Dmitri V Zaykin

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. pmc Correlation-based inference for linkage disequilibrium with multiple alleles
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genetics 180:533-45. 2008
  2. pmc Interval estimation of genetic susceptibility for retrospective case-control studies
    Dmitri V Zaykin
    Department of Population Genetics, GlaxoSmithKline Inc, Research Triangle Park NC 27709, USA
    BMC Genet 5:9. 2004
  3. ncbi Bounds and normalization of the composite linkage disequilibrium coefficient
    Dmitri V Zaykin
    Genetic Data Sciences, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:252-7. 2004
  4. pmc Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects
    Kyoko Shibata
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 33:63-78. 2009
  5. pmc Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 78:737-46. 2006
  6. pmc Combining p-values in large-scale genomics experiments
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Pharm Stat 6:217-26. 2007
  7. pmc Ranks of genuine associations in whole-genome scans
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 171:813-23. 2005
  8. pmc Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations
    Dmitri V Zaykin
    GlaxoSmithKline, Inc, Genetic Data Sciences, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 6:77-89. 2005
  9. ncbi Effectiveness of computational methods in haplotype prediction
    Chun Fang Xu
    Discovery Genetics, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
    Hum Genet 110:148-56. 2002
  10. pmc Novel rank-based approaches for discovery and replication in genome-wide association studies
    Chia Ling Kuo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 189:329-40. 2011

Detail Information

Publications15

  1. pmc Correlation-based inference for linkage disequilibrium with multiple alleles
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genetics 180:533-45. 2008
    ..Calculation of the new multiallele test statistic and its P-value is very simple and utilizes the approximate distribution of R2. We provide a computer program that evaluates approximate as well as "exact" permutational P-values...
  2. pmc Interval estimation of genetic susceptibility for retrospective case-control studies
    Dmitri V Zaykin
    Department of Population Genetics, GlaxoSmithKline Inc, Research Triangle Park NC 27709, USA
    BMC Genet 5:9. 2004
    ..This article describes classical and Bayesian interval estimation of genetic susceptibility based on random samples with pre-specified numbers of unrelated cases and controls...
  3. ncbi Bounds and normalization of the composite linkage disequilibrium coefficient
    Dmitri V Zaykin
    Genetic Data Sciences, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 27:252-7. 2004
    ..They provide standardized measures of composite linkage disequilibrium, defined as the proportion of its maximum attainable value, given observed allele or genotype frequencies...
  4. pmc Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effects
    Kyoko Shibata
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
    Genet Epidemiol 33:63-78. 2009
    ..An illustrative example of usefulness of the method is discussed, utilizing analysis of multilocus effects within the catechol-O-methyltransferase gene...
  5. pmc Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Am J Hum Genet 78:737-46. 2006
    ....
  6. pmc Combining p-values in large-scale genomics experiments
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
    Pharm Stat 6:217-26. 2007
    ..GM gives somewhat higher power than TPM, RTP, Fisher, and Simes methods across a range of simulations...
  7. pmc Ranks of genuine associations in whole-genome scans
    Dmitri V Zaykin
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 171:813-23. 2005
    ..Effects of multilocus (e.g., haplotype association) tests and impact of linkage disequilibrium on the distribution of ranks associated with TAs are evaluated and can be taken into account...
  8. pmc Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerations
    Dmitri V Zaykin
    GlaxoSmithKline, Inc, Genetic Data Sciences, Research Triangle Park, NC 27709, USA
    Pharmacogenomics 6:77-89. 2005
    ..RP is a straightforward way to create realistic subgroups, and prediction intervals for the within-subgroup disease incidence are easily obtained...
  9. ncbi Effectiveness of computational methods in haplotype prediction
    Chun Fang Xu
    Discovery Genetics, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
    Hum Genet 110:148-56. 2002
    ..However, none of the methods was accurate in predicting individual haplotype phases. The EM and the PHASE methods provided better estimates for overall haplotype frequencies than the subtraction method for both genomic regions...
  10. pmc Novel rank-based approaches for discovery and replication in genome-wide association studies
    Chia Ling Kuo
    National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
    Genetics 189:329-40. 2011
    ..Further, we relate ranking probabilities to the proportion of false discoveries among top u SNPs. A study-specific proportion can be estimated from P-values, and its expected value can be predicted for study design applications...
  11. ncbi Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individuals
    Dmitri V Zaykin
    GlaxoSmithKline Inc, Discovery Genetics, Research Triangle Park, NC 27709, USA
    Hum Hered 53:79-91. 2002
    ..The method appears to be successful in relating data from multiple, correlated markers to response...
  12. pmc Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associations
    Dahlia M Nielsen
    Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
    Genetics 168:1029-40. 2004
    ..Single-marker tests tend to prevail when pairwise LD is high. For moderate pairwise values and weak multilocus LD, either testing strategy may come out ahead, although it is also quite likely that neither has much power...
  13. pmc Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypes
    Zhaoling Meng
    Bioinformatics Research Center, Campus Box 7566, North Carolina State University, Raleigh, NC 27695 7566, USA
    Am J Hum Genet 73:115-30. 2003
    ..We also show that haplotype-association results that Hosking et al. obtained near CYP2D6 were almost identical before and after marker selection...
  14. ncbi Multiple tests for genetic effects in association studies
    Peter H Westfall
    Texas Tech University, Lubbock, TX, USA
    Methods Mol Biol 184:143-68. 2002
  15. pmc Genetic flip-flop without an accompanying change in linkage disequilibrium
    Dmitri V Zaykin
    Am J Hum Genet 82:794-6; author reply 796-7. 2008