- Pharmacological properties of the enhanced-affinity glucocorticoid fluticasone furoate in vitro and in an in vivo model of respiratory inflammatory diseaseMark Salter
Global Project Management, Bldg 1, GlaxoSmithKline, Park Rd, Ware SG12 0DP, UK
Am J Physiol Lung Cell Mol Physiol 293:L660-7. 2007..In conclusion, the potent and selective pharmacological profile of FF described here could deliver an effective, safe, and sustained topical treatment of respiratory inflammatory diseases such as allergic rhinitis and asthma...
- Design and synthesis of new nonsteroidal glucocorticoid modulators through application of an "agreement docking" methodMike Barker
RI CEDD, GlaxoSmithKline Medicines Research Centre, Stevenage, UK
J Med Chem 48:4507-10. 2005..The method was validated by the syntheses of 9 and related analogues, which are potent binders of GR. 15a is a partial agonist while 9e and 15a are micromolar antagonists in a mouse mammary tumor virus transactivation assay...