THEODORE GOODFRIEND

Summary

Country: USA

Publications

  1. ncbi request reprint Obesity, sleep apnea, aldosterone, and hypertension
    Theodore L Goodfriend
    Research Service, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Curr Hypertens Rep 10:222-6. 2008
  2. ncbi request reprint Oxidized products of linoleic acid stimulate adrenal steroidogenesis
    T L Goodfriend
    Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Endocr Res 28:325-30. 2002
  3. pmc Heparin, lipoproteins, and oxygenated fatty acids in blood: a cautionary note
    T L Goodfriend
    William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, 2500 Overlook Terrace, Madison, WI 53705, USA
    Prostaglandins Leukot Essent Fatty Acids 77:363-6. 2007
  4. ncbi request reprint Aldosterone--a hormone of cardiovascular adaptation and maladaptation
    Theodore L Goodfriend
    Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
    J Clin Hypertens (Greenwich) 8:133-9. 2006
  5. ncbi request reprint Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion
    Theodore L Goodfriend
    William S Middleton Memorial Veterans Hospital and Department of Medicine of the University of Wisconsin 53705, USA
    Hypertension 43:358-63. 2004
  6. ncbi request reprint Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy
    Theodore L Goodfriend
    Research Service, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Hypertension 43:518-24. 2004
  7. ncbi request reprint Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
    Heno F Lopes
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 16:331-6. 2003
  8. ncbi request reprint An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1631-5. 2003
  9. ncbi request reprint An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells
    Marcel D Payet
    Department of Physiology, University of Sherbrooke, QC, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 291:E1160-7. 2006
  10. ncbi request reprint DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003

Research Grants

  1. Oxidized Linoleic Acid, Aldosterone, and Obesity
    THEODORE GOODFRIEND; Fiscal Year: 2007

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Obesity, sleep apnea, aldosterone, and hypertension
    Theodore L Goodfriend
    Research Service, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Curr Hypertens Rep 10:222-6. 2008
    ..Features of visceral obesity and obstructive sleep apnea that may stimulate aldosterone secretion are described here. Possible therapeutic interventions addressing the hypertension associated with obesity are briefly mentioned...
  2. ncbi request reprint Oxidized products of linoleic acid stimulate adrenal steroidogenesis
    T L Goodfriend
    Wm S Middleton Memorial Veterans Hospital, Madison, WI 53705, USA
    Endocr Res 28:325-30. 2002
    ..Stimulation of steroidogenesis was observed after 15 min of incubation and continued for at least 2 hrs. The potential relevance of our findings to the hypertension of obesity is discussed...
  3. pmc Heparin, lipoproteins, and oxygenated fatty acids in blood: a cautionary note
    T L Goodfriend
    William S Middleton Memorial Veterans Hospital, University of Wisconsin Madison, 2500 Overlook Terrace, Madison, WI 53705, USA
    Prostaglandins Leukot Essent Fatty Acids 77:363-6. 2007
    ..Measurements of nonesterified lipids in human plasma may be distorted if heparin is administered to subjects before blood is drawn and if lipase inhibitors are omitted from stored samples...
  4. ncbi request reprint Aldosterone--a hormone of cardiovascular adaptation and maladaptation
    Theodore L Goodfriend
    Department of Medicine, University of Wisconsin Medical School, Madison, WI, USA
    J Clin Hypertens (Greenwich) 8:133-9. 2006
    ..Specific inhibitors of fibrosis and hypertrophy, and more effective inhibitors of the renin system should be useful in the future...
  5. ncbi request reprint Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion
    Theodore L Goodfriend
    William S Middleton Memorial Veterans Hospital and Department of Medicine of the University of Wisconsin 53705, USA
    Hypertension 43:358-63. 2004
    ..Compounds like EKODE, derived from linoleic acid, may affect adrenal steroid production in humans and mediate some of the deleterious effects of obesity and oxidative stress, especially in blacks...
  6. ncbi request reprint Resistant hypertension, obesity, sleep apnea, and aldosterone: theory and therapy
    Theodore L Goodfriend
    Research Service, William S Middleton Memorial Veterans Hospital, 2500 Overlook Terrace, Madison, WI 53705, USA
    Hypertension 43:518-24. 2004
    ....
  7. ncbi request reprint Acute hyperlipidemia increases oxidative stress more in African Americans than in white Americans
    Heno F Lopes
    Departments of Medicine and Pharmacology, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    Am J Hypertens 16:331-6. 2003
    ..The findings may have important implications for ethnic differences in the prevalence of hypertension and cardiovascular and renal disease...
  8. ncbi request reprint An oxidized metabolite of linoleic acid stimulates corticosterone production by rat adrenal cells
    Eric D Bruder
    Endocrine Research Laboratory, St Luke s Medical Center, Milwaukee, Wisconsin 53215, USA
    Am J Physiol Regul Integr Comp Physiol 284:R1631-5. 2003
    ..We conclude that EKODE stimulates corticosterone biosynthesis and amplifies the effect of ACTH. Increased levels of fatty acid metabolites may be involved in the increased glucocorticoid production observed in obese humans...
  9. ncbi request reprint An oxidized metabolite of linoleic acid increases intracellular calcium in rat adrenal glomerulosa cells
    Marcel D Payet
    Department of Physiology, University of Sherbrooke, QC, Canada J1H 5N4
    Am J Physiol Endocrinol Metab 291:E1160-7. 2006
    ..Similar bell-shaped dose-response curves for aldosterone and [Ca(2+)](i) increases reinforce this hypothesis...
  10. ncbi request reprint DASH diet lowers blood pressure and lipid-induced oxidative stress in obesity
    Heno F Lopes
    Department of Pharmacology, Medical University of South Carolina, 96 Jonathan Lucas St, CSB 826H, Charleston, SC 29425, USA
    Hypertension 41:422-30. 2003
    ..The findings are consistent with evidence that elevated BP in obese subjects may reflect an imbalance between antioxidant capacity and oxidative stress that is improved by the DASH-CD...
  11. ncbi request reprint Increasing plasma fatty acids elevates F2-isoprostanes in humans: implications for the cardiovascular risk factor cluster
    Milos P Stojiljkovic
    Department of Pharmacology and Medicine, Medical University of South Carolina, Charleston, South Carolina 29425, USA
    J Hypertens 20:1215-21. 2002
    ..To determine whether raised concentrations of non-esterified fatty acids (NEFAs) may contribute to the cardiovascular risk factor cluster by increasing oxidative stress in vivo...
  12. ncbi request reprint Treating resistant hypertension with a neglected old drug
    Theodore L Goodfriend
    Hypertension 49:763-4. 2007

Research Grants2

  1. Oxidized Linoleic Acid, Aldosterone, and Obesity
    THEODORE GOODFRIEND; Fiscal Year: 2007
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