Research Topics
| Dmitri V ZaykinSummaryAffiliation: GlaxoSmithKline Research and Development Country: USA Publications
| Collaborators
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Detail Information
Publications
Correlation-based inference for linkage disequilibrium with multiple allelesDmitri V Zaykin
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Genetics 180:533-45. 2008..We provide a computer program that evaluates approximate as well as "exact" permutational P-values...- Interval estimation of genetic susceptibility for retrospective case-control studiesDmitri V Zaykin
Department of Population Genetics, GlaxoSmithKline Inc, Research Triangle Park NC 27709, USA
BMC Genet 5:9. 2004..This article describes classical and Bayesian interval estimation of genetic susceptibility based on random samples with pre-specified numbers of unrelated cases and controls... - Bounds and normalization of the composite linkage disequilibrium coefficientDmitri V Zaykin
Genetic Data Sciences, GlaxoSmithKline Inc, Research Triangle Park, North Carolina 27709, USA
Genet Epidemiol 27:252-7. 2004..They provide standardized measures of composite linkage disequilibrium, defined as the proportion of its maximum attainable value, given observed allele or genotype frequencies... - Haplotype associations with quantitative traits in the presence of complex multilocus and heterogeneous effectsKyoko Shibata
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Genet Epidemiol 33:63-78. 2009..An illustrative example of usefulness of the method is discussed, utilizing analysis of multilocus effects within the catechol-O-methyltransferase gene... - Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping methodDmitri V Zaykin
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Am J Hum Genet 78:737-46. 2006.... - Combining p-values in large-scale genomics experimentsDmitri V Zaykin
National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA
Pharm Stat 6:217-26. 2007..GM gives somewhat higher power than TPM, RTP, Fisher, and Simes methods across a range of simulations... - Ranks of genuine associations in whole-genome scansDmitri V Zaykin
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Genetics 171:813-23. 2005..Effects of multilocus (e.g., haplotype association) tests and impact of linkage disequilibrium on the distribution of ranks associated with TAs are evaluated and can be taken into account... - Large recursive partitioning analysis of complex disease pharmacogenetic studies. II. Statistical considerationsDmitri V Zaykin
GlaxoSmithKline, Inc, Genetic Data Sciences, Research Triangle Park, NC 27709, USA
Pharmacogenomics 6:77-89. 2005..RP is a straightforward way to create realistic subgroups, and prediction intervals for the within-subgroup disease incidence are easily obtained... - Effectiveness of computational methods in haplotype predictionChun Fang Xu
Discovery Genetics, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, UK
Hum Genet 110:148-56. 2002..However, none of the methods was accurate in predicting individual haplotype phases. The EM and the PHASE methods provided better estimates for overall haplotype frequencies than the subtraction method for both genomic regions... - Novel rank-based approaches for discovery and replication in genome-wide association studiesChia Ling Kuo
National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA
Genetics 189:329-40. 2011..Further, we relate ranking probabilities to the proportion of false discoveries among top u SNPs. A study-specific proportion can be estimated from P-values, and its expected value can be predicted for study design applications... - Testing association of statistically inferred haplotypes with discrete and continuous traits in samples of unrelated individualsDmitri V Zaykin
GlaxoSmithKline Inc, Discovery Genetics, Research Triangle Park, NC 27709, USA
Hum Hered 53:79-91. 2002..The method appears to be successful in relating data from multiple, correlated markers to response... - Effect of two- and three-locus linkage disequilibrium on the power to detect marker/phenotype associationsDahlia M Nielsen
Program in Statistical Genetics, Department of Statistics, North Carolina State University, Raleigh, North Carolina 27695 7566, USA
Genetics 168:1029-40. 2004..Single-marker tests tend to prevail when pairwise LD is high. For moderate pairwise values and weak multilocus LD, either testing strategy may come out ahead, although it is also quite likely that neither has much power... - Selection of genetic markers for association analyses, using linkage disequilibrium and haplotypesZhaoling Meng
Bioinformatics Research Center, Campus Box 7566, North Carolina State University, Raleigh, NC 27695 7566, USA
Am J Hum Genet 73:115-30. 2003..We also show that haplotype-association results that Hosking et al. obtained near CYP2D6 were almost identical before and after marker selection... - Multiple tests for genetic effects in association studiesPeter H Westfall
Texas Tech University, Lubbock, TX, USA
Methods Mol Biol 184:143-68. 2002 - Genetic flip-flop without an accompanying change in linkage disequilibriumDmitri V Zaykin
Am J Hum Genet 82:794-6; author reply 796-7. 2008