Robert J Slack

Summary

Affiliation: GlaxoSmithKline Research and Development
Country: USA

Publications

  1. doi request reprint In vitro characterisation of the duration of action of the histamine-1 receptor antagonist azelastine
    Robert J Slack
    Respiratory CEDD Biology, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, UK
    Eur J Pharmacol 670:586-92. 2011
  2. doi request reprint In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action
    Robert J Slack
    Respiratory TAU, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
    J Pharmacol Exp Ther 344:218-30. 2013
  3. doi request reprint Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Med Chem 56:1946-60. 2013
  4. doi request reprint Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists
    Panayiotis A Procopiou
    Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    Bioorg Med Chem 20:6097-108. 2012
  5. doi request reprint Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, Respiratory CEDD, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom
    Bioorg Med Chem Lett 22:2730-3. 2012
  6. doi request reprint The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
    J Med Chem 54:2183-95. 2011

Detail Information

Publications6

  1. doi request reprint In vitro characterisation of the duration of action of the histamine-1 receptor antagonist azelastine
    Robert J Slack
    Respiratory CEDD Biology, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire, UK
    Eur J Pharmacol 670:586-92. 2011
    ..These studies indicate there is a tissue component contributing to azelastine's duration of action, in addition to its direct H₁ receptor binding, with evidence suggesting a role for the epithelial layer...
  2. doi request reprint In vitro pharmacological characterization of vilanterol, a novel long-acting β2-adrenoceptor agonist with 24-hour duration of action
    Robert J Slack
    Respiratory TAU, GlaxoSmithKline, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, UK
    J Pharmacol Exp Ther 344:218-30. 2013
    ..This pharmacological profile combined with clinical data is consistent with once a day dosing of vilanterol in the treatment of both asthma and chronic obstructive pulmonary disease (COPD)...
  3. doi request reprint Synthesis and structure-activity relationships of indazole arylsulfonamides as allosteric CC-chemokine receptor 4 (CCR4) antagonists
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    J Med Chem 56:1946-60. 2013
    ..X-ray diffraction studies on two indazole sulfonamide fragments suggested the presence of an important intramolecular interaction in the active conformation...
  4. doi request reprint Synthesis and pharmacological investigation of azaphthalazinone human histamine H(1) receptor antagonists
    Panayiotis A Procopiou
    Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, United Kingdom
    Bioorg Med Chem 20:6097-108. 2012
    ..The pharmacological profile of 44 was very similar to our intranasal clinical candidate 1...
  5. doi request reprint Lead optimisation of the N1 substituent of a novel series of indazole arylsulfonamides as CCR4 antagonists and identification of a candidate for clinical investigation
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, Respiratory CEDD, GlaxoSmithKline Medicines Research Centre, Stevenage, Hertfordshire, United Kingdom
    Bioorg Med Chem Lett 22:2730-3. 2012
    ..Synthesis and preliminary SAR of the N1 substituent of a novel series of indazole sulfonamide chemokine receptor 4 (CCR4) antagonist is reported. Compound 7r was identified for further development...
  6. doi request reprint The discovery of phthalazinone-based human H1 and H3 single-ligand antagonists suitable for intranasal administration for the treatment of allergic rhinitis
    Panayiotis A Procopiou
    Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire, SG1 2NY, United Kingdom
    J Med Chem 54:2183-95. 2011
    ....