Research Topics
| Pearl GrimesSummaryCountry: USA Publications
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Detail Information
Publications
Continuous therapy followed by a maintenance therapy regimen with a triple combination cream for melasmaPearl E Grimes
Division of Dermatology, University of California, Los Angeles, California, USA
J Am Acad Dermatol 62:962-7. 2010..Melasma is often recalcitrant to treatment. Triple combination (TC) cream is an effective and approved treatment for melasma...- New insights and new therapies in vitiligoPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
JAMA 293:730-5. 2005 - Tazarotene cream for postinflammatory hyperpigmentation and acne vulgaris in darker skin: a double-blind, randomized, vehicle-controlled studyPearl Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 77:45-50. 2006..In our study, tazarotene cream was effective and well tolerated in the treatment of PIH in patients with darker skin... - Management of hyperpigmentation in darker racial ethnic groupsPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA
Semin Cutan Med Surg 28:77-85. 2009..Maximal results are best achieved with repetitive, superficial, resurfacing modalities. In addition, ultraviolet protective measures such as broad-spectrum sunscreens are fundamental to the successful management of these conditions... - Light microscopic, immunohistochemical, and ultrastructural alterations in patients with melasmaPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA 90004, USA
Am J Dermatopathol 27:96-101. 2005..The results of this study suggest that melasma is a consequence of specific hyperfunctional melanocytes that cause excessive melanin deposition in the epidermis and dermis... - A four-month randomized, double-blind evaluation of the efficacy of botulinum toxin type A for the treatment of glabellar lines in women with skin types V and VIPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, California, USA
Dermatol Surg 35:429-35; discussion 435-6. 2009..Histologic differences (e.g., dermal thickness, collagen fibers) between Caucasian and other racial and ethnic groups may affect wrinkle formation and influence responses to treatment with botulinum toxin type A (BoNT-A)... - A microsponge formulation of hydroquinone 4% and retinol 0.15% in the treatment of melasma and postinflammatory hyperpigmentationPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 74:362-8. 2004..Microentrapped HQ 4% was well tolerated, with only one patient discontinuing because of an allergic reaction, which was not considered serious. In this open-label study, microentrapped HQ 4% with retinol 0.15% was safe and effective... - Topical tacrolimus therapy for vitiligo: therapeutic responses and skin messenger RNA expression of proinflammatory cytokinesPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, and the Division of Dermatology, David Geffen School of Medicine, University of California, Los Angeles, USA
J Am Acad Dermatol 51:52-61. 2004..Previous studies have documented humoral and cell-mediated immunologic defects in patients with vitiligo... - An efficacy study of 3 commercially available hydroquinone 4% treatments for melasmaPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 80:497-502. 2007..15% with antioxidants is safe and effective for use in treating melasma, and the data show that this novel nonsteroidal product should be considered when weighing long-term treatment options... - Evaluation of inherent differences between African American and white skin surface properties using subjective and objective measuresPearl Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 73:392-6. 2004.... - Safety and effectiveness of hyaluronic acid fillers in skin of colorPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, USA
J Cosmet Dermatol 8:162-8. 2009..To assess the safety and effectiveness of hyaluronic acid (HA) fillers in skin of color... - Topical tacrolimus for repigmentation of vitiligoPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, CA, USA
J Am Acad Dermatol 47:789-91. 2002..Moderate to excellent repigmentation was achieved in 5 patients. Although the number of cases in this noncontrolled, nonblinded series is small, tacrolimus ointment may be an efficacious and safe treatment option for vitiligo... - Community-based trial of a triple-combination agent for the treatment of facial melasmaPearl Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 77:177-84. 2006.... - Phase 4 study to assess tretinoin pump for the treatment of facial acneLawrence F Eichenfield
Rady Children s Hospital, San Diego, CA, USA
J Drugs Dermatol 7:1129-36. 2008..Most side effects were characteristic of topical retinoids. These results indicate TGM in a pump dispenser as an effective, well-tolerated acne treatment that is associated with a high rate of compliance... - White patches and bruised souls: advances in the pathogenesis and treatment of vitiligoPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California and the Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90004, USA
J Am Acad Dermatol 51:S5-7. 2004 - MicrodermabrasionPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, David Geffen School of Medicine, University of California Los Angeles, CA, USA
Dermatol Surg 31:1160-5; discussion 1165. 2005..Microdermabrasion has become one of the most popular forms of superficial resurfacing. The benefits and efficacy of microdermabrasion remain an intensely debated topic among dermatologic surgeons... - Surgical reconstruction of nasal sarcoidosis: a case reportMalcolm A Lesavoy
Department of Plastic and Reconstructive Surgery and Hand Surgery, UCLA School of Medicine Los Angeles, CA, USA
Ann Plast Surg 64:800-2. 2010..Although severe nasal deformities caused by sarcoidosis are very uncommon, this case demonstrates a simple and straight forward surgical approach to obtain an excellent nasal reconstruction... - Increasing our understanding of pigmentary disordersPearl Grimes
Vitiligo and Pigmentation Institute of Southern California, Division of Dermatology, University of California, Los Angeles, CA, USA
J Am Acad Dermatol 54:S255-61. 2006..This article also reports on the new health-related quality-of-life instrument (MELASQOL) that has been developed for women with melasma... - The use of polyhydroxy acids (PHAs) in photoaged skinPearl E Grimes
Vitiligo and Pigmentation Institute of Southern California, Los Angeles, USA
Cutis 73:3-13. 2004..Finally, PHA-containing products were shown to be compatible with African American, Caucasian, and Hispanic/Asian skin and provided significant improvements in photoaging in these populations... - Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasionPoonam Rajan
University of British Columbia, Vancouver, British Columbia, Canada
Dermatol Surg 28:390-3. 2002..These changes in epidermal barrier function may be responsible for the clinical improvement following microdermabrasion... - Idiopathic CD4+T-cell lymphocytopenia associated with vitiligoPaul S Yamauchi
Division of Dermatology, University of California Los Angeles School of Medicine, USA
J Am Acad Dermatol 46:779-82. 2002..He also had incidental psoriasis. The correlation between ICTL and autoimmune vitiligo suggests an aberration in the immune surveillance that leads to an abnormal response of CD4+ T lymphocytes in the host...