David S Goldfarb
- Metabolic evaluation of first-time and recurrent stone formersDavid S Goldfarb
New York University School of Medicine, New York, NY 10016, USA
Urol Clin North Am 40:13-20. 2013..Although twin studies demonstrate that heritability accounts for at least 50% of the kidney stone phenotype, the responsible genes are not clearly identified, and so genetic testing is rarely indicated...
- Facilitating the transition from physiology to hospital wards through an interdisciplinary case study of septic shockAlbert S Li
Nephrology Section, VA New York Harbor Health Care System, New York, NY, USA
BMC Med Educ 14:78. 2014..Much attention has been focused on curriculum overhauls, but our approach is to facilitate horizontal and vertical integration on a smaller scale through an interdisciplinary case study discussion and then to assess its utility...
- Evidence for inheritance of medullary sponge kidneyDavid S Goldfarb
Nephrology Division, New York University Langone Medical Center, Nephrology Section, Veterans Affairs New York Harbor Healthcare System, New York, New York 10010, USA
Kidney Int 83:193-6. 2013..Although a small proportion of MSK cases are associated with variants of glial cell-derived neurotrophic factor (GDNF), the genetic basis for most instances of MSK is not known...
- A woman with recurrent calcium phosphate kidney stonesDavid S Goldfarb
Nephrology Section, New York Harbor Department of Veterans Affairs Healthcare System, New York, NY 10010, USA
Clin J Am Soc Nephrol 7:1172-8. 2012..Thiazides lower urine calcium excretion and may help ensure the safety of citrate supplementation...
- Potential pharmacologic treatments for cystinuria and for calcium stones associated with hyperuricosuriaDavid S Goldfarb
Nephrology Section 111G, NY DVAMC, 423 E 23 Street, New York, NY 10010, USA
Clin J Am Soc Nephrol 6:2093-7. 2011..In vitro, l-cystine dimethyl ester had a significant inhibitory effect on crystal growth. The drug's safety and effectiveness will be tested in an Slc3a1 knockout mouse that serves as an animal model of cystinuria...
- Randomized controlled trial of febuxostat versus allopurinol or placebo in individuals with higher urinary uric acid excretion and calcium stonesDavid S Goldfarb
Nephrology Section, New York Harbor VA Medical Center, and Division of Nephrology, New York University Langone Medical Center, New York, New York, Global Medical Affairs, Takeda Pharmaceuticals International, Deerfield, Illinois, Clinical Science, and Statistics, Takeda Global Research and Development Center, Inc, Deerfield, Illinois, Experimental Medicine, Takeda California, San Diego, California
Clin J Am Soc Nephrol 8:1960-7. 2013..This work studied whether febuxostat, compared with allopurinol and placebo, would reduce 24-hour urinary uric acid excretion and prevent stone growth or new stone formation...
- Prevalence of contraindications and prescription of pharmacologic therapies for goutRobert T Keenan
Section of Rheumatology of the New York Harbor Health Care System, New York Campus of the US Department of Veterans Affairs, New York, USA
Am J Med 124:155-63. 2011..Patients with gout have comorbidities, but the impact of these comorbidities on treatment has not been studied...
- Institutional characteristics associated with receipt of emergency care for obstructive pyelonephritis at community hospitalsMichael S Borofsky
Department of Urology, New York University Langone Medical Center, New York, New York
J Urol 193:851-6. 2015..We determined the influence of hospital factors, particularly familiarity with urolithiasis, on the likelihood of decompression in such patients...
- Effect of vitamin D repletion on urinary calcium excretion among kidney stone formersDavid E Leaf
Department of Medicine, Columbia University, New York, New York, USA
Clin J Am Soc Nephrol 7:829-34. 2012..This study examined the effect of vitamin D repletion on urinary calcium excretion among stone formers...
- Update on cystinuriaNicola Sumorok
Nephrology Section, New York Harbor VA Healthcare System, and Nephrology Division, New York University School of Medicine, New York, New York, USA
Curr Opin Nephrol Hypertens 22:427-31. 2013..Treatment is focused on the prevention of stone formation. There have been few advances in the available therapeutic options for the disorder in the last 15-20 years...
- Febuxostat in gout: serum urate response in uric acid overproducers and underexcretorsDavid S Goldfarb
New York Veterans Affairs Medical Center, New York, NY, USA
J Rheumatol 38:1385-9. 2011..The objective of this post-hoc analysis was to determine the effectiveness of the xanthine oxidase inhibitor febuxostat in reducing serum urate (sUA) levels in gouty patients who were either overproducers or underexcretors...
- Randomized controlled trial of clopidogrel plus aspirin to prevent hemodialysis access graft thrombosisJames S Kaufman
Department of Veterans Affairs Boston Healthcare System and Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02130, USA
J Am Soc Nephrol 14:2313-21. 2003..22 to 1.26; P = 0.14). In the hemodialysis population, therapy with aspirin and clopidogrel was associated with a significantly increased risk of bleeding and probably would not result in a reduced frequency of graft thrombosis...
- How life imitates baseballDavid S Goldfarb
Nephrology Section, New York VA Medical Center, New York University School of Medicine, USA
Pharos Alpha Omega Alpha Honor Med Soc 67:34-5. 2004
- Microorganisms and calcium oxalate stone diseaseDavid S Goldfarb
New York Harbor VA Medical Center and NYU School of Medicine, New York, NY 10010, USA
Nephron Physiol 98:p48-54. 2004..formigenes which codes for that organism's oxalate uptake mechanism. The author is currently completing a small randomized controlled clinical trial with this preparation in calcium stone-forming patients with idiopathic hyperoxaluria...
- A twin study of genetic and dietary influences on nephrolithiasis: a report from the Vietnam Era Twin (VET) RegistryDavid S Goldfarb
Nephrology Section, New York Harbor VAMC, New York, NY, USA
Kidney Int 67:1053-61. 2005..Nephrolithiasis is a complex phenotype that is influenced by both genetic and environmental factors. We conducted a large twin study to examine genetic and nongenetic factors associated with stones...
- Optimal medical therapy with or without percutaneous coronary intervention for patients with stable coronary artery disease and chronic kidney diseaseSteven P Sedlis
New York University School of Medicine, New York, NY, USA
Am J Cardiol 104:1647-53. 2009..Although PCI did not reduce the risk of death or myocardial infarction when added to OMT for patients with CKD, it also was not associated with worse outcomes in this high-risk group...
- A pilot study of the effect of sodium thiosulfate on urinary lithogenicity and associated metabolic acid load in non-stone formers and stone formers with hypercalciuriaOnyeka W Okonkwo
Department of Medicine, New York Harbor VA Healthcare System and NYU School of Medicine, New York, New York, United States of America
PLoS ONE 8:e60380. 2013..Results were compared by non-parametric Wilcoxon signed rank test. The primary outcome was the resulting change in urine chemistry...
- Crystal growth inhibitors for the prevention of L-cystine kidney stones through molecular designJeffrey D Rimer
Department of Chemistry and the Molecular Design Institute, New York University NYU, 100 Washington Square East, New York, NY 10003 6688, USA
Science 330:337-41. 2010..The AFM observations are mirrored by reduced crystal yield and crystal size in the presence of L-CDME and L-CME, collectively suggesting a new pathway to the prevention of L-cystine stones by rational design of crystal growth inhibitors...
- A randomized, controlled trial of lactic acid bacteria for idiopathic hyperoxaluriaDavid S Goldfarb
Nephrology Section, New York Harbor VA Medical Center and New York University School of Medicine, New York, NY 10010, USA
Clin J Am Soc Nephrol 2:745-9. 2007..Some lactic acid bacteria can degrade oxalate in vitro. This study sought to reduce urinary oxalate excretion in calcium stone formers with idiopathic hyperoxaluria...
- Update on the pathophysiology and management of uric acid renal stonesJon Emile S Kenny
Department of Medicine, NYU Langone Medical Center, New York, NY, USA
Curr Rheumatol Rep 12:125-9. 2010..We review recent evidence from both the molecular and clinical realms to underline the importance of [H+] in the development and treatment of uric acid nephrolithiasis...
- Cystine growth inhibition through molecular mimicry: a new paradigm for the prevention of crystal diseasesMichael H Lee
NYU Langone Medical Center, New York, NY, USA
Curr Rheumatol Rep 17:510. 2015..The application of AFM to discover inhibitors of crystal growth through structural mimicry suggests a novel approach to preventing and treating crystal diseases. ..
- Ambient temperature as a contributor to kidney stone formation: implications of global warmingRobert J Fakheri
New York University School of Medicine, New York, USA
Kidney Int 79:1178-85. 2011..At this time the limited data available cannot substantiate this proposed mechanism but further studies to investigate this effect are warranted...
- Effect of two sports drinks on urinary lithogenicityJeffrey W Goodman
NYU School of Medicine, New York, NY 10010, USA
Urol Res 37:41-6. 2009..Most sports drinks with significant carbohydrate content however may contain too many calories, and fructose, to be preferred beverages for stone prevention...
- Diagnosis of medullary sponge kidney by computed tomographic urographyAnna M Maw
New York University School of Medicine, New York, NY, USA
Am J Kidney Dis 50:146-50. 2007..We report a case of medullary sponge kidney diagnosed by means of 3-dimensional multidetector-row computed tomographic urography...
- Health-related quality of life (HRQoL) in cystine compared with non-cystine stone formersFrank Modersitzki
Kidney Stone Prevention Programs, Nephrology Section 111G, DVAMC, New York Harbor VA Medical Center and NYU School of Medicine, 423 E 23 St, New York, NY, 10010, USA
Urolithiasis 42:53-60. 2014..Whether preventive strategies for cystinuria are being properly utilized by practitioners, and which strategies are most effective, should be established...
- Surgical decompression is associated with decreased mortality in patients with sepsis and ureteral calculiMichael S Borofsky
Department of Urology, Nephrology Division and Section on Value and Effectiveness, New York University Langone Medical Center, New York University, New York, New York 10016, USA
J Urol 189:946-51. 2013..We determined whether a mortality benefit is associated with this intervention...
- Uric acid stones and hyperuricosuriaTapan H Mehta
Department of Medicine, New York University Langone Medical Center, New York, NY, USA
Adv Chronic Kidney Dis 19:413-8. 2012..The cornerstone of therapy is raising urinary pH; xanthine dehydrogenase inhibitors should be used only when urinary alkalinization cannot be achieved...
- Progressive renal papillary calcification and ureteral stone formation in mice deficient for Tamm-Horsfall proteinYan Liu
Dept of Urology, New York Univ School of Medicine, NY 10010, USA
Am J Physiol Renal Physiol 299:F469-78. 2010....
- Effect of diet orange soda on urinary lithogenicityNicola T Sumorok
Department of Medicine and Nephrology Division, NYU Langone Medical Center, New York, NY, USA
Urol Res 40:237-41. 2012..The effect of Diet Sunkist Orange soda on urinary chemistry in patients with hypocitraturia and nephrolithiasis is not likely to have a clinically significant effect to prevent calcium or uric acid stones...
- Melamine-related kidney stones and renal toxicityRishikesh P Dalal
Department of Medicine, NYU Langone Medical Center, 550 First Avenue, New York, NY 10016, USA
Nat Rev Nephrol 7:267-74. 2011..Finally, the public health measures taken in the wake of the melamine contamination events are discussed...
- Health status and quality of life in patients with stable coronary artery disease and chronic kidney disease treated with optimal medical therapy or percutaneous coronary intervention (post hoc findings from the COURAGE trial)Steven P Sedlis
Department of Medicine, Veterans Affairs New York Harbor Health Care System, New York University School of Medicine, New York, New York Electronic address
Am J Cardiol 112:1703-8. 2013....
- A pilot clinical study to evaluate changes in urine osmolality and urine cAMP in response to acute and chronic water loading in autosomal dominant polycystic kidney diseaseIrina Barash
Department of Medicine, Division of Nephrology, 550 First Avenue, New York, NY 10016, USA
Clin J Am Soc Nephrol 5:693-7. 2010..Water loading, by suppressing arginine vasopressin (AVP)-stimulated cAMP production, is a proposed therapy for ADPKD...
- Prospects for dietary therapy of recurrent nephrolithiasisDavid S Goldfarb
Nephrology Division, NYU School of Medicine, New York, NY, USA
Adv Chronic Kidney Dis 16:21-9. 2009..Because the efficacy of thiazides in the prevention of stones in patients with hypercalciuria is clear, I propose dietary comparison of higher calcium intake to thiazides for the prevention of calcium-based kidney stones...
- Risk of chronic and end stage kidney disease in patients with nephrolithiasisJonathan Shoag
Department of Urology, Weill Cornell Medical College, New York, New York
J Urol 192:1440-5. 2014..We examine kidney stone disease as a potential risk factor for chronic kidney disease, end stage kidney disease and treatment with dialysis...
- Adverse metabolic side effects of thiazides: implications for patients with calcium nephrolithiasisSarah C Huen
Department of Medicine, New York University School of Medicine, New York, New York 10010, USA
J Urol 177:1238-43. 2007..Whether these side effects occur and are clinically significant in nonhypertensive patients with kidney stones treated with thiazides is unclear...
- Nephrolithiasis complicating treatment of diabetes insipidusSaurabh Mehandru
Kidney Stone Prevention Program, New York VA Medical Center, New York, USA
Urol Res 33:244-6. 2005..The challenge of the management of stones in the setting of DI requires balancing the conflicting goals of both decreasing and increasing urine volume...
- Predictive value of a positive fecal occult blood test increases as the severity of CKD worsensEdmund J Bini
Division of Gastroenterology, Veterans Affairs New York Harbor Healthcare System, New York, NY 10010, USA
Am J Kidney Dis 48:580-6. 2006....
- Radioisotope blood volume measurement in hemodialysis patientsSonika Puri
Nephrology Section, New York Harbor VA Medical Center, New York, New York, USA Nephrology Division, NYU School of Medicine, New York, New York, USA
Hemodial Int 18:406-14. 2014..This may prove useful in prescribing and monitoring ultrafiltration rates, establishment of optimal BV in HD patients and reducing morbidity and mortality associated with chronic HD...
- CystinuriaAditya Mattoo
Department of Medicine, NYU School of Medicine, New York, NY, USA
Semin Nephrol 28:181-91. 2008..Prevention of stone formation is the primary goal of management and includes hydration, dietary restriction of salt and animal protein, urinary alkalinization, and cystine-binding thiol drugs...
- Continuous renal replacement therapy does not have a clear role in the treatment of poisoningZae Kim
Division of Nephrology, Nassau University Medical Center, East Meadow, NY, USA
Nephron Clin Pract 115:c1-6. 2010..Hemodialysis remains the first choice among modalities of extracorporeal removal with CRRT reserved for patients who truly cannot tolerate hemodialysis...
- Effect of homocysteine lowering on mortality and vascular disease in advanced chronic kidney disease and end-stage renal disease: a randomized controlled trialRex L Jamison
Veterans Affairs Palo Alto Health Care Systems and Division of Nephrology, Department of Medicine, Stanford University School of Medicine, Stanford, California 94304, USA
JAMA 298:1163-70. 2007..Folic acid and B vitamins decrease homocysteine levels in this population but whether they lower mortality is unknown...
- Effect of cystine-binding thiol drugs on urinary cystine capacity in patients with cystinuriaDaniele J Dolin
Department of Urology, St Vincent Catholic Medical Center, 170 West 12th Streetm Cronin 205, New York, NY 10011, USA
J Endourol 19:429-32. 2005..To determine the effect of cystine-binding thiol drugs (CBTD) on urinary cystine capacity in patients with cystinuria...
- Interpretation and review of health-related quality of life data in CKD patients receiving treatment for anemiaDavid E Leaf
Department of Medicine, New York University School of Medicine, New York, New York, USA
Kidney Int 75:15-24. 2009..Beyond this range, additional normalization of hemoglobin (to 12-14 g/dl) results in continued (albeit blunted) improvements in HRQOL...
- The sorcerer's stoneDavid S Goldfarb
Kidney Stone Prevention Programs, New York VA Medical Center, New York, NY, USA
Pharos Alpha Omega Alpha Honor Med Soc 69:36-7. 2006
- The association of nephrolithiasis with hypertension and obesity: a reviewSergio H Obligado
Nephrology Section, New York University School of Medicine, New York, New York, USA
Am J Hypertens 21:257-64. 2008..In those patients in whom dietary modification and weight loss are ineffective, thiazide diuretics are likely to improve blood pressure control and decrease calciuria...
- Gout and its comorbiditiesMichael H Pillinger
New York University School of Medicine, NYU Hospital for Joint Diseases, New York, NY 10003, USA
Bull NYU Hosp Jt Dis 68:199-203. 2010..In addition, we briefly consider several neurological conditions in which the presence of gout or a high serum urate level may be associated with less disease, rather than more...
- The role of continuous renal replacement therapy in the treatment of poisoningJeffrey W Goodman
Nephrology Section, New York Harbor VA Medical Center, New York, New York 10010, USA
Semin Dial 19:402-7. 2006..We believe that the intelligent application of extracorporeal modalities requires a thorough knowledge of drug pharmacokinetics, of the techniques utilized, and a skeptical analysis of the available literature...
- Chitosan does not reduce post-prandial urinary oxalate excretionJoshua Wolf
Nephrology Section, University of California at San Francisco Medical Center, San Francisco, CA, and Nephrology Section, New York Harbor VAMC, Department of Urology, St Vincents Hospital, New York, NY 10010, USA
Urol Res 34:227-30. 2006..3+/-16.9 mg/g creatinine (P=0.57, NS). We conclude that chitosan does not reduce acute intestinal oxalate absorption and therefore does not affect post-prandial urinary oxalate excretion...
- Asymptomatic nephrolithiasis detected by ultrasoundAmar D Bansal
Department of Medicine, New York University School of Medicine, New York, New York, USA
Clin J Am Soc Nephrol 4:680-4. 2009..However, these studies have not analyzed the effect that increases in utilization of imaging modalities have had on detection of asymptomatic stones...
- Treatment of pregabalin toxicity by hemodialysis in a patient with kidney failureLawrence Yoo
Division of Nephrology, New York University Medical Center, New York, NY 10010, USA
Am J Kidney Dis 54:1127-30. 2009..23 Da), relatively low volume of distribution (0.5 L/kg), and not bound to plasma proteins. We achieved hemodialysis clearance of 88.8 mL/min, which was associated with resolution of symptoms immediately after hemodialysis...
- Use of hemodialysis and hemoperfusion in poisoned patientsWilliam J Holubek
Department of Emergency Medicine, New York Methodist Hospital, New York, New York, USA
Kidney Int 74:1327-34. 2008..Our study shows that the profile of toxins and the type of extracorporeal technique used to remove the toxins have changed over the years...
- Patients at the center: in our practice, and in our use of languageDavid S Goldfarb
New York Harbor VA Medical Center, NYU School of Medicine, New York, New York, USA
ACP J Club 140:A14; author reply A14-5. 2004