923, USA
    Arch Otolaryngol Head Neck Surg 137:390-5. 2011
    ..To confirm that central auditory dysfunction (CAD) may be a precursor to the onset of Alzheimer dementia (AD)...
  60. ncbi Pathologic correlates of dementia in individuals with Lewy body disease
    Joshua A Sonnen
    Department of Pathology, University of Washington, Seattle, WA 98104, USA
    Brain Pathol 20:654-9. 2010
    ..Diseases contributing to cognitive impairment and dementia in patients with bLBD are heterogeneous, providing diagnostic challenges as well as multiple opportunities for successful intervention in patients with PD...
  61. ncbi Older adults' views of "successful aging"--how do they compare with researchers' definitions?
    Elizabeth A Phelan
    Department of Medicine, Division of Gerontology and Geriatric Medicine, School of Public Health and Community Medicine, University of Washington, Seattle, Washington 98104, USA
    J Am Geriatr Soc 52:211-6. 2004
    ..To determine whether older adults have thought about aging and aging successfully and to compare their perceptions of successful aging with attributes of successful aging identified in the published literature...
  62. ncbi Impact on seniors of the patient-centered medical home: evidence from a pilot study
    Paul A Fishman
    Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Suite 1600, Seattle, WA 98101, USA
    Gerontologist 52:703-11. 2012
    ..To assess the impact on health care cost and quality among seniors of a patient-centered medical home (PCMH) pilot at Group Health Cooperative, an integrated health care system in Washington State...
  63. ncbi Association of incident dementia with hospitalizations
    Elizabeth A Phelan
    Division of Gerontology and Geriatric Medicine, Department of Medicine, School of Public Health and Community Medicine, University of Washington, Seattle, WA 98104 2499, USA
    JAMA 307:165-72. 2012
    ..New evidence is needed to determine whether some admissions of persons with dementia might be potentially preventable...
  64. ncbi Patient-centered medical home demonstration: a prospective, quasi-experimental, before and after evaluation
    Robert J Reid
    Group Health Research Institute, Group Health Cooperative, 1730 Minor Ave, Ste 1600, Seattle, WA 98101, USA
    Am J Manag Care 15:e71-87. 2009
    ..Five design principles guided development of the PCMH changes to staffing, scheduling, point-of-care, outreach, and management...
  65. ncbi Associations between microinfarcts and other macroscopic vascular findings on neuropathologic examination in 2 databases
    W T Longstreth
    Department of Neurology, University of Washington, Harborview Medical Center, 325 Ninth Avenue, Seattle, WA 98104 2420, USA
    Alzheimer Dis Assoc Disord 23:291-4. 2009
    ..9, 95% CI: 1.4, 6.3). These neuropathologic associations suggest that people whose cranial MRI shows macroinfarcts, hemorrhages, or leukoencephalopathy are more likely also to have microinfarcts...
  66. ncbi Evaluation of the group health cooperative access initiative: study design challenges in estimating the impact of a large-scale organizational transformation
    David Grembowski
    Group Health Cooperative, Center for Health Studies, Washington, Seattle, USA
    Qual Manag Health Care 17:292-303. 2008
    ..The methods may be generalizable to evaluating similar reforms in other integrated delivery systems with representative patient and physician data sources...
  67. ncbi Biomechanical properties of shoes and risk of falls in older adults
    Allan F Tencer
    Harborview Injury Prevention and Research Center, Orthopedic Sciences Laboratory, Harborview Medical Center, MS 359798, 325 Ninth Avenue, Seattle, WA 98104, USA
    J Am Geriatr Soc 52:1840-6. 2004
    ..To determine the relationships between the biomechanical properties of shoes worn in a cohort of healthy older adults and the risk of falling...
  68. ncbi Myocardial infarction and stroke associated with diuretic based two drug antihypertensive regimens: population based case-control study
    Inbal Boger-Megiddo
    Cardiovascular Health Research Unit, University of Washington, Seattle, WA 98101, USA
    BMJ 340:c103. 2010
    ..Design Population based case-control study. Setting Group Health Cooperative, Seattle, WA, USA...
  69. ncbi Current guidelines for using angiotensin-converting enzyme inhibitors and angiotensin II-receptor antagonists in chronic kidney disease: is the evidence base relevant to older adults?
    ANN M O'HARE
    Division of Nephrology, Department of Medicine, University of Washington and Veterans Affairs Puget Sound Health Care System, Seattle, Washington 98108, USA
    Ann Intern Med 150:717-24. 2009
    ....
  70. ncbi Use of a shared medical record with secure messaging by older patients with diabetes
    William G Weppner
    Department of Medicine, University of Washington, Seattle, Washington, USA
    Diabetes Care 33:2314-9. 2010
    ..Evaluate use of a web-based shared medical record (SMR) between older patients with diabetes and providers...
  71. ncbi Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease
    Erin M Ramos
    Institute for Public Health Genetics, Department of Medicine, University of Washington, Seattle, WA, USA
    Arch Neurol 63:1165-9. 2006
    ..Functional polymorphisms in tumor necrosis factor alpha (TNF-alpha) and interleukin 10 (IL-10) can affect immune response, inflammation, tissue injury, and possibly the susceptibility to Alzheimer disease (AD)...
  72. ncbi Empiric refinement of the pathologic assessment of Lewy-related pathology in the dementia patient
    James B Leverenz
    Department of Veterans Affairs Northwest Network Mental Illness and Parkinson s Disease Research, University of Washington, Seattle, WA 98108, USA
    Brain Pathol 18:220-4. 2008
    ..In addition, this modification allows for more limited sampling of brain regions for classification of LRP. We propose that these modified criteria for the categorization of LRP be utilized in patients with a history of dementia...
  73. ncbi Regional variation in health care intensity and treatment practices for end-stage renal disease in older adults
    ANN M O'HARE
    Department of Medicine, University of Washington, and VA Puget Sound Healthcare System, Seattle, WA 98108, USA
    JAMA 304:180-6. 2010
    ..An increasing number of older adults are being treated for end-stage renal disease (ESRD) with long-term dialysis...
  74. ncbi Statin use and risk of community acquired pneumonia in older people: population based case-control study
    Sascha Dublin
    Group Health Center for Health Studies, 1730 Minor Avenue, Suite 1600, Seattle WA 98101 1448, USA
    BMJ 338:b2137. 2009
    ..To test the hypothesis that hydroxymethyl glutaryl coenzyme A reductase inhibitors (statins) may decrease the risk of community acquired pneumonia...
  75. ncbi The group health medical home at year two: cost savings, higher patient satisfaction, and less burnout for providers
    Robert J Reid
    Group Health Research Institute, Seattle, WA, USA
    Health Aff (Millwood) 29:835-43. 2010
    ..We estimate total savings of $10.3 per patient per month twenty-one months into the pilot. We offer an operational blueprint and policy recommendations for adoption in other health care settings...
  76. ncbi Effectiveness of home blood pressure monitoring, Web communication, and pharmacist care on hypertension control: a randomized controlled trial
    Beverly B Green
    Group Health Center for Health Studies, 1730 Minor Ave, Ste 1600, Seattle, WA 98110, USA
    JAMA 299:2857-67. 2008
    ..Treating hypertension decreases mortality and disability from cardiovascular disease, but most hypertension remains inadequately controlled...
  77. ncbi Patient experience should be part of meaningful-use criteria
    James D Ralston
    Group Health Research Institute, Group Health Cooperative, in Seattle, Washington, USA
    Health Aff (Millwood) 29:607-13. 2010
    ..These results highlight the need to measure the patient experience as part of meaningful use and to enact policies supporting online and phone communication by patients and providers...
  78. ncbi Research agenda for understanding Alzheimer disease in diverse populations: work group on cultural diversity, Alzheimer's association
    Marie-Florence Shadlen
    Department of Medicine, University of Washington, Seattle, Washington 98104-2499, USA
    Alzheimer Dis Assoc Disord 16:S96-S100. 2002
    ....
  79. ncbi Association between acute care and critical illness hospitalization and cognitive function in older adults
    William J Ehlenbach
    Department of Medicine, University of Washington, Seattle, USA
    JAMA 303:763-70. 2010
    ..Studies suggest that many survivors of critical illness experience long-term cognitive impairment but have not included premorbid measures of cognitive functioning and have not evaluated risk for dementia associated with critical illness...
  80. ncbi Measuring, monitoring, and reducing medical harm from a systems perspective: a medical director's personal reflections
    Eric B Larson
    University of Washington Medical Center, and University of Washington School of Medicine, Seattle, Washington 98195 6330, USA
    Acad Med 77:993-1000. 2002
    ....
  81. ncbi Proteomic determination of widespread detergent-insolubility including Abeta but not tau early in the pathogenesis of Alzheimer's disease
    Randall L Woltjer
    Department of Pathology, Division of Neuropathology, University of Washington, Seattle, WA, USA
    FASEB J 19:1923-5. 2005
    ..These results are consistent with the amyloid hypothesis of AD and extend it to include widespread protein insolubility, not exclusively Abeta insolubility, early in AD pathogenesis even before the onset of clinical dementia...
  82. ncbi Similarities and differences in attitudes toward long-term care between Japanese Americans and Caucasian Americans
    Wayne C McCormick
    Harborview Medical Center, University of Washington, 325 9th Avenue, Mail Stop 359755, Seattle, WA 98104, USA
    J Am Geriatr Soc 50:1149-55. 2002
    ....
  83. ncbi Predictors of functional change: a longitudinal study of nondemented people aged 65 and older
    Li Wang
    Departments of Medicine, Biostatistics, and Epidemiology, University of Washington, Seattle, Washington, USA
    J Am Geriatr Soc 50:1525-34. 2002
    ..These observations, along with other published research, add to the growing understanding of the underlying process of functional change and could provide a basis to design effective strategies to delay functional decline...
  84. ncbi Medicine as a profession--back to basics: preserving the physician-patient relationship in a challenging medical marketplace
    Eric B Larson
    Department of Medicine, University of Washington, Seattle, USA
    Am J Med 114:168-72. 2003
  85. ncbi Racial inequities in the timing of breast cancer detection, diagnosis, and initiation of treatment
    Joann G Elmore
    Department of Medicine, University of Washington School of Medicine, Seattle, Washington 98104 2499, USA
    Med Care 43:141-8. 2005
    ..Recent studies suggest differences in quality and timeliness of care received may be major contributing sources to the racial disparity in breast cancer detection and related outcomes...
  86. ncbi Genomic research and wide data sharing: views of prospective participants
    Susan Brown Trinidad
    Department of Bioethics and Humanities, University of Washington, Seattle, WA 98195 7120, USA
    Genet Med 12:486-95. 2010
    ..This study was designed to explore the perceptions, beliefs, and attitudes of research participants and possible future participants regarding genome-wide association studies and repository-based research...
  87. ncbi Update in general internal medicine
    John V L Sheffield
    Harborview Medical Center and Group Health Cooperative, Seattle, Washington 98104, USA
    Ann Intern Med 143:212-21. 2005
  88. ncbi Esterified estrogens and conjugated equine estrogens and the risk of venous thrombosis
    Nicholas L Smith
    Department of Epidemiology, University of Washington, Seattle, USA
    JAMA 292:1581-7. 2004
    ..The findings from these trials, which used oral conjugated equine estrogens, may not be generalizable to other estrogen compounds...
  89. ncbi Mitochondrial genetic variants and Alzheimer disease: a case-control study of the T4336C and G5460A variants
    Steven D Edland
    Department of Epidemiology, University of Washington, Seattle, Washington, USA
    Alzheimer Dis Assoc Disord 16:1-7. 2002
    ..Substantially larger samples than are currently available would be required to resolve this question. G5460(A/T) variants were also investigated and found not to be associated with Alzheimer disease...
  90. ncbi Direct-to-consumer marketing of osteoporosis drugs and bone densitometry
    Matthew F Hollon
    Department of Medicine, School of Medicine, University of Washington, Seattle, WA, USA
    Ann Pharmacother 37:976-81. 2003
    ..To determine whether there is an association between a woman's exposure to direct-to-consumer (DTC) advertisements for 2 osteoporosis drugs and presentation for bone densitometry...
  91. ncbi Trends in the prevalence and mortality of cognitive impairment in the United States: is there evidence of a compression of cognitive morbidity?
    Kenneth M Langa
    Division of General Medicine, Department of Medicine, University of Michigan, Ann Arbor, MI, USA
    Alzheimers Dement 4:134-44. 2008
    ..To assess the impact of these multiple trends, we compared the prevalence and 2-year mortality of cognitive impairment (CI) consistent with dementia in the United States in 1993 to 1995 and 2002 to 2004...
  92. ncbi Developmental and vascular risk factors for Alzheimer's disease
    Amy R Borenstein
    Department of Epidemiology and Biostatistics, College of Public Health, University of South Florida, 13201 Bruce B Downs Blvd, Tampa, FL 33612 3805, USA
    Neurobiol Aging 26:325-34. 2005
    ..7-15.5; HR 3.3, 95% CI 1.4-8.1)). These findings indicate that clinical AD is a result of early life as well as later life risk factors, and that genetic predisposition to the disease may modify the constellation of predictors...
  93. ncbi Primary care, generalism, public good: déjà vu? Again!
    Eric B Larson
    Ann Intern Med 142:671-4. 2005
  94. ncbi Exercise, aging, and Alzheimer disease
    Eric B Larson
    Alzheimer Dis Assoc Disord 18:54-6. 2004
  95. ncbi Choosing your words carefully: how physicians would disclose harmful medical errors to patients
    Thomas H Gallagher
    Departments of Medicine and Medical History and Ethics, University of Washington School of Medicine, 4311 11th Avenue NW, Seattle, WA 98105, USA
    Arch Intern Med 166:1585-93. 2006
    ..Little is known about how physicians approach disclosure. The objective of the present study was to describe how physicians disclose errors to patients...
  96. ncbi "Successful aging"--where next?
    Elizabeth A Phelan
    J Am Geriatr Soc 50:1306-8. 2002
  97. ncbi Older adults and functional decline: a cross-cultural comparison
    Susan M McCurry
    Department of Psychosocial and Community Health, University of Washington, Seattle 98115 2053, USA
    Int Psychogeriatr 14:161-79. 2002
    ....
  98. ncbi Fruit and vegetable juices and Alzheimer's disease: the Kame Project
    Qi Dai
    Department of Medicine, Division of General Internal Medicine and Public Health, Vanderbilt Center for Health Services Research, Vanderbilt Ingram Cancer Center, Vanderbilt School of Medicine, Nashville, Tenn, USA
    Am J Med 119:751-9. 2006
    ..Many polyphenols, the most abundant dietary antioxidants, possess stronger neuroprotection against hydrogen peroxide than antioxidant vitamins...
  99. ncbi Primary care: the next renaissance
    Jonathan Showstack
    University of California, San Francisco, 3333 California Street, Suite 265, San Francisco, CA 94118-1944, USA
    Ann Intern Med 138:268-72. 2003
    ..If we keep the needs of persons and patients clearly in sight and design systems to meet those needs, primary care will thrive and our patients will be well served...
  100. ncbi Deferred care for patients in the emergency department
    Eric B Larson
    Ann Intern Med 137:764-5. 2002
  101. ncbi Alzheimer's disease medication: use and cost projections for Medicare Part D
    Nancy E Morden
    J Am Geriatr Soc 55:622-4. 2007

Research Grants6

  1. Re-Engineering the Clinical Research Enterprise
    Eric Larson; Fiscal Year: 2004
    ..abstract_text> ..
  2. Alzheimer's Disease Patient Registry (ADPR)
    Eric Larson; Fiscal Year: 2007
    ..The results of these studies will be invaluable to the development and testing of strategies to reduce the risk of AD and related conditions, and to reduce the burden of cognitive decline in the growing population of older persons. ..
  3. Development and Use of Network Infrastructure for High-Throughput GWA Studies
    Eric Larson; Fiscal Year: 2007
    ..The implications of this portfolio of research extend far beyond the specific phenotypes we have chosen to emphasize; we expect this work represents the beginning of a large and productive enterprise. ..